Article
Infectious Diseases
Selene Rebecca Boncompagni, Maria Micieli, Tiziana Di Maggio, Noemi Aiezza, Alberto Antonelli, Tommaso Giani, Gloria Padoani, Silvia Vailati, Lucia Pallecchi, Gian Maria Rossolini
Summary: This study investigated the activity of fosfomycin, colistin, and their combination against multidrug-resistant Gram-negative pathogens. The results showed that the combination of fosfomycin and colistin exhibited synergistic effects against biofilms and reduced the emergence of drug-resistant subpopulations.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Magdi A. Bayoumi, Omnia M. Hamid
Summary: This study aimed to detect multidrug resistant GIM-1 and SIM-1 producing Enterobacteriaceae clinical isolates. The results showed a high resistance pattern to antimicrobial agents in the isolated strains.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Infectious Diseases
Vincent H. Tam, Paul R. Merlau, Cole S. Hudson, Ellen G. Kline, Brianna M. Eales, James Smith, Amelia K. Sofjan, Ryan K. Shields
Summary: This study used a novel framework to determine the optimal drug exposure to suppress carbapenemase-producing bacteria. The results showed that ceftazidime/avibactam 2.5 g every 12 hours achieved the best outcome.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Su Young Lee, Christian M. Gill, David P. Nicolau, ERACE PA Global Study Grp
Summary: This study compared the in vitro activity of different drugs against serine beta-lactamase-producing Pseudomonas aeruginosa. Ceftazidime/avibactam demonstrated the best activity and is a rational treatment option.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Infectious Diseases
Alice Le Menestrel, Francois Guerin, Francoise Chau, Laurent Massias, Laura Benchetrit, Vincent Cattoir, Bruno Fantin, Victoire de Lastours
Summary: Combining colistin and fosfomycin shows synergistic and bactericidal effects against NDM-1-producing E. coli, reducing mortality and bacterial loads in vitro and in vivo, while preventing the selection of resistant mutants. However, the combination may not fully prevent the emergence of fosfomycin-resistant mutants in colistin-resistant strains.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Lubna Razaq, Fakhur Uddin, Shahzad Ali, Shah Muhammad Abbasi, Muhammad Sohail, Nabila E. Yousif, Hala M. Abo-Dief, Zeinhom M. El-Bahy
Summary: Antibiotic resistance in uropathogens has become a major issue in the treatment of urinary tract infections. New formulations such as MEV and CZA have shown significant activity against drug-resistant pathogens.
Article
Microbiology
Kazuyoshi Gotoh, Makoto Miyoshi, I. Putu Bayu Mayura, Koji Iio, Osamu Matsushita, Fumio Otsuka, Hideharu Hagiya
Summary: The study found that Biapenem shows good in vitro efficacy against carbapenemase-producing Enterobacteriaceae, potentially serving as a new therapeutic option for infections caused by IMP-producing CPE.
JOURNAL OF MEDICAL MICROBIOLOGY
(2021)
Article
Infectious Diseases
Tushar Kumar Dey, Johanna Frida Lindahl, Ake Lundkvist, Delia Grace, Ram Pratim Deka, Rajeswari Shome, Samiran Bandyopadhyay, Naresh Kumar Goyal, Garima Sharma, Bibek Ranjan Shome
Summary: This study investigated the prevalence of beta-lactamase-producing Enterobacteriaceae in milk samples from two Indian states, revealing the presence of various prevalent beta-lactamase genes. The findings underscore the potential risk of antimicrobial-resistant bacteria in dairy products and the need for comprehensive approaches to accurately assess antibiotic resistance.
