Article
Polymer Science
Lei Li, Pengfei Lu, Yuting Liu, Junhe Yang, Shengjuan Li
Summary: In this study, 3D bioactive glass/lignocellulose composite scaffolds were successfully fabricated by 3D-printing with NMMO as the ink solvent. The scaffolds showed uniform macropores and rough surfaces, with excellent mechanical properties and hydroxyapatite-forming capability. They also exhibited low cytotoxicity to human bone marrow mesenchymal stem cells. These 3D-printed BG/cellulose scaffolds have potential applications in bone tissue engineering.
Article
Biochemistry & Molecular Biology
Raul Llamas-Unzueta, Marta Suarez, Adolfo Fernandez, Raquel Diaz, Miguel A. Montes-Moran, J. Angel Menendez
Summary: Porous carbon structures derived from whey powders show promising potential as scaffolds in bone tissue engineering, with high porosity, hierarchical pore size distribution, exceptional compressive strength and elastic modulus, as well as non-cytotoxic and bioactive behavior due to their carbon-based composition.
Review
Polymer Science
Naiyu Cui, Chun-Yu Dai, Xuran Mao, Xun Lv, Yue Gu, Eui-Seok Lee, Heng-Bo Jiang, Yunhan Sun
Summary: Poloxamer, as a triblock copolymer with amphiphilicity and reversible thermal responsiveness, has wide application prospects in biomedicine. It plays a crucial role as injectable scaffolds in tissue engineering and 3D printing, creating an appropriate microenvironment for cell growth and vascular network formation.
Review
Polymer Science
Nurulhuda Arifin, Izman Sudin, Nor Hasrul Akhmal Ngadiman, Mohamad Shaiful Ashrul Ishak
Summary: This article reviews the potential of photo-polymerization 3D printing technique in tissue engineering scaffold fabrication. It also compares this technique with other scaffold fabrication methods. Various parameter settings affecting mechanical properties, biocompatibility, and porosity behavior are discussed in detail.
Article
Polymer Science
Qin Yao, Shuifeng Liu, Weihan Zheng, Manting Chen, Shuzhen Zhou, Minjian Liao, Wenhua Huang, Yang Hu, Wuyi Zhou
Summary: This study presents a simple and feasible method for preparing hierarchical scaffolds with customized shape and adjustable performance. The scaffolds have suitable hierarchical structure and high porosity, showing good biocompatibility and apatite formation ability, which makes them promising for bone tissue engineering applications.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Review
Polymer Science
Solmaz Saghebasl, Abolfazl Akbarzadeh, Armita Mahdavi Gorabi, Nasrin Nikzamir, Mirabdullah SeyedSadjadi, Ebrahim Mostafavi
Summary: Cardiovascular diseases are a major global health problem, with the loss of cardiac muscle function after myocardial damage being a critical challenge in cardiovascular medicine. Tissue engineering can target the substitution of damaged tissue with functional tissue, with the selection of ideal biomaterial being crucial in cardiac tissue engineering.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2022)
Article
Materials Science, Multidisciplinary
Yuting Lv, Jiawei Guo, Qiang Zhang, Guijiang Wei, Hao Yu
Summary: Biomedical porous scaffolds with low elastic modulus and high strength were successfully designed and prepared using variable gradient strategies and selective laser melting technology. The compressive strength and permeability of the scaffolds decrease with the increase of period number or the decrease of porosity variation magnitude, attributed to the reasonable adjustment of material distribution and aggregation degree by variable gradient strategies.
Article
Engineering, Biomedical
Dewei Qiu, Chuanliang Cao, Aruna Prasopthum, Zhenchang Sun, Shan Zhang, Hanwen Yang, Zhiyong Xu, Jun Tao, Fanrong Ai, Jing Yang
Summary: The study investigated the interfacial bonding formation and the role of immune cells in bone-scaffold material interfaces. Different levels of foreign body response (FBR) were elicited by two different 3D printed porous scaffolds, with polymer/hydroxyapatite composite scaffolds showing more intensive FBR compared to sintered hydroxyapatite scaffolds. The presence of FBR components appeared to inhibit osseointegration.
