期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 558, 期 -, 页码 311-318出版社
ELSEVIER
DOI: 10.1016/j.ijpharm.2019.01.008
关键词
Sulforaphane; Doxorubicin; Synergy; Intracellular distribution; Liposomes; Breast cancer
资金
- National Science Centre [UMO-2015/17/N/ST4/03926]
- National Medicines Institute, Warsaw, Poland [DS 3.01]
A new combination of sulforaphane (a natural compound obtained from Brassicaceae vegetables) and the cytostatic drug doxorubicin was entrapped in nanometer-sized liposomes. In vitro experiments were performed to investigate the cytotoxicity of these structures on the human breast cancer cell line MDA-MB-231. Confocal microscopy studies revealed enhanced cellular endocytotic internalization, followed by the release of the examined combination from the lysosomes. The in vitro interaction analysis using the Chou-Talalay approach showed high synergistic activity of the examined combination. This synergistic activity enables a considerable reduction in cytostatic dosage and an increase in cancer treatment efficiency.
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