期刊
JOURNAL OF CELLULAR PHYSIOLOGY
卷 234, 期 5, 页码 7141-7148出版社
WILEY
DOI: 10.1002/jcp.27468
关键词
gestational diabetes mellitus; IL-37; inflammation; microRNA; NF-kappa B
资金
- Shandong Medical and Health Science and Technology Development Program [2015WS0085]
- National Natural Science Foundation of China [81601408]
A number of studies have implicated that microRNAs (miRNAs) play a critical role in the development of gestational diabetes mellitus (GDM). However, the role of miR-657 in GDM remains vague up to date. We aim to investigate the modifying effect of miR-657 on GDM, which will provide new insight into the pathogenesis of GDM and may help to identify new diagnostic or therapeutic targets for GDM. Increased expression of miR-657 but decreased expression of interleukin-37 (IL-37) was observed in patients with GDM. Besides, negative association between miR-657 and IL-37 was demonstrated in this study. miR-657 could targetedly regulate IL-37 and enhance the proliferation of mononuclear macrophages. Moreover, miR-657 promoted the generation of inflammatory cytokines (IL-6 and tumor necrosis factor-alpha [TNF-alpha]) and activation of nuclear factor kappa B (NF-kappa B) in lipopolysaccharide-induced mononuclear macrophages, while its effect was significantly inhibited when exogenous recombinant IL-37 was administrated into cells. Accordingly, dysregulation of miR-657 contributes to the pathogenesis of GDM via IL-37/NF-kappa B signaling axis.
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