Review
Endocrinology & Metabolism
Ziwei Zhang, Qingxia Huang, Daqing Zhao, Fengmei Lian, Xiangyan Li, Wenxiu Qi
Summary: Diabetes mellitus (DM) is a metabolic disease characterized by chronic hyperglycemia, with insulin deficiency or resistance as the main cause, leading to damage in various target organs. Oxidative stress, resulting from an imbalance between free radicals production and antioxidant scavenging, is one of the main mechanisms linking DM and its complications. This paper reviews the dysfunction of mitochondria induced by high glucose-induced oxidative stress in the DM model and proposes a new treatment plan based on mitochondrial dysfunction.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Pharmacology & Pharmacy
Bao Sun, Shiqiong Huang, Jiecan Zhou
Summary: Diabetes mellitus increases the risk of viral infections, especially in cases of poor glycemic control. Patients with diabetes who are acutely unwell with suspected or confirmed COVID-19 face complex management and therapy. Antidiabetic agents play a crucial role in DM patients with coronavirus infection, guiding clinical therapeutic choices.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Natalia Belosludtseva, Vlada S. Starinets, Irina B. Mikheeva, Maxim N. Belosludtsev, Mikhail Dubinin, Galina D. Mironova, Konstantin N. Belosludtsev
Summary: Long-term hyperglycemia in diabetes mellitus can cause damage to cardiomyocytes and dysfunction in heart mitochondria. However, the use of uridine, a pyrimidine nucleoside, has been found to improve cardiac function, restore mitochondrial homeostasis, and protect against structural and functional damage to cardiac mitochondria in diabetic mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Emmanuel Makinde, Linlin Ma, George D. Mellick, Yunjiang Feng
Summary: Mitochondria are essential for energy metabolism and play key roles in calcium homeostasis, ROS balance, cell apoptosis, and biosynthetic pathways. Disruption of mitochondrial function is associated with various diseases. This review discusses the physiological and pathological functions of mitochondria, as well as bioactive compounds that protect mitochondria and their mechanisms of action. The article provides insights into promising compounds, challenges in therapeutic use, and future research directions on mitochondrial modulators.
Article
Medicine, General & Internal
Aarti Singh, Danilo Faccenda, Michelangelo Campanella
Summary: Mitochondria are crucial in cellular metabolism and are involved in various cellular processes. Dysfunctions in mitochondria are linked with a wide range of pathologies, and research is focused on developing novel compounds to correct mitochondrial aberrations for the treatment of related diseases.
Article
Biochemistry & Molecular Biology
Thiri Wai Linn, Anongporn Kobroob, Metas Ngernjan, Doungporn Amornlerdpison, Narissara Lailerd, Orawan Wongmekiat
Summary: The study found that long-term supplementation of crocodile oil did not improve the development of diabetic nephropathy in spontaneously diabetic Torii rats, but instead exacerbated kidney and mitochondrial dysfunction caused by diabetes. This may be due to the imbalanced omega-6: omega-3 ratio in crocodile oil.
Article
Biochemistry & Molecular Biology
Konstantin N. Belosludtsev, Vlada S. Starinets, Eugeny Yu Talanov, Irina B. Mikheeva, Mikhail Dubinin, Natalia Belosludtseva
Summary: Alisporivir has a positive impact on glucose utilization in diabetic mice, preventing diabetes-induced changes in mitochondrial ultrastructure and ATP synthase levels, and restoring mitochondrial function. Additionally, Alisporivir modulates mitochondrial gene expression, inhibits sensitivity to MPT pore opening, and normalizes mitochondrial dynamics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Krish Chandrasekaran, Neda Najimi, Avinash R. Sagi, Sushuma Yarlagadda, Mohammad Salimian, Muhammed Ikbal Arvas, Ahmad F. Hedayat, Yanni Kevas, Anand Kadakia, James W. Russell
Summary: Administration of NAD(+) precursors, NMN or NR, can prevent diabetic peripheral neuropathy, improve sensory function, and prevent nerve fiber loss.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Guo-Wei Zong, Wan-Ying Wang, Jun Zheng, Wei Zhang, Wei-Ming Luo, Zhong-Ze Fang, Qiang Zhang
Summary: The metabolic profile of DR patients in the early stages may have changed, suggesting the potential of metabolites to become new biomarkers. A metabolite-based prediction model for DR risk was constructed using amino acid and acylcarnitine variables, which had the best comprehensive evaluation and is valuable for predicting DR risk.
