Article
Chemistry, Multidisciplinary
Jinwon Park, Quoc-Viet Le, Yina Wu, Jaiwoo Lee, Yu-Kyoung Oh
Summary: A tolerogenic nanovaccine has been developed and tested on an animal model of multiple sclerosis. The nanovaccine delivers a self-antigen to dendritic cells, blocking the interaction between immune cells and reducing interferon gamma secretion. The results show that the nanovaccine has significant preventive and therapeutic effects in the experimental autoimmune encephalomyelitis (EAE) model.
ADVANCED MATERIALS
(2023)
Article
Immunology
Jie Song, Muyuan Li, Caiyan Li, Ke Liu, Yaxi Zhu, Huali Zhang
Summary: This review provides a basic understanding of RLR biology, summarizes recent findings on the regulatory mechanisms of RLR signaling cascade, and focuses on the relationship between RLRs and diseases such as SARS-CoV-2, malaria, bacterial infections, autoimmune diseases, and anti-tumor immunity. These findings offer insights and guidance for antiviral and immunomodulatory therapies targeting RLRs.
AUTOIMMUNITY REVIEWS
(2022)
Review
Biochemistry & Molecular Biology
Massimo De Martinis, Alessandro Allegra, Maria Maddalena Sirufo, Alessandro Tonacci, Giovanni Pioggia, Martina Raggiunti, Lia Ginaldi, Sebastiano Gangemi
Summary: Vitamin D is crucial for bone health and has pleiotropic effects on various organs and tissues in the body. Deficiency in Vitamin D can lead to osteoporosis and affect the function of organs like the brain, heart, and stomach. Adequate Vitamin D supplementation can help manage these pathologies and improve overall health.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Giuseppe A. Ramirez, Chiara Asperti, Valentina Cucca, Mona-Rita Yacoub
Summary: Aberrant deployment of the immune response is a key feature of COVID-19, with vaccination against SARS-CoV-2 being effective and safe for patients with immune-mediated diseases. However, tailored strategies are needed for these patients to optimize vaccination outcomes, especially for those with primary immunodeficiencies. Additional data is necessary for this specific patient population to further understand the impact of vaccination.
Review
Biotechnology & Applied Microbiology
Guojiao Lin, Jialiang Wang, Yong-Guang Yang, Yuning Zhang, Tianmeng Sun
Summary: This paper reviews the research progress on how nano-delivery systems can be modulated for targeted delivery to dendritic cells and induce immune tolerance.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Cell Biology
Yuhong Liu, Zhihua Tu, Xi Zhang, Keqian Du, Zhengquan Xie, Zhiming Lin
Summary: Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disease with a complex pathogenesis. Neuropsychiatric systemic lupus erythematosus (NPSLE) is a serious complication of SLE that involves the nervous system and produces neurological or psychiatric symptoms. The mechanisms of NPSLE involve genetic factors, blood-brain barrier dysfunction, vascular lesions, multiple autoimmune antibodies, cytokines, and neuronal cell death. Due to the complexity and clinical overlap with other neurological or psychiatric disorders, the accurate diagnosis and treatment of NPSLE is challenging.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Immunology
Stella Amarachi Ihim, Sharafudeen Dahiru Abubakar, Zeineb Zian, Takanori Sasaki, Mohammad Saffarioun, Shayan Maleknia, Gholamreza Azizi
Summary: IL-18, a potent pro-inflammatory cytokine, plays a crucial role in various autoimmune diseases. Drugs targeting IL-18 have shown partial effectiveness or complete ineffectiveness in clinical studies, possibly due to the involvement of other cytokines and proteins in the inflammatory signaling pathway along with IL-18.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Berengere Molina, Roberto Padoan, Maria Letizia Urban, Pavel Novikov, Marco Caminati, Camille Taille, Antoine Neel, Laurence Bouillet, Paolo Fraticelli, Nicolas Schleinitz, Christine Christides, Laura Moi, Bertrand Godeau, Ann Knight, Jan Walter Schroeder, Sylvain Marchand-Adam, Helder Gil, Vincent Cottin, Cecile-Audrey Durel, Elena Gelain, Boris Lerais, Marc Ruivard, Matthieu Groh, Maxime Samson, Luca Moroni, Jens Thiel, Anna Kernder, Jan Willem Cohen Tervaert, Giulia Costanzo, Marco Folci, Sonia Rizzello, Pascal Cohen, Giacomo Emmi, Benjamin Terrier
