Review
Cell Biology
Maria C. Rezcallah, Trisha Al-mazi, Alaina J. Ammit
Summary: TTP is an important mRNA binding protein that regulates gene expression through phosphorylation, with key S sites being recognized as crucial. In addition to these key sites, other sites on TTP also play an important role in regulating cellular signaling and functions. Understanding phosphorylation sites and regulatory mechanisms of TTP is crucial for studying treatments for inflammatory diseases.
CELLULAR SIGNALLING
(2021)
Article
Geriatrics & Gerontology
Mohammad Reza Asadi, Mahnaz Talebi, Jalal Gharesouran, Hani Sabaie, Abbas Jalaiei, Shahram Arsang-Jang, Mohammad Taheri, Arezou Sayad, Maryam Rezazadeh
Summary: Alzheimer's disease is a globally increasing degenerative brain disorder that may disrupt gene expression regulation. The study found that TTP and miR-16 may play a role in Alzheimer's disease by regulating BDNF expression, although this expression pattern was not observed in peripheral blood samples.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Cell Biology
Jie Zhou, Jie Yang, Yu-Meng Wang, Hong Ding, Tu-Shuai Li, Zhi-Hong Liu, Li Chen, Rui-Qing Jiao, Dong-Mei Zhang, Ling-Dong Kong
Summary: High fructose can induce podocyte hypertrophy by down-regulating TTP, activating IL-6/STAT3 signaling, leading to abnormal podocyte proliferation and apoptosis. Inhibiting KHK-A to increase TTP may be a novel strategy for preventing high fructose-induced podocyte injury and proteinuria.
CELLULAR SIGNALLING
(2021)
Article
Multidisciplinary Sciences
Malgorzata M. Duszczyk, Harry Wischnewski, Tamara Kazeeva, Rajika Arora, Fionna E. Loughlin, Christine von Schroetter, Ugo Pradere, Jonathan Hall, Constance Ciaudo, Frederic H. -T. Allain
Summary: DND1 is an RNA-binding protein essential for germline development, mediating its function through a non-canonical AU-rich RNA recognition mode by the tandem RRMs, while the dsRBD plays a role in recruiting effector complexes for target regulation. The authors report an unusual mode of AU-rich RNA recognition by the RRMs of DND1 in a 27.5 kDa NMR structure and provide additional insight on DND1 function from cell-based experiments.
NATURE COMMUNICATIONS
(2022)
Review
Plant Sciences
E. Garmash
Summary: This review discusses important issues in the regulation of terminal alternative oxidase (AOX) of plant mitochondria. AOX plays a crucial role in electron transport and maintaining redox balance in cells. The review summarizes key findings on AOX signaling, including studies on the expression of AOX1a gene in Arabidopsis thaliana and analysis of AOX expression in different plant species. It also describes the mechanisms of transcriptional and posttranscriptional control over AOX gene expression and the role of cis-regulatory elements and transcription factors. The review provides insights into mitochondrial retrograde regulation of AOX, as well as ROS-dependent and ROS-independent signal pathways. The integration of AOX into cell signal pathways and its interaction with hormonal signal pathways and plastid-origin signals are also discussed.
RUSSIAN JOURNAL OF PLANT PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jeong-Min Park, Ji Ye Choi, Joo Mi Yi, Jin Woong Chung, Sun-Hee Leem, Sang Seok Koh, Tae-Hong Kang
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2015)
Article
Biochemistry & Molecular Biology
Jeong-Min Lee, Jeong-Min Park, Tae-Hong Kang
Article
Oncology
Ji Ye Choi, Hea Min Joh, Jeong-Min Park, Min Ji Kim, Tae Hun Chung, Tae-Hong Kang
Article
Nanoscience & Nanotechnology
Hea Min Joh, Ji Ye Choi, Sun Ja Kim, Tae Hong Kang, T. H. Chung
Article
Multidisciplinary Sciences
Geun-Hyoung Ha, Jae-Hoon Ji, Sunyoung Chae, Jihyun Park, Suhyeon Kim, Jin-Kwan Lee, Yonghyeon Kim, Sunwoo Min, Jeong-Min Park, Tae-Hong Kang, Ho Lee, Hyeseong Cho, Chang-Woo Lee
NATURE COMMUNICATIONS
(2019)
Review
Biochemistry & Molecular Biology
Tae-Hee Lee, Tae-Hong Kang
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Biochemistry & Molecular Biology
Tae-Hee Lee, Ji Ye Choi, Jeong-Min Park, Tae-Hong Kang
Review
Biochemistry & Molecular Biology
Tae-Hong Kang
Summary: Studies have shown that DNA damage responses are evolved to limit genomic instability caused by UV radiation, and they are under the control of circadian clock systems, showing daily oscillations in their catalytic activities. The molecular basis for the circadian rhythm of UV-induced DNA damage responses in mammalian cells will be discussed.
Article
Biochemistry & Molecular Biology
Jeseok Jeon, Sanggon Lee, Jeong-Min Park, Tae-Hee Lee, Tae-Hong Kang
Summary: Our study investigated whether circadian rhythm affects the DNA damage responses induced by cisplatin. The results showed that the DNA damage responses are regulated by circadian control only in cells with a circadian rhythm, and not in cells without a circadian rhythm. These findings have potential implications for improving or designing chronotherapy approaches for cancer patients.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jeong-Min Park, Tae-Hong Kang
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2016)
Article
Biochemistry & Molecular Biology
Se-Lyun Yoon, Yun-Gil Roh, In-Sun Chu, Jeonghoon Heo, Seung Il Kim, Heekyung Chang, Tae-Hong Kang, Jin Woong Chung, Sang Seok Koh, Vladimir Larionov, Sun-Hee Leem
EXPERIMENTAL AND MOLECULAR MEDICINE
(2016)