Article
Biochemistry & Molecular Biology
Dahae Lee, Hee Jae Kwak, Byoung Ha Kim, Seung Hyun Kim, Dong-Wook Kim, Ki Sung Kang
Summary: The study investigated the anti-adipogenic effects of hispidulin and p-synephrine alone and in combination, with the combination showing greater inhibition of lipid droplet formation. It may be a potential alternative strategy for developing novel anti-obesity drugs.
Article
Pharmacology & Pharmacy
Ji Young Je, Jae Eun Park, Youngwan Seo, Ji Sook Han
Summary: This study demonstrated that HM-chromanone extracted from Portulaca oleracea L. inhibits adipocyte differentiation and adipogenesis in 3T3-L1 cells by regulating adipogenic transcription factors and activating AMPK. The results suggest that HM-chromanone may be a potential anti-adipogenesis agent that targets adipogenic transcription factors.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Plant Sciences
Shuai Qiu, Jae Seok Cho, Jin Tae Kim, Ji Hyun Moon, Yimeng Zhou, Seung Beom Lee, Ho Jin Park, Hong Jin Lee
Summary: The study demonstrated that the C-21 steroid caudatin inhibits adipogenesis and obesity by activating the Hh signaling pathway, reducing lipid accumulation and body weight gain.
Article
Biochemistry & Molecular Biology
Yeon Woo Jung, Jung A. Lee, Ji Eun Lee, Hanna Cha, Yun-Hyeok Choi, Wonsik Jeong, Chun Whan Choi, Joa Sub Oh, Eun-Kyung Ahn, Seong Su Hong
Summary: This study extracted 19 secondary metabolites, including a new alpha-hydroxy acid derivative and two new lanostane-type triterpenoids, from the Smilacaceae plant. These compounds showed inhibitory effects on fat accumulation, with compounds 4, 7, 9, and 19 reducing lipid content by 37.05%, 8.60%, 15.82%, and 17.73%, respectively, at a concentration of 100 μM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Yimeng Zhou, Jin Tae Kim, Shuai Qiu, Seung Beom Lee, Ho Jin Park, Moon Jeong Soon, Hong Jin Lee
Summary: In this study, the researchers investigated the effect of 1,3,5,8-tetrahydroxyxanthone (THX) on the adipogenesis of 3T3-L1 adipocytes. They found that THX inhibited lipid accumulation and reduced the protein levels of key adipogenic transcriptional factors. They also discovered that THX enhanced the activity of the Hedgehog signaling pathway, leading to the suppression of fat formation. These findings suggest that THX may be a potential agent for the prevention of obesity.
FOOD SCIENCE AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Medicinal
Shuai Qiu, Jing Chen, Jin Tae Kim, Yimeng Zhou, Ji Hyun Moon, Seung Beom Lee, Ho Jin Park, Hong Jin Lee
Summary: Studies have shown that vitexin can suppress adipogenesis by regulating the Hh signaling pathway and phosphorylation of AMPK, which leads to reduced lipid accumulation and obesity.
JOURNAL OF MEDICINAL FOOD
(2022)
Article
Biochemistry & Molecular Biology
Wona Jee, Seung-Hyeon Lee, Hyun Min Ko, Ji Hoon Jung, Won-Seok Chung, Hyeung-Jin Jang
Summary: The study showed that Polygalin C (PC) extracted from Polygala japonica Houtt. has a significant anti-obesity effect on 3T3-L1 adipocytes by reducing lipid accumulation, suppressing adipogenesis and lipogenesis factors, and regulating AMPK/ACC and MAPK/Akt signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Mi Hwa Park, Hak-Ju Kim, Ji-Sook Han
Summary: A compound called pheophorbide A, isolated from Gelidium amansii, has been found to inhibit adipogenesis and may be useful in preventing obesity.
