Review
Physiology
Ankan Gupta, Kevin R. Rarick, Ramani Ramchandran
Summary: This review discusses the state of knowledge on embryonic brain vascular patterning in zebrafish and mouse model systems, focusing on the origins and distinguishing features of brain endothelial cells. The interplay between brain endothelial cells and neural stem cells, mechanisms of Wnt signaling in brain vascular patterning, and emerging areas in vertebrates' cerebrovascular structures are explored.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Marco Ponzetti, Nadia Rucci
Summary: Osteoblasts, the cells responsible for skeletal development, require tight regulation throughout their differentiation process. While classical pathways for osteoblastic differentiation are well-established, new players such as miRNAs, lncRNAs, circRNAs, and extracellular vesicles play important roles in regulating osteoblasts and their communication with the surrounding microenvironment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Electrical & Electronic
Zhaowang Cao, Gengjiang Yao, Dace Zha, Yong Zhao, Yi Wu, Ling Miao, Shaowei Bie, Jianjun Jiang
Summary: In this study, a new design concept of a single-layer impedance-well (IW) passive absorber is proposed for the first time, which exhibits enhanced absorption bandwidth and effectively approaches the Rozanov thickness limit for passive absorbers. The design concept is explained using transmission line theory and circuit analysis.
IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION
(2022)
Review
Biochemistry & Molecular Biology
Peter Valent, Cem Akin, Michel Arock, Karoline V. Gleixner, Hildegard Greinix, Olivier Hermine, Hans-Peter Horny, Daniel Ivanov, Alberto Orfao, Werner Rabitsch, Andreas Reiter, Axel Schulenburg, Karl Sotlar, Wolfgang R. Sperr, Celalettin Ustun
Summary: This article discusses treatment options for patients with drug-resistant advanced SM, including novel KIT-targeting drugs, antibody-based drugs, and stem cell-eradicating therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Environmental Sciences
Bjoern Guse, Simone Fatichi, Shervan Gharari, Lieke A. Melsen
Summary: The article discusses the importance of fidelity and accuracy in hydrological models, highlighting the need for improved representation of process dynamics. It also offers potential solutions and strategies for enhancing and testing the representation of hydrological processes.
WATER RESOURCES RESEARCH
(2021)
Review
Medicine, General & Internal
Oliver Sartor, Ali Baghian
Summary: Prostate specific membrane antigen (PSMA) is a validated target for prostate cancer therapeutics. The FDA has approved Lu-177-PSMA-617 for advanced metastatic castrate-resistant prostate cancer (mCRPC), and other PSMA targeted radiopharmaceuticals are under development. The field is rapidly developing, with promising potential for targeted alpha therapies and the possibility of combining beta and alpha-targeted therapies.
FRONTIERS IN MEDICINE
(2022)
Review
Engineering, Environmental
Casey Q. LaMarche, Ben Freireich, Ray Cocco, Jia Wei Chew
Summary: Numerical methods like computational fluid dynamics (CFD) for predicting multiphase flow involving solid particles offer promising benefits to a wide range of applications. Accurate representation of the fluid-particle momentum exchange, i.e., the drag and buoyancy forces, is crucial for studying fluid-particle hydrodynamics. However, there is a lack of widely accepted guidance on the most appropriate drag correlations for flow past homogeneous suspensions of spherical particles with narrow size distributions. This review addresses this gap and highlights the need for further development and validation of drag models in industrial fluid particle flows.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Physical
Tsuneo Hirano, Umpei Nagashima, Masaaki Baba
Summary: The relationship r0 > re holds true because the r0,eff derived from a set of B0 values is not the actual rovibrationally averaged bond length r0, but its projection onto the principal axes of the moment of inertia. In anomalous cases like benzene and linear molecules, the properly and literally determined r0 bond-length is longer than re.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Toxicology
Alessandro Maugeri, Giovanni E. Lombardo, Michele Navarra, Santa Cirmi, Antonio Rapisarda
Summary: This study aimed to optimize data extrapolation from CAM assay, leading to greater reliability and richness of data for evaluating potential pro- and anti-angiogenic activity of new candidate drugs, while saving eggs and time for experiments.
JOURNAL OF APPLIED TOXICOLOGY
(2022)
Article
Construction & Building Technology
Tiansen Liu, Xinpeng Xing, Yi Zhang, Yazhi Song, Jiayu Wang, Sihan Wang
Summary: This study suggests that exploration strategy has a more positive impact on financial performance in new ventures, while the combination of exploration and exploitation strategies can better improve financial performance. Additionally, adopting an appropriate strategy combination based on different technology standards can help new ventures better deal with uncertainty.
SUSTAINABLE CITIES AND SOCIETY
(2021)
Review
Cell Biology
Muhammed Kocak, Saba Ezazi Erdi, Guillem Jorba, Ines Maestro, Judith Farres, Vladimir Kirkin, Ana Martinez, Ole Pless
Summary: Autophagy is a conserved pathway responsible for clearing cellular debris and dysfunctional components, with implications in various human diseases. Research on autophagy modulation for therapeutic purposes is ongoing, but is hindered by the lack of selective pharmacological agents and biomarkers.
