Article
Biochemistry & Molecular Biology
Jose M. Bermudez-Munoz, Adelaida M. Celaya, Angela Garcia-Mato, Daniel Munoz-Espin, Lourdes Rodriguez-de la Rosa, Manuel Serrano, Isabel Varela-Nieto
Summary: DUSP1 plays a critical role in controlling the cross-talk between oxidative stress and inflammation in sensorineural hearing loss. Knockout of Dusp1 gene in mice accelerates SNHL progression and triggers inflammation, redox imbalance, and hair cell death. N-acetylcysteine treatment delays the onset of SNHL, mitigates cochlear damage, and improves redox balance.
Review
Biochemistry & Molecular Biology
Yukimasa Takeda, Yoshinori Harada, Toshikazu Yoshikawa, Ping Dai
Summary: Brown fats specialize in thermogenesis by increasing the utilization of circulating blood glucose and fatty acids, and they prevent the incidence of obesity-associated metabolic diseases and several types of cancers in humans. Mitochondrial energy metabolism in brown/beige adipocytes regulates both uncoupling protein 1 (UCP1)-dependent and -independent thermogenesis, and the mass and activity of human BAT are inversely correlated with the body mass index (BMI) and visceral adiposity. Modulation of obesity-associated repression in human brown fats is a promising strategy to counteract obesity and related metabolic diseases through the activation of thermogenic capacity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Yupeng Zhu, Zhengtang Qi, Shuzhe Ding
Summary: The effects of exercise on adipose tissue thermogenesis and browning are controversial. This review discusses factors contributing to conflicting experimental results and explains the impact of cellular redox state on thermogenesis. Furthermore, it proposes a network model in which exercise coordinates adipose tissue browning and thermogenesis through multiple pathways and organs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Physiology
Eric D. Queathem, Maggie Fitzgerald, Rebecca Welly, Candace C. Rowles, Kylie Schaller, Shahad Bukhary, Christopher P. P. Baines, R. Scott Rector, Jaume Padilla, Camila Manrique-Acevedo, Dennis B. Lubahn, Victoria J. Vieira-Potter
Summary: Dysfunction of white adipose tissue (WAT) is a predictor of cardiometabolic disease, and current therapeutics targeting adipocytes are not effective. This study found that estrogen receptor (ER) beta may enhance the response of WAT to B3AR agonists. Understanding the role of ER beta in adipocyte metabolism could have important clinical applications.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Lugen Zuo, Zhijun Geng, Xue Song, Jing Li, Yueyue Wang, Xiaofeng Zhang, Sitang Ge, Lian Wang, Guangyong Liu, Lele Zhang, Mengyu Xu, Yajing Zhao, Li Shen, Yuanyuan Ge, Rong Wu, Jianguo Hu
Summary: In this study, it was found that white adipocyte browning occurs in hypertrophic mesenteric adipose tissue (htMAT) of Crohn's disease (CD) patients and has anti-inflammatory and lipid-depleting effects. Browning can be induced in both human htMAT and primary mesenteric adipocytes from CD patients and controls, and this induction increases their anti-inflammatory and lipid-depleting activities. Inducing MAT browning can ameliorate mesenteric hypertrophy, inflammation, and colitis in mice, suggesting that it could be a potential therapeutic target for CD.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Multidisciplinary Sciences
Dandan Zhao, Yanyun Pan, Na Yu, Ying Bai, Rufeng Ma, Fangfang Mo, Jiacheng Zuo, Beibei Chen, Qiangqiang Jia, Dongwei Zhang, Jiaxian Liu, Guanjian Jiang, Sihua Gao
Summary: Accumulating evidence suggests that curcumin promotes the adipogenic differentiation of preadipocytes and enhances mitochondrial oxygen consumption in 3T3-L1 mature adipocytes by regulating the expression of UCP1, PRDM16, PPAR gamma, and PGC-1 alpha.
