Article
Chemistry, Inorganic & Nuclear
Andreia Forte, Sandra Gago, Manuela Ribeiro Carrott, Peter Carrott, Celso Alves, Fernando Teodoro, Rui Pedrosa, Isabel M. Marrucho, Luis C. Branco
Summary: Organic salts based on different choline derivative cations and metal ions were immobilized in mesoporous silica nanoparticles through a two-step synthetic method, characterized using various techniques and evaluated for cytotoxicity in different cell lines. The characterization data confirmed successful functionalization and provided insights into the materials' properties, while the cytotoxicity results revealed differences between the metal organic salts and their immobilized analogues.
DALTON TRANSACTIONS
(2021)
Article
Engineering, Chemical
Shuzi Liu, Dongkun Yu, Yu Chen, Ruifen Shi, Fengyi Zhou, Tiancheng Mu
Summary: This paper introduces the evaluation method of thermal stability of deep eutectic solvents (DESs). Traditional thermogravimetric analysis (TGA) has issues such as decomposition overlap and low resolution, while high-resolution TGA (HR-TGA) can more accurately evaluate the thermal stability of DESs.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2022)
Article
Energy & Fuels
Ana Carolina Lima, Khadidja Hachemane, Antonio E. Ribeiro, Ana Queiroz, Maria Carolina Sergi Gomes, Paulo Brito
Summary: Ionic liquid choline hydroxide (ChOH) was successfully applied as a catalyst for the transesterification reaction of triacylglycerols present in sunflower oil with methanol. The experimental results showed that a high ester yield can be achieved in a short reaction time under specific conditions. Kinetic modeling study indicated that a first-order model is the best fit for the reaction.
Article
Chemistry, Physical
Usman Saeed, Asim Laeeq Khan, Mazhar Amjad Gilani, Muhammad Roil Bilad, Asad Ullah Khan
Summary: This study focused on utilizing deep eutectic solvents (DESs) impregnated into PVDF membranes for the separation of CO2 from CH4. The DES-SLMs showed high CO2 permeability and selectivity, indicating potential for new pathways in CO2 capture using DESs.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Physical
Jean-Pierre Mbakidi, Florica Lazar, Luc Marchal, Eric Leroy, Sandrine Bouquillon
Summary: Paramylon is a water insoluble linear glucan produced by Euglena gracilis microalgae. It has a stable triple helix conformation and high crystallinity due to its macromolecular structure containing only b(1-3) linkages. The solubility of paramylon was evaluated using eco-friendly ionic liquids as solvents, and the structure and thermal properties of the biopolymer before and after solubilization and regeneration were discussed. (C) 2022 Elsevier B.V. All rights reserved.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Multidisciplinary
Malgorzata Musia, Edward Zorebski, Katarzyna Malarz, Michal Kuczak, Anna Mrozek-Wilczkiewicz, Johan Jacquemin, Marzena Dzida
Summary: The study revealed that imidazolium-based ILs combined with dialkyl phosphate anions or with the ethyl sulfate anion are the least cytotoxic. Some ILs can potentially be used as hydraulic fluids or efficient solvents, while others have potential as heat transfer media and base fluids.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2021)
Article
Chemistry, Physical
Ana Rita Pereira, Ines B. Gomes, Manuel Simoes
Summary: Choline-based ionic liquids have demonstrated antimicrobial and antibiofilm activity, although their effectiveness is lower than that of commonly used quaternary ammonium compounds. The mode of action of these ionic liquids involves the dysfunction and disruption of the bacterial outer layer. The combination of choline-based ionic liquids and quaternary ammonium compounds shows additive effects against biofilm formation.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Biotechnology & Applied Microbiology
Fabiane O. Farias, Ariel A. C. Toledo Hijo, Cassamo U. Mussagy, Ramon S. B. Ferreira, Valeria C. Santos-Ebinuma, Eduardo A. C. Batista, Antonio J. A. Meirelles
Summary: This study investigates two different approaches for vegetable oil deacidification using an ionic liquid as a solvent. The oligomeric IL approach removes oleic acid from soybean oil, and the multicomponent IL approach achieves a FFA removal rate of 85%. Both methods result in lower oil loss compared to conventional chemical processes.
