Bacterial persistence promotes the evolution of antibiotic resistance by increasing survival and mutation rates

Persistent bacterial infections and persister cells

(2017) Robert A. Fisher et al.   NATURE REVIEWS MICROBIOLOGY

Antibiotic tolerance facilitates the evolution of resistance

(2017) Irit Levin-Reisman et al.   SCIENCE

Phagocytes, Antibiotics, and Self-Limiting Bacterial Infections

(2017) Bruce R. Levin et al.   TRENDS IN MICROBIOLOGY

Adaptive tuning of mutation rates allows fast response to lethal stress in Escherichia coli

(2017) Toon Swings et al.   eLife

Coupling phenotypic persistence to DNA damage increases genetic diversity in severe stress

(2017) Gilad Yaakov et al.   Nature Ecology & Evolution

In VitroEmergence of High Persistence upon Periodic Aminoglycoside Challenge in the ESKAPE Pathogens

(2016) Joran Elie Michiels et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

De Novo Emergence of Genetically Resistant Mutants of Mycobacterium tuberculosis from the Persistence Phase Cells formed against Antituberculosis Drugs In Vitro

(2016) Jees Sebastian et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Molecular mechanisms and clinical implications of bacterial persistence

(2016) Joran Elie Michiels et al.   DRUG RESISTANCE UPDATES

Should we develop screens for multi-drug antibiotic tolerance?

(2016) Bram Van den Bergh et al.   Expert Review of Anti-Infective Therapy

Persistence and resistance as complementary bacterial adaptations to antibiotics

(2016) T. Vogwill et al.   JOURNAL OF EVOLUTIONARY BIOLOGY

The cellular origins of drug resistance in cancer

(2016) Geoffrey R Oxnard   NATURE MEDICINE

Distinguishing between resistance, tolerance and persistence to antibiotic treatment

(2016) Asher Brauner et al.   NATURE REVIEWS MICROBIOLOGY

Antibiotic treatment enhances the genome-wide mutation rate of target cells

(2016) Hongan Long et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of bacterial persistence during stress and antibiotic exposure

(2016) Alexander Harms et al.   SCIENCE

Frequency of antibiotic application drives rapid evolutionary adaptation of Escherichia coli persistence

(2016) Bram Van den Bergh et al.   Nature Microbiology

A Novel Point Mutation Promotes Growth Phase-Dependent Daptomycin Tolerance in Staphylococcus aureus

(2015) Lukas Mechler et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Heterogeneous Host-Pathogen Encounters: Act Locally, Think Globally

(2015) Dirk Bumann   Cell Host & Microbe

Phenotypic Heterogeneity Enables Uropathogenic Escherichia coli To Evade Killing by Antibiotics and Serum Complement

(2015) Marta Putrinš et al.   INFECTION AND IMMUNITY

Fitness trade-offs explain low levels of persister cells in the opportunistic pathogenPseudomonas aeruginosa

(2015) Kristine Stepanyan et al.   MOLECULAR ECOLOGY

Staphylococcus aureuschronic and relapsing infections: Evidence of a role for persister cells

(2014) Brian P. Conlon   BIOESSAYS

Strength of Selection Pressure Is an Important Parameter Contributing to the Complexity of Antibiotic Resistance Evolution

(2014) Tugce Oz et al.   MOLECULAR BIOLOGY AND EVOLUTION

Optimization of lag time underlies antibiotic tolerance in evolved bacterial populations

(2014) Ofer Fridman et al.   NATURE

Unbiased Estimation of Mutation Rates under Fluctuating Final Counts

(2014) Bernard Ycart et al.   PLoS One

Exploring the collaboration between antibiotics and the immune response in the treatment of acute, self-limiting infections

(2014) P. Ankomah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolution in changing environments: Modifiers of mutation, recombination, and migration

(2014) Oana Carja et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combating Evolution to Fight Disease

(2014) S. M. Rosenberg et al.   SCIENCE

Genome-wide analysis captures the determinants of the antibiotic cross-resistance interaction network

(2014) Viktória Lázár et al.   Nature Communications

Genomewide Screen for Modulators of Evolvability under Toxic Antibiotic Exposure

(2013) Orsolya Méhi et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Microbial Persistence and the Road to Drug Resistance

(2013) Nadia R. Cohen et al.   Cell Host & Microbe

Molecular Mechanism of Bacterial Persistence by HipA

(2013) Elsa Germain et al.   MOLECULAR CELL

Population Dynamics of Bacterial Persistence

(2013) Pintu Patra et al.   PLoS One

Use of Collateral Sensitivity Networks to Design Drug Cycling Protocols That Avoid Resistance Development

(2013) L. Imamovic et al.   Science Translational Medicine

HipA-mediated antibiotic persistence via phosphorylation of the glutamyl-tRNA-synthetase

(2013) Ilana Kaspy et al.   Nature Communications

Phylomark, a Tool To Identify Conserved Phylogenetic Markers from Whole-Genome Alignments

(2012) Jason W. Sahl et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Stress-induced mutation via DNA breaks inEscherichia coli: A molecular mechanism with implications for evolution and medicine

(2012) Susan M. Rosenberg et al.   BIOESSAYS

Outwitting Evolution: Fighting Drug-Resistant TB, Malaria, and HIV

(2012) Daniel E. Goldberg et al.   CELL

THE EVOLUTION OF STRESS-INDUCED HYPERMUTATION IN ASEXUAL POPULATIONS

(2012) Yoav Ram et al.   EVOLUTION

Identity and Function of a Large Gene Network Underlying Mutagenic Repair of DNA Breaks

(2012) A. A. M. Al Mamun et al.   SCIENCE

Stress responses as determinants of antimicrobial resistance in Gram-negative bacteria

(2012) Keith Poole   TRENDS IN MICROBIOLOGY

Statistics for the Luria-Delbrück distribution

(2012) Agnès Hamon et al.   Electronic Journal of Statistics

Combination therapies for combating antimicrobial resistance

(2011) Michael A Fischbach   CURRENT OPINION IN MICROBIOLOGY

GENETIC VARIATION FOR ANTIBIOTIC PERSISTENCE IN ESCHERICHIA COLI

(2011) Balint Stewart et al.   EVOLUTION

Metabolite-enabled eradication of bacterial persisters by aminoglycosides

(2011) Kyle R. Allison et al.   NATURE

Emergence of Pseudomonas aeruginosa Strains Producing High Levels of Persister Cells in Patients with Cystic Fibrosis

(2010) L. R. Mulcahy et al.   JOURNAL OF BACTERIOLOGY

Origins and Evolution of Antibiotic Resistance

(2010) J. Davies et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Sublethal Antibiotic Treatment Leads to Multidrug Resistance via Radical-Induced Mutagenesis

(2010) Michael A. Kohanski et al.   MOLECULAR CELL

Patients with Long-Term Oral Carriage Harbor High-Persister Mutants of Candida albicans

(2009) M. D. LaFleur et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY