Article
Cell Biology
Yining Xu, Teng Yao, Haonan Ni, Rujie Zheng, Kangmao Huang, Yizhen Huang, Jun Gao, Di Qiao, Shuying Shen, Jianjun Ma
Summary: Recent studies have identified circSIPA1L1 as an upregulated circular RNA in osteosarcoma, which acts as a molecular sponge for miR-411-5p to increase RAB9A expression, promoting tumorigenesis. Silencing circSIPA1L1 attenuates the malignant properties of OS cells, and inhibition of miR-411-5p or overexpression of RAB9A reverses the anti-tumor effects caused by circSIPA1L1 knockdown.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Quanbin Zhang, Lina Wang, Lili Cao, Tao Wei
Summary: Recent research has shown that circRNAs play critical roles in osteosarcoma biology. CircATRNL1 was found to be highly expressed in osteosarcoma tissues and cells, correlating with aggressive features and serving as an independent risk factor for patients' survival. Functionally, circATRNL1 promotes osteosarcoma aerobic glycolysis by up-regulating LDHA expression via the miR-409-3p axis. This suggests a novel therapeutic target for osteosarcoma.
Editorial Material
Oncology
Kaniz Fatema, Jared J. Barrott
Summary: This commentary evaluates the study conducted by Peng et al. on the identification and function of the signaling axis circ_0088212/miR_520 h/APOA1 in osteosarcoma. The study demonstrates the anti-tumor functions of APOA1 and provides novel context of correlative gene expression with patient outcome. The authors further speculate the potential reasons for contradicting findings in osteosarcoma studies involving circRNAs. The results of the study give confidence that circ_0088212 is a bona fide tumor suppressor in osteosarcoma.
TRANSLATIONAL ONCOLOGY
(2022)
Article
Oncology
Ruoxuan Hei, Jinnan Chen, Xiaojing Zhang, Huiqin Bian, Chen Chen, Xuan Wu, Tiaotiao Han, Yiming Zhang, Junxia Gu, Yaojuan Lu, Qiping Zheng
Summary: This study reveals the suppressive role of circNRIP1 in osteosarcoma cells, which may be mediated by sponging miR-1200 to upregulate MIA2 gene expression.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Wenwen Wei, Jiajia Pan, Jinghan Wang, Shihui Mao, Yu Qian, Xiangjie Lin, Qing Ling, Wenle Ye, Yutong Zhou, Yanchun Zhao, Jiansong Huang, Xin Huang, Zhixin Ma, Huanping Wang, Chenying Li, Jie Sun, Jie Jin
Summary: A novel circRNA, circSLC25A13, was found to be increased in acute myeloid leukemia (AML) patients with poor overall survival (OS). Knockdown of circSLC25A13 inhibited AML cell proliferation and increased apoptosis in vitro and in vivo. Mechanistically, circSLC25A13 acted as a miR-616-3p sponge, promoting AML progression by upregulating ADCY2 expression. Therefore, circSLC25A13 may serve as a potential biomarker for AML prognosis and a therapeutic target for AML treatment.
MOLECULAR CARCINOGENESIS
(2023)
Article
Orthopedics
Qinglei Yang, Hongying Yu, Konghe Hu
Summary: This study reveals the significant role of circ_0001017 in osteosarcoma, promoting cell proliferation, migration, and invasion through targeting miR-145-5p and inhibiting apoptosis.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Article
Oncology
Zhengjun Lin, Xubin Xie, Shiyao Lu, Tang Liu
Summary: Osteosarcoma is the most frequent bone malignancy in children and adolescents, with the development of multi-drug resistance posing a major obstacle in improving chemotherapy efficacy. Research has shown that noncoding RNAs play significant roles in osteosarcoma progression and chemosensitivity, highlighting their potential as biomarkers and therapeutic targets for improving patient prognosis.
Article
Medicine, Research & Experimental
Zizheng Chen, Wenbin Xu, Deguang Zhang, Junjie Chu, Shuying Shen, Yan Ma, Qingxin Wang, Gang Liu, Teng Yao, Yizhen Huang, Huali Ye, Jiying Wang, Jianjun Ma, Shunwu Fan
Summary: This study identified up-regulated circCAMSAP1 in osteosarcoma, which promotes tumorigenesis through the circCAMSAP1/miR-145-5p/FLI1 pathway, suggesting it as a potential therapeutic target for human osteosarcoma.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Oncology
Bo Wei, Le Wang, Jingwei Zhao
Summary: Glioma, the most common type of brain tumor, remains difficult to treat with a poor prognosis. This study identified differentially expressed circRNAs between glioma and normal brain tissues using sequencing data, and proposed potential therapeutic targets based on the ceRNA regulatory hypothesis.
Article
Oncology
Weiguo Ma, Ning Xue, Junhua Zhang, Dan Wang, Xiaobin Yao, Lin Lin, Qingxia Xu
Summary: The study showed that circular RNA-ubiquitin associated protein 2 is upregulated in osteosarcoma and regulates malignant behavior of osteosarcoma cells through the miR-204-3p/HMGA2 axis.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2021)
Article
Cell Biology
Gang Ma, Guichen Li, Wufeng Fan, Yuanhong Xu, Shaowei Song, Kejian Guo, Zhe Liu
Summary: The study reveals that circ-0005105 is upregulated in PDAC tissues and cells, promoting cellular proliferation and invasion. By modulating the miR-20a-3p-COL11A1 axis, circ-0005105 activates epithelial-mesenchymal transition and is associated with malignant clinical phenotype and poor prognosis in PDAC patients.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Yu Wen, Bin Li, Ming He, Songling Teng, Yuxiu Sun, Guangbin Wang
Summary: The study revealed that circHIPK3 was upregulated in osteosarcoma and promoted cell proliferation, migration, and invasion by sponging miR-637 to increase HDAC4 expression. This circHIPK3/miR-637/HDAC4 axis plays a crucial role in the progression of osteosarcoma.
Article
Cell Biology
Lei Gao, Xiaolong Tang, Qingsi He, Guorui Sun, Chao Wang, Hui Qu
Summary: In this study, we found that the upregulation of circCOG2 in colorectal cancer (CRC) promoted tumor proliferation, migration, and invasion through the miR-1305/TGF-beta 2/SMAD3 pathway. Furthermore, the effect of circCOG2 could be transmitted via exosomes from CRC cells with high metastatic potential to those with low metastatic potential, suggesting a potential therapeutic target for CRC.
CELL DEATH DISCOVERY
(2021)
Article
Cell Biology
Tao He, Wen Tao, Lei-Lei Zhang, Bang-Yu Wang, Ke Li, Hui-Min Lu, Guo-Jun Tang, Ya-Di He, Liao-Yuan Li
Summary: circRNA circSCAF8 in prostate cancer activates the LIF-STAT3 pathway to promote proliferation, migration, and invasion, and its expression is a strong predictor of progression-free survival.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Shuo Ma, Xinliang Gu, Lei Shen, Yinhao Chen, Chen Qian, Xianjuan Shen, Shaoqing Ju
Summary: The specific circRNA circHAS2 was upregulated in gastric cancer tissues and cells, and was positively correlated with tumor metastasis. Knockdown of circHAS2 or addition of hsa-miR-944 mimics inhibited proliferation, migration, and invasion of GC cells. The circHAS2/hsa-miR-944/PPM1E axis may be involved in the progression of GC, suggesting circHAS2 as a potential biomarker and therapeutic target for GC.
CELL DEATH & DISEASE
(2021)