Article
Multidisciplinary Sciences
Carlos Henrique Camargo, Amanda Yaeko Yamada, Andreia Rodrigues de Souza, Marcos Paulo Vieira Cunha, Pedro Smith Pereira Ferraro, Claudio Tavares Sacchi, Marlon Benedito dos Santos, Karoline Rodrigues Campos, Monique Ribeiro Tiba-Casas, Maristela Pinheiro Freire, Pasqual Barretti
Summary: Carbapenem-resistant Klebsiella pneumoniae (CRKP) is highly disseminated worldwide, and evaluating the activity of novel antimicrobial drugs is necessary. In this study, the in vitro activity of novel antimicrobial drugs/combinations against 97 KPC-producing Klebsiella pneumoniae isolates from Brazil was evaluated. Meropenem-vaborbactam, cefiderocol, and ceftazidime-avibactam showed the highest activity, while resistance to ceftazidime-avibactam was associated with specific variants. Strict antimicrobial stewardship policies are urgently needed to preserve the effectiveness of these drugs.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Zackery P. Bulman, Xing Tan, Ting-Yu Chu, Yanqin Huang, Amisha P. Rana, Nidhi Singh, Stephanie A. Flowers, Yasuhiro Kyono, Barry N. Kreiswirth, Liang Chen
Summary: The combination of carbapenem resistance and hypervirulence in Klebsiella pneumoniae poses an emerging and urgent threat. Transcriptomic analysis suggests that altered transcription of multiple key pathways contributes to antibiotic tolerance in carbapenem-resistant K. pneumoniae with hypervirulence plasmids.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Infectious Diseases
Anna Olsson, Lisa Allander, Ayda Shams, Hissa Al-Farsi, Pernilla Lagerback, Thomas Tangden
Summary: This study assessed the effects of polymyxin B combinations against carbapenemase-producing Klebsiella pneumoniae (K. pneumoniae). Synergistic and bactericidal effects were observed with polymyxin B in combination with other antibiotics. Specific genotype-phenotype associations were found. This study provides important information for the search for promising combinations and individualized treatment.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Infectious Diseases
Maxwell J. Lasko, Kamilia Abdelraouf, David P. Nicolau
Summary: This study aimed to assess the efficacy of WCK 5222 against serine-carbapenemase-producing Klebsiella pneumoniae in a neutropenic murine pneumonia model using human-simulated plasma and ELF exposures. The results showed that WCK 5222 achieved a significant reduction in bacterial burden in both plasma and ELF exposures, demonstrating its potential efficacy in treating carbapenem-resistant Enterobacterales.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Infectious Diseases
Matthew Gethers, Iris Chen, Kamilia Abdelraouf, David P. Nicolau
Summary: This study evaluated the efficacy of ertapenem and zidebactam alone and in combination against carbapenemase-producing Klebsiella pneumoniae. The results showed potent in vivo activity of the combination therapy against the bacteria.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Yuki Igarashi, Wataru Takemura, Xiaoxi Liu, Nana Kojima, Takumi Morita, Victor Tuan Giam Chuang, Yuki Enoki, Kazuaki Taguchi, Kazuaki Matsumoto
Summary: This study aimed to establish a practical PK/PD analysis method to determine the practical PK/PD parameters of aztreonam/nacubactam. It was found that fT(>MICi) is the optimal PK/PD parameter for aztreonam/nacubactam and is highly correlated with in vivo bactericidal effect.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Review
Infectious Diseases
Simone Meini, Bruno Viaggi, Carlo Tascini
Summary: The efficacy of novel BLBLIs in treating CPE infections and whether combination therapy should be used are still subject to further research, with limited empirical evidence currently available.
Article
Microbiology
Jose M. Entenza, Andreas Haldimann, Marlyse Giddey, Sergio Lociuro, Stephen Hawser, Philippe Moreillon
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2009)
Article
Infectious Diseases
Christian Oefner, Monica Bandera, Andreas Haldimann, Heike Laue, Henk Schulz, Seema Mukhija, Sandro Parisi, Laurent Weiss, Sergio Lociuro, Glenn E. Dale
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2009)
Article
Microbiology
Melissa D. Barnes, Magdalena A. Taracila, Caryn E. Good, Saralee Bajaksouzian, Laura J. Rojas, David van Duin, Barry N. Kreiswirth, Michael R. Jacobs, Andreas Haldimann, Krisztina M. Papp-Wallace, Robert A. Bonomo
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2019)
Article
Infectious Diseases
Anders N. Kristoffersson, Caterina Bissantz, Rusudan Okujava, Andreas Haldimann, Isabelle Walter, Tianlai Shi, Claudia Zampaloni, Elisabet Nielsen
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2020)
Article
Multidisciplinary Sciences
Dor Russ, Fabian Glaser, Einat Shaer Tamar, Idan Yelin, Michael Baym, Eric D. Kelsic, Claudia Zampaloni, Andreas Haldimann, Roy Kishony
NATURE COMMUNICATIONS
(2020)
Article
Microbiology
B Hove-Jensen, TJ Rosenkrantz, A Haldimann, BL Wanner
JOURNAL OF BACTERIOLOGY
(2003)
Article
Microbiology
A Haldimann, BL Wanner
JOURNAL OF BACTERIOLOGY
(2001)