Article
Cardiac & Cardiovascular Systems
Juan P. Hernandez del Rincon, Mari C. Olmo Conesa, Ana Rodriguez Serrano, Helena Garcia Pulgar, David Lopez Cuenca, Carmen Munoz Esparza, Marina Navarro Penalver, Juan Jose Santos Mateo, Elisa Nicolas Rocamora, Cristina Gil Ortuno, Maria Sabater-Molina, Juan Ramon Gimeno Blanes, Francisco Pastor Quirante
Summary: Inherited cardiovascular diseases are a major cause of sudden cardiac death, but the prevention rate remains low at 35.6%. Among resuscitated cases, female sex and channelopathies were more prevalent, with 60.4% of patients achieving good neurological recovery.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Laura Keil, Celeste Chevalier, Paulus Kirchhof, Stefan Blankenberg, Gunnar Lund, Kai Muellerleile, Christina Magnussen
Summary: Non-ischemic cardiomyopathy (NICM) is a significant risk factor for arrhythmias and sudden cardiac death (SCD), with lower benefit of implantable cardioverter-defibrillator (ICD) therapy compared to ischemic cardiomyopathy (ICM). Risk stratification is needed to identify NICM patients who are likely to benefit from ICD therapy, with predictors such as genetic mutations, left-ventricular ejection fraction (LVEF), left-ventricular end-diastolic volume (LVEDD), and T-wave alternans (TWA). Cardiovascular magnetic resonance imaging (CMR) has the potential to improve risk stratification through comprehensive analysis of cardiac function and myocardial tissue composition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Lutong Pu, Jialin Li, Weitang Qi, Jinquan Zhang, Hongyu Chen, Zihuan Tang, Yuchi Han, Jie Wang, Yucheng Chen
Summary: This article reviews the latest research findings on the pathogenesis, risk stratification, and prevention of sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HCM) patients, with a focus on the clinical application of cardiovascular magnetic resonance imaging for SCD management.
HEART FAILURE REVIEWS
(2023)
Review
Cardiac & Cardiovascular Systems
Gherardo Finocchiaro, Nabeel Sheikh, Ornella Leone, Joe Westaby, Francesco Mazzarotto, Antonis Pantazis, Cecilia Ferrantini, Leonardo Sacconi, Michael Papadakis, Sanjay Sharma, Mary N. Sheppard, Iacopo Olivotto
Summary: Myocardial disarray is characterized by disorganized spatial distribution of cardiomyocytes, without physiological fiber alignment. While initially thought to be specific to hypertrophic cardiomyopathy, recent studies suggest disarray may be present in other cardiac conditions. Further research is needed to determine the diagnostic value and clinical significance of disarray in HCM.
Review
Medicine, General & Internal
Natallia Laptseva, Valentina A. Rossi, Isabella Sudano, Rahel Schwotzer, Frank Ruschitzka, Andreas J. Flammer, Firat Duru
Summary: Amyloidosis is a systemic disease characterized by extracellular deposits of insoluble amyloid in various tissues and organs. Cardiac amyloidosis is a frequent feature of the disease, causing a progressive, restrictive type of cardiomyopathy, and is associated with adverse clinical outcomes and increased mortality. This review aims to provide insights into the arrhythmic features of cardiac amyloidosis by discussing the pathogenesis, challenges in risk stratification, and management strategies for these arrhythmias.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Curt J. Daniels, Saurabh Rajpal, Joel T. Greenshields, Geoffrey L. Rosenthal, Eugene H. Chung, Michael Terrin, Jean Jeudy, Scott E. Mattson, Ian H. Law, James Borchers, Richard Kovacs, Jeffrey Kovan, Sami F. Rifat, Jennifer Albrecht, Ana I. Bento, Lonnie Albers, David Bernhardt, Carly Day, Suzanne Hecht, Andrew Hipskind, Jeffrey Mjaanes, David Olson, Yvette L. Rooks, Emily C. Somers, Matthew S. Tong, Jeffrey Wisinski, Jason Womack, Carrie Esopenko, Christopher J. Kratochvil, Lawrence D. Rink
Summary: In this study of 1597 competitive athletes in the US who underwent CMR screening after COVID-19 infection, 37 athletes (2.3%) were diagnosed with clinical and subclinical myocarditis. There was variability in prevalence across universities, and testing protocols were closely associated with the detection of myocarditis. The unique CMR imaging data highlight the need for standardized timing and interpretation of cardiac testing for safe return to play in athletes.