FOOD AND BIOPRODUCTS PROCESSING
(2023)
Review
Chemistry, Multidisciplinary
Harender S. Dhattarwal, Hemant K. Kashyap
Summary: Bio-compatible ionic liquids (Bio-ILs) are solvents with unique properties that have great potential for applications in various fields, such as biomass dissolution, CO2 sequestration, and biodegradation of pesticides. This review focuses on the microscopic structure of bio-ILs based on cholinium cation and amino acid anions, using advanced ab initio and classical molecular dynamics simulations. The structure of these green ILs plays a crucial role in their suitability for specific applications, and the side chain of amino acid anions greatly affects their structure and biomass dissolution efficiency. Understanding the microscopic structure of bio-ILs will contribute to the development of targeted applications for these green ILs.
Article
Polymer Science
Yeasmin Nahar, James Horne, Vinh Truong, Alex C. Bissember, Stuart C. Thickett
Summary: Thermoresponsive poly(N-isopropylacrylamide) (polyNIPAM) hydrogels were prepared via free radical polymerization in deep eutectic monomer solvents (DEMs) for the first time, where NIPAM served as a polymerizable hydrogen bond donor. The hydrogels prepared with DEMs showed increased cross-linking density and mechanical strength compared to those prepared in aqueous polymerization, exhibiting unique thermoresponsive swelling behavior.
Article
Chemistry, Physical
Yuting Li, Fan Yang, Yuan Li, Meng Cai, Hao Li, Xiaoqiang Fan, Minhao Zhu
Summary: In this study, a series of eco-friendly, non-corrosive and cost-effective choline amino acid ionic liquids ([Ch][AA] ILs) were synthesized, and the tribological behavior was regulated through the assembly of anionic structure. It was found that the lubrication performance of these ILs was comparable to that of polyalphaolefin oil (PAO 40) under various friction conditions.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Biochemistry & Molecular Biology
Ting He, Cheng-Bin Hong, Peng-Chong Jiao, Heng Xiang, Yan Zhang, Hua-Qiang Cai, Shuang-Long Wang, Guo-Hong Tao
Summary: The study systematically examined the Bronsted acidity of [AAE]X PILs in green solvents and found that the cationic structures had little effect on the acidity, while the anions had no effect. Four different methods were used to determine the acidic strength, including the overlapping indicator method, potential titration method, Hammett method, and DFT method. These methods were reliable for assessing the acidity of [AAE]X.
Article
Pharmacology & Pharmacy
Xiaodan Li, Nannan Ma, Lijing Zhang, Guixia Ling, Peng Zhang
Summary: This article reviews the applications of choline-based ILs formed by choline and organic acid and choline-based ionic liquids-pharmaceutical active ingredients in transdermal delivery, topical delivery and oral delivery.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Chemistry, Physical
Sweety Verma, Kanhaiya Saini, Sanjeev Maken
Summary: Deep eutectic solvents (DESs) are a class of mixtures with lower melting points, offering potential as low-cost, customizable solvents with adjustable physicochemical features. However, there is currently a lack of predictive understanding of their microscopic mechanisms and structure-property connections, making it important to conduct research using simulations and experiments to gain a better understanding of DESs and establish a foundational framework.