JOURNAL OF DIABETES RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Elisa Martino, Amalia Luce, Anna Balestrieri, Luigi Mele, Camilla Anastasio, Nunzia D'Onofrio, Maria Luisa Balestrieri, Giuseppe Campanile
Summary: Endothelial dysfunction plays a critical role in the progression of type 2 diabetes mellitus (T2DM), leading to cardiovascular complications. Whey (WH), a dairy by-product with a considerable content of bioactive compounds, showed protective effects on human endothelial cell function under diabetic conditions mimicked in vitro.
Review
Endocrinology & Metabolism
Yuyan Zhu, Xuan Xia, Qian He, Qing-Ao Xiao, Decheng Wang, Meirong Huang, Xiaolin Zhang
Summary: Neutrophil extracellular traps (NETs) are released by activated neutrophils and consist of antimicrobial proteins and DNA. NETosis, a form of neutrophilic cell death, plays a crucial role in diabetes and its complications. Increased levels of NETs in the blood of diabetic patients confirm the association between NETosis and complications such as impaired wound healing, retinopathy, and atherosclerosis. This article summarizes the mechanisms of NETosis and discusses potential therapeutic targets using small molecule compounds.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biology
Natalia Belosludtseva, Vlada S. Starinets, Irina B. Mikheeva, Dmitriy A. Serov, Maxim E. Astashev, Maxim N. Belosludtsev, Mikhail Dubinin, Konstantin N. Belosludtsev
Summary: Diabetes mellitus is a systemic metabolic disorder associated with mitochondrial dysfunction, and targeting mitochondrial dysfunction with alisporivir, a non-immunosuppressive cyclosporin derivative, can alleviate the development of mitochondrial dysfunction in the diabetic heart. Alisporivir appears to act as a mitochondria-targeted metabolic reprogramming agent, attenuating oxidative damage and stimulating mitophagy in cardiomyocytes of diabetic mice.
Review
Cell Biology
Yifan Wu, Huixin Lan, Deju Zhang, Ziyan Hu, Jing Zhang, Zhangwang Li, Panpan Xia, Xiaoyi Tang, Xia Cai, Peng Yu
Summary: This review summarizes the research progress on the regulation of mitochondrial dynamics by noncoding RNAs in diabetes and its complications, which provides a promising direction for the development of antibodies or targeted drugs in the future.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Zhiwei Zhang, Xiaowei Zhang, Lei Meng, Mengqi Gong, Jian Li, Wen Shi, Jiuchun Qiu, Yajuan Yang, Jianping Zhao, Ya Suo, Xue Liang, Xinghua Wang, Gary Tse, Ning Jiang, Guangping Li, Yungang Zhao, Tong Liu
Summary: Diabetes induces adverse atrial structural and electrophysiological remodeling as well as mitochondrial damage and dysfunction, which can be prevented by pioglitazone through the PPAR-gamma/PGC-1 alpha pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Food Science & Technology
Susmita Barman, Krishnapura Srinivasan
Summary: Zinc plays a crucial role in the synthesis, storage, and secretion of insulin. Studies have shown that supplementing with zinc can reduce hyperglycemia, improve metabolic abnormalities and antioxidant status, and alleviate complications associated with diabetes. Additionally, zinc can also alleviate renal lesions, cataract, cardiovascular disease risk, and restore gastrointestinal health in experimental diabetes.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Cell Biology
Habib Yaribeygi, Mina Maleki, Fatemeh Nasimi, Alexandra E. Butler, Tannaz Jamialahmadi, Amirhossein Sahebkar
Summary: SGLT2 inhibitors may enhance hematopoiesis and stimulate erythropoiesis in diabetic patients, potentially providing additional benefits.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Habib Yaribeygi, Mina Maleki, Thozhukat Sathyapalan, Tannaz Jamialahmadi, Amirhossein Sahebkar