ROYAL SOCIETY OPEN SCIENCE
(2021)
Article
Food Science & Technology
Se-Jun Park, Dong-Hyun Shon, Yang-Hwan Ryu, Yong Ko
Summary: Herbal extracts from Ephedra sinica show dual effects on adipocytes, inhibiting adipogenesis in immature cells and promoting browning in mature cells.
Article
Biochemistry & Molecular Biology
Mara Fiorani, Rita De Matteis, Barbara Canonico, Giulia Blandino, Alessandro Mazzoli, Mariele Montanari, Andrea Guidarelli, Orazio Cantoni
Summary: The conversion of human SW872 preadipocytes to mature adipocytes involves time-dependent changes in differentiation markers' expression, morphological changes, and accumulation of lipid droplets. Reactive oxygen species (ROS) formation was significant at specific time points during differentiation, with NADPH oxidase (NOX)-2 playing a role. Mitochondrial ROS (mROS) were only detected in the late phase of differentiation, indicating potential mitochondrial dysfunction. These findings suggest a potential link between ROS, adipogenesis, and adipose tissue dysfunction in SW872 cells.
Article
Medicine, General & Internal
Farah Omran, Alice M. Murphy, Awais Z. Younis, Ioannis Kyrou, Jana Vrbikova, Vojtech Hainer, Petra Sramkova, Martin Fried, Graham Ball, Gyanendra Tripathi, Sudhesh Kumar, Philip G. McTernan, Mark Christian
Summary: This study investigated the impact of endotoxin on mitochondrial function and browning capacity in human adipocytes. The results showed that endotoxin directly contributes to impaired mitochondrial function and reduced browning capacity of adipocytes, exacerbating metabolic consequences. Bariatric surgery, which reduces endotoxin levels, is associated with improved adipocyte functionality.
Article
Cell Biology
Hui-Jeon Jeon, Dong Kyu Choi, JaeHeon Choi, Seul Lee, Heejin Lee, Ji Hoon Yu, Sang-Hyun Min
Summary: The study found that D-mannitol induces the browning of white adipocytes by enhancing the expression of brown fat-specific genes and proteins, and upregulating lipid metabolism markers. Its dual regulatory role includes inducing a brown fat-like phenotype and enhancing lipid metabolism, suggesting its potential as an anti-obesity supplement.
Article
Multidisciplinary Sciences
Catarina M. Quinzii, Luis C. Lopez
Summary: Mitochondrial disorders are genetic diseases with inadequate therapy due to the heterogeneity and tissue-specificity of pathomechanisms. Abnormalities in hydrogen sulfide (H2S) metabolism are emerging as a novel mechanism in mitochondrial dysfunction, but further studies are needed to understand the effects and relevance in mitochondrial diseases. The review focuses on derangement of H2S metabolism in primary Coenzyme Q (CoQ) deficiency and emphasizes the need for more research on the consequences of abnormalities in H2S and GSH synthesis on the oxidation pathway.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Plant Sciences
Anka Cebulj, Andreja Vanzo, Joze Hladnik, Damijana Kastelec, Urska Vrhovsek
Summary: Selecting a non-browning cultivar is one of the most effective ways to prevent browning of apple and apple products. The Slovenian cultivar 'Majda' stands out for its high acidity, low phenol content, and high reduced glutathione content, contributing to its non-browning characteristics.