Review
Cardiac & Cardiovascular Systems
Nilanka N. Mannakkara, Gherardo Finocchiaro
Summary: Exercise has multiple health benefits and reduces cardiovascular morbidity and mortality. However, sudden cardiac death may occur in high-level athletes. Identifying and treating individuals at risk can reduce this burden. The cardiotoxic effects of intense exercise are still controversial, and exercise is generally safe for the majority, even with cardiovascular disease. This review focuses on the benefits and risks of exercise and sports, as well as exercise recommendations for healthy individuals and those with cardiovascular disease.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Gabrielle Norrish, Tao Ding, Ella Field, Elena Cervi, Lidia Ziolkowska, Iacopo Olivotto, Diala Khraiche, Giuseppe Limongelli, Aris Anastasakis, Robert Weintraub, Elena Biagini, Luca Ragni, Terrence Prendiville, Sophie Duignan, Karen McLeod, Maria Ilina, Adrian Fernandez, Chiara Marrone, Regina Bokenkamp, Anwar Baban, Peter Kubus, Piers E. F. Daubeney, Georgia Sarquella-Brugada, Sergi Cesar, Sabine Klaassen, Tiina H. Ojala, Vinay Bhole, Constancio Medrano, Orhan Uzun, Elspeth Brown, Ferran Gran, Gianfranco Sinagra, Francisco J. Castro, Graham Stuart, Gabriele Vignati, Hirokuni Yamazawa, Roberto Barriales-Villa, Luis Garcia-Guereta, Satish Adwani, Katie Linter, Tara Bharucha, Pablo Garcia-Pavia, Ana Siles, Torsten B. Rasmussen, Margherita Calcagnino, Caroline B. Jones, Hans De Wilde, Toru Kubo, Tiziana Felice, Anca Popoiu, Jens Mogensen, Sujeev Mathur, Fernando Centeno, Zdenka Reinhardt, Sylvie Schouvey, Costas O'Mahony, Rumana Z. Omar, Perry M. Elliott, Juan Pablo Kaski
Summary: This study in a large international pediatric HCM cohort found an inverted U-shaped relationship between left ventricular hypertrophy and estimated SCD risk, with the presence of additional risk factors having a cumulative effect. These findings suggest that MLVWT should not be used alone as a binary variable or in isolation to guide implantable cardioverter defibrillator implantation decisions in children with HCM.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Karen L. Kelly, Peter T. Lin, Cristina Basso, Melanie Bois, L. Maximilian Buja, Stephen D. Cohle, Giulia d'Amati, Emily Duncanson, John T. Fallon, Dennis Firchau, Gregory Fishbein, Carla Giordano, Charles Leduc, Silvio H. Litovsky, Shannon Mackey-Bojack, Joseph J. Maleszewski, Katarzyna Michaud, Robert F. Padera, Stavroula A. Papadodima, Sarah Parsons, Stanley J. Radio, Stefania Rizzo, Susan J. Roe, Maria Romero, Mary N. Sheppard, James R. Stone, Carmela D. Tan, Gaetano Thiene, Allard C. van der Wal, John P. Veinot
Summary: Sudden cardiac death is an unexpected death caused by a cardiac condition, accounting for approximately 15-20% of all deaths. It commonly occurs in older adults with acquired heart disease but can also happen in young individuals due to genetic transmission. Investigation of these deaths is crucial due to the potential impact on other family members and the lack of consistent guidelines for cardiac examination in these cases.