Summary: Type 2 diabetes is a major cause of mortality and morbidity worldwide, often leading to long-term complications such as diabetic nephropathy. Preventing and delaying the development of diabetic nephropathy is a key goal in managing patients with type 2 diabetes. Empagliflozin, a sodium-glucose cotransporter 2 inhibitor, has been shown to have renoprotective effects in patients with type 2 diabetes. This study reviews the available clinical data on the potential renoprotective effects of empagliflozin from a mechanistic and molecular perspective.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Habib Yaribeygi, Mina Maleki, Alexandra E. Butler, Tannaz Jamialahmadi, Amirhossein Sahebkar
Summary: Epicardial adipose tissue plays a physiological role in normal heart function, but can become a cardiac risk factor in pathological conditions. Recent studies suggest that SGLT2 inhibitors can modulate epicardial adiposity and reduce the risk of cardiac complications in diabetic patients.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Habib Yaribeygi, Mina Maleki, Alexandra E. Butler, Tannaz Jamialahmadi, Amirhossein Sahebkar
Summary: SGLT2 inhibitors are a new class of antidiabetic drugs that normalize hyperglycemia through urinary glucose excretion. However, they may cause side effects such as ketoacidosis, which can negatively affect their therapeutic benefits. In this study, we present the current knowledge and shed light on the cellular pathways involved, aiming to prevent adverse side effects in diabetic patients treated with these drugs.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Habib Yaribeygi, Mina Maleki, Fatemeh Nasimi, Tannaz Jamialahmadi, Fatima C. Stanford, Amirhossein Sahebkar
Summary: The epicardial adipose tissue, known as the adipose tissue surrounding the myocardium, can cause cardiovascular problems through various mechanisms. Controlling its volume and thickness, especially in diabetic patients, is crucial. Incretin-based drugs, as newly developed antidiabetics, have the potential to reduce cardiovascular risks by regulating epicardial adiposity. This study aims to evaluate the impact of incretin-based drugs on both physiological and pathological epicardial adiposity.
CURRENT MEDICINAL CHEMISTRY
(2023)
Review
Pharmacology & Pharmacy
Bahador Bagheri, Habib Yaribeygi, Erfan Taherifard, Azita Hajhossein Talasaz, Haleh Bagheri, Mahboubeh Darban, Reza Tabrizi, Siamak Najafi, Mahmoud Khodadost, Maryam Akbari
Summary: SGLT2 inhibitors have shown promise as new medications for cardiovascular and kidney diseases, in addition to their approved use for type 2 diabetes. However, the mechanisms underlying these new benefits are not fully understood.
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2023)
Review
Medicine, General & Internal
Habib Yaribeygi, Mina Maleki, Zeljko Reiner, Tannaz Jamialahmadi, Amirhossein Sahebkar
Summary: Chronic hyperglycemia in diabetes leads to dyslipidemia, which is a major risk factor for complications such as atherosclerosis and coronary heart disease. Sodium-glucose cotransporter-2 (SGLT2) inhibitors, in addition to their hypoglycemic effects, have been shown to potentially improve lipid metabolism and prevent dyslipidemia-induced complications. However, the exact mechanisms of these benefits are not fully understood.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Habib Yaribeygi, Mina Maleki, Stephen L. Atkin, Tannaz Jamialahmadi, Amirhossein Sahebkar
Summary: Autophagy is a dual process that can promote cell survival and efficiency in normal conditions but become pathological in disease states such as diabetes. Chronic hyperglycemia induces aberrant autophagy and leads to cellular death, which is a major underlying cause of diabetes-related complications. Sodium-glucose cotransporter 2 inhibitors (SGLT2is) are newly introduced antidiabetic drugs that may have additional benefits beyond glycemic control, but their effect on autophagy remains unclear. This review aims to elucidate the potential effects of SGLT2is on autophagy.
