Challenges facing antiangiogenesis therapy: The significant role of hypoxia-inducible factor and MET in development of resistance to anti-vascular endothelial growth factor-targeted therapies
出版年份 2018 全文链接
标题
Challenges facing antiangiogenesis therapy: The significant role of hypoxia-inducible factor and MET in development of resistance to anti-vascular endothelial growth factor-targeted therapies
作者
关键词
-
出版物
JOURNAL OF CELLULAR PHYSIOLOGY
Volume -, Issue -, Pages -
出版商
Wiley
发表日期
2018-12-05
DOI
10.1002/jcp.27414
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Production of human mutant biologically active hepatocyte growth factor in Chinese hamster ovary cells
- (2017) Dongsheng Xu et al. PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY
- Gene of the month:HGF
- (2016) Ana Belen Fajardo-Puerta et al. JOURNAL OF CLINICAL PATHOLOGY
- The role of HGF/c-MET signaling pathway in lymphoma
- (2016) Bao Quoc Lam et al. Journal of Hematology & Oncology
- Foreword: Special focus issue on semaphorins
- (2016) Masahiko Taniguchi Cell Adhesion & Migration
- Hepatocyte growth factor (HGF) upregulates heparanase expression via the PI3K/Akt/NF-κB signaling pathway for gastric cancer metastasis
- (2015) Ning-Bo Hao et al. CANCER LETTERS
- Neuropilin Functions as an Essential Cell Surface Receptor
- (2015) Hou-Fu Guo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- DEC2 expression is positively correlated with HIF-1 activation and the invasiveness of human osteosarcomas
- (2015) Tu Hu et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- HIF-1α pathway: role, regulation and intervention for cancer therapy
- (2015) Georgina N. Masoud et al. Acta Pharmaceutica Sinica B
- Neuropilins are multifunctional coreceptors involved in tumor initiation, growth, metastasis and immunity
- (2015) Gerald J Prud'homme et al. Oncotarget
- Hypoxia-Inducible Factor-1 Promotes Pancreatic Ductal Adenocarcinoma Invasion and Metastasis by Activating Transcription of the Actin-Bundling Protein Fascin
- (2014) X. Zhao et al. CANCER RESEARCH
- Cabozantinib Suppresses Tumor Growth and Metastasis in Hepatocellular Carcinoma by a Dual Blockade of VEGFR2 and MET
- (2014) Q. Xiang et al. CLINICAL CANCER RESEARCH
- Chronic lymphocytic leukemia nurse-like cells express hepatocyte growth factor receptor (c-MET) and indoleamine 2,3-dioxygenase and display features of immunosuppressive type 2 skewed macrophages
- (2014) P. Giannoni et al. HAEMATOLOGICA
- HIF-1 Alpha Overexpression Correlates with Poor Overall Survival and Disease-Free Survival in Gastric Cancer Patients Post-Gastrectomy
- (2014) Li Chen et al. PLoS One
- Roles of PI3K/Akt and c-Jun Signaling Pathways in Human Papillomavirus Type 16 Oncoprotein-Induced HIF-1α, VEGF, and IL-8 Expression and In Vitro Angiogenesis in Non-Small Cell Lung Cancer Cells
- (2014) Erying Zhang et al. PLoS One
- Angiogenesis and the Tumor Microenvironment: Vascular Endothelial Growth Factor and Beyond
- (2014) Kriti Mittal et al. SEMINARS IN ONCOLOGY
- Mechanisms of Hepatocyte Growth Factor Activation in Cancer Tissues
- (2014) Makiko Kawaguchi et al. Cancers
- The Role of Hypoxia-Inducible Factor in Wound Healing
- (2014) Wan Xing Hong et al. Advances in Wound Care
- Hypoxia-inducible Factor 1 Alpha (HIF-1α) as a Prognostic Indicator in Patients with Gastric Tumors: A Meta-analysis
- (2013) Zhi-Gang Zhang et al. Asian Pacific Journal of Cancer Prevention
- Mechanisms of resistance to anti-angiogenesis therapies
- (2013) Sandy Giuliano et al. BIOCHIMIE
- Hypoxia regulates FGFR3 expression via HIF-1α and miR-100 and contributes to cell survival in non-muscle invasive bladder cancer
- (2013) C Blick et al. BRITISH JOURNAL OF CANCER
- Overcoming acquired resistance to anticancer therapy: focus on the PI3K/AKT/mTOR pathway
- (2013) Howard A. Burris CANCER CHEMOTHERAPY AND PHARMACOLOGY
- HIF expression and the role of hypoxic microenvironments within primary tumours as protective sites driving cancer stem cell renewal and metastatic progression
- (2013) B. Philip et al. CARCINOGENESIS
