Potential use of melatonin in skin cancer treatment: A review of current biological evidence

Mitochondrial cytochrome P450 (CYP) 1B1 is responsible for melatonin-induced apoptosis in neural cancer cells

(2018) Zhenlong Yu et al.   JOURNAL OF PINEAL RESEARCH

Temporal Trends in Treatment and Subsequent Neoplasm Risk Among 5-Year Survivors of Childhood Cancer, 1970-2015

(2017) Lucie M. Turcotte et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Human transporters, PEPT1/2, facilitate melatonin transportation into mitochondria of cancer cells: An implication of the therapeutic potential

(2017) Xiaokui Huo et al.   JOURNAL OF PINEAL RESEARCH

Intratumor and Intertumor Heterogeneity in Melanoma

(2017) Tomasz M. Grzywa et al.   Translational Oncology

DNA methylation/hydroxymethylation in melanoma

(2017) Siqi Fu et al.   Oncotarget

Overcoming resistance to targeted therapy with immunotherapy and combination therapy for metastatic melanoma

(2017) Hilary R. Keller et al.   Oncotarget

Challenging the standard of care in advanced melanoma: focus on pembrolizumab

(2017) Raghad Abdul-Karim et al.   Cancer Management and Research

Hsp70 suppresses apoptosis of BRL cells by regulating the expression of Bcl-2, cytochrome C, and caspase 8/3

(2016) Fanzhi Kong et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Cancer metastasis: Mechanisms of inhibition by melatonin

(2016) Shih-Chi Su et al.   JOURNAL OF PINEAL RESEARCH

The natural anthraquinones from Rheum palmatum induced the metabolic disorder of melatonin by inhibiting human CYP and SULT enzymes

(2016) Weiru Jiang et al.   TOXICOLOGY LETTERS

Sex-specific genetic effects associated with pigmentation, sensitivity to sunlight, and melanoma in a population of Spanish origin

(2016) Barbara Hernando et al.   Biology of Sex Differences

Highlights of Recent Findings on Quality-of-Life Management for Patients With Cancer and Their Survivors

(2016) Charles L. Shapiro   JAMA Oncology

Sulfation of melatonin: Enzymatic characterization, differences of organs, species and genders, and bioactivity variation

(2015) Xiangge Tian et al.   BIOCHEMICAL PHARMACOLOGY

How the environment shapes cancer genomes

(2015) Gerd P. Pfeifer   CURRENT OPINION IN ONCOLOGY

Antioxidant Supplementation on Cancer Risk and During Cancer Therapy: An Update

(2015) Tomris Ozben   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Melatonin as a possible antidote to UV radiation induced cutaneous damages and immune-suppression: An overview

(2015) Soumik Goswami et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Melatonin sensitizes human cervical cancer HeLa cells to cisplatin-induced cytotoxicity and apoptosis: effects on oxidative stress and DNA fragmentation

(2015) Roberto Pariente et al.   JOURNAL OF PINEAL RESEARCH

Pan-cancer analysis of the extent and consequences of intratumor heterogeneity

(2015) Noemi Andor et al.   NATURE MEDICINE

Extracellular Hsp70: Export and Function

(2014) Antonio De Maio   CURRENT PROTEIN & PEPTIDE SCIENCE

Melatonin compensates silencing of heat shock protein 70 and suppresses ultraviolet radiation-induced inflammation in human skin ex vivo and cultured keratinocytes

(2014) Konrad Kleszczyński et al.   JOURNAL OF PINEAL RESEARCH

Comparative efficacy and the window of radioprotection for adrenergic and serotoninergic agents and aminothiols in experiments with small and large animals

(2014) M. V. Vasin et al.   JOURNAL OF RADIATION RESEARCH

Melatonin Combined with Endoplasmic Reticulum Stress Induces Cell Death via the PI3K/Akt/mTOR Pathway in B16F10 Melanoma Cells

(2014) Han Sung Kim et al.   PLoS One

Melatonin Enhances the Anti-Tumor Effect of Fisetin by Inhibiting COX-2/iNOS and NF-κB/p300 Signaling Pathways

(2014) Canhui Yi et al.   PLoS One

Pharmacological doses of melatonin induce alterations in mitochondrial mass and potential, bcl-2 levels and K+currents in UVB-exposed U937 cells

(2013) Barbara Canonico et al.   CELL BIOLOGY INTERNATIONAL

Human cytochromes P450 in health and disease

(2013) D. W. Nebert et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Coordinate Autophagy and mTOR Pathway Inhibition Enhances Cell Death in Melanoma

(2013) Xiaoqi Xie et al.   PLoS One

The efficacy and safety of melatonin in concurrent chemotherapy or radiotherapy for solid tumors: a meta-analysis of randomized controlled trials

(2012) Ye-min Wang et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Melatonin prevents ultraviolet radiation-induced alterations in plasma membrane potential and intracellular pH in human keratinocytes

(2012) Konrad Kleszczyński et al.   JOURNAL OF PINEAL RESEARCH

A review of the molecular aspects of melatonin’s anti-inflammatory actions: recent insights and new perspectives

(2012) José L. Mauriz et al.   JOURNAL OF PINEAL RESEARCH

Melatonin and Metformin Inhibit Skin Carcinogenesis and Lipid Peroxidation Induced by Benz(a)pyrene in Female Mice

(2011) T. A. Man’cheva et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Melatonin Induces Apoptotic Cell Death via p53 in LNCaP Cells

(2011) Chi Hyun Kim et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Efficacy and Safety of Melatonin as an Anxiolytic and Analgesic in the Perioperative Period

(2010) Farhanah Yousaf et al.   ANESTHESIOLOGY

Antiinflammatory Activity of Melatonin in Central Nervous System

(2010) Emanuela Esposito et al.   Current Neuropharmacology

Vertical Inhibition of the mTORC1/mTORC2/PI3K Pathway Shows Synergistic Effects against Melanoma In Vitro and In Vivo

(2010) Johannes Werzowa et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The melatonin-producing system is fully functional in retinal pigment epithelium (ARPE-19)

(2009) Michał A. Żmijewski et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

MC1R variants, melanoma and red hair color phenotype: A meta-analysis

(2008) Sara Raimondi et al.   INTERNATIONAL JOURNAL OF CANCER

Melatonin maintains mitochondrial membrane potential and attenuates activation of initiator (casp-9) and effector caspases (casp-3/casp-7) and PARP in UVR-exposed HaCaT keratinocytes

(2008) T. W. Fischer et al.   JOURNAL OF PINEAL RESEARCH

Cytochrome P450 and Chemical Toxicology

(2007) F. Peter Guengerich   CHEMICAL RESEARCH IN TOXICOLOGY