CELL BIOCHEMISTRY AND FUNCTION
(2023)
Review
Biochemistry & Molecular Biology
Habib Yaribeygi, Mina Maleki, Stephen L. Atkin, Prashant Kesharwani, Tannaz Jamialahmadi, Amirhossein Sahebkar
Summary: COVID-19 is a systemic inflammatory disorder, and patients with underlying chronic inflammatory diseases like diabetes mellitus are at high risk of severe complications. Preventing or suppressing inflammation is crucial in diabetic patients. Sodium-glucose cotransporters-2 inhibitors (SGLT2i) are new anti-diabetic drugs with hypoglycemic effects and potential anti-inflammatory properties. Although there is no direct data in diabetic patients with COVID-19, evidence suggests that SGLT2i can reduce systemic inflammation and the cytokine storm effect through various cellular mechanisms. This review aims to categorize and describe the molecular and cellular pathways by which SGLT2i exert anti-inflammatory effects in diabetic patients with COVID-19.
Article
Medicine, General & Internal
Habib Yaribeygi, Mohammad Amin Hemmati, Fatemeh Nasimi, Mina Maleki, Tannaz Jamialahmadi, Ivan Reiner, Zeljko Reiner, Amirhossein Sahebkar
Summary: Diabetic nephropathy involves oxidative stress as one of the main pathologic mechanisms. This study aimed to evaluate the effects of the SGLT2 inhibitor empagliflozin on oxidative stress and renal function in diabetes. Results showed that empagliflozin improved renal function by reducing urea, uric acid, and creatinine levels, increasing antioxidant capacity, and reducing oxidative damage.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Seyed Ali Seyedinia, Parnia Tarahomi, Davood Abbarin, Katayoun Sedaghat, Ali Rashidy-Pour, Habib Yaribeygi, Abbas Ali Vafaei, Payman Raise-Abdullahi
Summary: This study aimed to determine the effects of saffron extract and crocin on brain oxidative stress and behavioral, motor, and cognitive deficits in an animal model of autism. The results showed that saffron and crocin can alleviate behavioral abnormalities, reduce brain oxidative stress levels, and hold promise as herbal-based pharmacological treatments for individuals with autism.
METABOLIC BRAIN DISEASE
(2023)
Review
Biology
Habib Yaribeygi, Mina Maleki, Tannaz Jamialahmadi, Seyed Adel Moallem, Amirhossein Sahebkar
Summary: Diabetic patients are more prone to liver dysfunction, making it crucial to use hypoglycemic agents to improve liver efficiency. Sodium-glucose cotransporters-2 inhibitors (SGLT2i) are newly developed antidiabetic drugs with potent glucose-lowering effects. Recent evidence suggests that they may have extra-glycemic benefits and can potentially protect the liver against different hepatic disorders. This review discusses the current knowledge about the effects of SGLT2 inhibitors on various forms of liver complications and the underlying mechanisms.
Review
Biology
Habib Yaribeygi, Mina Maleki, Alexandra E. Butler, Tannaz Jamialahmadi, Amirhossein Sahebkar
Summary: Poor cognitive ability is a growing health problem in the elderly and patients with diabetes, and the underlying cause is not well-defined. Recent studies have suggested a possible link between brain insulin signaling and cognitive ability, as insulin has extrametabolic impacts on neuronal circuits. This review discusses the role of brain insulin signaling in cognition and explores potential connections between brain insulin signaling and cognitive ability.
Review
Biology
Habib Yaribeygi, Mina Maleki, Alexandra E. Butler, Tannaz Jamialahmadi, Amirhossein Sahebkar
Summary: SGLT2is, a class of newly introduced antidiabetic drugs, have potent hypoglycemic effects and may also provide additional non-glycemic benefits, including the improvement of mitochondrial function.
Review
Biology
Habib Yaribeygi, Mina Maleki, Alexandra E. Butler, Tannaz Jamialahmadi, Amirhossein Sahebkar
Summary: There is strong evidence supporting the relationship between stress and insulin resistance. Stress can impair glucose homeostasis through multiple molecular pathways, potentially leading to the development of diabetes.