Article
Environmental Sciences
Jianping Tang, Qianqian Su, Zhenkun Guo, Jinfu Zhou, Fuli Zheng, Guangxia Yu, Wenya Shao, Hong Hu, Siying Wu, Huangyuan Li
Summary: In this study, the role of m(6)A modification and FTO in cobalt-induced neurotoxicity was investigated using human neuroglioma H4 cells as an in vitro model. The findings suggest that cobalt exposure affects m(6)A modification of apoptosis-related genes by decreasing FTO expression, leading to the activation of apoptosis.
ENVIRONMENTAL POLLUTION
(2022)
Review
Biochemistry & Molecular Biology
Miguel Fontecha-Barriuso, Ana M. Lopez-Diaz, Juan Guerrero-Mauvecin, Veronica Miguel, Adrian M. Ramos, Maria D. Sanchez-Nino, Marta Ruiz-Ortega, Alberto Ortiz, Ana B. Sanz
Summary: Acute kidney injury (AKI) and chronic kidney disease (CKD) are interconnected conditions, and mitochondrial dysfunction and oxidative stress play important roles in the progression of both diseases. New therapeutic approaches targeting mitochondria are needed, but there are barriers to clinical development, such as the lack of diagnostic tests for renal mitochondrial dysfunction.
Article
Cell Biology
Xiaochen Niu, Wencheng Di, Zhe Zhang, Ning Li, Zhenye Qiu, Wenzhen Shi, Wangrui Lei, Jaiyou Tang, Yang Yang, Biao Xu, Ye Tian
Summary: ITLN-1 exerts neuroprotective effects against oxidative stress injury primarily through the SIRT1/PGC-1 alpha axis.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Neurosciences
Jing Wen, Shangming Li, Chengyou Zheng, Fengjiao Wang, Yangwen Luo, Liangmiao Wu, Jie Cao, Baojian Guo, Pei Yu, Gaoxiao Zhang, Shupeng Li, Yewei Sun, Xifei Yang, Zaijun Zhang, Yuqiang Wang
Summary: ALS is a fatal neurodegenerative disease characterized by the progressive loss of motor neurons. The novel tetramethylpyrazine derivative TBN shows promise as a therapeutic agent by slowing disease progression through various pathways.
Article
Biology
Wei Chen, Yushi Chen, Ruifan Wu, Guanqun Guo, Youhua Liu, Botao Zeng, Xing Liao, Yizhen Wang, Xinxia Wang
Summary: This study found that DHA can promote mitochondrial biogenesis and skeletal muscle fiber remodeling through the FTO/m(6)A/DDIT4/PGC1 alpha signaling pathway, protecting against obesity-induced decline in skeletal muscle function.
Article
Medicine, Research & Experimental
Kaiping Deng, Yixuan Fan, Yaxu Liang, Yu Cai, Guomin Zhang, Mingtian Deng, Zhibo Wang, Jiawei Lu, Jianfei Shi, Feng Wang, Yanli Zhang
Summary: N6-methyladenosine (m(6)A) modification regulates the expression of GADD45B gene, which impacts myogenic differentiation and mitochondrial biogenesis, through activating the p38 mitogen-activated protein kinase (MAPK) pathway and regulating other related factors. This study provides a molecular mechanism for the regulation of myogenesis via RNA methylation.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Pharmacology & Pharmacy
Linzhong Zhang, Wei Wang, Lipeng Liu, Yanghao Zhang, Xiuying Zhang
Summary: The study revealed that decreased expression of PGC-1 alpha in fibrotic liver leads to impaired liver regeneration. By modulating the expression of PGC-1 alpha, the regenerative capacity of fibrotic liver can be improved. The findings suggest that targeting PGC-1 alpha could be a strategy to enhance the treatment of PH in patients with liver fibrosis.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2022)
Article
Cell Biology
Yoko Ozawa, Eriko Toda, Kohei Homma, Hideto Osada, Norihiro Nagai, Kazuo Tsubota, Hideyuki Okano
Summary: In this study, the researchers demonstrated that 4-phenylbutyric acid (PBA) can protect photoreceptor function and prevent death in a hereditary blinding disease called retinitis pigmentosa (RP). They found that constant PBA treatment preserved a greater number of photoreceptors and upregulated key mitochondrial regulators, leading to improved mitochondrial function. This protection was also achieved through epigenetic changes. These findings provide evidence for the potential use of PBA as a treatment for RP and highlight its neuroprotective effects.