CARDIOVASCULAR PATHOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Nour Raad, Philip Bittihn, Marine Cacheux, Dongtak Jeong, Zeki Ilkan, Delaine Ceholski, Erik Kohlbrenner, Lu Zhang, Chen-Leng Cai, Evangelia G. Kranias, Roger J. Hajjar, Francesca Stillitano, Fadi G. Akar
Summary: This study highlights the crucial role of primary electrical remodeling caused by the hPLN(R14del) mutation in early-stage arrhythmogenic phenotype. The preferential right ventricular action potential prolongation and steep repolarization gradient at the left ventricular/right ventricular interface are key mechanisms underlying the increased arrhythmia susceptibility in R14del hearts. The unique spatiotemporal dynamics of high-frequency rotors pinned to the right ventricle contribute to their increased stability in R14del compared with wildtype hearts.
Article
Veterinary Sciences
K. Tess Sykes, Sonya Wesselowski, Ashley B. B. Saunders, Sonja S. S. Tjostheim, Brianna M. M. Potter, Anna R. M. Gelzer, Natalie Katz, Jessica L. L. Ward, Emily T. T. Karlin, Lauren E. E. Markovic, Aliya N. N. Magee, Jonathan A. A. Abbott, Saki Kadotani, Giulio Menciotti
Summary: This study found that Borzoi commonly have mild atrioventricular valve insufficiencies and may develop ventricular arrhythmias and dilated cardiomyopathy.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Cardiac & Cardiovascular Systems
Xuefeng Wang, Yong Luo, Jian Feng
Summary: A 68-year-old woman with a 15-year history of seasonal dermatitis presented with frequent heart failure and shock. Diagnosed with tertiary adrenal insufficiency, she recovered rapidly with hydrocortisone replacement therapy and did not experience any episodes of heart failure and shock during the two-year follow-up. Her unique clinical course strongly suggested that her cardiomyopathy resulted from tertiary adrenal insufficiency, highlighting the risk for refractory cardiomyopathy and sudden cardiac death in patients on corticosteroids.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Gherardo Finocchiaro, Davide Radaelli, Stefano D'Errico, Michael Papadakis, Elijah R. Behr, Sanjay Sharma, Joseph Westaby, Mary N. Sheppard
Summary: This study investigated the causes of sudden cardiac death (SCD) in adolescents and found that the most common autopsy finding was structurally normal heart, indicative of sudden arrhythmic death syndrome. Among young athletes, arrhythmogenic cardiomyopathy, coronary artery anomalies, and commotio cordis were more common causes of SCD.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Hyun-Jung Lee, Hyung-Kwan Kim, Sang Chol Lee, Jihoon Kim, Jun-Bean Park, In-Chang Hwang, You-Jung Choi, Seung-Pyo Lee, Sung-A Chang, Whal Lee, Eun-Ah Park, Goo-Yeong Cho, Yong-Jin Kim
Summary: This study investigated the prognostic role of LV-GLS and its incremental value in predicting SCD in patients with HCM. The results showed that lower LV-GLS values were associated with higher rates of SCD events. LV-GLS provided additional information to established risk models and improved their predictive performance for SCD.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Article
Medicine, Legal
Pavel Votypka, Alice Krebsova, Patricia Norambuena-Poustkova, Petra Peldova, Stepanka Pohlova Kucerova, Marketa Kulvajtova, Petra Dohnalova, Matej Bilek, Veronika Stufka, Kristina Rucklova, Iva Grossova, Hanka Wuenschova, Terezia Tavacova, Jana Haskova, Marketa Seget'ova, Jakub Stocek, Andrea Gregorova, Veronika Zoubkova, Jana Petrkova, Martin Dobias, Michal Makusa, Alzbeta Blankova, David Vajtr, Hynek Rehulka, Ivan Subrt, Alexander Pilin, Petr Tomasek, Jan Janousek, Josef Kautzner, Milan Macek
Summary: This study analyzed 100 Sudden Cardiac Death (SCD) cases and identified pathogenic or likely pathogenic variants in 22 cases. Additionally, the study revealed 83 relatives at risk of SCD through cardiological and genetic screening. These findings highlight the clinical importance of genetic testing and family screening in the diagnosis and risk assessment of SCD. The establishment of a national collaboration group is crucial for further development of these diagnostic tests.