MATERIALS TODAY BIO
(2023)
Review
Polymer Science
Meaghan E. Harley-Troxell, Richard Steiner, Rigoberto C. Advincula, David E. Anderson, Madhu Dhar
Summary: Neural injuries can greatly impact people's quality of life, so regenerative medicine and tissue engineering have become promising fields for research on nerve repair. This review evaluates the use of natural and synthetic polymers and different fabrication methods that can influence cell behavior. The review also assesses the body's reactions to implanted materials.
Article
Dentistry, Oral Surgery & Medicine
Y. Yao, J. E. Raymond, F. Kauffmann, S. Maekawa, J. Sugai, J. Lahann, W. Giannobile
Summary: This study designed and fabricated highly ordered multicompartmental scaffolds using melt electrowriting, aiming to mimic the hierarchical structure of native periodontal tissues. The multicompartmental constructs successfully achieved coordinated proliferation and differentiation of multiple cell types in vitro, and effectively recapitulated the key features of interfacial tissues in periodontium. This tissue-engineered approach offers a fundament for engineering periodontal tissue constructs with characteristic 3D microenvironments similar to native tissues.
JOURNAL OF DENTAL RESEARCH
(2022)
Article
Nanoscience & Nanotechnology
Thiago Domingues Stocco, Mayara Cristina Moreira Silva, Marcus Alexandre Finzi Corat, Gabriely Goncalves Lima, Anderson Oliveira Lobo
Summary: This study presents a new biofabrication strategy for developing biomimetic meniscus scaffolds. The use of bioprinted cell-laden hydrogel reinforced by aligned nanofiber sheets improved the structural integrity, shape fidelity, and mechanical properties of the scaffolds. Importantly, the introduction of nanofiber mats did not negatively affect cell viability. This bioengineering approach offers a promising strategy for tissue engineering of the knee meniscus.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Tiantang Fan, Jingwen Qin, Jiafeng Li, Jifa Liu, Ying Wang, Qing Liu, Tianyun Fan, Fengzhen Liu
Summary: The study introduces flexible p-dioxanone (PDO) and highly reactive glycolide (GA) units into poly(L-lactic acid) (PLLA) to prepare poly(L-lactide-ran-p-dioxanone-ran-glycolide) (PLPG) copolymers. The copolymers are then processed into PLPG scaffolds using 3D printing technology. The results show that introducing PDO and GA units improves the mechanical and degradation properties of the PLLA scaffolds, and the PLPG scaffolds support cell proliferation, growth, and differentiation. The controllable degradation rates and mechanical performance of the PLPG scaffolds make them potentially useful in bone tissue engineering.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Nanoscience & Nanotechnology
Kun Luo, Li Wang, Man-Xi Wang, Rui Du, Li Tang, Ke-Ke Yang, Yu-Zhong Wang
Summary: The complexity of surgical treatments for large-area soft tissue injuries makes placing large implants into injury sites challenging. Aliphatic polyesters are often used for scaffold preparation in tissue engineering owing to their excellent biodegradability and biocompatibility. Scaffolds with shape-memory effect (SME) can also avoid large-volume trauma during the implantation. However, the complexity and diversity of diseases require more adaptable and precise processing methods. Four-dimensional (4D) printing, a booming smart material additive manufacturing technology, provides a new opportunity for developing shape memory scaffolds.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biotechnology & Applied Microbiology
Jurga Jersovaite, Ugne Sarachovaite, Ieva Matulaitiene, Gediminas Niaura, Daiva Baltriukiene, Mangirdas Malinauskas
Summary: Providing a 3D environment that mimics the native extracellular matrix is becoming increasingly important for various applications. Stereolithography based on photopolymerization is an emerging technique to create volumetric structures from liquid resin. However, the biocompatibility of the scaffold is an important parameter that is currently underestimated.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Engineering, Biomedical
Tejas M. Koushik, Catherine M. Miller, Elsa Antunes
Summary: Bone tissue engineering has become a well-known field of study in the past decade, with advancements in materials, processing techniques, and understanding of bone healing pathways. Synthetic scaffolds face the challenge of providing load-bearing capability and interaction with the local extracellular matrix for promoting bone healing. This article discusses the usage and processing of multi-materials and hierarchical structures to mimic the structure of natural bone tissues for bioactive and load-bearing synthetic scaffolds.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Applied
Javeria Ayub, Muhammad Usama Saeed, Nazim Hussain, Iqra Zulfiqar, Tahir Mehmood, Hafiz M. N. Iqbal, Muhammad Bilal
Summary: Nanobiocatalysis is a technique that combines biotechnology with nanotechnology to enhance bioprocessing capabilities. Immobilized enzymes improve enzyme activity, stability, and reusability. Recent advancements in nano-biotechnology allow for the incorporation of natural biocatalysts into nanostructures that provide additional properties. The use of nanomaterials as carriers for enzymes has led to the development of stable and active nanobiocatalysts.