Article
Chemistry, Multidisciplinary
Kui Chen, Sen Liu, Linwen Lv, Jianfei Tong, Junyang Chen, Haojun Liang, Yujiao Wang, Fan Hu, Qiuyang Liu, Hao Li, Ziteng Chen, Jiacheng Li, Zhijie Wang, Ya-nan Chang, Juan Li, Hui Yuan, Shinian Fu, Tianjiao Liang, Gengmei Xing
Summary: In this study, a carrier-free nano-boron agent was developed to enhance immune responses, inhibit tumor growth and metastasis, and achieve a high rate of complete tumor regression in vivo. Furthermore, long-term anti-tumor effects could be achieved through immunization.
Article
Green & Sustainable Science & Technology
Toshiyuki Sueyoshi, Ruchuan Zhang, Jingjing Qu, Aijun Li
Summary: This study introduces the concept of environment-health DEA and explores its construction methods. Empirical analysis reveals differences between methods, the impact of health variables on efficiency, and the presence of technology inequality and diffusion barriers across Chinese provinces.
JOURNAL OF CLEANER PRODUCTION
(2021)
Review
Biochemistry & Molecular Biology
Aleksandra H. Opinc, Joanna S. Makowska
Summary: This article summarizes the latest research on the association between idiopathic inflammatory myopathies and malignancy, the understanding of its pathogenesis. It analyzes the potential risk and protective factors for developing cancer-associated myositis (CAM), and proposes management recommendations and a new cancer screening scheme.
Article
Multidisciplinary Sciences
Greg Lackey, Harihar Rajaram, James Bolander, Owen A. Sherwood, Joseph N. Ryan, Chung Yan Shih, Grant S. Bromhal, Robert M. Dilmore
Summary: This study found that a significant number of oil and gas wells in several US states exhibit compromised integrity, with particular concern in Pennsylvania where 14.1% of wells tested prior to 2018 showed signs of issues. Data from different regions in Colorado and New Mexico demonstrated a wider range of SCP and/or CVF occurrences compared to previous reports, emphasizing the need for a better understanding of regional well integrity trends. Additionally, directional wells were more likely to exhibit SCP and/or CVF than vertical wells, with their installation corresponding to statewide increases in compromised well integrity in Colorado and Pennsylvania.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Physiology
Bruno Grassi, Joanna Majerczak, Eleonora Bardi, Alessia Buso, Marina Comelli, Stefan Chlopicki, Magdalena Guzik, Irene Mavelli, Zenon Nieckarz, Desy Salvadego, Urszula Tyrankiewicz, Tomasz Skorka, Roberto Bottinelli, Jerzy A. Zoladz, Maria Antonietta Pellegrino
JOURNAL OF APPLIED PHYSIOLOGY
(2017)
Article
Neurosciences
Desy Salvadego, Michail E. Keramidas, Roger Koelegard, Lorenza Brocca, Stefano Lazzer, Irene Mavelli, Joern Rittweger, Ola Eiken, Igor B. Mekjavic, Bruno Grassi
JOURNAL OF PHYSIOLOGY-LONDON
(2018)
Article
Physiology
Lucrezia Zuccarelli, Paulo Cesar do Nascimento Salvador, Alessio Del Torto, Riccardo Fiorentino, Bruno Grassi
JOURNAL OF APPLIED PHYSIOLOGY
(2020)
Editorial Material
Neurosciences
Jerzy A. Zoladz, Bruno Grassi
JOURNAL OF PHYSIOLOGY-LONDON
(2020)
Article
Neurosciences
Simone Porcelli, Letizia Rasica, Brian S. Ferguson, Andreas N. Kavazis, James McDonald, Michael C. Hogan, Bruno Grassi, L. Bruce Gladden
JOURNAL OF PHYSIOLOGY-LONDON
(2020)
Article
Physiology
Desy Salvadego, Bruno Grassi, Michail E. Keramidas, Ola Eiken, Adam C. McDonnell, Igor B. Mekjavic
Summary: This study demonstrated a similar variability in peak O2 uptake and peak muscle fractional O2 extraction among subjects during normoxic and hypoxic bed rests, independent of exposure duration. Additionally, mitochondrial respiration showed significant individual variability in response to different rest conditions. There was no correlation between changes in normoxic and hypoxic bed rests, indicating distinct effects of hypoxia on mitochondrial adaptations.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2021)
Letter
Physiology
Bruno Grassi, Valentina Quaresima
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Neurosciences
Andrea M. Pilotto, Alessandra Adami, Raffaele Mazzolari, Lorenza Brocca, Emanuela Crea, Lucrezia Zuccarelli, Maria A. Pellegrino, Roberto Bottinelli, Bruno Grassi, Harry B. Rossiter, Simone Porcelli
Summary: The final steps of the O-2 cascade during exercise depend on the product of the microvascular-to-intramyocyte PO2 difference and muscle O-2 diffusing capacity (DmO(2)). Non-invasive methods to determine DmO(2) in humans are currently unavailable. Muscle oxygen uptake (m.VO2) recovery rate constant (k), measured by near-infrared spectroscopy (NIRS) using intermittent arterial occlusions, is associated with muscle oxidative capacity in vivo.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Letter
Neurosciences
Andrea M. Pilotto, Alessandra Adami, Raffaele Mazzolari, Lorenza Brocca, Emanuela Crea, Lucrezia Zuccarelli, Maria A. Pellegrino, Roberto Bottinelli, Bruno Grassi, Harry B. Rossiter, Simone Porcelli
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Physiology
Desy Salvadego, Alessandro Sartorio, Fiorenza Agosti, Gabriella Tringali, Alessandra Patrizi, Miriam Isola, Antonella LoMauro, Andrea Aliverti, Bruno Grassi
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2017)
