Article
Oncology
Ting-Chieh Huang, Chi-Jen Chen, Yi-Fang Ding, Yi-No Kang
Summary: IC-CCRT may be beneficial for patients with nasopharyngeal carcinoma in the medium term, although no significant difference was observed in 5-year survival compared with CCRT. All outcomes had decreased survival rate from the 3-year to 5-year follow-up. Differences in patient ethnicities and regimens of IC-CCRT may be sources of heterogeneity.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Xinmao Song, Shengzi Wang, Ji Li, Li Yan, Fu Chen, Jie Wang
Summary: The study found that the combination of nimotuzumab with chemoradiotherapy is effective for the treatment of nasopharyngeal carcinoma, especially when used in combination with induction chemotherapy and concurrent chemoradiotherapy. The addition of nimotuzumab did not result in a significant increase in toxicities.
ARCHIVES OF MEDICAL SCIENCE
(2021)
Article
Oncology
Jingjing Miao, Lin Wang, Sze Huey Tan, Jin-Gao Li, Junlin Yi, Enya H. W. Ong, Laura L. Y. Tan, Ye Zhang, Xiaochang Gong, Qiuyan Chen, Yan-Qun Xiang, Ming-Yuan Chen, Ying Guo, Xing Lv, Wei-Xiong Xia, Linquan Tang, Xiaowu Deng, Xiang Guo, Fei Han, Hai-Qiang Mai, Melvin L. K. Chua, Chong Zhao
Summary: In this randomized clinical trial, adjuvant capecitabine at the full dose following CCRT was well tolerated and improved failure-free survival among patients with LA-NPC and high-risk factors. Further investigations assessing optimal dose and duration are warranted.
Article
Oncology
Guoqiang Xu, Qiaoli Wang, Xingrao Wu, Chunyan Lv, Guilin Zeng, Zhihong Xue, Ruixue Cao, Nan Zhang, Wei Xiong, Qin Huang
Summary: The study found that induction chemotherapy plus concurrent chemoradiotherapy improved survival outcomes in patients with locally advanced nasopharyngeal carcinoma compared to concurrent chemoradiotherapy alone, but also increased the risk of certain adverse reactions. Subgroup analysis suggested different outcomes depending on the cisplatin regimen used, warranting further investigation.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2021)
Article
Cell Biology
Xiaoli Mu, Hongyan Liu, Juan Wu, Shi Chen, Xingchen Peng, Jingjing Wang, Zhigong Wei, Ling He, Jiyan Liu, Zejun Lu, Yonglin Su
Summary: In patients with locoregionally advanced nasopharyngeal carcinoma, induction chemotherapy plus concurrent chemoradiotherapy achieved comparable survival outcomes to concurrent chemoradiotherapy plus adjuvant chemotherapy with a lower incidence of toxicity.
Article
Oncology
Zhi-Cheng Liu, Ke-Hao Zeng, Zhen-Bang Gu, Run-Pu Chen, Yi-Jing Luo, Lin-Quan Tang, Kai -Bin Zhu, Yan Liu, Xue-Song Sun, Lei Zeng
Summary: This study investigated the efficacy of induction chemotherapy (IC) followed by concurrent chemoradiotherapy (CCRT) versus CCRT alone in patients with N3 nasopharyngeal carcinoma (NPC). The results showed that IC + CCRT achieved better survival outcomes compared with CCRT alone, indicating the positive impact of chemotherapy on the treatment of N3 NPC patients.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Qiulu Zhong, Danjing Luo, Xiangde Li, Qinghua Du, Qianfu Liang, Wenqi Liu, Jian Li, Xiaodong Zhu
Summary: This study aimed to evaluate the efficacy of adding induction chemotherapy or adjuvant chemotherapy to concurrent chemoradiotherapy in patients with T3-4N0-1M0 nasopharyngeal carcinoma. The study found that adding induction chemotherapy or adjuvant chemotherapy did not significantly improve the prognosis of these patients.
CANCER BIOLOGY & THERAPY
(2023)
Article
Oncology
Maimouna Mane, Sofian Benkhaled, Tatiana Dragan, Marianne Paesmans, Sylvie Beauvois, Yassine Lalami, Petr Szturz, P. Macoumba Gaye, Jan B. Vermorken, Dirk Van Gestel
Summary: The study found that adding induction chemotherapy (ICT) followed by concurrent chemoradiotherapy (CCRT) to treatment for locally advanced nasopharyngeal carcinoma (LA-NPC) significantly improved overall survival and progression-free survival compared to CCRT alone.