TOPICS IN CATALYSIS
(2023)
Article
Environmental Sciences
Marise Silva de Carvalho, Luiz Henrique Sales de Menezes, Adriana Bispo Pimentel, Floriatan Santos Costa, Polyane Cabral Oliveira, Marta Maria Oliveira dos Santos, Iasnaia Maria de Carvalho Tavares, Muhammad Irfan, Muhammad Bilal, Joao Carlos Teixeira Dias, Julieta Rangel de Oliveira, Marcelo Franco
Summary: In this study, a comprehensive investigation was conducted on the production of xylanase by solid-state fermentation using Aspergillus oryzae ATCC 10124. Enzyme production was optimized through statistical designs for both the mixture of waste residues and fermentation parameters. The optimized process resulted in a significant increase (up to 165%) in enzymatic activity. The xylanase produced in this fermentation process exhibited alkaline characteristics and high thermal stability. Moreover, the multienzyme extract obtained directly from the fermentation process showed efficient saccharification capabilities without the need for enzyme purification.
WASTE AND BIOMASS VALORIZATION
(2023)
Article
Biotechnology & Applied Microbiology
Arjumand Riaz, Umme Kalsoom, Haq Nawaz Bhatti, Teofil Jesionowski, Muhammad Bilal
Summary: Dye-contaminated toxic waste is a significant environmental problem, but peroxidase from lemon peels has been found to efficiently degrade dyes. In this study, the enzyme successfully degraded two dyes with environmental and cost advantages.
BIOPROCESS AND BIOSYSTEMS ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Veer Singh, Jyoti Singh, Nidhi Singh, Sachchida Nand Rai, Manoj Kumar Verma, Manisha Verma, Vishal Singh, Mahesh Sanjay Chivate, Muhammad Bilal, Vishal Mishra
Summary: In this study, the removal of Cd (II), Pb (II), and Cr (VI) at a concentration of 50 mg/L was investigated using Microbacterium paraoxydans strain VSVM IIT(BHU). X-ray photoelectron spectroscopy and energy dispersive X-ray confirmed the binding of heavy metals on the bacterial cell surface, as well as the reduction of Cr (VI) to Cr (III). The dynamics of heavy metal removal were determined to be a combination of diffusion and transfer control based on the dimensionless values of N-k (9.49 x 10(-3), 9.92 x 10(-3), and 1.23 x 10(-2) for Cr (VI), Cd (II), and Pb (II) ions, respectively). The isolated bacterial strain showed a high removal efficiency for heavy metal ions, with maximum values of 91.62% for Cr (VI), 89.29% for Pb (II), and 83.29% for Cd (II) at 50 mg/L.
Review
Biotechnology & Applied Microbiology
Tehreem Mahmood, Nazim Hussain, Areej Shahbaz, Sikandar Mulla, Hafiz M. N. Iqbal, Muhammad Bilal
Summary: The worldwide depletion of fossil fuel reserves and the associated environmental and health risks are discussed in this study. The need for alternative renewable energy sources, with a focus on algae-based biofuels, is emphasized. Different cultivation systems for algae and various factors affecting biomass yield and biofuel production are outlined. The economic benefits of algae-based biofuels are highlighted.