Article
Biochemistry & Molecular Biology
Milind Padmakar Shipra, Manoj Kumar Tembhre, Milind Padmakar Hote, Neetu Bhari, Ramakrishnan Lakshmy, S. Senthil Kumaran
Summary: Cardiomyopathy significantly contributes to heart failure, and inflammatory factors worsen the symptoms. In this study, a PGC-1a agonist was used to rescue the deleterious effects of doxorubicin-induced cardiomyopathy. The results suggest that PGC-1a agonist has therapeutic potential in mitigating the effects of cardiomyopathy.
Article
Food Science & Technology
Huan Liu, Wenna Han, Siyu Zhu, Zhongyi Li, Chunhong Liu
Summary: DEHP and DnOP, commonly used plasticizers, induce oxidative stress and mitochondrial damage in HepG2 cells by inhibiting the Nrf2 pathway and mitochondrial biogenesis, leading to excessive autophagy and cell death. The two plasticizers differ in their effects on the Nrf2 pathway, autophagic pathway, and MAPK pathway, possibly due to structural differences.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lijing Hou, Shuang Li, Shasha Li, Ru Wang, Mengke Zhao, Xiaomin Liu
Summary: This study found that FTO can increase the expression of Nrf2 by mediating the m6A demethylation of Nrf2 mRNA, thereby inhibiting oxidative stress response and ultimately alleviating cerebral I/R injury.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Yuqiang Liu, Han Yang, Nanbo Luo, Yifei Fu, Fang Qiu, Zhenglong Pan, Xiongjuan Li, Wenling Jian, Xinping Yang, Qingsheng Xue, Yan Luo, Buwei Yu, Zhiheng Liu
Summary: This study investigated the protective effects of an Fgr kinase inhibitor in sepsis-associated encephalopathy (SAE) and the underlying mechanisms. The results showed that the Fgr inhibitor can attenuate neuroinflammation, oxidative stress, and mitochondrial dysfunction, and exert neuroprotective effects by activating the SIRT1/PGC-1a pathway. This study provides a promising therapeutic target for SAE.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Cell Biology
Mei Huang, Jianmin Guo, Lifei Liu, Haiming Jin, Xi Chen, Jun Zou
Summary: Osteoporosis is a common bone disease with unclear mechanisms. The m6A demethylase FTO plays an important role in regulating bone metabolism and osteoporosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yawei Xu, Jingcheng Zhou, Lei Li, Wuping Yang, Zedan Zhang, Kenan Zhang, Kaifang Ma, Haibiao Xie, Zheng Zhang, Lin Cai, Yanqing Gong, Kan Gong
Summary: The m6A modification is suppressed and closely related to autophagic flux in ccRCC. Elevated FTO is inhibited, leading to increased autophagic flux and impaired growth and metastasis of ccRCC. SIK2 is identified as a functional target of m6A-mediated autophagy.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Chunli Yang, Wenkai Yang, Zhaohui He, Jinghua Guo, Xiaogang Yang, Rongsheng Wang, Hongbo Li
Summary: Kaempferol improves lung ischemia-reperfusion injury (LIRI) by enhancing mitochondrial function, reducing oxidative stress, and inhibiting cell apoptosis. The molecular mechanism involves the SIRT 1/PGC-1 alpha/mitochondria signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chunman Li, Xiaomin Luo, Shan Zhao, Gavin K. Y. Siu, Yongheng Liang, Hsiao Chang Chan, Ayano Satoh, Sidney S. B. Yu
Article
Immunology
Lin Zhang, William K. K. Wu, Richard L. Gallo, Evandro F. Fang, Wei Hu, Thomas K. W. Ling, Jing Shen, Ruby L. Y. Chan, Lan Lu, Xiao M. Luo, Ming X. Li, Kam M. Chan, Jun Yu, Vincent W. S. Wong, Siew C. Ng, Sunny H. Wong, Francis K. L. Chan, Joseph J. Y. Sung, Matthew T. V. Chan, Chi H. Cho
JOURNAL OF IMMUNOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Fangfang Chen, Chunxiao Zhang, Haonan Wu, Yue Ma, Xiaomin Luo, Xinqi Gong, Fan Jiang, Yaoting Gui, Hui Zhang, Fei Lu
