Review
Nutrition & Dietetics
Katherina V. Gantenbein, Christina Kanaka-Gantenbein
Summary: Healthy nutrition, especially the Mediterranean diet, rich in anti-inflammatory and antioxidant components, helps reduce the incidence of obesity, diabetes, and other non-communicable diseases. The MD not only benefits physical health but also improves reproductive health, reduces the risk of neurodegenerative diseases, and provides protection against mental health issues.
Review
Nutrition & Dietetics
Paula Silva, Maria Rodriguez-Perez, Oscar Gomez-Torres, Emma Burgos-Ramos
Summary: This study reviews the protective effect of polyphenolic compounds from extra virgin olive oil and wine in Alzheimer's disease (AD) and emphasizes that they could be potential therapeutic tools. Polyphenols have beneficial effects in beta-aggregation, neurofibrillary tangles, autophagy, mitochondrial function, and cerebral insulin resistance. Additionally, no harmful dose has been identified.
NUTRITION RESEARCH REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Paula Silva, Maria Rodriguez-Perez, Emma Burgos-Ramos
Summary: This review explores the potential of a zebrafish model in investigating the antioxidant effects of olive oil and wine, which are key components of the Mediterranean diet, in preventing age-related diseases, particularly cardiovascular conditions. The review highlights the genetic proximity of zebrafish to humans, offering a unique opportunity for translational insights into the health benefits of olive oil and wine.
Review
Nutrition & Dietetics
Mohamad Khalil, Harshitha Shanmugam, Hala Abdallah, Jerlin Stephy John Britto, Ilaria Galerati, Javier Gomez-Ambrosi, Gema Fruhbeck, Piero Portincasa
Summary: Abnormal expansion of body fat leads to metabolic abnormalities and increases the risk of cardiovascular disease. Adopting a healthy diet, such as the Mediterranean diet, can improve mitochondrial function and metabolism.
Review
Biochemistry & Molecular Biology
Carla Petrella, Maria Grazia Di Certo, Francesca Gabanella, Christian Barbato, Flavio Maria Ceci, Antonio Greco, Massimo Ralli, Antonella Polimeni, Antonio Angeloni, Cinzia Severini, Mario Vitali, Giampiero Ferraguti, Mauro Ceccanti, Marco Lucarelli, Carola Severi, Marco Fiore
Summary: The Mediterranean diet, known for its intake of foods rich in antioxidants and polyphenols like olives and extra virgin olive oil, as well as resveratrol, shows beneficial properties for human health. These polyphenols could potentially be used in pharmaceutical formulations for disease treatment and have emerging importance in the prevention and management of neurodegenerative and neuromuscular disorders.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Oncology
Enrique Almanza-Aguilera, Ainara Cano, Mercedes Gil-Lespinard, Nerea Burguera, Raul Zamora-Ros, Antonio Agudo, Marta Farras
Summary: Olive oil is the main source of added fat in the Mediterranean diet, and it has been shown to improve obesity-related factors. However, the relationship between Mediterranean diet, olive oil, and obesity-related cancers, as well as the underlying mechanisms, are not well understood.
SEMINARS IN CANCER BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Julian Lozano-Castellon, Anallely Lopez-Yerena, Alexandra Olmo-Cunillera, Olga Jauregui, Maria Perez, Rosa Ma Lamuela-Raventos, Anna Vallverdu-Queralt
Summary: Extra virgin olive oil (EVOO) is rich in nutritional and antioxidant compounds compared to other vegetable oils, making it an important component of the Mediterranean diet. This study developed a simple UHPLC-ESI-MS/MS method for quantifying secoiridoids in EVOO, overcoming challenges posed by their complex transformations during production and analysis. Validation of the method according to AOAC guidelines showed satisfactory results in terms of matrix effect and recoveries.
