Article
Medicine, General & Internal
Ahsan Alam, Emilie Cornec-Le Gall, Ronald D. Perrone
Summary: This article describes autosomal dominant polycystic kidney disease, its signs and symptoms, diagnosis, and treatment options.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Multidisciplinary Sciences
Kiyotaka Uchiyama, Chigusa Kitayama, Akane Yanai, Yoshitaka Ishibashi
Summary: The study showed that trichlormethiazide can significantly reduce urine volume and increase urinary osmolarity in ADPKD patients, as well as improve multiple HRQOL subscales, without significantly affecting renal function slope or plasma/urinary biomarkers.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Alexander R. Chang, Bryn S. Moore, Jonathan Z. Luo, Gino Sartori, Brian Fang, Steven Jacobs, Yoosif Abdalla, Mohammed Taher, David J. Carey, William J. Triffo, Gurmukteshwar Singh, Tooraj Mirshahi
Summary: This study reveals substantial genetic and phenotypic variability in autosomal dominant polycystic kidney disease (ADPKD) among patients within a regional health system in the US. In addition to PKD1 and PKD2, LOF variants in IFT140, GANAB, and HNF1B were associated with ADPKD diagnosis. Patients with a family history of ADPKD had a higher yield for genetic determinants of the disease.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Review
Pharmacology & Pharmacy
Thomas Bais, Ron T. Gansevoort, Esther Meijer
Summary: This review discusses the development of new drugs for the treatment of ADPKD, such as CFTR modulators and micro RNA inhibitors. It also explores methods to improve the tolerability of V2RA, select patients with rapid disease progression, and translate preclinical data into clinical practice.
Review
Pharmacology & Pharmacy
Shunichiro Tsukamoto, Shingo Urate, Takayuki Yamada, Kengo Azushima, Takahiro Yamaji, Sho Kinguchi, Kazushi Uneda, Tomohiko Kanaoka, Hiromichi Wakui, Kouichi Tamura
Summary: This study used a network meta-analysis to compare the effects of different treatments for ADPKD. The results showed that tolvaptan and somatostatin analogs had significant efficacy in preserving kidney function and inhibiting TKV growth.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Nutrition & Dietetics
Lauren Pickel, Ioan-Andrei Iliuta, James Scholey, York Pei, Hoon-Ki Sung
Summary: Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive growth of renal cysts and loss of functional nephrons. Evidence suggests that dietary interventions such as caloric restriction, intermittent fasting, and ketogenic diets have the potential to slow disease progression and confer metabolic benefits.
ADVANCES IN NUTRITION
(2022)
Article
Urology & Nephrology
Cortney N. Steele, Ester S. Oh, Wei Wang, Heather Farmer-Bailey, Berenice Y. Gitomer, Michel Chonchol, Kristen L. Nowak
Summary: Cerebrovascular dysfunction, characterized by increased brain pulsatile flow, reduced cerebrovascular reactivity, and cerebral hypoperfusion, precedes the onset of dementia and is linked to cognitive dysfunction. Patients with autosomal dominant polycystic kidney disease (ADPKD) have a higher risk of dementia and are more likely to develop intracranial aneurysms, but cerebrovascular function in ADPKD patients has not been previously characterized.
AMERICAN JOURNAL OF NEPHROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Claudio Ponticelli, Gabriella Moroni, Francesco Reggiani
Summary: Autosomal-Dominant Polycystic Kidney Disease (ADPKD) is a genetic disorder caused by mutations in PKD1 or PKD2 genes. The involvement of autophagy in ADPKD remains a subject of investigation, with potential implications on cyst formation and fibrosis. Autophagy inducers have shown promising results in preclinical studies and may provide a potential avenue for future investigations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Guangying Shao, Shuai Zhu, Baoxue Yang
Summary: ADPKD is a common hereditary kidney disease characterized by progressively enlarged cysts that destroy renal function, potentially leading to ESRD. Herbal medicines have shown potential in inhibiting cyst development and ADPKD progression, providing new insights for clinical therapeutic strategies.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Jin Liu, Xiaorui Yin, Hreedi Dev, Xianfu Luo, Jon D. D. Blumenfeld, Hanna Rennert, Martin R. R. Prince
Summary: This study investigates the association between autosomal dominant polycystic kidney disease (ADPKD) and pleural effusion. Pleural effusions were observed in 21% of ADPKD subjects compared to 8% in controls. In a subpopulation controlling for renal function, 25% of ADPKD subjects had pleural effusions compared to 5% of controls.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Urology & Nephrology
Jessica T. T. Camargo, Camilo A. Gonzalez, Lina Herrera, Nancy Yomayusa-Gonzalez, Milciades Ibanez, Ana M. M. Valbuena-Garcia, Lizbeth Acuna-Merchan
Summary: This study investigated the prevalence, geographical location, and ethnic groups of ADPKD patients undergoing dialysis or kidney transplant in Colombia between 2015 and 2019. The prevalence of ADPKD was lower compared to Europe and the US, and further genetic prevalence studies may be needed in some states with higher prevalence.
