Review
Engineering, Biomedical
Tianjiao Zhao, Wei Wu, Lihua Sui, Qiong Huang, Yayun Nan, Jianhua Liu, Kelong Ai
Summary: This article discusses the biology and molecular mechanisms of myocardial ischemia reperfusion injury, and summarizes the application of ROS-based nanoparticles, highlighting the latest advances in nanotechnology research for the treatment of myocardial ischemia reperfusion injury.
BIOACTIVE MATERIALS
(2022)
Article
Multidisciplinary Sciences
Khaled Dastagir, Jaba Gamrekelashvili, Nadjib Dastagir, Anne Limbourg, Dustin Kijas, Tamar Kapanadze, Peter M. Vogt, Florian P. Limbourg
Summary: In this study, the researchers found that the Notch ligand Delta-like 1 (Dll1), expressed in vascular endothelial cells, regulates flap arteriogenesis, inflammation, and survival. The loss of Dll1 impaired collateral vessel formation and led to aberrant vascularization and necrosis of the tissue. Furthermore, Dll1 deficiency also resulted in severe inflammation in the flap dominated by monocytes and macrophages. These findings demonstrate the importance of Dll1 in vascular adaptation to flap surgery and provide insights into the molecular and cellular regulators of flap healing and survival.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Panagiotis Chronopoulos, Caroline Manicam, Jenia Kouchek Zadeh, Panagiotis Laspas, Johanna Charlotte Unkrig, Marie Luise Goebel, Aytan Musayeva, Norbert Pfeiffer, Matthias Oelze, Andreas Daiber, Huige Li, Ning Xia, Adrian Gericke
Summary: This study demonstrates that resveratrol has a protective effect against ischemia-reperfusion injury in the murine retina, reducing the loss of retinal ganglion cells and endothelial dysfunction of retinal blood vessels. This protective effect may be achieved by suppressing upregulation of nitric oxide synthase 2 and alleviating nitro-oxidative stress.
Review
Biochemistry & Molecular Biology
Pasquale Pagliaro, Claudia Penna
Summary: Myocardial ischemia-reperfusion injury (MIRI) is caused by various mechanisms, including ROS production, altered cellular osmolarity, and inflammatory response. Calcium overload, altered oxygen levels, and mitochondrial ROS are also involved, leading to the opening of mPTP. NLRP3 inflammasome priming and activation play a role in these processes and are associated with cell death and endothelial dysfunction. ROS inhibitors and NLRP3 inhibitors have been studied as potential therapeutic agents in ischemic heart disease, but further research is needed to confirm their clinical use.
Article
Immunology
Ji-Bing He, Xin-Yi Ma, Wen-Jie Li, Ying-Ying Liu, Ding-Sheng Lin
Summary: The study showed that Exenatide can increase the survival area of random skin flaps, improve microvascular density and blood flow intensity, up-regulate SOD level, down-regulate MDA level, enhance VEGF expression, reduce expression of inflammatory cytokines, promote angiogenesis, and inhibit inflammation in a rat model.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Fabian Gendrisch, Philipp R. Esser, Christoph M. Schempp, Ute Woelfle
Summary: Luteolin, a flavonoid found in plants, possesses antioxidant and anti-inflammatory activities, modulating various inflammatory processes in the skin. It shows promise in the development of formulations for treating inflammatory skin diseases.