Article
Oncology
Marta Farras, Enrique Almanza-Aguilera, Alvaro Hernaez, Nuria Agusti, Josep Julve, Montserrat Fito, Olga Castaner
Summary: Virgin olive oil is a key component of the Mediterranean diet, containing a variety of beneficial health compounds. Consumption of olive oil has been linked to improvements in human health and reduced risk of cancer.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Nutrition & Dietetics
Maria S. Hershey, Mercedes Sotos-Prieto, Miguel Ruiz-Canela, Costas A. Christophi, Steven Moffatt, Miguel Angel Martinez-Gonzalez, Stefanos N. Kales
Summary: The study found that adherence to traditional Mediterranean lifestyle habits, as measured by the MEDLIFE index, was associated with a lower prevalence of metabolic syndrome and a more favorable cardiometabolic profile in a non-Mediterranean working population.
CLINICAL NUTRITION
(2021)
Article
Pharmacology & Pharmacy
Samantha J. Snow, Andres R. Henriquez, Jenifer I. Fenton, Travis Goeden, Anna Fisher, Beena Vallanat, Michelle Angrish, Judy E. Richards, Mette C. Schladweiler, Wan-Yun Cheng, Charles E. Wood, Haiyan Tong, Urmila P. Kodavanti
Summary: This study found that diets enriched with coconut oil, fish oil, or olive oil can modify ozone-induced metabolic changes in a diet-specific manner. Different types of dietary oils have different impacts on metabolic responses, potentially leading to alterations in peripheral energy homeostasis.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Chemistry, Applied
Anallely Lopez-Yerena, Blanca Grases-Pinto, Sonia Zhan-Dai, Francisco J. Perez-Cano, Rosa M. Lamuela-Raventos, Maria J. Rodriguez-Lagunas, Anna Vallverdu-Queralt
Summary: This study evaluated the vertical transmission of phenolic compounds and their metabolites from mother rats fed with EVOO to their offspring. The results showed that significant levels of phenolic compounds and their metabolites from EVOO were found in the plasma of offspring, providing further support for the importance of maternal diet during pregnancy and lactation.
Article
Agriculture, Multidisciplinary
Hualu Zhou, Bingjing Zheng, David Julian McClements
Summary: The bioavailability of lipophilic polyphenols is often hindered by poor solubility and stability in the human gut. Encapsulating these polyphenols within digestible lipid droplets can enhance their solubility and stability. Different polyphenols, such as quercetin, curcumin, and resveratrol, exhibit varying levels of chemical stability and solubility under simulated gastrointestinal conditions, which can be attributed to factors like pH-dependent charge and logD values. Understanding these factors is crucial for designing nanoemulsion-based delivery systems to improve the efficacy of lipophilic polyphenols.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Nutrition & Dietetics
Teresa Louro, Carla Simoes, Maria Joao Penetra, Laura Carreira, Paula Midori Castelo, Henrique Luis, Pedro Moreira, Elsa Lamy
Summary: The study found a relationship between adherence to the Mediterranean Diet and saliva protein composition, depending on individuals' Body Mass Index (BMI). Polyphenol intake was positively associated with S-type cystatins levels, particularly when flavanols were considered separately. Results suggest that normal weight and overweight individuals may have different salivary responses to diet.
Review
Nutrition & Dietetics
Aurelio Seidita, Maurizio Soresi, Lydia Giannitrapani, Vita Di Stefano, Roberto Citarrella, Luigi Mirarchi, Antonella Cusimano, Giuseppa Augello, Antonio Carroccio, Juan Lucio Iovanna, Melchiorre Cervello
Summary: Changing lifestyle, diet, and incorporating extra virgin olive oil (EVOO) play a crucial role in preventing metabolic syndrome (MS) and its related complications. Intake of EVOO provides various health benefits such as antioxidant, anti-inflammatory, and cardioprotective effects.
FRONTIERS IN NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
Aline Yammine, Amira Namsi, Dominique Vervandier-Fasseur, John J. Mackrill, Gerard Lizard, Norbert Latruffe
Summary: The Mediterranean diet, rich in polyphenols, plays a crucial role in preventing various diseases, especially colorectal cancer. Selected dietary phytophenols can benefit health by increasing polyphenol metabolites and influencing the microbiome. The emergence of polyphenol formulations may enhance the effectiveness of the Mediterranean diet in cancer prevention.