INTERNATIONAL JOURNAL OF LEGAL MEDICINE
(2023)
Article
Geriatrics & Gerontology
Giorgio Varesco, Cecile Coudy-Gandilhon, Thomas Lapole, Alice Decourt, Marine Gueugneau, Jean-Claude Barthelemy, Frederic Roche, Daniel Bechet, Leonard Feasson, Vianney Rozand
Summary: The study found that physical activity level was positively associated with the capacity of very old women to perform a fatiguing test, while the physical activity of very old men was not correlated with muscle performance. Increasing steps per day count could provide a sufficient stimulus for adaptations in less active very old women.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Jean-Baptiste Guichard, Frederic Anselme, Pascal Defaye, Jacques Mansourati, Dominique Pavin, Jean-Luc Pasquie, Yannick Saludas, Jean-Claude Barthelemy, Frederic Roche, Silvy Laporte, Celine Chapelle, Arnauld Garcin, Cecile Romeyer, Karl Isaaz, Antoine Da Costa
Summary: The study investigated the effect of ramipril compared with placebo on atrial fibrillation occurrence in patients hospitalized for atrial flutter ablation, and found no significant difference between the two groups.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Mathieu Berger, Vincent Pichot, Geoffroy Solelhac, Pedro Marques-Vidal, Jose Haba-Rubio, Peter Vollenweider, Gerard Waeber, Martin Preisig, Jean-Claude Barthelemy, Frederic Roche, Raphael Heinzer
Summary: This study aimed to evaluate the association between nocturnal HRV and cardiovascular disease incidence. The results showed that novel HRV parameters such as AC, DC, and HRF during the night were better predictors of CVD events than traditional HRV parameters.
Article
Immunology
Manon Vogrig, Anne-Emmanuelle Berger, Thomas Bourlet, Louis Waeckel, Alice Haccourt, Alice Chanavat, David Hupin, Frederic Roche, Elisabeth Botelho-Nevers, Bruno Pozzetto, Stephane Paul
Summary: This study compared the performance of Interferon Gamma Release Assay (IGRA) and anti-spike serological test with the gold standard plaque reduction neutralization test (PRNT). The results showed that IGRA and serology assay were predictive of neutralizing antibody titers and correlated with vaccine protection. Older patients had a reduced immune response, and heterologous schemes and mRNA-1273 vaccine showed better responses in younger patients. IGRA and serology tests can be used to monitor vaccine response and identify non-responding individuals.
JOURNAL OF CLINICAL IMMUNOLOGY
(2023)
Review
Physiology
Jean-Baptiste Guichard, Eduard Guasch, Frederic Roche, Antoine Da Costa, Lluis Mont
Summary: Previously considered a benign phenomenon, an increased burden of premature atrial contractions (PACs) is now recognized as being associated with atrial fibrillation (AF), ischemic stroke, and excess mortality. This article reviews the pathophysiology of PACs, its impact on patient prognosis, and proposes potential future clinical implications, including the link between PACs and AF, the evidence of supraventricular ectopic activity as a marker of cardiomyopathy, and the limitations of the current concept.
FRONTIERS IN PHYSIOLOGY
(2022)
Editorial Material
Clinical Neurology
Frederic Roche, Vincent Pichot, Martin Garet, Mathieu Berger
Editorial Material
Clinical Neurology
Frederic Roche, Mathieu Berger
Article
Radiology, Nuclear Medicine & Medical Imaging
Pierre-Benoit Bonnefoy, Elodie Jacqueroux, Xavier Delavenne, Frederic Roche, Anthony Clotagatide, Patrick Mismetti, Nathalie Prevot, Nathalie Perek
Summary: This study found that Tc-99m(V)-DMSA can track the calcification process of vascular smooth muscle cells through the PiT-1 transporter. This research contributes to understanding the metabolic changes in VSMCs during the atherosclerosis process.
QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Review
Clinical Neurology
Hugues Patural, Vincent Pichot, Frederic Roche, Antoine Giraud
Summary: The evaluation of autonomic reactivity in newborns through heart rate variability (HRV) analysis is a simple and essential method to identify pathological dysautonomia. By using HRV analysis, pediatricians can identify and monitor high-risk children who have insufficient capacity for cardiorespiratory self-regulation and may face life-threatening events. Mathematical algorithms that analyze variations in the length of the RR interval can provide insights into the autonomic maturation of newborns. HRV analysis is an important non-invasive tool to assess the functioning of the autonomic nervous system and the balance between parasympathetic and sympathetic activities. Despite its recognized diagnostic and therapeutic implications, the application of HRV analysis in neonatal medicine is still not well understood.
NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Endocrinology & Metabolism
Hourfil-Gabin Ntougou Assoumou, Vincent Pichot, Jean-Claude Barthelemy, Sebastien Celle, Arnauld Garcin, Thierry Thomas, Frederic Roche
Summary: This study analyzed the relationship between body fat composition and metabolic syndrome, and compared them with common obesity indicators. The study found that body fat index and body adiposity index were the best indicators to characterize overall obesity, while waist-hip ratio was highly predictive of the presence and severity of metabolic syndrome.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Article
Physiology
Antoine Raberin, Cyril Martin, Sebastien Celle, David Hupin, Frederic Roche, Jean-Claude Barthelemy, Philippe Connes
Summary: The elderly population is growing and cardiovascular diseases are a leading cause of death among them. There are sex differences in cardiovascular diseases, with middle-aged males being at higher risk than females. After menopause, females are no longer protected by hormones and the effect of sex on cardiovascular parameters is still unclear. This study aimed to investigate the effect of sex on endothelial function, blood viscosity and cardiovascular diseases in the elderly.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Endocrinology & Metabolism
Radwan Kassir, Pierre Gimet, David Hupin, Claire Boutet, Jean-Claude Barthelemy, Frederic Roche, Sebastien Celle
Summary: This study aims to explore the relationship between the brain and obesity, using two different measures of obesity (BMI and BFI). The results show that in the elderly population, the relationship between the brain and obesity may differ from that in younger subjects. Higher BMI and BFI are associated with increased grey matter volume in the left cerebellum and increased white matter volume in the cerebellum and near the right medial orbital gyrus. This suggests that the cerebellum may be one of the key structures related to obesity.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Caroline Dupre, Marlene Bregere, Mathieu Berger, Vincent Pichot, Sebastien Celle, Martin Garet, Herve Fundenberger, Nathalie Barth, Jessica Guyot, Bienvenu Bongue, Jean-Claude Barthelemy, Frederic Roche, David Hupin
Summary: It is important to promote all activities including light intensity physical activity (LPA) rather than just focusing on moderate-to-vigorous intensity physical activity (MVPA) as stated in current international physical activity guidelines. The evidence on the effects of LPA and its relationship with sedentary behavior (SB) is currently limited. Clarification of these effects is crucial for promoting public health.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Medicine, General & Internal
Anne-Noelle Heizmann, Celine Chapelle, Silvy Laporte, Frederic Roche, David Hupin, Claire Le Hello
Summary: This systematic review and meta-analysis aimed to evaluate the effectiveness of using wearable physical activity monitoring devices as an intervention to increase daily walking activity and improve physical capacities in patients with cardiovascular disease. The results showed that wearing physical activity monitoring devices with feedback significantly improved daily number of steps, particularly when the intervention duration was less than 3 months. Overall, wearable physical activity monitoring devices appear to be beneficial for increasing daily walking activity in patients with cardiovascular disease.
Article
Psychology, Clinical
Romain Ceresetti, Sebastien Celle, Frederic Roche, Jean-Claude Barthelemy, George A. Michael, Celine Borg
Summary: This study presents relevant norms for evaluating pathological aging in the French population over a 20-year period. It emphasizes the importance of educational level and gender in assessing memory and executive function in elderly individuals.
ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
(2023)