Article
Chemistry, Multidisciplinary
Liping Wang, Shuwen Qiu, Xi Li, Yabing Zhang, Minfeng Huo, Jianlin Shi
Summary: Ischemic heart disease is a major cause of death worldwide. This study focuses on the synthesis of tannic acid-assembled tetravalent cerium nanocatalysts for the treatment of ischemia/reperfusion injury. The nanocatalysts effectively rescue cardiomyocytes from oxidative stress and reduce myocardial infarct area in a murine model. This research highlights the potential of nanocatalytic metal complexes as a therapeutic approach for ischemic heart diseases.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biochemistry & Molecular Biology
Kazuya Odake, Masaya Tsujii, Takahiro Iino, Katsura Chiba, Takeshi Kataoka, Akihiro Sudo
Summary: The study demonstrated that febuxostat had a protective effect against I/R injury in skin flaps, reducing inflammation and oxidative stress. This indicates its potential as a treatment for skin flap necrosis in reconstructive surgery.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Shuangyu Lv, Huiyang Liu, Honggang Wang
Summary: Ischemia/reperfusion (I/R) injury is characterized by limited blood supply to organs followed by restoration of blood flow and reoxygenation. The interaction between autophagy and the NLRP3 inflammasome plays a crucial role in I/R injury, but the specific mechanisms are not fully understood and require further research for clarification.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cardiac & Cardiovascular Systems
Qinyuan Pan, Yang Liu, Wenrui Ma, Rongsheng Kan, Hong Zhu, Dongye Li
Summary: Luteolin has cardioprotective effects against myocardial ischemia-reperfusion injury (MIRI) by reducing myocardial infarct size and improving intracardiac hemodynamics. It exerts anti-apoptosis, anti-oxidation, and anti-inflammation effects through different signaling pathways.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Ping Pang, Wei Si, Han Wu, Jiaming Ju, Kuiwu Liu, Chunlei Wang, Yingqiong Jia, Hongtao Diao, Linghua Zeng, Weitao Jiang, Yang Yang, Yuting Xiong, Xue Kong, Zhengwei Zhang, Feng Zhang, Jinglun Song, Ning Wang, Baofeng Yang, Yu Bian
Summary: YTHDF2 affects myocardial ischemia-reperfusion injury by regulating RNA stability. Silencing YTHDF2 protects cardiac function and reduces infarct size, while overexpressing YTHDF2 exacerbates pathological processes. RNA analysis reveals that YTHDF2 recognizes m6A modification sites to promote the degradation of SLC7A11. Inhibition of SLC7A11 impairs heart function, increases infarct size, and the release of LDH. These findings provide novel potential therapeutic targets for treating ischemic cardiac diseases.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Biochemistry & Molecular Biology
Kun Zhang, Tao Wang, Gui-Feng Sun, Jin-Xing Xiao, Li-Ping Jiang, Fang-Fang Tou, Xin-Hui Qu, Xiao-Jian Han
Summary: This study aimed to evaluate the protective effect of metformin against retinal ischemia/reperfusion (I/R) injury and its underlying mechanism. The results showed that metformin could alleviate I/R-induced retinal injury through AMPK-mediated mitochondrial fusion and decreased generation of mitochondrial ROS.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Peripheral Vascular Disease
Xichun Qin, Hao Qin, Zhimin Li, Song Xue, Bing Huang, Xiucheng Liu, Dongjin Wang
Summary: The study suggests that luteolin may prevent microvascular damage caused by ischemia-reperfusion by inhibiting oxidative stress and regulating the Wnt/beta-catenin pathway, reducing the occurrence of the no-reflow phenomenon.
MICROVASCULAR RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Xiudi Zhou, Qiang Chen, Chunjing Guo, Yanguo Su, Huimin Guo, Min Cao, Zhongxin Liu, Dandan Zhang, Ningning Diao, Huaying Fan, Daquan Chen
Summary: A novel drug delivery system has been developed to precisely deliver drugs to pathological renal tissue for attenuating renal ischemia-reperfusion injury. The system exhibits responsive properties to reactive oxygen species, biocompatibility, and cell penetration. The intracellular concentration of hydrogen sulfide released by the system is threefold higher than that in the control group, and it demonstrates anti-inflammatory effects by blocking the NF-KB signaling pathway. This research provides a promising strategy for pharmaceutical treatment of renal ischemia-reperfusion injury.
Article
Chemistry, Multidisciplinary
Xinhai Mo, Huijing Xiang, Lu Wei, Lianghua Xia, Xiaoying Chen, Yu Chen, Bo Zhang
Summary: Using self-assembly synthesis, allomelanin nanoparticles (AMNPs) show potential in treating myocardial I/R injury by providing antioxidative and anti-inflammatory effects, with targeted therapy at damaged cardiac sites.