Article
Oncology
Supreet Kaur, Christopher Auger, Dalia Barayan, Priyal Shah, Anna Matveev, Carly M. Knuth, Thurl E. Harris, Marc G. Jeschke
Summary: Hypermetabolism following severe burn injuries can lead to adipocyte dysfunction and other adverse consequences, with adipose triglyceride lipase (ATGL) playing a crucial role in regulating these processes. Targeting ATGL may reduce adipose tissue changes and improve patient outcomes, as demonstrated by selective ATGL inhibitor studies.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Review
Physiology
Hongbing Song, Xiaohan Zhang, Jing Wang, Yanling Wu, Taimin Xiong, Jieqiong Shen, Ruiyi Lin, Tianfang Xiao, Weimin Lin
Summary: Adipose tissue is crucial for maintaining energy balance and dysfunctional adipose tissue is linked to obesity-related metabolic diseases. Mitochondria in adipocytes play a key role in energy metabolism and interact with other organelles to regulate metabolic processes and reduce the occurrence of obesity-related diseases.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Geriatrics & Gerontology
Anders Gudiksen, Albina Qoqaj, Stine Ringholm, Jorgen Wojtaszewski, Peter Plomgaard, Henriette Pilegaard
Summary: The study suggests that lifelong high-intensity exercise can enhance mitochondrial oxidative capacity in subcutaneous white adipose tissue (sWAT), potentially contributing to healthy aging.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yanling Wu, Belen Chanclon, Peter Micallef, Elisabet Stener-Victorin, Ingrid Wernstedt Asterholm, Anna Benrick
Summary: The study demonstrates that elevated levels of adiponectin in utero can improve insulin sensitivity, reduce body weight and fat mass gain in adult offspring, and protect against PNA-induced visceral adiposity in the offspring.
Article
Biochemistry & Molecular Biology
Peter Micallef, Yanling Wu, Marco Bauza-Thorbrugge, Belen Chanclon, Milica Vujicic, Eduard Peris, C. Joakim Ek, Ingrid Wernstedt Asterholm
Summary: In studying the metabolic symbiosis between breast cancer and adipose tissue, it was found that adipose tissue promotes tumor growth by stimulating lipogenesis. However, targeting lipogenesis alone may have adverse effects. To overcome tumor adaptation to treatment, it is suggested to apply aggressive therapy targeting multiple metabolic pathways simultaneously along with conventional treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
William Lovfors, Christian Simonsson, Ali M. Komai, Elin Nyman, Charlotta S. Olofsson, Gunnar Cedersund
Summary: The regulation of adiponectin exocytosis is important for understanding metabolic diseases associated with obesity. Mathematical modeling and simulation experiments have provided insights into the mechanisms of adiponectin exocytosis, particularly involving adrenergic signaling pathways. The model developed in this study successfully predicted adiponectin release dynamics and cAMP levels, contributing to a better understanding of the intricate regulation of adiponectin exocytosis.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Man Mohan Shrestha, Sanne Wermelin, Elisabet Stener-Victorin, Ingrid Wernstedt Asterholm, Anna Benrick
Summary: Adiponectin deficiency affects fetal growth and placental function, particularly in obese individuals. Low levels of adiponectin lead to placental dysfunction and increased fetal triglyceride load, which could have long-term effects on the offspring's metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Saliha Musovic, Ali M. Komai, Marina Kalds Said, Man Mohan Shrestha, Yanling Wu, Ingrid Wernstedt Asterholm, Charlotta S. Olofsson
Summary: This study investigates the regulation of adiponectin exocytosis in white adipocytes by noradrenaline (NA) and ATP. It found that sympathetic innervation plays a critical role in adiponectin exocytosis and disruption of this regulation is associated with a reduction in the levels of HMW/total adiponectin in circulation, which is related to obesity.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Article
Nutrition & Dietetics
Ivana Maric, Jean-Philippe Krieger, Pauline van der Velden, Stina Borchers, Mohammed Asker, Milica Vujicic, Ingrid Wernstedt Asterholm, Karolina P. Skibicka
Summary: The prevalence and health consequences of obesity differ between men and women. Research shows that male and female rodents respond differently to high-fat diet (HFD) challenge, with female rodents displaying a higher preference for HFD but experiencing a delay in weight gain and fewer metabolic complications compared to males. These sex-based differences are divergent in rats and mice, with male SD rats being a better model for the lower prevalence of overweight in women, while C57BL/6 mice may better represent the increased prevalence of morbid obesity in women.