BIOPROCESS AND BIOSYSTEMS ENGINEERING
(2023)
Article
Biotechnology & Applied Microbiology
Umme Kalsoom, Haq Nawaz Bhatti, Kiran Aftab, Faiza Amin, Teofil Jesionowski, Muhammad Bilal
Summary: This study investigated the potential of Brassica oleracea peroxidase in degrading reactive textile dyes Remazol Turquoise Blue 133 G and Drim Red CL4BN. The results showed that optimal conditions for enzymatic decolorization of these dyes were achieved with specific pH, temperature, enzyme activity, hydrogen peroxide concentration, and dye concentration. The findings suggest that Brassica oleracea peroxidase has the potential to efficiently remediate dye pollutants and dye-based industrial effluents in a green technology theme.
BIOPROCESS AND BIOSYSTEMS ENGINEERING
(2023)
Article
Chemistry, Physical
Muhammad Khalid Azeem, Atif Islam, Muhammad Rizwan, Atta Rasool, Nafisa Gul, Rafi Ullah Khan, Shahzad Maqsood Khan, Tahir Rasheed
Summary: In this study, pH-responsive composite hydrogels based on carrageenan and poly(N-vinyl-2-pyrrolidone) were synthesized using 3-aminopropyl triethoxysilane as cross-linker. The formation of the hydrogel was confirmed by FTIR spectroscopy, and the thermal stability was evaluated using TGA. The composite hydrogels showed higher thermal stability and exhibited good antibacterial activities. The swelling behavior of the hydrogels was influenced by the concentration of the cross-linker and the pH of the solution. The synthesized hydrogels also demonstrated sustainable biodegradation and controlled release of fertilizers.
COLLOID AND POLYMER SCIENCE
(2023)
Article
Biophysics
Muhammad Bilal, Nida Khaliq, Mubeen Ashraf, Nazim Hussain, Zulqarnain Baqar, Jakub Zdarta, Teofil Jesionowski, Hafiz M. N. Iqbal
Summary: Nanozymes are efficient nanomaterials with enzyme-like characteristics, which have attracted researchers' attention as alternatives to natural enzymes. Despite their unique physicochemical properties and catalytic activity, constraints such as denaturation, high manufacturing cost, and reutilization challenges have hindered their deployment in industrial processes. The article provides an overview of nanozyme research, compares them with natural and synthetic enzymes, and highlights their distinct properties and applications in various fields, introducing a new field called nanozymology.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Environmental Sciences
Nimra Ismail, Muhammad Imran, Muhammad Ramzan, Ayesha Anwar, Ibrahim A. Alsafari, Muhammad Asgher, Hafiz M. N. Iqbal
Summary: This work synthesized a functional porous material, aspartic acid-functionalized graphene oxide-zinc oxide, and studied its potential to remove levofloxacin (LFXN). The adsorbent was characterized using various techniques and found to have an average crystallite size of 17.30 nm. Batch adsorption studies were conducted to understand the adsorption process for LFXN. The kinetics and mechanism were analyzed using different models, revealing that the Langmuir isotherm and pseudo-first-order kinetic model were the most fitting. The GO/Asp-ZnO composite showed promising efficiency in removing LFXN.
