A functional ex vivo assay to detect PARP1-EJ repair and radiosensitization by PARP-inhibitor in prostate cancer

BCL2-overexpressing prostate cancer cells rely on PARP1-dependent end-joining and are sensitive to combined PARP inhibitor and radiation therapy

(2018) Christoph Oing et al.   CANCER LETTERS

Loss of PTEN-assisted G2/M checkpoint impedes homologous recombination repair and enhances radio-curability and PARP inhibitor treatment response in prostate cancer

(2018) W. Y. Mansour et al.   Scientific Reports

Ex vivo γH2AX radiation sensitivity assay in prostate cancer: Inter-patient and intra-patient heterogeneity

(2017) Chiara De-Colle et al.   RADIOTHERAPY AND ONCOLOGY

The combined effect of USP7 inhibitors and PARP inhibitors in hormone-sensitive and castration-resistant prostate cancer cells

(2017) Francesco Morra et al.   Oncotarget

Loss of CHD1 causes DNA repair defects and enhances prostate cancer therapeutic responsiveness

(2016) Vijayalakshmi Kari et al.   EMBO REPORTS

DNA damage foci: Meaning and significance

(2015) Kai Rothkamm et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Involvement of ATM in homologous recombination after end resection and RAD51 nucleofilament formation

(2015) A. Bakr et al.   NUCLEIC ACIDS RESEARCH

Residual γH2AX foci after ex vivo irradiation of patient samples with known tumour-type specific differences in radio-responsiveness

(2015) Apostolos Menegakis et al.   RADIOTHERAPY AND ONCOLOGY

γH2AX assay in ex vivo irradiated tumour specimens: A novel method to determine tumour radiation sensitivity in patient-derived material

(2015) Apostolos Menegakis et al.   RADIOTHERAPY AND ONCOLOGY

DNA Damage Response Assessments in Human Tumor Samples Provide Functional Biomarkers of Radiosensitivity

(2015) Henning Willers et al.   SEMINARS IN RADIATION ONCOLOGY

Aberrant Presentation of HPA-Reactive Carbohydrates Implies Selectin-Independent Metastasis Formation in Human Prostate Cancer

(2014) T. Lange et al.   CLINICAL CANCER RESEARCH

Functional Ex Vivo Assay to Select Homologous Recombination-Deficient Breast Tumors for PARP Inhibitor Treatment

(2014) K. A. T. Naipal et al.   CLINICAL CANCER RESEARCH

Inhibition of PARP1-dependent end-joining contributes to Olaparib-mediated radiosensitization in tumor cells

(2014) Annika Kötter et al.   Molecular Oncology

The absence of Ku but not defects in classical non-homologous end-joining is required to trigger PARP1-dependent end-joining

(2013) Wael Y. Mansour et al.   DNA REPAIR

Poly(ADP-ribose)polymerases are involved in microhomology mediated back-up non-homologous end joining in Arabidopsis thaliana

(2013) Qi Jia et al.   PLANT MOLECULAR BIOLOGY

Residual γH2AX foci predict local tumour control after radiotherapy

(2013) Ulrike Koch et al.   RADIOTHERAPY AND ONCOLOGY

Human Prostate Cancer in a Clinically Relevant Xenograft Mouse Model: Identification of β(1,6)-Branched Oligosaccharides as a Marker of Tumor Progression

(2012) Tobias Lange et al.   CLINICAL CANCER RESEARCH

Radiation-induced double-strand breaks require ATM but not Artemis for homologous recombination during S-phase

(2012) Sabrina Köcher et al.   NUCLEIC ACIDS RESEARCH

Inhibition of PARP-1 by Olaparib (AZD2281) Increases the Radiosensitivity of a Lung Tumor Xenograft

(2011) J. M. Senra et al.   MOLECULAR CANCER THERAPEUTICS

Cancer Statistics, 2010

(2010) A. Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Pre-clinical and clinical evaluation of PARP inhibitors as tumour-specific radiosensitisers

(2010) C. Powell et al.   CANCER TREATMENT REVIEWS

Copy number and targeted mutational analysis reveals novel somatic events in metastatic prostate tumors

(2010) C. M. Robbins et al.   GENOME RESEARCH

Poly(ADP)-Ribose Polymerase Inhibition: Frequent Durable Responses inBRCACarrier Ovarian Cancer Correlating With Platinum-Free Interval

(2010) Peter C. Fong et al.   JOURNAL OF CLINICAL ONCOLOGY

The alternative end-joining pathway for repair of DNA double-strand breaks requires PARP1 but is not dependent upon microhomologies

(2010) Wael Y. Mansour et al.   NUCLEIC ACIDS RESEARCH

Inhibition of Poly(ADP-Ribose) Polymerase in Tumors fromBRCAMutation Carriers

(2009) Peter C. Fong et al.   NEW ENGLAND JOURNAL OF MEDICINE

Backup pathways of NHEJ in cells of higher eukaryotes: Cell cycle dependence

(2009) George Iliakis   RADIOTHERAPY AND ONCOLOGY

Individual Radiosensitivity Measured With Lymphocytes May Predict the Risk of Acute Reaction After Radiotherapy

(2008) Kerstin Borgmann et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Hierarchy of nonhomologous end-joining, single-strand annealing and gene conversion at site-directed DNA double-strand breaks

(2008) W. Y. Mansour et al.   NUCLEIC ACIDS RESEARCH