FRONTIERS IN NUTRITION
(2022)
Article
Endocrinology & Metabolism
Clair Crewe, Shiuhwei Chen, Dawei Bu, Christy M. Gliniak, Ingrid Wernstedt Asterholm, Xin Xin Yu, Nolwenn Joffin, Camila O. de Souza, Jan-Bernd Funcke, Da Young Oh, Oleg Varlamov, Jacob J. Robino, Ruth Gordillo, Philipp E. Scherer
Summary: Caveolin-1 (cav1) is a crucial component of plasma membrane invaginations called caveolae and has important roles in adipocyte function. Ablation of cav1 in adipocytes leads to improved glucose clearance, reduced insulin secretion and activation of AKT in metabolic tissues, partial lipodystrophy, and metabolic abnormalities. This phenotype is partly mediated by extracellular vesicles (EVs) secreted by adipose tissue, which propagate the effects to other organs. Loss of cav1 also leads to inflammation, mitochondrial dysfunction, and dysregulated lipid metabolism in adipose tissue.
Article
Endocrinology & Metabolism
Marco Bauza-Thorbrugge, Elin Banke, Belen Chanclon, Eduard Peris, Yanling Wu, Saliha Musovic, Cecilia Jonsson, Peter Stralfors, Patrik Rorsman, Charlotta S. Olofsson, Ingrid Wernstedt Asterholm
Summary: This study found that SERCA2 expression is downregulated in adipocytes from obese and type-2 diabetes patients, and ablation of SERCA2 leads to disturbed calcium homeostasis, impaired hormone secretion, and abnormal glucose metabolism in adipocytes. Furthermore, adipocyte-specific SERCA2 knockout also affects glucose uptake in white and brown adipose tissue, which is associated with regulated mitochondrial function.
MOLECULAR METABOLISM
(2022)
Article
Biology
Mathieu Cinato, Ismena Mardani, Azra Miljanovic, Christina Drevinge, Marion Laudette, Entela Bollano, Marcus Henricsson, Johan Tolo, Marcos Bauza Thorbrugge, Max Levin, Malin Lindbom, Muhammad Arif, Pal Pacher, Linda Andersson, Charlotta S. Olofsson, Jan Boren, Malin C. Levin
Summary: The adult heart undergoes hypertrophy to reduce ventricular wall stress and maintain cardiac function in response to increased workload. Cardiac-specific overexpression of perilipin 5 (Plin5) promotes cardiac hypertrophy and enhances cardiac contractility through improved Ca2+ signaling. This study provides insights into the beneficial effects of physiological hypertrophy and the potential role of Plin5 in maintaining heart function.
LIFE SCIENCE ALLIANCE
(2023)
Article
Biochemistry & Molecular Biology
Marco Bauza-Thorbrugge, Eduard Peris, Shabnam Zamani, Peter Micallef, Alexandra Paul, Stefano Bartesaghi, Anna Benrick, Ingrid Wernstedt Asterholm
Summary: Oxidative stress can lead to an adaptive browning process, which may be a potential treatment for obesity and its associated metabolic disturbances.
Article
Nanoscience & Nanotechnology
Alexandra Paul, Sachin Kumar, Tamer S. Kaoud, Madison R. Pickett, Amanda L. Bohanon, Janet Zoldan, Kevin N. Dalby, Sapun H. Parekh
Summary: Elderly people are more vulnerable to the current SARS-CoV-2 pandemic, possibly due to changes in the lungs rather than natural biomechanical changes increasing the susceptibility to SARS-CoV-2 infection.
ACS APPLIED BIO MATERIALS
(2022)
Article
Biophysics
Sachin Kumar, Alexandra Paul, Sayantan Chatterjee, Sabine Puetz, Natasha Nehra, Daniel S. Wang, Arsalan Nisar, Christian M. Jennings, Sapun H. Parekh
Summary: The novel coronavirus SARS-CoV-2 infects host cells primarily through binding to the ACE-2 receptor on the cell surface, with temperature having minimal impact on viral transmission and virus-host cell interaction.