Article
Multidisciplinary Sciences
Mona Heiland, Niamh M. C. Connolly, Omar Mamad, Ngoc T. Nguyen, Jaideep C. Kesavan, Elena Langa, Kevin Fanning, Albert Sanfeliu, Yan Yan, Junyi Su, Morten T. Veno, Lara S. Costard, Valentin Neubert, Tobias Engel, Thomas D. M. Hill, Thomas M. Freiman, Arun Mahesh, Vijay K. Tiwari, Felix Rosenow, Sebastian Bauer, Jorgen Kjems, Gareth Morris, David C. Henshall
Summary: This study suggests that modulation of miR-335-5p may be a potential strategy to regulate voltage-gated sodium channels (VGSCs) and affect neuronal excitability and seizures. Changes in miR-335-5p may reflect compensatory mechanisms to control excitability and could provide biomarker or therapeutic strategies for different types of treatment-resistant epilepsy.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Heejoo Kim, Hwee Won Ji, Hyeon Woo Kim, Sung Hwan Yun, Jae Eun Park, Sun Jung Kim
Summary: The research revealed that Rg3 regulates the expression of lncRNA ATXN8OS and miR-424-5p in MCF-7 cancer cells, impacting cell proliferation and apoptosis, and subsequently affecting the expression of oncogenic target genes.
Article
Genetics & Heredity
Xuan Guo, Yanjun Qin, Lili Wang, Shimin Dong, Yan Yan, Xiaohua Bian, Caiyan Zhao
Summary: This study identified key lncRNAs associated with sepsis through constructing a ceRNA network. Several significant KEGG pathways and hub proteins related to sepsis were discovered. Functional experiments demonstrated that silencing of LINC00963 affected cell proliferation, cytokine expression, and inflammasome activation in sepsis.
MOLECULAR GENETICS & GENOMIC MEDICINE
(2021)
Article
Genetics & Heredity
Xuan Guo, Yanjun Qin, Lili Wang, Shimin Dong, Yan Yan, Xiaohua Bian, Caiyan Zhao
Summary: This study established a ceRNA network associated with sepsis, identified key lncRNAs, and uncovered some biological pathways related to sepsis pathogenesis. Experimental validation showed that silencing of LINC00963 could impact cell functions, indicating its crucial role in sepsis.
MOLECULAR GENETICS & GENOMIC MEDICINE
(2021)
Article
Genetics & Heredity
Bin Zhai, Yinli Zhao, Shengxin Fan, Pengtao Yuan, Hongtai Li, Shuaihao Li, Yuanfang Li, Yanhua Zhang, Hetian Huang, Hong Li, Xiangtao Kang, Guoxi Li
Summary: This study characterized the expression profile of lncRNAs in abdominal fat of Gushi chickens for the first time and constructed the interaction regulatory network of DE-lncRNAs. The results expanded the known lncRNA repertoire in chicken abdominal fat and provided valuable resources for further understanding the posttranscriptional regulatory mechanism of chicken abdominal fat development or deposition.
FRONTIERS IN GENETICS
(2021)
Article
Medicine, Research & Experimental
Wei Zhu, Xiangming Xiao, Jinqin Chen
Summary: In epithelial ovarian cancer (EOC), the overexpression of LINC01132 is significantly associated with poor patient prognosis. LINC01132 exhibits oncogenic activities in EOC cells by regulating the miR-431-5p/SOX9 axis, influencing the malignant behaviors of EOC cells in vitro and in vivo.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Oncology
Bo Chen, Zhan Yang, Zhichao Lang, Qiqi Tao, Rongrong Zhang, Yating Zhan, Xuantong Xu, Kai Zhu, Jianjian Zheng, Zhengping Yu, Suhui Yu
Summary: This study identifies an m6A-related lncRNA prognostic signature and molecular subtypes that accurately predict the prognosis of hepatocellular carcinoma (HCC) and provide potential novel therapeutic targets.
