期刊
JOURNAL OF CELLULAR BIOCHEMISTRY
卷 120, 期 5, 页码 7657-7666出版社
WILEY
DOI: 10.1002/jcb.28040
关键词
gastric cancer; metastasis; proliferation; USP28
资金
- Outstanding Young Talent Research Fund of Zhengzhou University [1521331002]
- National Natural Science Foundation of China [21372206, 81430085]
- Key Research Program of Henan Province [1611003110100]
- National Natural Science Foundation of Youth Fund [81602961, 2016YFA0501800]
USP28, a member of the deubiquitinating enzymes family, plays a vital role in the physiological process of cell proliferation, differentiation and apoptosis, DNA repair, immune response, and stress response. USP28 has been reported to be overexpressed in bladder cancer, colon cancer, breast carcinomas, and so on. Nevertheless, the role of USP28 in gastric cancer has not yet been investigated. In our study, we examined the USP28 expression in 87 paired samples of gastric cancer and normal gastric tissues. We found that USP28 was overexpressed in gastric cancer compared with normal gastric tissues (P < 0.01), and its overexpression was related to the degree of differentiation and metastases. Inhibiting USP28 expression in vitro suppressed the proliferation and invasion of gastric cancer cells by downregulating lysine specific demethylase 1. On the basis of our data, it can be concluded that USP28 may be a novel therapeutic target for gastric cancer.
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