Article
Plant Sciences
Jose R. Cruz-Munoz, Tonatiuh Barrios-Garcia, Eduardo E. Valdez-Morales, Maria F. Duran-Vazquez, Karen B. Mendez-Rodriguez, Alma Barajas-Espinosa, Fernando Ochoa-Cortes, Maria C. Martinez-Saldana, Yenny A. Gomez-Aguirre, Raquel Guerrero Alba
Summary: The ethanolic extract of Lepidium virginicum L. has anti-inflammatory properties in the treatment of inflammatory bowel disease.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Environmental Sciences
Nagwa Mohamed, Dalia H. El-Kashef, Ghada M. Suddek
Summary: Flavocoxid demonstrated a potential protective effect in acetic acid-induced colitis model, by attenuating oxidative stress, inflammation, and apoptosis in colonic tissues of rats.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Microbiology
Yanisa Olaranont, Alyssa B. Stewart, Wisuwat Songnuan, Paweena Traiperm
Summary: This study investigated the interaction between Periglandula fungus and different plant parts of Ipomoea asarifolia. The findings suggest that the fungus primarily distributes along external plant surfaces, and its density varies depending on glandular trichome density and the growth stage of the host plant. The detection of the fungus in the flowers of the host plant fills a missing link in understanding the vertical transmission of Periglandula species.
Article
Microbiology
Vincent Billy, Zuzana Lhotska, Milan Jirku, Oldriska Kadlecova, Lucia Frgelecova, Laura Wegener Parfrey, Katerina Jirku Pomajbikova
Summary: Protists, such as Blastocystis, are common intestinal eukaryotes that have been reported as pathogens but are more prevalent in healthy individuals and are closely associated with the gut microbiota, potentially playing a protective role. Studies suggest that colonization by Blastocystis may promote faster recovery from intestinal inflammation.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Nutrition & Dietetics
Francesca Algieri, Jose Garrido-Mesa, Teresa Vezza, Maria Jesus Rodriguez-Sojo, Maria Elena Rodriguez-Cabezas, Monica Olivares, Federico Garcia, Julio Galvez, Rocio Moron, Alba Rodriguez-Nogales
Summary: The study found that different probiotics have intestinal anti-inflammatory effects, particularly with slight differences in miRNA expression. Additionally, probiotics improved colitis-associated dysbiosis, although the specific bacterial groups affected varied among the probiotics tested.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Multidisciplinary Sciences
Won Ho Yang, Julia S. Westman, Douglas M. Heithoff, Markus Sperandio, Jin Won Cho, Michael J. Mahan, Jamey D. Marth
Summary: Intestinal inflammation is the underlying cause of colitis and inflammatory bowel diseases, influenced by genetic and environmental factors. Alteration in neuraminidase activity may trigger disease onset, and inhibition of Neu3 can protect against severe colitis development.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Pharmacology & Pharmacy
Kanchana K. Ayyar, Alan C. Moss
Summary: Exosomes are small vesicles released by cells, containing a variety of molecules, and can be found in various tissues of humans and other mammals. A unique exosome profile can be detected in blood and fecal samples of patients with Inflammatory Bowel Disease (IBD), making them potential targets for IBD therapy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Vanessa D'Antongiovanni, Carolina Pellegrini, Laura Benvenuti, Matteo Fornai, Clelia Di Salvo, Gianfranco Natale, Larisa Ryskalin, Lorenzo Bertani, Elena Lucarini, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Zoltan H. Nemeth, Gyorgy Hasko, Luca Antonioli
Summary: This study evaluated the anti-inflammatory effects of two selective P2X4 receptor antagonists in a murine model of DNBS-induced colitis and investigated their molecular mechanisms. These drugs were found to alleviate colonic tissue damage, regulate inflammatory cytokine levels, and manage bowel inflammation by inhibiting the NLRP3 inflammasome signaling pathway.