JOURNAL OF MOLECULAR LIQUIDS
(2024)
Article
Engineering, Chemical
Ruizhuan Wang, Jiahui Chen, Zhen Song, Zhiwen Qi
Summary: The combination of Redlich-Kister theory and machine learning is used to predict the solid-liquid equilibria of eutectic solvent systems, which is crucial for their design.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Yuehong Ren, Wei Wu, Xingwang Zhang
Summary: Targeted drug delivery is being constantly improved based on a better understanding of diseases. Oral delivery of particulates is challenging due to biochemical aggressivity and immune exclusion in the gut. The feasibility of oral targeting to remote sites beyond the gastrointestinal tract is still not clear. The limited evidence and lack of quantification of systemically exposed particles do not support the success of oral targeting, but the lymphatic pathway may provide an alternative portal for peroral particles to reach remote target sites.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Biotechnology & Applied Microbiology
Kaiheng Liu, Wenjuan Liu, Zirong Dong, Luyu Zhang, Qiuyu Li, Renjie Zhang, Haisheng He, Yi Lu, Wei Wu, Jianping Qi
Summary: This study utilized enteric mesoporous silica nanoparticles to load ionic liquids, improving oral drug delivery. The in vitro experiments showed enhanced oral absorption of the drugs, suggesting the potential of this platform for delivering poorly water-soluble drugs and biologics orally.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Chemistry, Medicinal
Hulin Fan, Wei Wu, Zhongjian Chen, Quangang Zhu, Xun Sun
Summary: Triple-negative breast cancer (TNBC) is a highly heterogeneous and aggressive disease. Real-time monitoring of surgical resection would be beneficial for the surgical treatment of TNBC. In this study, a novel NIR-II fluorescent probe, FD-1050@NPs-cRGD, was designed and synthesized to target TNBC, showing great potential for tumor imaging.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2023)
Article
Engineering, Electrical & Electronic
Xueyou Shi, Shanzhe Yu, Runkun Zhu, Guangyi Chen, Yacong Zhang, Wengao Lu, Zhongjian Chen
Summary: This article presents a behavior model and a correction method for temperature-dependent fixed pattern noise (TD-FPN) in uncooled bolometric thermal imagers. A model-based two point correction method is proposed, and an infrared imaging system is implemented to validate the model and correction method. The results show the model's accuracy and the effectiveness of the correction method in reducing residual noise.
IEEE SENSORS JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Ni Dong, Zhenyun Liu, Haisheng He, Yi Lu, Jianping Qi, Wei Wu
Summary: In this study, different shapes of red blood cell membrane-coated mesoporous silica nanoparticles were synthesized to verify the concept of multivalent interactions. The experiments demonstrated strengthened binding and internalization of disk-shaped particles with cells, further confirming the significance of multivalent interactions in enhancing active targeting efficiency.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Chemistry, Multidisciplinary
Tingrui Zhang, Lu Li, Suticha Chunta, Wei Wu, Zhongjian Chen, Yi Lu
Summary: The oral route is considered the most ideal method for drug administration. Food protein nanoparticles show potential for oral drug delivery, offering improved safety and cost-effectiveness compared to polymeric nanoparticles. These nanoparticles have the ability to enhance oral bioavailability of a wide range of drugs, from small molecules to biomacromolecules, due to the variety of food proteins available and their easy surface modification capabilities. Despite being in its early stages, food protein nanoparticles hold promise for the development of oral drug delivery systems.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Pharmacology & Pharmacy
Wanting Zhang, Yuxin Jiang, Yonglong He, Hamza Boucetta, Jun Wu, Zhongjian Chen, Wei He
Summary: This study provides an overview of the applications of lipid carriers in mRNA delivery and the development of lipid-based formulations as vaccine delivery systems, with a focus on the recent advancements in COVID-19 mRNA vaccines. It highlights the significance of these advancements in developing effective vaccines and treatment methods.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Biotechnology & Applied Microbiology
Xiying Wu, Min Shen, Huan Wang, Xue He, Jingwen Tan, Ruiping Wang, Lianjuan Yang, Hong Yang, Jianping Qi, Zhongjian Chen, Quangang Zhu
Summary: This study evaluated the efficacy and safety of an ionic liquid (IL) containing ketoconazole (KCZ) in the treatment of tinea pedis. The results showed that ILs loading KCZ had better efficacy and lower recurrence rate compared to the marketed antifungal medication Daktarin(R). Importantly, KCZ-ILs were found to be safe and well-tolerated. This study provides a new opportunity for the management of skin diseases caused by fungal infection.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Fulong Man, Yinqian Yang, Haisheng He, Jianping Qi, Wei Wu, Yi Lu
Summary: We attempted to establish an in vitro dissolution protocol that is similar to in vivo dissolution by physically embedding aggregation-caused quenching (ACQ) fluorophores inside the lattice of aripiprazole (APZ) crystals. The fluorescence of the fluorophore illuminated the APZ crystals but was quenched upon dissolution of APZ-HCs, allowing for real-time monitoring of intact APZ-HCs. The good correlation between fluorescent quenching and dissolution justified reliable quantification of intact APZ crystals. By comparing the residual percentage of fluorescence intensity in rats treated with APZ-HCs over time, which was converted to in vivo dissolution, the in vitro dissolution profile of APZ was established with a similarity factor larger than 50 compared to in vivo dissolution.
