期刊
JOURNAL OF BIOPHOTONICS
卷 12, 期 6, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jbio.201800317
关键词
blood flow velocity oscillations; laser Doppler flowmetry; occlusion test; reverse blood flow; videocapillaroscopy; wavelet coherence
资金
- Academy of Finland [318281]
- Ministry of Science and Higher Education of the Russian Federation [8.2501.2017/4.6]
- Russian Science Foundation [18-15-00201]
- Russian Science Foundation [18-15-00201] Funding Source: Russian Science Foundation
The dynamic light scattering methods are widely used in biomedical diagnostics involving evaluation of blood flow. However, there exist some difficulties in quantitative interpretation of backscattered light signals from the viewpoint of diagnostic information. This study considers the application of the high-speed videocapillaroscopy (VCS) method that provides the direct measurement of the red blood cells (RBCs) velocity into a capillary. The VCS signal presents true oscillation nature of backscattered light caused by moving RBCs. Thus, the VCS signal can be assigned as a reference one with respect to more complicated signals like in laser Doppler flowmetry (LDF). An essential correlation between blood flow velocity oscillations in a separate human capillary and the integral perfusion estimate obtained by the LDF method has been found. The observation of blood flow by the VCS method during upper arm occlusion has shown emergence of the reverse blood flow effect in capillaries that corresponds to the biological zero signal in the LDF. The reverse blood flow effect has to be taken into account in interpretation of LDF signals.
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