- Cellular and molecular mechanisms in the hypoxic tissue: role of HIF-1 and ROS
- (2013) Andrea B. Zepeda et al. CELL BIOCHEMISTRY AND FUNCTION
- Signaling for lymphangiogenesis via VEGFR-3 is required for the early events of metastasis
- (2013) Masataka Matsumoto et al. CLINICAL & EXPERIMENTAL METASTASIS
- Targeting the HGF/c-MET Pathway in Hepatocellular Carcinoma
- (2013) L. Goyal et al. CLINICAL CANCER RESEARCH
- Zinc Promotes the Death of Hypoxic Astrocytes by Upregulating Hypoxia-Induced Hypoxia-Inducible Factor-1alpha Expression via Poly(ADP-ribose) Polymerase-1
- (2013) Rong Pan et al. CNS Neuroscience & Therapeutics
- Roles of EGFR, PI3K, AKT, and mTOR in Heavy Metal-Induced Cancer
- (2013) Richard L. Carpenter et al. CURRENT CANCER DRUG TARGETS
- Oxygen-independent Regulation of HIF-1: Novel Involvement of PI3K/ AKT/mTOR Pathway in Cancer
- (2013) Faton Agani et al. CURRENT CANCER DRUG TARGETS
- The tip cell concept 10 years after: New players tune in for a common theme
- (2013) Arndt F. Siekmann et al. EXPERIMENTAL CELL RESEARCH
- Multicenter phase II trial of topotecan, cisplatin and bevacizumab for recurrent or persistent cervical cancer
- (2013) Israel Zighelboim et al. GYNECOLOGIC ONCOLOGY
- Hypoxia-inducing factors as master regulators of stemness properties and altered metabolism of cancer- and metastasis-initiating cells
- (2013) Murielle Mimeault et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Tumor VEGF:VEGFR2 autocrine feed-forward loop triggers angiogenesis in lung cancer
- (2013) Sampurna Chatterjee et al. JOURNAL OF CLINICAL INVESTIGATION
- HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
- (2013) Gregg L. Semenza JOURNAL OF CLINICAL INVESTIGATION
- Markers of Response for the Antiangiogenic Agent Bevacizumab
- (2013) Diether Lambrechts et al. JOURNAL OF CLINICAL ONCOLOGY
- Mechanisms of neovascularization and resistance to anti-angiogenic therapies in glioblastoma multiforme
- (2013) Yasushi Soda et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Angiogenesis and Its Therapeutic Opportunities
- (2013) So Young Yoo et al. MEDIATORS OF INFLAMMATION
- HGF and c-Met Interaction Promotes Migration in Human Chondrosarcoma Cells
- (2013) Hsi-Kai Tsou et al. PLoS One
- MET: A Critical Player in Tumorigenesis and Therapeutic Target
- (2013) C. R. Graveel et al. Cold Spring Harbor Perspectives in Biology
- The VEGF Pathway in Cancer and Disease: Responses, Resistance, and the Path Forward
- (2013) M. W. Kieran et al. Cold Spring Harbor Perspectives in Medicine
- Signal Transduction by Vascular Endothelial Growth Factor Receptors
- (2013) S. Koch et al. Cold Spring Harbor Perspectives in Medicine
- Progress in cancer therapy targeting c-Met signaling pathway
- (2012) Kyung Hee Jung et al. ARCHIVES OF PHARMACAL RESEARCH
- Notoginsenoside Ft1 promotes angiogenesis via HIF-1α mediated VEGF secretion and the regulation of PI3K/AKT and Raf/MEK/ERK signaling pathways
- (2012) Kaikai Shen et al. BIOCHEMICAL PHARMACOLOGY
- Neuropilin signalling in angiogenesis
- (2012) Sina Koch BIOCHEMICAL SOCIETY TRANSACTIONS
- Function of Members of the Neuropilin Family as Essential Pleiotropic Cell Surface Receptors
- (2012) Matthew W. Parker et al. BIOCHEMISTRY
- VEGF Inhibits Tumor Cell Invasion and Mesenchymal Transition through a MET/VEGFR2 Complex
- (2012) Kan V. Lu et al. CANCER CELL
- Hypoxia-inducible factor 1 alpha mediates epidermal growth factor-induced down-regulation of E-cadherin expression and cell invasion in human ovarian cancer cells
- (2012) Jung-Chien Cheng et al. CANCER LETTERS
- Anti-VEGF/VEGFR Therapy for Cancer: Reassessing the Target
- (2012) B. Sitohy et al. CANCER RESEARCH
- VEGF Exerts an Angiogenesis-Independent Function in Cancer Cells to Promote Their Malignant Progression
- (2012) Ying Cao et al. CANCER RESEARCH
- HIF-1α-induced histone demethylase JMJD2B contributes to the malignant phenotype of colorectal cancer cells via an epigenetic mechanism
- (2012) Linna Fu et al. CARCINOGENESIS
- VEGF and bone cell signalling: an essential vessel for communication?