Article
Multidisciplinary Sciences
Katharina Hopp, Victoria A. Catenacci, Nidhi Dwivedi, Timothy L. Kline, Wei Wang, Zhiying You, Dustin T. Nguyen, Kristen Bing, Bhavya Poudyal, Ginger C. Johnson, Matthew R. Jackman, Marsha Miller, Cortney N. Steele, Natalie J. Serkova, Paul S. MacLean, Raphael A. Nemenoff, Berenice Gitomer, Michel Chonchol, Kristen L. Nowak
Summary: This study demonstrates that both daily caloric restriction (DCR) and intermittent fasting (IMF) can lead to significant weight loss and slow cyst growth in ADPKD patients. DCR has better efficacy in weight loss compared to IMF, and patients showed higher adherence and tolerability to DCR.
Article
Biochemistry & Molecular Biology
Johannes Leierer, Paul Perco, Benedikt Hofer, Susanne Eder, Alexander Dzien, Julia Kerschbaum, Michael Rudnicki, Gert Mayer
Summary: Changes in protein concentrations in the body fluids of ADPKD patients mainly involve dysregulation of various molecular processes, including markers such as EGF, APLN, VEGFA, and AGT. These markers are significantly correlated with renal function and disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Urology & Nephrology
Djalila Mekahli, Lisa M. Guay-Woodford, Melissa A. Cadnapaphornchai, Larry A. Greenbaum, Mieczyslaw Litwin, Tomas Seeman, Ann Dandurand, Lily Shi, Kimberly Sikes, Susan E. Shoaf, Franz Schaefer
Summary: This study evaluated the safety and efficacy of Tolvaptan in children/adolescents with ADPKD. The results showed that Tolvaptan effectively inhibited antidiuretic hormone activity and reduced kidney volume increase. Adverse events were manageable and quality of life remained stable.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Review
Medicine, General & Internal
Jing Xu, Cheng Xue, Xiaodong Wang, Lei Zhang, Changlin Mei, Zhiguo Mao
Summary: ADPKD, the most common inherited kidney disease worldwide, is mainly influenced by genes PKD1 and PKD2. Epigenetic modifications, particularly chromatin methylation and histone modifications, play a significant role in the development and progression of ADPKD. More research is needed to better understand and potentially treat the methylation abnormalities in ADPKD.
FRONTIERS IN MEDICINE
(2022)
Article
Transplantation
Crissy F. Rudolphi, Charles J. Blijdorp, Hester van Willigenburg, Mahdi Salih, Ewout J. Hoorn
Summary: Urinary extracellular vesicles (uEVs) offer a noninvasive approach to study tubular transport in health and disease. They have been applied to both rare and common diseases, but challenges in technical and biological aspects still need to be addressed.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Cardiac & Cardiovascular Systems
Kunihiro Matsushita, Stephen Kaptoge, Steven H. J. Hageman, Yingying Sang, Shoshana H. Ballew, Morgan E. Grams, Aditya Surapaneni, Luanluan Sun, Johan Arnlov, Milica Bozic, Hermann Brenner, Nigel J. Brunskill, Alex R. Chang, Rajkumar Chinnadurai, Massimo Cirillo, Adolfo Correa, Natalie Ebert, Kai Uwe Eckardt, Ron T. Gansevoort, Orlando Gutierrez, Farzad Hadaegh, Jiang He, Shih Jen Hwang, Tazeen H. Jafar, Simerjot K. Jassal, Takamasa Kayama, Csaba P. Kovesdy, Gijs W. Landman, Andrew S. Levey, Donald M. Lloyd-Jones, Rupert W. Major, Katsuyuki Miura, Paul Muntner, Girish N. Nadkarni, Christoph Nowak, Takayoshi Ohkubo, Michelle J. Pena, Kevan R. Polkinghorne, Toshimi Sairenchi, Elke Schaeffner, Markus P. Schneider, Varda Shalev, Michael G. Shlipak, Marit D. Solbu, Nikita Stempniewicz, James Tollitt, Jose M. Valdivielso, Joep van der Leeuw, Angela Yee Moon Wang, Chi Pang Wen, Mark Woodward, Kazumasa Yamagishi, Hiroshi Yatsuya, Luxia Zhang, Jannick A. N. Dorresteijn, Emanuele Di Angelantonio, Frank L. J. Visseren, Lisa Pennells, Josef Coresh