Article
Public, Environmental & Occupational Health
Giuseppe Limongelli, Stefano Iucolano, Emanuele Monda, Pasquale Elefante, Chiara De Stasio, Imma Lubrano, Martina Caiazza, Marialuisa Mazzella, Fabio Fimiani, Maria Galdo, Giulia De Marchi, Martina Esposito, Marta Rubino, Annapaola Cirillo, Adelaide Fusco, Augusto Esposito, Ugo Trama, Salvatore Esposito, Gioacchino Scarano, Joseph Sepe, Generoso Andria, Valentina Orlando, Enrica Menditto, Paolo Chiodini
Summary: This study investigates the capacity of the rare disease healthcare network in Campania to diagnose patients with rare diseases during the Covid-19 outbreak, and sheds light on problematic diagnoses during this period. The results show that the prevalence of new diagnoses of rare disease was significantly lower during the outbreak, and various issues such as lack of diagnostic resources and guidelines were identified.
JOURNAL OF PUBLIC HEALTH
(2022)
Article
Clinical Neurology
Ilaria Di Donato, Antonio Gallo, Ivana Ricca, Nicola Fini, Gabriella Silvestri, Fiorella Gurrieri, Mario Cirillo, Alfonso Cerase, Gemma Natale, Federica Matrone, Vittorio Riso, Mariarosa Anna Beatrice Melone, Alessandra Tessa, Giovanna De Michele, Antonio Federico, Alessandro Filla, Maria Teresa Dotti, Filippo Maria Santorelli
Summary: Mutations in the POLR3A gene exhibit high phenotypic heterogeneity, with manifestations ranging from severe diseases to milder symptoms. Late-onset spastic ataxia without hypomyelinating leukodystrophy has been linked to the c.1909 + 22G > A mutation in POLR3A. This cohort of patients with POLR3A-related disorders showed various neurological symptoms, with one patient displaying features not previously reported in association with late-onset POLR3A-related disorders.
NEUROLOGICAL SCIENCES
(2022)
Article
Sport Sciences
Paolo De Blasiis, Allegra Fullin, Paolo Caravaggi, Giacomo Lus, Mariarosa A. Melone, Simone Sampaolo, Antonio De Luca, Angela Lucariello
Summary: This study quantitatively evaluated the long-term effects of training on body posture in competitive boxers using baropodometric analysis. The results showed differences in foot load and posture control between boxers and non-sport controls, indicating the influence of long-term training on body posture. Additionally, competitive boxers exhibited enhanced proprioceptive function and reduced visual dependence on posture control.
JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS
(2022)
Article
Biochemistry & Molecular Biology
Claudia Riccardi, Federica D'Aria, Filomena Anna Digilio, Maria Rosaria Carillo, Jussara Amato, Dominga Fasano, Laura De Rosa, Simona Paladino, Mariarosa Anna Beatrice Melone, Daniela Montesarchio, Concetta Giancola
Summary: This study identified a guanine-rich aptamer named MS3 that can recognize and modulate the functions of the huntingtin protein with an expanded polyglutamine tract. Experimental results demonstrate that MS3 can effectively internalize and exhibit good efficacy in vivo.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Polymer Science
Ilenia De Luca, Francesca Di Cristo, Anna Valentino, Gianfranco Peluso, Anna Di Salle, Anna Calarco
Summary: The bioavailability of polyphenols in the Mediterranean diet is limited, but nanotechnological approaches have been developed to enhance their bioavailability and retention time in the body. This review focuses on the encapsulation and delivery of bioactive molecules in commonly consumed Mediterranean foods, as well as the possibility of recovering polyphenols from food waste. The circular economy strategy represents an excellent approach to meet the demand for functional foods and obtain valuable biomolecules at a low cost and in high quantity.
Article
Biochemistry & Molecular Biology
Mauro Finicelli, Filomena Anna Digilio, Umberto Galderisi, Gianfranco Peluso
Summary: This review discusses the role of macrophages in COPD and their impact on inflammatory and oxidative stress processes. Macrophages exhibit plasticity by responding to stimuli from the surrounding tissue, which is crucial in COPD. The regulatory influence of extracellular vesicles (EVs) in cell-to-cell communications is also explored.