NUTRITION RESEARCH
(2022)
Article
Toxicology
Elvis Ticiani, Yong Pu, Madison White, Victoria Adomshick, Almudena Veiga-Lopez
Summary: Butyltins and phenyltins, widely used organometallic chemicals, have been found to stimulate adipogenic differentiation. Among them, tributyltin (TBT) is the most potent inducer, followed by triphenyltin (TPT) and dibutyltin (DBT). However, TPT and DBT can weaken the adipogenic effect of TBT. These findings indicate the antagonistic effects among organotins and the involvement of PPAR gamma signaling in their adipogenic outcomes.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Multidisciplinary Sciences
Laurie B. Cook, Henry D. Ophardt, Rongkun Shen, Bryan H. Pratt, Lucas A. Galbier
Summary: Understanding adipocyte responsiveness to GPCR-derived signals requires consideration of membrane microenvironments, with specific sub-populations of proteins showing significant variation across regions of the cell. Differentiation from pre-adipocytes to adipocytes involves the development of a transient primary cilium, with the MCH receptor 1 translocating to this structure during early adipogenesis. RNA-Seq analysis reveals that MCH signaling is influenced by its receptor localization, impacting the adipogenic transcriptional program and revealing novel signaling pathways related to circadian rhythm, inflammatory response, and ciliary biogenesis in 3T3-L1 cells. These findings suggest potential unintended consequences of using MCH receptor 1 antagonists for clinical interventions on adipose tissue development.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Sung Ho Lim, Ho Seon Lee, Hyo-Kyung Han, Chang-Ik Choi
Summary: Saikosaponin A (SSA) and saikosaponin D (SSD) inhibit lipid accumulation and fat deposition by suppressing adipogenesis pathways, suggesting potential therapeutic effects for obesity. Further research in animals and humans is needed to confirm their efficacy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Food Science & Technology
Jinhee Song, Hana Lee, Huijin Heo, Junsoo Lee, Younghwa Kim
Summary: We investigated the effects of chrysoeriol on fat cell formation and breakdown and identified the underlying mechanisms. Chrysoeriol inhibited fat accumulation in adipocytes and downregulated the expression of key genes involved in fat synthesis. Furthermore, chrysoeriol activated a protein kinase that promotes fat breakdown and increased the levels of free glycerol and fatty acids. Overexpression of specific enzymes for fat breakdown contributed to the enhanced lipolysis induced by chrysoeriol. Overall, chrysoeriol exhibited anti-adipogenic and lipolytic properties in fat cells.
Article
Biochemistry & Molecular Biology
Pere Bibiloni, Catalina A. Pomar, Andreu Palou, Juana Sanchez, Francisca Serra
Summary: Elevated miR-222 levels are linked to metabolic syndrome, insulin resistance, and diabetes. Rats fed an obesogenic diet during lactation have higher miR-222 content in breast milk, leading to increased body fat mass and impaired insulin sensitivity in their offspring. Transfection experiments with miR-222 mimics or inhibitors on 3T3-L1 preadipocytes reveal that miR-222 plays a role in pathways related to insulin signaling, lipid metabolism, and adipogenesis.
Article
Biochemistry & Molecular Biology
Dahae Lee, Ji-Youn Kim, Hae-Won Kim, Jeong-Eun Yoo, Ki Sung Kang
Summary: The combination of genistein and atorvastatin significantly suppresses preadipocyte differentiation and downregulates adipogenic marker proteins, suggesting a potential alternative treatment for menopause-associated lipid metabolic disorders and obesity.
Article
Pharmacology & Pharmacy
Chaiwat Monmai, Jin-Suk Kim, Hyun Bo Sim, Doh-Won Yun, Sung-Dug Oh, Eui-Shik Rha, Jong-Jin Kim, So-Hyeon Baek
Summary: This study evaluated the effects of extracts from transgenic rice on inhibiting adipogenesis and anti-inflammatory activity. The results showed that the extracts significantly reduced lipid accumulation in cells and inhibited the expression of adipogenesis-related mRNA and inflammation-related factors. Therefore, transgenic rice may have potential as an obesity-reducing and/or -preventing agent.
Article
Food Science & Technology
Cheng Bao, Jing Chen, Jin Tae Kim, Shuai Qiu, Jae Seok Cho, Hong Jin Lee
JOURNAL OF FUNCTIONAL FOODS
(2019)
Article
Chemistry, Multidisciplinary
Cheng Bao, Bin Liu, Bin Li, Jingjing Chai, Liwei Zhang, Lulu Jiao, Dan Li, Zhengquan Yu, Fazheng Ren, Xinghua Shi, Yuan Li
Article
Plant Sciences
Jing Chen, Shuai Qiu, Jin Tae Kim, Jae Seok Cho, Ji Hyun Moon, Yimeng Zhou, Joong-Hyuck Auh, Hong Jin Lee
Article
Environmental Sciences
Jin Tae Kim, Hong Jin Lee, Hee-Seok Lee
Summary: The study revealed that four organophosphorus pesticides may induce adipogenesis by interacting with the estrogen receptor, leading to lipid droplet accumulation and regulation of gene expression related to fat metabolism.
ENVIRONMENTAL POLLUTION
(2021)
Article
Biotechnology & Applied Microbiology
Jin Tae Kim, Shuai Qiu, Yimeng Zhou, Ji Hyun Moon, Seung Beom Lee, Ho Jin Park, Hong Jin Lee
Summary: The study investigated the effect of freeze-dried powder of Rubus coreanus Miquel (RCP) on oxidative stress and prevention of organ damage in an isoproterenol-induced myocardial infarction model. Results showed that RCP reduced toxicity markers, increased glutathione levels, decreased malonaldehyde levels, and ameliorated damages in a dose-dependent manner, suggesting beneficial effects on organ damage prevention.