- (2012) Claire E. Clarkin et al. CELL BIOCHEMISTRY AND FUNCTION
- Regulation of HGF-mediated cell proliferation and invasion through NF-κB, JunB, and MMP-9 cascades in stomach cancer cells
- (2012) Kyung Hee Lee et al. CLINICAL & EXPERIMENTAL METASTASIS
- Critical Role of Hypoxia Sensor - HIF-1α in VEGF Gene Activation. Implications for Angiogenesis and Tissue Injury Healing
- (2012) A. Ahluwalia et al. CURRENT MEDICINAL CHEMISTRY
- Monoclonal antibody therapeutics: history and future
- (2012) Nicholas APS Buss et al. CURRENT OPINION IN PHARMACOLOGY
- Recent advances in hypoxia-inducible factor (HIF)-1 inhibitors
- (2012) Yan Xia et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Hypoxia and hypoxia-inducible factors in glioblastoma multiforme progression and therapeutic implications
- (2012) Liuqi Yang et al. EXPERIMENTAL CELL RESEARCH
- Targeting the VEGF signaling pathway in cancer therapy
- (2012) Maximilian J Waldner et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Targeting the HGF/Met signaling pathway in cancer therapy
- (2012) Fabiola Cecchi et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Hypoxia-Mediated Regulation of Stem Cell Fate
- (2012) Rashim Pal Singh et al. HIGH ALTITUDE MEDICINE & BIOLOGY
- HGF regulates VEGF expression via the c-Met receptor downstream pathways, PI3K/Akt, MAPK and STAT3, in CT26 murine cells
- (2012) ATSUSHI MATSUMURA et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Vascular endothelial growth factor and its receptor system: physiological functions in angiogenesis and pathological roles in various diseases
- (2012) M. Shibuya JOURNAL OF BIOCHEMISTRY
- Structural Basis for Selective Vascular Endothelial Growth Factor-A (VEGF-A) Binding to Neuropilin-1
- (2012) Matthew W. Parker et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Resistance and Escape From Antiangiogenesis Therapy: Clinical Implications and Future Strategies
- (2012) Justin N. Bottsford-Miller et al. JOURNAL OF CLINICAL ONCOLOGY
- Autocrine VEGF–VEGFR2–Neuropilin-1 signaling promotes glioma stem-like cell viability and tumor growth
- (2012) Petra Hamerlik et al. JOURNAL OF EXPERIMENTAL MEDICINE
- MET Signaling: Novel Targeted Inhibition and Its Clinical Development in Lung Cancer
- (2012) Yan Feng et al. Journal of Thoracic Oncology
- PI3 kinase/Akt/HIF-1α pathway is associated with hypoxia-induced epithelial–mesenchymal transition in fibroblast-like synoviocytes of rheumatoid arthritis
- (2012) Guo-Qing Li et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Association of growth factors, HIF-1 and NF-κB expression with proteasomes in endometrial cancer
- (2012) Ludmila V. Spirina et al. MOLECULAR BIOLOGY REPORTS
- The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity
- (2012) Daniel E. Foxler et al. NATURE CELL BIOLOGY
- MET: a promising anticancer therapeutic target
- (2012) Solange Peters et al. Nature Reviews Clinical Oncology
- Hypoxia—a key regulator of angiogenesis and inflammation in rheumatoid arthritis
- (2012) Sofia Konisti et al. Nature Reviews Rheumatology
- In vivo imaging of lymphatic vessels in development, wound healing, inflammation, and tumor metastasis
- (2012) I. Martinez-Corral et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hypoxia-inducible factor 1-dependent expression of platelet-derived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells
- (2012) L. Schito et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Corneal Neovascularization: An Anti-VEGF Therapy Review
- (2012) Jin-Hong Chang et al. SURVEY OF OPHTHALMOLOGY
- Passing the baton: the HIF switch
- (2012) Mei Yee Koh et al. TRENDS IN BIOCHEMICAL SCIENCES
- Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy
- (2012) Gregg L. Semenza TRENDS IN PHARMACOLOGICAL SCIENCES
- Making sense of low oxygen sensing
- (2012) Julia Bailey-Serres et al. TRENDS IN PLANT SCIENCE
- Knockdown of hypoxia-inducible factor-1α accelerates peritoneal dissemination via the upregulation of MMP-1 expression in gastric cancer cell lines
- (2012) MASATSUGU HIRAKI et al. Experimental and Therapeutic Medicine
- HIF-1α is critical for hypoxia-mediated maintenance of glioblastoma stem cells by activating Notch signaling pathway
- (2011) L Qiang et al. CELL DEATH AND DIFFERENTIATION
- HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs
- (2011) H Zhang et al. ONCOGENE
- A high HIF-1α expression genotype is associated with poor prognosis of upper aerodigestive tract carcinoma patients
- (2011) Carlos Alberto de Carvalho Fraga et al. ORAL ONCOLOGY
- ERβ Impedes Prostate Cancer EMT by Destabilizing HIF-1α and Inhibiting VEGF-Mediated Snail Nuclear Localization: Implications for Gleason Grading
- (2010) Paul Mak et al. CANCER CELL
- Pericellular activation of hepatocyte growth factor by the transmembrane serine proteases matriptase and hepsin, but not by the membrane-associated protease uPA
- (2009) Kate A. Owen et al. BIOCHEMICAL JOURNAL
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started