JOURNAL OF BIOLOGICAL CHEMISTRY
(2017)
Article
Oncology
Chengle Zhuang, Xinbo Huang, Changshui Zhuang, Xiaomin Luo, Xiaowei Zhang, Zhiming Cai, Yaoting Gui
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2017)
Article
Oncology
Xiaomin Luo, Chunman Li, Ran Tan, Xiaohui Xu, William K. K. Wu, Ayano Satoh, Tuanlao Wang, Sidney Yu
Article
Multidisciplinary Sciences
Shan Zhao, Chun Man Li, Xiao Min Luo, Gavin Ka Yu Siu, Wen Jia Gan, Lin Zhang, William K. K. Wu, Hsiao Chang Chan, Sidney Yu
SCIENTIFIC REPORTS
(2017)
Article
Pharmacology & Pharmacy
Dinglan Wu, Zhu Wang, Muqi Lin, Yi Shang, Fei Wang, JiaYi Zhou, Xiantong Zhang, Xiaomin Luo, Weiren Huang
FRONTIERS IN PHARMACOLOGY
(2019)
Article
Obstetrics & Gynecology
Lina Cui, Yanli Gu, Shuo Liu, Minghua Li, Jing Ye, Fanting Zhang, Xiaomin Luo, Wen-Lin Chang, Yaoting Gui
REPRODUCTIVE SCIENCES
(2020)
Article
Cell Biology
Caiyun Zhang, Chunman Li, Gavin Ka Yu Siu, Xiaomin Luo, Sidney Yu
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Article
Multidisciplinary Sciences
Qian Ma, Ye Du, Xiaomin Luo, Jing Ye, Yaoting Gui
Summary: This study identified novel ESX1 mutations in a large cohort of Chinese males, with the p.P365R mutation potentially conferring a high risk for NOA in the Han Chinese population, likely via affecting cell cycle control. The effects of ESX1 mutations on cyclin A degradation and cell cycle progression were analyzed, with the compound mutant p.[P365R; L366V] compromising the stabilizing effect of ESX1 on polyubiquitinated cyclin A, causing failure of M phase arrest in cells. Moreover, the deleterious effect of the compound mutations on ESX1 protein function was attributed to p.P365R alteration.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Zhiming Li, Yan Zhang, Xinzong Zhang, Congcong Cao, Xiaomin Luo, Yaoting Gui, Yunge Tang, Shuiqiao Yuan
Summary: While mutations in the OTOGL gene have been linked to deafness, the study demonstrates that OTOGL is not essential for male germ cell development and spermatogenesis; knockout mouse models of Otogl show normal development and fertility.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Cell Biology
Qian Ma, Congcong Cao, Changshui Zhuang, Xiaomin Luo, Xiaofeng Li, Huijuan Wan, Jing Ye, Fangfang Chen, Lina Cui, Yan Zhang, Yujiao Wen, Shuiqiao Yuan, Yaoting Gui
Summary: AXDND1, a novel testis-enriched gene, is essential for spermiogenesis and male fertility. Knockout of AXDND1 leads to infertility, reduced testis size, abnormal sperm morphology, and structural defects in spermatozoa.
CELL DEATH DISCOVERY
(2021)
Article
Oncology
Yufei Long, Tuotuo Chong, Xiaoming Lyu, Lujia Chen, Xiaomin Luo, Oluwasijibomi Damola Faleti, Simin Deng, Fei Wang, Mingliang He, Zhipeng Qian, Hongli Zhao, Wenyan Zhou, Xia Guo, Ceshi Chen, Xin Li
Summary: In this study, a FOXD1-dependent RalA-ANXA2-Src complex that promotes CTC formation via activating ERK1/2 signal in BC was discovered. FOXD1 may serve as a prognostic factor in evaluating BC metastasis risks. This signaling cascade is druggable and effective for overcoming early stages of BC CTC formation.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Xiaona Chen, Yi Hao, Yong Liu, Sheng Zhong, Yuehua You, Keyi Ao, Tuotuo Chong, Xiaomin Luo, Minuo Yin, Ming Ye, Hui He, Anwei Lu, Jianjun Chen, Xin Li, Jian Zhang, Xia Guo
Summary: This study reveals the oncogenic role of NAT10 in cervical cancer, as well as the mechanism by which the NAT10/ac4C/FOXP1 axis accelerates glycolysis and promotes infiltration of immunosuppressive Tregs into the tumor microenvironment. Additionally, NAT10 knockdown enhances the efficacy of PD-L1 blockade therapy in cervical cancer.