期刊
JOURNAL OF CELLULAR PHYSIOLOGY
卷 234, 期 6, 页码 8241-8248出版社
WILEY
DOI: 10.1002/jcp.27666
关键词
drug resistance; gastrointestinal malignancies; heat-shock protein 27; survival
资金
- Mashhad University of Medical Sciences [960371, 940937, 961077, 940938]
Heat-shock protein 27 (HSP27) is a chaperone molecule that plays a critical role in the refolding and activity of several proteins responsible for cancer cell drug toxicity. Upregulation of HSP27 is associated with decreased drug sensitivity as well as poorer survival in gastrointestinal (GI) malignancies. It is, therefore, possible that HSP27 may be of value in the assessment of prognostic and therapeutic efficacy in the treatment of GI cancers. Pharmacological and biological inhibitors of HSP27 enhance tumor cell chemosensitivity. This review summarizes the potential role of HSP27 in chemotherapy drug resistance and the therapeutic potential of HSP27 inhibitors as a novel strategy in the treatment of GI cancers.
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