Article
Multidisciplinary Sciences
Yue Cui, Bozhong Shi, Zijie Zhou, Bo Chen, Xiaoyang Zhang, Cong Li, Kai Luo, Zhongqun Zhu, Jinghao Zheng, Xiaomin He
Summary: A long non-coding RNA (CFRL) associated with cardiac fibrosis has been identified, which can promote the proliferation and migration of cardiac fibroblasts. Silencing CFRL significantly alleviates cardiac fibrosis and improves ventricular function. Interfering with CFRL may be considered as a multitarget strategy for treating cardiac fibrosis and heart failure.
Article
Oncology
Yurui Peng, Chenxin Xu, Jun Wen, Yuanchuan Zhang, Meng Wang, Xiaoxiao Liu, Kang Zhao, Zheng Wang, Yanjun Liu, Tongtong Zhang
Summary: Abnormal fatty acid metabolism is an emerging hallmark of cancer, particularly in colorectal cancer. This study investigated the prognostic value of fatty acid metabolism-related lncRNAs in CRC and identified a potential prognostic signature and nomogram based on these lncRNAs and clinical variables. In vitro assays demonstrated the important role of lncRNA TSPEAR-AS2 in modulating fatty acid metabolism of CRC, providing valuable information for targeted therapies in CRC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pathology
Faramarz Vejdandoust, Rahmaneh Moosavi, Nasrin Fattahi Dolatabadi, Atefeh Zamani, Hossein Tabatabaeian
Summary: Incomplete knowledge of the molecular basis of colorectal cancer has led to its high mortality rate. By analyzing TCGA data and using qPCR, this study identified two down-regulated long noncoding RNAs (lncRNAs), MIMT1 and LINC01550, in colorectal cancer. The results suggest that MIMT1 and LINC01550 may play important roles as tumor suppressor genes and in regulating the cancer signaling pathway(s).
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Xiao-Feng Cui, Si-Lin Zhang, Wei-Ping Wang, Xiao-Wu Huang, Xiang-Jun Chen
Summary: In this study, key long noncoding RNAs (lncRNAs) involved in the competitive endogenous RNA (ceRNA) network associated with laryngeal squamous cell carcinoma (LSCC) were investigated. Through functional enrichment analysis and construction of the ceRNA regulatory network, the functions of these lncRNAs and their importance in LSCC were determined. The results were further validated by quantitative real-time polymerase chain reaction (qRT-PCR) analysis.
Review
Oncology
Maria Teresa Di Martino, Caterina Riillo, Francesca Scionti, Katia Grillone, Nicoletta Polera, Daniele Caracciolo, Mariamena Arbitrio, Pierosandro Tagliaferri, Pierfrancesco Tassone
Summary: Cancer onset and progression are influenced by immune system dysregulation, with noncoding RNAs playing a role in cancer cell immune escape and modulation of the tumor microenvironment. While immunotherapy holds promise for cancer treatment, efforts are needed to achieve cure for immune-refractory tumors.
Article
Multidisciplinary Sciences
Jia-Lin Feng, Wen-Jie Zheng, Le Xu, Qin-Yi Zhou, Jun Chen
Summary: This study identified differentially expressed lncRNAs associated with papillary thyroid cancer (PTC) by analyzing RNA sequencing data, and found a potential new biomarker, LINC02407, which may have important implications in the diagnosis and lymph node metastasis prediction of PTC.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Tao Sun, Lin Dong, Yan Guo, Hai Zhao, Manzhi Wang
Summary: This study revealed key lncRNAs in CN-AML and demonstrated their important roles in the development of AML.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Kai Chen, Yifu Hou, Rui Liao, Youzan Li, Hongji Yang, Jun Gong
Summary: Studies have shown that lncRNA SNHG6 is upregulated in HCC, promoting cell proliferation and inhibiting the targeting of E2F1 by competitively binding miR-204-5p.