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Plant Sciences
Shuai Qiu, Jae Seok Cho, Jin Tae Kim, Ji Hyun Moon, Yimeng Zhou, Seung Beom Lee, Ho Jin Park, Hong Jin Lee
Summary: The study demonstrated that the C-21 steroid caudatin inhibits adipogenesis and obesity by activating the Hh signaling pathway, reducing lipid accumulation and body weight gain.
Article
Food Science & Technology
Jin Tae Kim, Yimeng Zhou, Shuai Qiu, Seung Beom Lee, Ho Jin Park, Min Jeong Kim, Sung Keun Jung, Eunbin Seo, Young-Jun Kim, Hong Jin Lee
Summary: This study evaluated the effect of Capsicum annuum L. cv. DANGJO (DJ) freeze-dried powder on ameliorating hyperglycemia in a type 2 diabetes rat model. The results showed that DJ significantly reduced blood glucose, insulin levels, and glycated hemoglobin levels. Quercitrin, quantified in DJ, was identified as the key component responsible for reducing blood glucose levels in the rats.
FOOD SCIENCE AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Medicinal
Shuai Qiu, Jing Chen, Jin Tae Kim, Yimeng Zhou, Ji Hyun Moon, Seung Beom Lee, Ho Jin Park, Hong Jin Lee
Summary: Studies have shown that vitexin can suppress adipogenesis by regulating the Hh signaling pathway and phosphorylation of AMPK, which leads to reduced lipid accumulation and obesity.
JOURNAL OF MEDICINAL FOOD
(2022)
Article
Food Science & Technology
Yimeng Zhou, Jin Tae Kim, Shuai Qiu, Seung Beom Lee, Ho Jin Park, Moon Jeong Soon, Hong Jin Lee
Summary: In this study, the researchers investigated the effect of 1,3,5,8-tetrahydroxyxanthone (THX) on the adipogenesis of 3T3-L1 adipocytes. They found that THX inhibited lipid accumulation and reduced the protein levels of key adipogenic transcriptional factors. They also discovered that THX enhanced the activity of the Hedgehog signaling pathway, leading to the suppression of fat formation. These findings suggest that THX may be a potential agent for the prevention of obesity.
FOOD SCIENCE AND BIOTECHNOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Yimeng Zhou, Shuai Qiu, Jin Tae Kim, Seung Beom Lee, Ho Jin Park, Moon Jeong Son, Hong Jin Lee, Jing Chen
Summary: Hyperactivation of hedgehog signaling in colorectal cancer stem-like cells can be suppressed by Garcinone C, a xanthone compound isolated from mangosteen. Garcinone C inhibits the proliferation and self-renewal of cancer stem-like cells by targeting Gli1-dependent noncanonical hedgehog signaling. It also decreases the expression of stemness markers and invasive-related markers, and enhances the degradation of Gli1. Garcinone C may have potential as a natural agent against colorectal cancer relapse.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Food Science & Technology
Jin Tae Kim, Seung Beom Lee, Moon Jeong Son, Yimeng Zhou, Shuai Qiu, Ho Jin Park, Dong Hyeon Jeon, Young-Jun Kim, Hong Jin Lee
Summary: In this study, the effect of perilla oil (PO) on thrombosis induced by collagen and epinephrine (CE) in rats was investigated. The administration of PO increased prothrombin time and activated partial thromboplastin time, and inhibited the expression of cells adhesion markers in the aorta tissue. Moreover, PO suppressed pulmonary occlusion induced by CE in rats.
FOOD SCIENCE AND BIOTECHNOLOGY
(2023)
Article
Food Science & Technology
Kyeong Jin Kim, Soo-yeon Park, Jin Tae Kim, Hong Jin Lee, Sung Keun Jung, Young-Jun Kim, Choong Hwan Lee, Sanguine Byun, Ji Yeon Kim
Summary: This study found that Dangjo chili pepper has the potential to lower blood glucose levels after carbohydrate intake, and it exerts its effect by inhibiting the activity of alpha-glucosidase. Quercitrin is one of the most abundant flavonoids in Dangjo chili pepper.
Article
Biochemistry & Molecular Biology
Jing Chen, Jiwon Ko, Jin Tae Kim, Jae Seok Cho, Shuai Qiu, Gyoung-Deuck Kim, Joong-Hyuck Auh, Hong Jin Lee
Article
Biochemistry & Molecular Biology
Shuai Qiu, Yimeng Zhou, Jin Tae Kim, Cheng Bao, Hong Jin Lee, Jing Chen
Summary: The study demonstrated that amentoflavone inhibited the migration and invasion of TNF alpha-induced breast cancer cells by modulating the AKT/mTOR/S6K1 signaling pathway, ultimately reducing the invasiveness of human breast cancer cells. Amentoflavone may be considered as a potent food ingredient for slowing down mammary tumorigenesis.
