期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 66, 期 3, 页码 927-934出版社
IOS PRESS
DOI: 10.3233/JAD-180592
关键词
Amyloid; DNA methylation; late-onset Alzheimer's disease; tau proteins
资金
- NIH [ADRC P50 AGO33514, RO1 AG027161]
- University of Wisconsin ADRC pilot award
- Ruth L. Kirschstein National Research Service Award [MH113351-02]
- NATIONAL INSTITUTE OF MENTAL HEALTH [F31MH113351] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [RF1AG027161, P50AG033514, R01AG027161] Funding Source: NIH RePORTER
Differentially methylated positions (DMPs) between persons with and without late-onset Alzheimer's disease (LOAD) were observed at 477 of 769,190 loci in a plurality of genes. Of these, 17 were shared with DMPs identified using clinical LOAD markers analyzed independently as continuous variables comprising Rey Auditory Verbal Learning Test scores, cerebrospinal fluid total tau (t-tau) and phosphorylated tau 181 (p-tau(181)) levels, and t-tau/A beta 1-42 (A beta(42)), p-tau(181)/A beta(42), and A beta(42)/A beta 1-40 (A beta(40)) ratios. In patients with LOAD, 12 of the shared 17 DMPs were hypomethylated in B3GALT4 (Beta-1,3-galatcosyltransferase 4) (EC 2.4.1.62), and 5 were hypomethylated in ZADH2 (Prostaglandin reductase 3) (EC 1.3.1.48).
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