期刊
JOURNAL OF BIOCHEMISTRY
卷 165, 期 4, 页码 301-307出版社
OXFORD UNIV PRESS
DOI: 10.1093/jb/mvy115
关键词
kinase; phosphoproteomics; protein phosphorylation; signal transduction; substrate
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT) [17H01380, 25251021, 17K07383, 23590357]
- Grants-in-Aid for Scientific Research [17H01380, 23590357, 17K07383, 25251021] Funding Source: KAKEN
Accumulating information on eukaryotic protein phosphorylation implies a large and complicated phospho-signalling network in various cellular processes. Although a large number of protein phosphorylation sites have been detected, their physiological consequences and the linkage between each phosphorylation site and the responsible protein kinase remain largely unexplored. To understand kinase-oriented phospho-signalling pathways, we have developed novel substrate screening technologies. In this review, we described the in vitro and in vivo screening methods named kinase-interacting substrate screening analysis and kinase-oriented substrate screening analysis, respectively.
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