Article
Immunology
Shmuel Avlas, Hala Kassis, Michal Itan, Hadar Reichman, Avishay Dolitzky, Inbal Hazut, Sharon Grisaru-Tal, Yaara Gordon, Ilan Tsarfaty, Danielle Karo-Atar, Perri Rozenberg, Almog Bitton, Ariel Munitz
Summary: Chronic inflammation is a characteristic feature of various inflammatory diseases, including inflammatory bowel disease (IBD). CD300 receptor family members have been shown to play important roles in innate immunity, as well as in allergic and autoimmune diseases. CD300b has been found to have a central and distinct role in colonic inflammation and subsequent repair, and it may be a future therapeutic target in inflammatory gastrointestinal (GI) diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tommaso Venneri, Giada Giorgini, Nadine Leblanc, Nicolas Flamand, Francesca Borrelli, Cristoforo Silvestri, Vincenzo Di Marzo
Summary: The gut microbiota and eCBome are closely linked and form the eCBome - miBIome axis, which may be of special relevance to colitis. This study found that GF mice had higher levels of eCBome lipid mediators and reduced inflammation in DNBS-induced colitis.
LIPIDS IN HEALTH AND DISEASE
(2023)
Article
Multidisciplinary Sciences
Lijun Dong, Jingwen Xie, Youyi Wang, Honglian Jiang, Kai Chen, Dantong Li, Jing Wang, Yunzhi Liu, Jia He, Jia Zhou, Liyun Zhang, Xiao Lu, Xiaoming Zou, Xiang-Yang Wang, Qingqing Wang, Zhengliang Chen, Daming Zuo
Summary: The study shows that mannose supplementation can alleviate symptoms of inflammatory bowel disease, including colitis. It improves intestinal barrier integrity, reduces the release of proteins, and prevents mitochondrial dysfunction. Mannose also synergizes with the conventional drug mesalamine in colitis treatment.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Jiapei Cai, Jiuxi Liu, Peng Fan, Xue Dong, Kunpeng Zhu, Xiaobo Liu, Naisheng Zhang, Yongguo Cao
Summary: Dioscin, a natural steroid saponin derived from plants of the genus Dioscoreaceae, shows protective effects on DSS-induced colitis in mice by reducing disease activity, maintaining intestinal barrier function, and inhibiting excessive inflammation. It may be a promising candidate for future ulcerative colitis therapy.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Noemie Saraux, Deniza Imeri, Luis Quiros-Guerrero, Soumana Karimou, Philippe Christen, Muriel Cuendet
Summary: Ipomoea asarifolia, a herbaceous plant from the Convolvulaceae family, has shown antiproliferative activity against multiple myeloma cells. A total of 15 compounds were isolated from the plant, with compound 3 demonstrating the most potent activity with an IC50 value of 3.0 μM against RPMI 8226 cells.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Biochemistry & Molecular Biology
Wendy A. Goodman, Shrikanth C. Basavarajappa, Angela R. Liu, Franklin D. Staback Rodriguez, Tailor Mathes, Parameswaran Ramakrishnan
Summary: Studies have shown that Sam68 is an important inflammatory driver in experimental colitis, reducing the expression of proinflammatory genes and suggesting that targeting Sam68 may hold promise for treating UC patients.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Luca Massimino, Orazio Palmieri, Amanda Facoetti, Davide Fuggetta, Salvatore Spano, Luigi Antonio Lamparelli, Silvia D'Alessio, Stefania Cagliani, Federica Furfaro, Ferdinando D'Amico, Alessandra Zilli, Gionata Fiorino, Tommaso Lorenzo Parigi, Daniele Noviello, Anna Latiano, Fabrizio Bossa, Tiziana Latiano, Alessandra Pirola, Luca Mologni, Rocco Giovanni Piazza, Danilo Abbati, Francesco Perri, Chiara Bonini, Laurent Peyrin-Biroulet, Alberto Malesci, Vipul Jairath, Silvio Danese, Federica Ungaro
Summary: This study found that the virome-associated protein encoded by the hepatitis B virus (HBx) is detected in about 45% of patients with ulcerative colitis (UC) and is associated with UC progression. Experimental findings showed that HBx induces colonic inflammation and its silencing reverses the colitis phenotype. HBx acts as a transcriptional regulator in epithelial cells, leading to barrier leakage and altering mucosal immunity. This study provides a new perspective on targeted treatments for the virome composition of the gut microbiota.