ENVIRONMENTAL RESEARCH
(2023)
Article
Chemistry, Physical
Jakub Zdarta, Agnieszka Kolodziejczak-Radzimska, Karolina Bachosz, Agnieszka Rybarczyk, Muhammad Bilal, Hafiz M. N. Iqbal, Boguslaw Buszewski, Teofil Jesionowski
Summary: The combination of biotechnology and nanotechnology has led to the development of multienzyme co-immobilization as a promising approach in biocatalysis engineering. This has resulted in the creation of multipurpose biocatalysts, such as multienzyme co-immobilized constructs, to meet industrial demands. These biocatalysts offer selectivity, stability, and high catalytic turnover, making them essential tools in biocatalysis/protein engineering.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2023)
Review
Chemistry, Inorganic & Nuclear
Ayesha Anwar, Muhammad Imran, Hafiz M. N. Iqbal
Summary: Enzymes are extensively researched for their selectivity, efficiency, and environmental friendliness, but their lack of stability and reusability hinders their applications. Nano biocatalysts, which combine biotechnology and nanotechnology, offer attractive possibilities for enhancing enzyme activity, stability, and engineering performances. Carbon-based nanostructures coated with polymeric materials have been studied as carriers for enzyme immobilization in various fields, and co-immobilization of multiple enzymes has been highlighted. This study comprehensively analyzes immobilization techniques, carriers, biocatalytic matrices, and the influence of carrier characteristics on biocatalyst performance, as well as discussing the challenges and potential of using nanostructures for enzyme immobilization.
COORDINATION CHEMISTRY REVIEWS
(2023)
Review
Chemistry, Analytical
Chandrabhan Verma, Tahir Rasheed, Muhammad Tuoqeer Anwar, M. A. Quraishi
Summary: Metal-organic frameworks (MOFs) are hybrid materials consisting of organic ligands and metal clusters or ions, which possess impressive orderliness and crystalline structure. Recently, there has been increasing attention on the synthesis, characterization, and application of doped MOFs, particularly metal-doped MOFs (MDMOFs), due to their enhanced properties and performance. This review provides a comprehensive overview of the various applications of doped MOFs, including gas reduction and storage, wastewater treatment, catalysis, sensing, energy, and more. The improved properties of MDMOFs, such as enhanced reaction rates, increased gas intake potential, and improved sensing capabilities, are attributed to factors such as increased adsorption sites, optimized electronic structure, and chemically active surface area.
MICROCHEMICAL JOURNAL
(2023)
Article
Engineering, Electrical & Electronic
Syed Khawar Hussain Shah, Mohsin Islam Tiwana, Moazzam Islam Tiwana, Ghulam Abbas Gohar, Muhammad Tuoqeer Anwar, Tahir Rasheed
Summary: Tactile sensing is crucial for humans and robots to perceive their surroundings, and the performance of prosthetic hands is limited by the limited tactile information provided by their sensors. This paper presents a novel bio-mimicking tactile sensor design that can detect both static and dynamic forces in the frequency range of mechanoreceptors.
MICROSYSTEM TECHNOLOGIES-MICRO-AND NANOSYSTEMS-INFORMATION STORAGE AND PROCESSING SYSTEMS
(2023)
Article
Engineering, Environmental
Jakub Zdarta, Filip Ciesielczyk, Muhammad Bilal, Katarzyna Jankowska, Karolina Bachosz, Oliwia Degorska, Agnieszka Rybarczyk, Teofil Jesionowski, Anne S. Meyer
Summary: Synthetic hormones are dangerous pollutants that pose risks to the reproductive health of both ecosystems and humans through water, including drinking water. Traditional wastewater treatment methods are not efficient enough. In this study, a new biosystem made of CaSiO3 and laccase was designed and fabricated, and its application for the removal of the synthetic estrogen 17 alpha-ethynylestradiol (EE2) from aqueous systems was demonstrated. The biosystem achieved 100% removal efficiency and showed synergistic degradation through simultaneous adsorption and biocatalytic conversion, with enzymatic conversion dominating.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Engineering, Chemical
Peikun Li, Jiahui Jia, Zixin Geng, Saizhao Pang, Ruirui Wang, Muhammad Bilal, Hongjie Bian, Jiandong Cui, Shiru Jia
Summary: The glutamate oxidase (GLOX) and horseradish peroxidase (HRP) hybrid nanoflowers (GLOX&HRP-HNFs) were successfully prepared for the detection of glutamic acid (Glu). The GLOX&HRP-HNFs exhibited higher storage stability and resistance to organic solvents than free GLOX and HRP. Additionally, it showed a good linear range and a low limit of detection for glutamate.
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