MOLECULAR PHARMACEUTICS
(2023)
Review
Dermatology
Hao Huang, Rujuan Xin, Xiaolong Li, Xinyue Zhang, Zhongjian Chen, Quangang Zhu, Zongguang Tai, Leilei Bao
Summary: Diabetes foot ulcer (DFU) is a challenging complication of diabetes, involving various risk factors. The therapy for DFU is difficult and requires long-term interdisciplinary collaboration, causing physical and emotional pain for patients and increasing medical costs. It is crucial to accurately identify the causes and treatment techniques of DFU in order to alleviate patient suffering and reduce excessive healthcare expenditure.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Congcong Zhu, Ya Chen, Zongguang Tai, Huijun Pan, Min Shen, Zhongjian Chen, Quangang Zhu
Summary: This study aimed to explore the underlying mechanisms of Longkui Yinxiao Soup in a psoriasis-like mouse model. The results showed that Longkui Yinxiao Soup significantly ameliorated the psoriatic symptoms in mice, and this might be due to the inhibition of inflammatory factor secretion, keratinocyte proliferation, and the Rap1-MAPK signal pathway.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Qiuyue Liu, Jiahui Zou, Zhongjian Chen, Wei He, Wei Wu
Summary: This review elaborates on the development trends of nanomedicines, emerging nanocarriers, in vivo fate and safety of nanomedicines, and their extensive applications. The potential challenges and obstacles hindering the clinical translation of nanomedicines are also discussed. It provides a comprehensive overview of research activities in the field of nanomedicines.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Pharmacology & Pharmacy
Yuze Sheng, Qin Yu, Yanping Huang, Quangang Zhu, Zhongjian Chen, Wei Wu, Tao Yi, Yi Lu
Summary: Nanocrystals (NCs) have the potential to enhance the oral bioavailability of Class IV drugs. Drug NCs have been used as solid emulsifiers to prepare nanocrystal self-stabilized Pickering emulsions (NCSSPEs), which can increase drug loading and reduce side effects. These emulsions impede the dissolution of drug NCs and can further enhance their oral bioavailability, especially for BCS IV drugs. In this study, CUR-NCs stabilized Pickering emulsions were prepared using either indigestible or digestible oils. The emulsions significantly increased the oral bioavailability of CUR-NCs, with the digestibility of the oil phase affecting the intactness of the NCs.
Article
Chemistry, Multidisciplinary
Xin Wu, Xinmei Chen, Xinyu Wang, Haisheng He, Jianming Chen, Wei Wu
Summary: Paclitaxel-loaded liposomes hold potential for the treatment of breast carcinoma and other cancers. By conjugating paclitaxel with lipids of different chain lengths, the drug release and enzymatic conversion rates can be controlled, affecting the pharmacokinetics, tumor accumulation, and anti-tumor efficacy of liposomal paclitaxel.
CHINESE CHEMICAL LETTERS
(2024)
Article
Endocrinology & Metabolism
Wei Wu, Chunxiu Gong, Yuchuan Li, Yuhua Hu, Haihong Gong, Junfen Fu, Ke Huang, Pin Li, Xiaoping Luo
Summary: This study assessed the long-term efficacy and safety of growth hormone (GH) treatment in Chinese children born small for gestational age (SGA). The results showed that long-term GH treatment was effective at improving height in these children, with normal glucose metabolism and thyroid function throughout the treatment.
HORMONE AND METABOLIC RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