Review
Nutrition & Dietetics
Mauro Finicelli, Anna Di Salle, Umberto Galderisi, Gianfranco Peluso
Summary: The Mediterranean Diet, originating from the eating practices of people living in the Mediterranean basin, has shown to have beneficial effects on health and specific diseases. Clinical trials have provided evidence of its anti-inflammatory, anti-oxidant properties, and its effectiveness in controlling waist circumference and obesity. Strict and long-lasting adherence to the diet, as well as the beneficial effects of specific components, are valuable insights for intervention improvements.
Editorial Material
Biochemistry & Molecular Biology
Mauro Finicelli, Gianfranco Peluso, Tiziana Squillaro
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Rosina Paterra, Paola Bettinaglio, Arianna Borghi, Eleonora Mangano, Viviana Tritto, Claudia Cesaretti, Carla Schettino, Roberta Bordoni, Claudia Santoro, Sabrina Avignone, Marco Moscatelli, Mariarosa Anna Beatrice Melone, Veronica Saletti, Giulio Piluso, Federica Natacci, Paola Riva, Marica Eoli
Summary: Currently, there is a lack of systematic study on the clinical spectrum and molecular characteristics of spinal neurofibromatosis (SNF) in patients with neurofibromatosis 1 (NF1). This study provides evidence that SNF patients are at high risk of problematic neurofibromas, including bilateral neurofibromas involving all spinal roots, and a higher incidence of internal neurofibromas and nerve root swelling.
Article
Biochemistry & Molecular Biology
Paola Bettinaglio, Eleonora Mangano, Viviana Tritto, Roberta Bordoni, Rosina Paterra, Arianna Borghi, Marinella Volonte, Cristina Battaglia, Veronica Saletti, Claudia Cesaretti, Federica Natacci, Mariarosa A. B. Melone, Marica Eoli, Paola Riva
Summary: Spinal neurofibromatosis (SNF) is a form of neurofibromatosis type 1 (NF1) characterized by bilateral neurofibromas involving all spinal roots. The pathogenic mechanisms determining the SNF form are currently unknown. Our study found a higher prevalence of NF1 3' tertile mutations and increased expression of syndecans in SNF, suggesting their potential role in the pathogenesis of SNF.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Polymer Science
Raffaele Conte, Mauro Finicelli, Alessia Borrone, Sabrina Margarucci, Gianfranco Peluso, Anna Calarco, Michela Bosetti
Summary: Research has shown that matrix metalloproteinases (MMPs) play a crucial role in the development of osteoarthritis, and inhibiting their activity can protect chondrocytes from degeneration.
Article
Pharmacology & Pharmacy
Francesca Di Cristo, Anna Valentino, Ilenia De Luca, Gianfranco Peluso, Irene Bonadies, Anna Di Salle, Anna Calarco
Summary: Diabetic wound infections (DWI) are costly and disruptive complications in diabetic mellitus. The hyperglycemic state induces persistent inflammation that impairs wound healing processes and promotes infection. The currently available therapies are painful and expensive, so it is important to develop specific therapies for DWI. The study developed fibers loaded with quercetin (QUE) and demonstrated their potential for effective treatment of diabetic wound infections.
Article
Neurosciences
Paolo De Blasiis, Allegra Fullin, Davide Mazzoli, Giorgia Bruno, Filomena Napolitano, Antonio De Luca, Mariarosa Anna Beatrice Melone, Simone Sampaolo
Summary: This study investigates the sagittal kinematics and imbalance of the spine and whole body in patients with Late-onset Pompe disease (LOPD) using three-dimensional motion analysis. The results reveal a specific pathological postural pattern and a biomechanical compensation strategy of LOPD patients to maintain balance against the instability of the spinopelvic region, as verified by an increase in excursion ranges. The introduced kinematic parameters could be useful for functional evaluation, monitoring response to treatment, rehabilitation projects, and disease progression.
JOURNAL OF NEUROPHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Francesca Di Cristo, Anna Valentino, Ilenia De Luca, Gianfranco Peluso, Irene Bonadies, Anna Calarco, Anna Di Salle
Summary: The management of periodontitis is a clinical challenge due to the interaction between dental biofilm microorganisms and the host inflammatory response. Quercetin-loaded electrospun nanofibers show promise as a pH-sensitive drug delivery system for treating periodontitis by inhibiting biofilm maturation and reducing inflammatory response.