Article
Oncology
Rui Zou, Jing-Jing Yuan, Qiang Li, Jian-Wu Ding, Bing Liao, Zi-Wei Tu, Rong-Huan Hu, Dan Gong, Jia-Li Hu, Lei Zeng
Summary: The study analyzed the outcomes and toxicities of ICT followed by CCRT plus ACT in LA-NPC patients, and found that this treatment approach did not significantly improve DFS and OS compared to adding ICT to CCRT, with more acute adverse events. Longer-term clinical studies are needed to evaluate treatment outcomes and late toxicities.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Hao-Yun Tao, Ze-Jiang Zhan, Wen-Ze Qiu, Kai Liao, Ya-Wei Yuan, Tai-Ze Yuan, Rong-Hui Zheng
Summary: The study demonstrated that in patients with locoregionally advanced nasopharyngeal carcinoma, the TP+TP regimen can reduce distant metastasis and improve overall survival compared to TP+DDP, with a similar effect to TPF+DDP and clinical feasibility.
Article
Otorhinolaryngology
Min Tang, Zhongxiong Jia, Ju Zhang
Summary: Induction chemotherapy followed by cisplatin-based concurrent chemoradiotherapy significantly improves survival outcomes for patients with locally advanced nasopharyngeal carcinoma compared to cisplatin-based CCRT alone, but is also associated with a markedly increased risk of treatment-related adverse events.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Article
Oncology
Leifeng Liang, Zhibing Liu, Haisheng Zhu, Hongqian Wang, Yan Wei, Xuejian Ning, Zhiling Shi, Liujun Jiang, Zhan Lin, Haolin Yan, Rensheng Wang, Kai Hu
Summary: This multicenter clinical trial found that thalidomide could prolong the latency period of oral mucositis, reduce its incidence, and have no impact on the short-term efficacy of concurrent chemoradiotherapy in patients with nasopharyngeal carcinoma.
Article
Oncology
Yuzhen Xi, Xiuhong Ge, Haiming Ji, Luoyu Wang, Shaofeng Duan, Haonan Chen, Mengze Wang, Hongjie Hu, Feng Jiang, Zhongxiang Ding
Summary: This study established an MRI radiomics model and a Delta radiomics model to predict tumor retraction after induction chemotherapy combined with concurrent chemoradiotherapy for primary nasopharyngeal carcinoma in non-endemic areas and validated their efficacy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Zhining Yang, Zeman Cai, Qingxin Cai, Yingji Hong, Cuidai Zhang, Kaichun Huang, Zhixiong Lin, Mei Li
Summary: The study compared the efficacy and safety of induction chemotherapy followed by intensity-modulated radiotherapy versus concurrent chemotherapy in patients with locoregionally advanced nasopharyngeal carcinoma. The results showed similar outcomes in terms of PFS, OS, LRRFS, and DMFS between the two treatment arms, but the IC plus IMRT arm had lower incidences of leukopenia and anemia.
Article
Oncology
Xi Luo, Xiaodong Huang, Jingwei Luo, Jianping Xiao, Kai Wang, Yuan Qu, Xuesong Chen, Ye Zhang, Runye Wu, Jingbo Wang, Jianghu Zhang, Guozhen Xu, Li Gao, Shaoyan Liu, Xiaolei Wang, Xiaohui He, Dehong Luo, Junlin Yi
Summary: The study aimed to compare the efficacy of induction chemotherapy (IC) followed by concurrent chemoradiotherapy (CCRT) with CCRT alone in treating locally advanced hypopharyngeal carcinoma. The results showed that adding IC did not improve survival and larynx-preservation rate, but resulted in a higher incidence of acute hematological toxicities.
Article
Otorhinolaryngology
Shan Peng, Cheng Wu, Wei Sun, Dongbo Liu, Min Luo, Beibei Su, Linli Zhang, Qi Mei, Guoqing Hu
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2018)
Article
Oncology
Guan-Qun Zhou, Chen-Fei Wu, Jian Zhang, Yan-Ping Mao, Ling-Long Tang, Lei Chen, Rui Guo, Jun Ma, Ying Sun
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2018)
Article
Radiology, Nuclear Medicine & Medical Imaging
