期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 20, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/ijms20020352
关键词
radiation; liver; testicle; synthetic torpor; torpor; hypothermia; hibernation; raphe pallidus; ATM; space exploration
资金
- commission CSN5 of the Istituto Nazionale di Fisica Nucleare (Project HIBRAD)
- Progetto Premiale SPARE of the Italian Ministry of University and Research (MIUR)
- European Space Agency (ESA IBER contract)
- EU [730983]
Hibernation has been proposed as a tool for human space travel. In recent years, a procedure to induce a metabolic state known as synthetic torpor in non-hibernating mammals was successfully developed. Synthetic torpor may not only be an efficient method to spare resources and reduce psychological problems in long-term exploratory-class missions, but may also represent a countermeasure against cosmic rays. Here we show the preliminary results from an experiment in rats exposed to ionizing radiation in normothermic conditions or synthetic torpor. Animals were irradiated with 3 Gy X-rays and organs were collected 4 h after exposure. Histological analysis of liver and testicle showed a reduced toxicity in animals irradiated in torpor compared to controls irradiated at normal temperature and metabolic activity. The expression of ataxia telangiectasia mutated (ATM) in the liver was significantly downregulated in the group of animal in synthetic torpor. In the testicle, more genes involved in the DNA damage signaling were downregulated during synthetic torpor. These data show for the first time that synthetic torpor is a radioprotector in non-hibernators, similarly to natural torpor in hibernating animals. Synthetic torpor can be an effective strategy to protect humans during long term space exploration of the solar system.
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