期刊
AAPS JOURNAL
卷 19, 期 1, 页码 54-81出版社
SPRINGER
DOI: 10.1208/s12248-016-0003-2
关键词
bioavailability; cancer chemoprevention; curcumin; drug delivery; pharmacokinetics
资金
- Educational Affairs and Mission sector, Ministry of Higher Education of Egyptian government [JS-3062]
- Kutsche Family Memorial Chair in Internal Medicine, Department of Internal Medicine, University of Michigan
Curcumin is widely available, inexpensive spice that has been used in ancient folk medicine for millennia, especially in India. Curcumin has the pharmacological properties that slow or reverse cellular proliferation and enhance apoptosis and differentiation associated with a diverse array of molecular effects. Despite its effective anticarcinogenesis properties, curcumin's poor solubility, instability, and extensive metabolism result in poor oral bioavailability. Strategies to enhance curcumin delivery include encapsulating or incorporating curcumin in a nanoparticle or microparticle drug delivery system, synthesizing more stable curcumin analogs that resist metabolism while retaining curcumin's pharmacological properties, and adding another natural product that has bioenhancing properties to curcumin or combination of two of these strategies. This review comprehensively explores curcumin's chemistry and pharmacology followed by comparing and contrasting a vast number of strategies designed to enhance curcumin's bioavailability and its therapeutic effects. The review provides insights into which curcumin formulation strategies have the greatest promise to reach clinical application.
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