Li Lin, Qi Dou, Yue-Ming Jin, Guan-Qun Zhou, Yi-Qiang Tang, Wei-Lin Chen, Bao-An Su, Feng Liu, Chang-Juan Tao, Ning Jiang, Jun-Yun Li, Ling-Long Tang, Chuan-Miao Xie, Shao-Min Huang, Jun Ma, Pheng-Ann Heng, Joseph T. S. Wee, Melvin L. K. Chua, Hao Chen, Ying Sun
Article
Medicine, General & Internal
Lu-Lu Zhang, Meng-Yao Huang, Yan Li, Jin-Hui Liang, Tian-Sheng Gao, Bin Deng, Ji-Jin Yao, Li Lin, Fo-Ping Chen, Xiao-Dan Huang, Jia Kou, Chao-Feng Li, Chuan-Miao Xie, Yao Lu, Ying Sun
Article
Oncology
Hao Peng, Di Dong, Meng-Jie Fang, Lu Li, Ling-Long Tang, Lei Chen, Wen-Fei Li, Yan-Ping Mao, Wei Fan, Li-Zhi Liu, Li Tian, Ai-Hua Lin, Ying Sun, Jie Tian, Jun Ma
CLINICAL CANCER RESEARCH
(2019)
Article
Oncology
Xiao-Dan Huang, Yang-Chan Li, Fo-Ping Chen, Wei-Hong Zheng, Guan-Qun Zhou, Li Lin, Jiang Hu, Wen-Jun He, Lu-Lu Zhang, Jia Kou, Jun Ma, Wei-Dong Zhang, Zhen-Yu Qi, Ying Sun
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2019)
Article
Oncology
Min Luo, Cheng Wu, Ergang Guo, Shan Peng, Linli Zhang, Wei Sun, Dongbo Liu, Guangyuan Hu, Guoqing Hu
Review
Medicine, General & Internal
Yu-Pei Chen, Anthony T. C. Chan, Quynh-Thu Le, Pierre Blanchard, Ying Sun, Jun Ma
Article
Medicine, General & Internal
Yuan Zhang, Lei Chen, Guo-Qing Hu, Ning Zhang, Xiao-Dong Zhu, Kun-Yu Yang, Feng Jin, Mei Shi, Yu-Pei Chen, Wei-Han Hu, Zhi-Bin Cheng, Si-Yang Wang, Ye Tian, Xi-Cheng Wang, Yan Sun, Jin-Gao Li, Wen-Fei Li, Yu-Hong Li, Ling-Long Tang, Yan-Ping Mao, Guan-Qun Zhou, Rui Sun, Xu Liu, Rui Guo, Guo-Xian Long, Shao-Qiang Liang, Ling Li, Jing Huang, Jin-Hua Long, Jian Zang, Qiao-Dan Liu, Li Zou, Qiong-Fei Su, Bao-Min Zheng, Yun Xiao, Ying Guo, Fei Han, Hao-Yuan Mo, Jia-Wei Lv, Xiao-Jing Du, Cheng Xu, Na Liu, Ying-Qin Li, Melvin L. K. Chua, Fang-Yun Xie, Ying Sun, Jun Ma
NEW ENGLAND JOURNAL OF MEDICINE
(2019)
Article
Oncology
Ji-Jin Yao, Zhen-Yu Qi, Zhi-Gang Liu, Guan-Min Jiang, Xi-Wei Xu, Shao-Yi Chen, Feng-Ting Zhu, Wang-Jian Zhang, Wayne R. Lawrence, Jun Ma, Guan-Qun Zhou, Ying Sun
RADIOTHERAPY AND ONCOLOGY
(2019)
Article
Oncology
Cheng Wu, Ergang Guo, Jun Ming, Wei Sun, Xin Nie, Lu Sun, Shan Peng, Min Luo, Dongbo Liu, Linli Zhang, Qi Mei, Guoxian Long, Guangyuan Hu, Guoqing Hu
MOLECULAR THERAPY-ONCOLYTICS
(2020)
Article
Medicine, General & Internal
Yu-Pei Chen, Xu Liu, Qin Zhou, Kun-Yu Yang, Feng Jin, Xiao-Dong Zhu, Mei Shi, Guo-Qing Hu, Wei-Han Hu, Yan Sun, Hong-Fen Wu, Hui Wu, Qin Lin, Hui Wang, Ye Tian, Ning Zhang, Xi-Cheng Wang, Liang-Fang Shen, Zheng-Zheng Liu, Jing Huang, Xiu-Ling Luo, Ling Li, Jian Zang, Qi Mei, Bao-Min Zheng, Dan Yue, Jing Xu, San-Gang Wu, Yan-Xia Shi, Yan-Ping Mao, Lei Chen, Wen-Fei Li, Guan-Qun Zhou, Rui Sun, Rui Guo, Yuan Zhang, Cheng Xu, Jia-Wei Lv, Ying Guo, Hui-Xia Feng, Ling-Long Tang, Fang-Yun Xie, Ying Sun, Jun Ma
Summary: This study found that adding oral metronomic capecitabine as adjuvant chemotherapy significantly improved failure-free survival in patients with high-risk locoregionally advanced nasopharyngeal carcinoma, with a good safety profile. These results support the potential role of metronomic chemotherapy as an adjuvant therapy in the treatment of nasopharyngeal carcinoma.
Article
Oncology
Yuxin Liu, Swati Bhardwaj, Keith Sigel, John Winters, Joseph Terlizzi, Michael M. Gaisa
Summary: This study investigated the prevalence and severity of anal HPV disease among MSM LWH under the age of 35, finding a high prevalence of HPV infection and precancer but no cases of invasive anal cancer. This supports the adoption of age-based anal cancer screening for this population.
INTERNATIONAL JOURNAL OF CANCER
(2024)
Correction
Oncology
J. Gu, S. Xie, S. Wang
INTERNATIONAL JOURNAL OF CANCER
(2024)