期刊
AAPS PHARMSCITECH
卷 18, 期 4, 页码 974-982出版社
SPRINGER
DOI: 10.1208/s12249-016-0619-7
关键词
focal adhesion; melanoma; N-sulfopropyl chitosan; proliferation
资金
- Spanish Ministry of Economy and Competitiveness [MAT 2010-20001, CONSOLIDER CSD2009-00088]
- Spanish Ministry of Science and Innovation [SAF2011-27863, PET2008_0168]
- Seventh Framework Program of the European Commission (EuroNanomed ERA-NET initiative, REBONE project) [PI10/02985FIS]
Three types of chitosan-based films have been prepared and evaluated: a non-modified chitosan film bearing cationizable aliphatic amines and two films made of N-sulfopropyl chitosan derivatives bearing both aliphatic amines and negative sulfonate groups at different ratios. Cell adhesion and proliferation on chitosan films of C2C12 pre-myoblastic cells and B16 cells as tumoral model have been tested. A differential cell behavior has been observed on chitosan films due to their different surface modification. B16 cells have shown lower vinculin expression when cultured on sulfonated chitosan films. This study shows how the interaction among cells and material surface can be modulated by physicochemical characteristics of the biomaterial surface, altering tumoral cell adhesion and proliferation processes.
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