Article
Chemistry, Medicinal
Nayara Sousa da Silva, Nathalia Kelly Araujo, Alessandra Daniele-Silva, Johny Wysllas de Freitas Oliveira, Julia Maria de Medeiros, Renata Mendonca Araujo, Leandro De Santis Ferreira, Hugo Alexandre Oliveira Rocha, Arnobio Antonio Silva-Junior, Marcelo Sousa Silva, Matheus de Freitas Fernandes-Pedrosa
Summary: The study focused on the enzymatic production, characterization, and in vitro evaluation of the cytotoxic, antibacterial, antifungal, and antiparasitic effects of chitooligosaccharides (COSs) obtained from the hydrolysis of chitosan. NMR and mass spectrometry analyses revealed the presence of a mixture with 81% deacetylated COS and acetylated hexamers. COSs demonstrated no cytotoxicity at concentrations below 2 mg/mL, and showed promising activity against bacteria, yeasts, and exhibited time-dependent parasitic inhibition.
Article
Biochemistry & Molecular Biology
Alessandra Daniele-Silva, Suedson de Carvalho Silva Rodrigues, Elizabeth Cristina Gomes dos Santos, Moacir Fernandes de Queiroz Neto, Hugo Alexandre de Oliveira Rocha, Arnobio Antonio da Silva-Junior, Jarbas Magalhaes Resende, Renata Mendonca Araujo, Matheus de Freitas Fernandes-Pedrosa
Summary: Stigmurin, a cationic peptide from scorpion venom, exhibits multifunctional activities including antioxidant, antibacterial, and wound healing effects. Its attractive structural information makes it a promising candidate for the design of novel therapeutic agents.
Article
Biochemistry & Molecular Biology
Luana Carvalho de Oliveira, Danielle Lima Bezerra de Menezes, Valeria Costa da Silva, Estela Mariana Guimaraes Lourenco, Paulo Henrique Santana Miranda, Marcia de Jesus Amazonas da Silva, Emerson Silva Lima, Valdir Florencio da Veiga Junior, Ricardo Neves Marreto, Attilio Converti, Euzebio Guimaraes Barbosa, Adley Antonini Neves de Lima
Summary: In this study, inclusion complexes of ABAME with gamma- and beta-cyclodextrins were developed to improve its solubility and biological activity. The complexes showed enhanced stability and inhibition of lipase activity, suggesting their potential use as promising ingredients in future formulations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Rocco Giordano, Zeinab Saii, Malthe Fredsgaard, Laura Sini Sofia Hulkko, Thomas Bouet Guldbaek Poulsen, Mikkel Eggert Thomsen, Nanna Henneberg, Silvana Maria Zucolotto, Lars Arendt-Nielsen, Jutta Papenbrock, Mette Hedegaard Thomsen, Allan Stensballe
Summary: Pharmacological activities in bioactive plant extracts, particularly key compounds with anti-inflammatory, bactericidal, and pain relief effects, have drawn significant attention for medicinal and cosmetic applications. This systematic review focuses on the availability and potential biomedical applications of bioactive compounds from salt-tolerant plant species, including Aster tripolium, Crithmum maritimum, and Salicornia europaea, known for their traditional medicinal uses and potential future nutraceutical applications.
