The inflammasome adapter ASC assembles into filaments with integral participation of its two Death Domains, PYD and CARD

Single-Molecule Fluorescence Reveals the Oligomerization and Folding Steps Driving the Prion-like Behavior of ASC

(2018) Yann Gambin et al.   JOURNAL OF MOLECULAR BIOLOGY

The structural basis of flagellin detection by NAIP5: A strategy to limit pathogen immune evasion

(2017) Jeannette L. Tenthorey et al.   SCIENCE

The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation

(2017) Rojo A. Ratsimandresy et al.   Nature Communications

SNAPIN is critical for lysosomal acidification and autophagosome maturation in macrophages

(2016) Bo Shi et al.   Autophagy

The killer protein Gasdermin D

(2016) John A Wright et al.   CELL DEATH AND DIFFERENTIATION

ASC Pyrin Domain Self-associates and Binds NLRP3 Protein Using Equivalent Binding Interfaces

(2016) Javier Oroz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly

(2016) Florian I. Schmidt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The HADDOCK2.2 Web Server: User-Friendly Integrative Modeling of Biomolecular Complexes

(2016) G.C.P. van Zundert et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism

(2016) Alvin Lu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism

(2016) Alvin Lu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Inhibiting the inflammasome: one domain at a time

(2015) Andrea Dorfleutner et al.   IMMUNOLOGICAL REVIEWS

Structure and assembly of the mouse ASC inflammasome by combined NMR spectroscopy and cryo-electron microscopy

(2015) Lorenzo Sborgi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization

(2015) L. Zhang et al.   SCIENCE

An updated view on the structure and function of PYRIN domains

(2014) Lan Hoang Chu et al.   APOPTOSIS

Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes

(2014) Alvin Lu et al.   CELL

Structural mechanisms of inflammasome assembly

(2014) Alvin Lu et al.   FEBS Journal

Molecular Imprinting as a Signal-Activation Mechanism of the Viral RNA Sensor RIG-I

(2014) Bin Wu et al.   MOLECULAR CELL

Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex

(2014) S. M. Man et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Formation and Structure of a NAIP5-NLRC4 Inflammasome Induced by Direct Interactions with Conserved N- and C-terminal Regions of Flagellin

(2012) Els F. Halff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of inflammasome signaling

(2012) Vijay A K Rathinam et al.   NATURE IMMUNOLOGY

A comprehensive manually curated protein–protein interaction database for the Death Domain superfamily

(2011) Dongseop Kwon et al.   NUCLEIC ACIDS RESEARCH

The death-fold superfamily of homotypic interaction motifs

(2011) Kristof Kersse et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Structure and Interdomain Dynamics of Apoptosis-associated Speck-like Protein Containing a CARD (ASC)

(2009) Eva de Alba   JOURNAL OF BIOLOGICAL CHEMISTRY

Macrophages Create an Acidic Extracellular Hydrolytic Compartment to Digest Aggregated Lipoproteins

(2009) Abigail S. Haka et al.   MOLECULAR BIOLOGY OF THE CELL