Transient selective brain cooling confers neurovascular and functional protection from acute to chronic stages of ischemia/reperfusion brain injury

Regulatory T-cells within bone marrow-derived stem cells actively confer immunomodulatory and neuroprotective effects against stroke

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Endovascular treatment for acute ischaemic stroke in routine clinical practice: prospective, observational cohort study (MR CLEAN Registry)

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Synergistically Induced Hypothermia and Enhanced Neuroprotection by Pharmacological and Physical Approaches in Stroke

(2018) Jun Zhang et al.   Aging and Disease

Dimethyl fumarate improves white matter function following severe hypoperfusion: Involvement of microglia/macrophages and inflammatory mediators

(2017) Jill H Fowler et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The vascular basement membrane in the healthy and pathological brain

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How long is sufficient for optimal neuroprotection with cerebral cooling after ischemia in fetal sheep?

(2017) Joanne O Davidson et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Longitudinal MRI evaluation of neuroprotective effects of pharmacologically induced hypothermia in experimental ischemic stroke

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Endothelium-targeted overexpression of heat shock protein 27 ameliorates blood–brain barrier disruption after ischemic brain injury

(2017) Yejie Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRPV1-mediated Pharmacological Hypothermia Promotes Improved Functional Recovery Following Ischemic Stroke

(2017) Zhijuan Cao et al.   Scientific Reports

Posttraumatic therapeutic hypothermia alters microglial and macrophage polarization toward a beneficial phenotype

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Regulation of therapeutic hypothermia on inflammatory cytokines, microglia polarization, migration and functional recovery after ischemic stroke in mice

(2016) Jin Hwan Lee et al.   NEUROBIOLOGY OF DISEASE

Macrophages are essential for maintaining a M2 protective response early after ischemic brain injury

(2016) Carlo Perego et al.   NEUROBIOLOGY OF DISEASE

Pharmacological hypothermia: a potential for future stroke therapy?

(2016) Kaiyin Liu et al.   NEUROLOGICAL RESEARCH

APE1/Ref-1 facilitates recovery of gray and white matter and neurological function after mild stroke injury

(2016) R. Anne Stetler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapid endothelial cytoskeletal reorganization enables early blood–brain barrier disruption and long-term ischaemic reperfusion brain injury

(2016) Yejie Shi et al.   Nature Communications

White matter injury and microglia/macrophage polarization are strongly linked with age-related long-term deficits in neurological function after stroke

(2015) Jun Suenaga et al.   EXPERIMENTAL NEUROLOGY

Therapeutic hypothermia for stroke: Where to go?

(2015) Ziping Han et al.   EXPERIMENTAL NEUROLOGY

European Stroke Organisation (ESO) Guidelines for the Management of Temperature in Patients with Acute Ischemic Stroke

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HDAC inhibition prevents white matter injury by modulating microglia/macrophage polarization through the GSK3β/PTEN/Akt axis

(2015) Guohua Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Very Mild Hypothermia (35°C) Postischemia Reduces Infarct Volume and Blood/Brain Barrier Breakdown Following tPA Treatment in the Mouse

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EuroHYP-1: European Multicenter, Randomized, Phase III Clinical Trial of Therapeutic Hypothermia plus Best Medical Treatment vs. Best Medical Treatment Alone for Acute Ischemic Stroke

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The effect of a microcatheter-based selective intra-arterial hypothermia on hemodynamic changes following transient cerebral ischemia

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Molecular dialogs between the ischemic brain and the peripheral immune system: Dualistic roles in injury and repair

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Drug-Induced Hypothermia in Stroke Models: Does it Always Protect?

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IL-10-producing B-cells limit CNS inflammation and infarct volume in experimental stroke

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Feasibility of hypothermia beyond 3weeks in severe ischemic stroke

(2012) Isabelle Mourand et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Neuroprotective mechanisms of hypothermia in brain ischaemia

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Microglia/Macrophage Polarization Dynamics Reveal Novel Mechanism of Injury Expansion After Focal Cerebral Ischemia

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Spatiotemporal Characteristics of Postischemic Hyperperfusion with Respect to Changes in T1, T2, Diffusion, Angiography, and Blood–Brain Barrier Permeability

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Oligodendrocyte vulnerability following traumatic brain injury in rats

(2011) George Lotocki et al.   NEUROSCIENCE LETTERS

Local Brain Temperature Reduction Through Intranasal Cooling With the RhinoChill Device

(2011) Alex Abou-Chebl et al.   STROKE

Oligodendrocyte Vulnerability Following Traumatic Brain Injury in Rats: Effect of Moderate Hypothermia

(2011) George Lotocki et al.   Therapeutic Hypothermia and Temperature Management

The dual role of the neuroinflammatory response after ischemic stroke: modulatory effects of hypothermia

(2010) An-Gaëlle Ceulemans et al.   Journal of Neuroinflammation

Hypothermia as a cytoprotective strategy in ischemic tissue injury

(2009) Xian N. Tang et al.   AGEING RESEARCH REVIEWS

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(2009) Kees H. Polderman   CRITICAL CARE MEDICINE

When Hypothermia Meets Hypotension and Hyperglycemia: The Diverse Effects of Adenosine 5′-Monophosphate on Cerebral Ischemia in Rats

(2009) Feng Zhang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The Protective Effect of Early Hypothermia on PTEN Phosphorylation Correlates with Free Radical Inhibition in Rat Stroke

(2009) Sang Mi Lee et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Induced hypothermia and fever control for prevention and treatment of neurological injuries

(2008) Kees H Polderman   LANCET

Hypothermia effects on neurovascular coupling and cerebral metabolic rate of oxygen

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Review: Therapeutic applications of hypothermia in cerebral ischaemia

(2008) Bruno P. Meloni et al.   Therapeutic Advances in Neurological Disorders