期刊
INTERNATIONAL IMMUNOLOGY
卷 31, 期 1, 页码 13-21出版社
OXFORD UNIV PRESS
DOI: 10.1093/intimm/dxy065
关键词
epithelial-immune cell interaction; host-microbe interaction; intestinal organoids
类别
资金
- Ministry of Education, Culture, Sports, Science and Technology (MEXT KAKENHI) [26112705]
- Japan Society for the Promotion of Science London (JSPS KAKENHI) [24390186, 26221307]
- Japan Agency for Medical Research and Development
- Ministry of Health, Labor and Welfare of Japan
- Takeda Science Foundation
- Grants-in-Aid for Scientific Research [26221307, 26112705, 24390186] Funding Source: KAKEN
The intestinal epithelium not only acts as the physical structure that separates the intestinal lumen from the body but also actively participates in intestinal barrier functions. In the past decade, significant progress has been made in the development of culture technologies to maintain intestinal epithelial cells (IECs) as various forms of intestinal organoids. As these organoids allow for restoration of the physiological composition of IECs, they represent suitable models to study the mechanisms of development and differentiation or the molecular basis of functions in specific types of IECs, such as goblet cells, Paneth cells, tuft cells and M cells. In addition, intestinal organoids are now widely used as model systems to investigate the dynamic processes occurring at the host-microbe interface and the mutual interactions between IECs and the cells involved in the maintenance of local immune homeostasis. In this review article, I showcase recent work that has utilized intestinal organoids to study various aspects of intestinal epithelial barrier functions.
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