期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 20, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/ijms20020340
关键词
Mycobacterium tuberculosis; macrophages; apoptosis; immunology; immune escape
资金
- National Natural Science Foundation of China [81471048]
- Natural Science Foundation of Shandong Province [ZR2012HL42, ZR2018MH001]
- Shandong Province Higher Educational Science and Technology Program [J12LK01]
- Doctoral Scientific Research Foundation ofWeifang Medical University [2017BSQD01]
Epidemiological data from the Center of Disease Control (CDC) and the World Health Organization (WHO) statistics in 2017 show that 10.0 million people around the world became sick with tuberculosis. Mycobacterium tuberculosis (MTB) is an intracellular parasite that mainly attacks macrophages and inhibits their apoptosis. It can become a long-term infection in humans, causing a series of pathological changes and clinical manifestations. In this review, we summarize innate immunity including the inhibition of antioxidants, the maturation and acidification of phagolysosomes and especially the apoptosis and autophagy of macrophages. Besides, we also elaborate on the adaptive immune response and the formation of granulomas. A thorough understanding of these escape mechanisms is of major importance for the prevention, diagnosis and treatment of tuberculosis.
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