Summary: This study developed an "Add-on" method to incorporate chronic kidney disease (CKD) measures into cardiovascular disease (CVD) risk prediction algorithms, which improved the predictive accuracy. This approach will assist clinicians and patients in more precise risk assessment and personalized preventive therapies for CKD.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Pediatrics
Agnes Trautmann, Olivia Boyer, Elisabeth Hodson, Arvind Bagga, Debbie S. Gipson, Susan Samuel, Jack Wetzels, Khalid Alhasan, Sushmita Banerjee, Rajendra Bhimma, Melvin Bonilla-Felix, Francisco Cano, Martin Christian, Deirdre Hahn, Hee Gyung Kang, Koichi Nakanishi, Hesham Safouh, Howard Trachtman, Hong Xu, Wendy Cook, Marina Vivarelli, Dieter Haffner
Summary: Idiopathic nephrotic syndrome is a common pediatric glomerular disease, and patients who are sensitive to steroids have a risk of relapse and may require long-term medication to maintain remission. The optimal dose and duration of steroid treatment to prolong time between relapses are still debated, and there is variation in practice regarding drug selection and timing. Therefore, international evidence-based clinical practice recommendations are needed to guide treatment and reduce practice variation.
PEDIATRIC NEPHROLOGY
(2023)
Article
Urology & Nephrology
Obbo W. Bredewold, Joe Chan, My Svensson, Annette Bruchfeld, Johan W. de Fijter, Hans Furuland, Josep M. Grinyo, Anders Hartmann, Hallvard Holdaas, Olof Hellberg, Alan Jardine, Lars Mjornstedt, Karin Skov, Knut T. Smerud, Inga Soveri, Soren S. Sorensen, Anton-Jan van Zonneveld, Bengt Fellstrom
Summary: A study compared belatacept and calcineurin inhibitor treatments in kidney transplant recipients and found that belatacept was associated with improved cardiovascular risk factors. However, switching to belatacept did not affect the calculated cardiovascular risk.
Article
Urology & Nephrology
Esther N. M. de Rooij, Johan W. de Fijter, Saskia Le Cessie, Ewout J. Hoorn, Kitty J. Jager, Nicholas C. Chesnaye, Marie Evans, Karin Windahl, Fergus J. Caskey, Claudia Torino, Maciej Szymczak, Christiane Drechsler, Christoph Wanner, Friedo W. Dekker, Ellen K. Hoogeveen
Summary: This study found a U-shaped relationship between serum potassium and the risk of death or initiation of kidney replacement therapy in patients with stage 4-5 chronic kidney disease, with the lowest risk observed at a potassium level of approximately 4.9 mmol/L.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Article
Pharmacology & Pharmacy
Soufian Meziyerh, Pim Bouwmans, Teun van Gelder, Danny van Der Helm, Lianne Messchendorp, Paul J. M. W. van Der Boog, Johan de Fijter, Dirk Jan A. R. Moes, Aiko P. J. de Vries
Summary: Despite boosting, kidney transplant recipients (KTRs) may have an increased risk of severe COVID-19 due to a substantial number of individuals with low antibody levels. The use of mycophenolic acid, an immunosuppressive drug, has been found to negatively affect antibody formation and is a modifiable risk factor. This study investigated the relationship between mycophenolic acid exposure and seroconversion after mRNA-1273 SARS-CoV-2 vaccination in KTRs, finding that higher exposure to mycophenolic acid was associated with lower seroconversion rates and antibody titers.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Floris M. Thunnissen, Daan J. Comes, Carmen S. S. Latenstein, Martijn W. J. Stommel, Cornelis J. H. M. van Laarhoven, Joost P. H. Drenth, Marten A. Lantinga, Femke Atsma, Philip R. de Reuver
Summary: This study defined the ideal outcome for the treatment of uncomplicated gallstone disease through expert meetings and surveys, and found that 64.2% of patients achieved this outcome based on analysis of Dutch patient data.
