期刊
JOURNAL OF CELLULAR PHYSIOLOGY
卷 234, 期 6, 页码 7948-7956出版社
WILEY
DOI: 10.1002/jcp.28014
关键词
demethylases; m(6)A; methyltransferases; mRNA methylation
资金
- National Natural Science Foundation of China [31572413]
- Natural Science Foundation ofZhejiang Province [LZ17C1700001]
N-6-methyladenosine (m(6)A), as the most abundant RNA epigenetic modifications, has been shown to play critical roles in various biological functions. Research about enzymes that can catalyze and remove m(6)A have revealed its comprehensive roles in messenger RNA (mRNA) metabolism and other physiological processes. The readers including YTH domain-containing proteins, hnRNPC, hnRNPG, hnRNPA2B1, IGF2BP1, IGF2BP2, and IGF2BP3, which can affect the fates of mRNA in an m(6)A-dependent manner. In this review, we focus on recent advances in the research of the m(6)A modifications, especially about the latest functions of its writers, erasers, readers in RNA metabolism, cancer, and lipid metabolism. In the end, we provide insights into the underlying molecular mechanisms of m(6)A modifications.
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