Summary: This study investigated the safety and efficacy of off-label use of Dupilumab in patients with relapsing and/or refractory EGPA. The results suggest that Dupilumab may be effective in treating EGPA-related ENT manifestations, but caution is required as EGPA flares occurred in one-third of patients and were preceded by eosinophilia in 88% of cases.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Immunology
Yanfei Qi, Rongchao Zhang, Yaoping Lu, Xueyang Zou, Wei Yang
Summary: The regulation of tissue-specific antigens (TSAs) and their relationship with autoimmune diseases are still under debate. This review compares the roles of Aire and Fezf2 in regulating TSAs and highlights their molecular mechanisms in autoimmune diseases, laying the foundation for improved diagnostic and therapeutic approaches.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Sophia Sokolova, Irina L. Grigorova
Summary: Follicular regulatory T cells have diverse roles in immune responses, including both positive and negative regulation of B cell responses, control over autoimmune reactions and allergy development. Studies in mice have identified subsets of these cells that contribute differently to immune regulation. Recent studies on human Tfr cells have revealed similar complexity with different subsets originating from diverse sources and exhibiting immunosuppressive or immunostimulatory characteristics. This review discusses the identified Tfr subsets in mice and humans, their origins, antigen specificity, and their potential roles in controlling autoimmune and allergic reactions.
INTERNATIONAL IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Miren Garcia-Cortes, Aida Ortega-Alonso, Gonzalo Matilla-Cabello, Inmaculada Medina-Caliz, Agustin Castiella, Isabel Conde, Elvira Bonilla-Toyos, Jose Pinazo-Bandera, Nelia Hernandez, Martin Tagle, Vinicius Nunes, Raymundo Parana, Fernando Bessone, Neil Kaplowitz, M. Isabel Lucena, Ismael Alvarez-Alvarez, Mercedes Robles-Diaz, Raul J. Andrade
Summary: This study compares DILI cases with autoimmune features to those without autoimmune features and reveals that DILI with autoimmune features has different clinical characteristics and a higher risk of relapse. The study also finds that this condition is more common in females and associated with the use of certain drugs.
LIVER INTERNATIONAL
(2023)
Review
Medicine, Research & Experimental
Xiaoyan Huang, Xiangyu Huang, Yi Huang, Jiarong Zheng, Ye Lu, Zizhao Mai, Xinyuan Zhao, Li Cui, Shaohong Huang
Summary: The human body is colonized by a diverse microbiome, including over 700 species of bacteria in the oral cavity. The balance between the oral microbiota and the immune system is crucial for maintaining a healthy state. Dysbiosis in the oral microbiome is involved in the development of autoimmune diseases through various mechanisms. Factors driving oral microbiota dysbiosis include genetics, diet, stress, smoking, antibiotics, tissue injury, and infection. Maintaining a balanced oral microbiome through good oral hygiene, diet, lifestyle, and microbial therapies may be beneficial in treating oral microbiota-mediated autoimmune diseases.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Chemistry, Medicinal
Xu Gao, Xian Lin, Qingwen Wang, Jian Chen
Summary: Autoimmune diseases are challenging to treat due to the immune system's attack on one's own tissues. However, artemisinin and its derivatives have promising therapeutic potential in regulating the immune system and treating autoimmune diseases.
MEDICINAL RESEARCH REVIEWS
(2023)
Article
Immunology
Ahreum Song, Jieun Jang, Ayeong Lee, Seo Yeon Min, Sang Gyun Lee, Soo-Chan Kim, Jaeyong Shin, Jong Hoon Kim
Summary: The study found that the reimbursement policy for rituximab in South Korea decreased the time to initiate treatment and the corticosteroid use for pemphigus patients. Additionally, the frequency of circulating desmoglein-specific atypical memory B cells can serve as a surrogate marker for a good prognosis after rituximab therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
George N. Dalekos, Pinelopi Arvaniti, Nikolaos K. Gatselis, Anna Samakidou, Stella Gabeta, Eirini Rigopoulou, George K. Koukoulis, Kalliopi Zachou
Summary: Through a propensity matching study, we have demonstrated for the first time that mycophenolate mofetil (MMF) has better efficacy in the treatment of autoimmune hepatitis (AIH), particularly with a higher complete biochemical response rate at the end of follow-up.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)