Article
Medicine, Research & Experimental
Joquebede Rodrigues Pereira, Aldilane Goncalves da Fonseca, Luzia Leiros de Sena Fernandes, Allanny Alves Furtado, Valeria Costa da Silva, Valdir Florencio da Veiga Junior, Antonio Euzebio Goulart Sant'Ana, Claudia Nunes Oliveira, Gerlane Coelho Bernardo Guerra, Matheus De Freitas Fernandes-Pedrosa, Elaine Cristina Gavioli, Jose Fernando Oliveira-Costa, Milena Botelho Pereira Soares, Adley Antonini Neves de Lima, Daniel de Melo Silva, Telma Maria Araujo Moura Lemos
Summary: This study demonstrated that MHF has potential anti-inflammatory and analgesic effects without causing acute or subchronic toxic effects, making it a promising natural source for further exploration.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Thalita Sevia Soares de Almeida Magalhaes, Pollyana Cristina de Oliveira Macedo, Erika Cibely Pinheiro da Costa, Emanuella de Aragao Tavares, Valeria Costa da Silva, Gerlane Coelho Bernardo Guerra, Joquebede Rodrigues Pereira, Telma Maria de Araujo Moura Lemos, Marilia Medeiros Fernandes de Negreiros, Hugo Alexandre de Oliveira Rocha, Attilio Converti, Adley Antonini Neves de Lima
Summary: This study analyzed the antioxidant capacity of complexes of Euterpe oleracea oil and selected a β-cyclodextrin complex with better complexation for in vivo anti-inflammatory assays, showing a significant reduction in inflammation in vivo.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Sarah de Sousa Ferreira, Diana Pontes da Silva, Manoela Torres-Rego, Arnobio Antonio Da Silva-Junior, Matheus De Freitas Fernandes-Pedrosa
Summary: Snakebite envenoming is a serious global health issue, and current treatment options have limitations, necessitating the exploration of new alternatives. Research on plant-derived compounds to counter the effects of snake venom has shown promise, particularly the use of phenolic acids. Studies indicate that these acids have potential antiophidic properties and could be a valuable area for future drug development in snakebite treatment.
Article
Food Science & Technology
Larissa Marina Pereira Silva, Maria Raquel Cavalcanti Inacio, Gualter Guenter Costa da Silva, Jucier Magson de Souza e Silva, Jefferson Romaryo Duarte da Luz, Maria das Gracas Almeida, Edgar Perin Moraes, Debora Esposito, Leandro De Santis Ferreira, Silvana Maria Zucolotto
Summary: Moringa oleifera leaves are rich in flavonoids, and the highest flavonoid content can be obtained through ultrasound-assisted extraction. The optimal cultivation condition is using mineral soil fertilizer in the drought season, with the optimized extraction conditions being 80% ethanol and 13.4 minutes extraction time. The extract is safe and significantly reduces inflammation, with major compounds derived from apigenin, quercetin, and kaempferol glycosides.
Article
Plant Sciences
Maria Jose Sarmento-Filha, Manoela Torres-Rego, Alessandra Daniele-Silva, Moacir Fernandes de Queiroz-Neto, Hugo Alexandre Oliveira Rocha, Celso Amorim Camara, Renata Mendonca Araujo, Arnobio Antonio da Silva-Junior, Tania Maria Sarmento Silva, Matheus de Freitas Fernandes-Pedrosa
Summary: This study investigated the antioxidant and anti-inflammatory potential of Cochlospermum vitifolium flowers. The results showed that the ethanolic extract and ethyl acetate fraction exhibited higher concentrations of phenolic compounds and stronger antioxidant action compared to other fractions. The extract and fraction also demonstrated effectiveness in reducing paw edema and decreasing leukocytes cells, total proteins, and cytokines levels in the inflammation models. This research provides evidence for the antioxidant and anti-inflammatory effects of the ethanolic extract and ethyl acetate fraction of C. vitifolium flowers.
SOUTH AFRICAN JOURNAL OF BOTANY
(2022)
Article
Food Science & Technology
Emanuell dos Santos-Silva, Manoela Torres-Rego, Fiamma Glaucia-Silva, Renata Carvalho Feitosa, Ariane Ferreira Lacerda, Hugo Alexandre de Oliveira Rocha, Matheus de Freitas Fernandes-Pedrosa, Arnobio Antonio da Silva-Junior
Summary: This study investigated a novel immunoadjuvant - biocompatible cationic nanoparticles loaded with Bothrops jararaca venom, demonstrating similar or improved immune response in antibody production. These nanoparticles can stably release proteins, activate immune response, and have been proven to be a promising immunoadjuvant.