Article
Gastroenterology & Hepatology
Felix Theunissen, Marten Alexander Lantinga, Pieter C. J. ter Borg, Rob J. T. D. Ouwendijk, Peter J. Siersema, Marco Bruno, TransIT Fdn Study Grp
Summary: This study evaluated the efficacy and compliance of currently used bowel preparations with the European Society of Gastrointestinal Endoscopy (ESGE) performance measures. It found that different volumes of bowel preparation regimens met the minimum ESGE performance measures, and the Boston Bowel Preparation Scale could be further improved by combining ultra low volume regimens with bisacodyl. Therefore, the choice of bowel preparation method can be based on volume-tolerance and patient preference.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Article
Urology & Nephrology
Frank Geurts, Laixi Xue, Bart J. Kramers, Robert Zietse, Ron T. Gansevoort, Robert A. Fenton, Esther Meijer, Mahdi Salih, Ewout J. Hoorn, DIPAK Consortium
Summary: This study found that higher urinary excretions of PGE2 and PGEM in patients with ADPKD are associated with impaired osmoregulation, disease severity, and progression.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Surgery
Floris M. Thunnissen, Cleo Baars, Rianne Arts, Carmen S. S. Latenstein, Joost P. H. Drenth, Cornelis J. H. M. van Laarhoven, Marten A. Lantinga, Philip R. de Reuver, Dutch Gallbladder Res Grp
Summary: Post-cholecystectomy symptoms mainly include flatulence, frequent bowel movements, and restricted eating. New-onset symptoms may involve frequent bowel movements, bowel urgency, and diarrhea. These findings provide clinical guidance for monitoring, managing, and treating patients with symptoms after cholecystectomy.
Article
Urology & Nephrology
Yassine Laghrib, Annick Massart, Johan Willem de Fijter, Daniel Abramowicz, Christophe De Block, Rachel Hellemans
Summary: Post-transplant diabetes mellitus occurs in 10-40% of kidney transplant recipients and is associated with increased risk of cardiovascular diseases. This study aimed to establish a model for predicting the risk of post-transplant diabetes mellitus. The results showed that pre-transplant HbA1c level was the strongest predictor for post-transplant diabetes mellitus.
JOURNAL OF NEPHROLOGY
(2023)
Meeting Abstract
Urology & Nephrology
Ilana Heckler, Coralien Vink, Anne-Els van de Logt, Alexander Kuehnl, Cornelia Daehnrich, Wolfgang Schlumberger, Jack Wetzels
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Article
Urology & Nephrology
Paul Geertsema, Ron T. Gansevoort, Lisanne P. J. Brenkman, Shosha E. I. Dekker, Damia V. P. Eleveld, Johan W. de Fijter, Anna M. Leliveld, Maya Levy, Esther Meijer, Robert A. Pol, Emmelien E. M. Schillern, Jan-Stephan F. Sanders, Niek F. Casteleijn
Summary: This study investigates the effect of pre-transplantation nephrectomy on quality of life in ADPKD patients. The results show that nephrectomy improves quality of life and bilateral nephrectomy may be preferred for better outcomes.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Urology & Nephrology
Uta Erdbrugger, Ewout J. J. Hoorn, Thu H. H. Le, Charles J. J. Blijdorp, Dylan Burger
Summary: Extracellular vesicles (EVs) are emerging as important mediators and biomarkers in kidney health and disease. They can provide valuable information about the state of the cells in the kidney and their role in various kidney diseases. However, the heterogeneity of EVs poses challenges in their separation and characterization. More sensitive tools are being developed to overcome these challenges. The therapeutic potential of EVs in kidney diseases has been extensively studied in animal models and the field of EV diagnostics and therapeutics is advancing rapidly.
Article
Urology & Nephrology
Steven D. Podos, Howard Trachtman, Gerald B. Appel, Andrew S. Bomback, Bradley P. Dixon, Jack F. M. Wetzels, H. Terence Cook, Samir V. Parikh, Matthew C. Pickering, James Tumlin, Craig B. Langman, Liz Lightstone, C. John Sperati, Erica Daina, Koenraad Peter Bouman, Kara Rice, Jane A. Thanassi, Mingjun Huang, Carla Nester, Giuseppe Remuzzi
Summary: This study investigated biomarkers in patients with C3G and found associations between complement biomarkers, kidney function, and kidney histology. These findings are important for understanding C3G and characterizing patients with this heterogeneous disease.
AMERICAN JOURNAL OF NEPHROLOGY
(2023)