期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 20, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/ijms20020341
关键词
cancer therapy; transition metal complex; natural product; cytotoxicity
资金
- Hong Kong Baptist University [FRG2/16-17/007, FRG2/17-18/003]
- Health and Medical Research Fund [HMRF/14150561]
- Research Grants Council [HKBU/12301115]
- National Natural Science Foundation of China [21575121, 21775131]
- Hong Kong Baptist University Century Club Sponsorship Scheme 2018
- Interdisciplinary Research Matching Scheme [RC-IRMS/16-17/03]
- Interdisciplinary Research Clusters Matching Scheme [RC-IRCs/17-18/03]
- Innovation and Technology Fund [ITS/260/16FX]
- Collaborative Research Fund [C5026-16G]
- Matching Proof of Concept Fund [MPCF-001-2017/18]
- SKLEBA and HKBU Strategic Development Fund [SKLP_1718_P04]
- Science and Technology Development Fund, Macao SAR [0072/2018/A2]
- University of Macau [MYRG2018-00187-ICMS, MYRG2016-00151-ICMS-QRCM]
Platinum-based drugs have revolutionized cancer care, but are unfortunately associated with various adverse effects. Meanwhile, natural product scaffolds exhibit multifarious bioactivities and serve as an attractive resource for cancer therapy development. Thus, the conjugation of natural product scaffolds to metal complexes becomes an attractive strategy to reduce the severe side effects arising from the use of metal bearing drugs. This review aims to highlight the recent examples of natural product-conjugated metal complexes as cancer therapies with enhanced selectivity and efficacy. We discuss the mechanisms and features of different conjugate complexes and present an outlook and perspective for the future of this field.
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