Article
Pharmacology & Pharmacy
Edilane Rodrigues Dantas Araujo, Jacinthia Beatriz Xavier-Santos, Valeria Costa da Silva, Juliana Bessa Figueiredo de Lima, Jade Schlamb, Matheus de Freitas Fernandes-Pedrosa, Arnobio Antonio da Silva Junior, Raimundo Fernandes de Araujo Junior, Thirumurugan Rathinasabapathy, Marvin Moncada, Debora Esposito, Gerlane Coelho Bernardo Guerra, Silvana Maria Zucolotto
Summary: This study evaluated the stability and healing effects of a gel formulation containing Bryophyllum pinnatum leaf extract on skin wounds. The results showed that the gel formulation stimulated wound healing, reduced inflammation, and promoted angiogenesis. Therefore, it has the potential to be used as an active ingredient in wound healing pharmaceuticals.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Plant Sciences
Emanuella de Aragao Tavares, Gerlane Coelho Bernardo Guerra, Nadja Maria da Costa Melo, Renato Dantas-Medeiros, Elaine Cristine Souza da Silva, Anderson Wilbur Lopes Andrade, Daline Fernandes de Souza Araujo, Valeria Costa da Silva, Ana Caroline Zanatta, Thais Gomes de Carvalho, Aurigena Antunes de Araujo, Raimundo Fernandes de Araujo-Junior, Silvana Maria Zucolotto
Summary: This study investigated the phytochemical profile of Nopalea cochenillifera extract and its potential toxic and anti-inflammatory effects on DNBS-induced colitis in rats. The extract was found to be rich in phenolic compounds that are beneficial to intestinal health. The results showed that the extract had a significant anti-inflammatory effect and improved the integrity of the colon epithelium.
Article
Behavioral Sciences
Emmanuella de Oliveira Moura Araujo, Elaine Cristina Gavioli, Victor Anastacio Duarte Holanda, Valeria Costa da Silva, Tayanna Bernardo Oliveira Nunes Messias, Larissa Maria Gomes Dutra, Matheus Cardoso de Oliveira, Rita de Cassia Ramos do Egypto Queiroga, Gerlane Coelho Bernardo Guerra, Juliana Kessia Barbosa Soares
Summary: This study investigated the effects of donkey milk consumption on neural functioning. The results showed that donkey milk reduced anxiety and depression, and provided neural protection. It suggests that donkey milk may be a promising food for the treatment of anxiety-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Jaluza Luana C. de Queiroz, Isaiane Medeiros, Mayara S. R. Lima, Fabiana Maria C. de Carvalho, Christina S. Camillo, Pedro Paulo de A. Santos, Gerlane C. B. Guerra, Valeria C. da Silva, Helena T. Schroeder, Mauricio Krause, Ana Heloneida de A. Morais, Thais S. Passos
Summary: The effect of gelatin-based nanoparticles (EPG) loaded with carotenoid-rich crude extract (CE) on systemic and adipose tissue inflammatory response in an inflammation-induced model was investigated. Wistar rats were divided into untreated, conventional treatment, treatment 1, and treatment 2 groups. EPG-treated group showed beneficial effects on dietary intake, caloric efficiency, weight, inflammatory cytokines, and adipose tissue. The results suggest that EPG can be used as a nutraceutical in treating inflammatory diseases associated with adipose tissue accumulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Eduardo Augusto da Silva Diniz, Diana Pontes da Silva, Sarah de Sousa Ferreira, Matheus de Freitas Fernandes-Pedrosa, Davi Serradella Vieira
Summary: Snakebite envenoming-induced myotoxicity is a major problem in ophidic accidents, and current serum therapy is ineffective in neutralizing it. An alternative approach is to search for small molecule inhibitors that can target multiple venom components. This study investigates the inhibitory effect of Rosmarinic (RSM) and Chlorogenic (CHL) acids on the catalytic properties of snake venom Phospholipase A(2) (PLA(2)) from Bothrops brazili through experimental and computational approaches, providing important information for future inhibitor design.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
