Article
Chemistry, Inorganic & Nuclear
Pragti, Sreshtha Nayek, Satyam Singh, Avinash Sonawane, Ivo Grabchev, Rakesh Ganguly, Suman Mukhopadhyay
Summary: In this study, three Ru(II) arene complexes with a bidentate benzimidazole-based ligand were synthesized and their antitumor activity was studied by varying the co-ligand X. The synthesized compounds showed good interactions with serum albumin proteins, had good drug stability and lipophilic character. They were found to bind with DNA and could induce apoptosis in cancer cells, as well as upregulate cleaved caspase-3 expression and downregulate BCLXL expression. These findings provide a new direction for the investigation of antitumor ruthenium-based metallodrugs using benzimidazole-based ligands.
DALTON TRANSACTIONS
(2023)
Review
Chemistry, Inorganic & Nuclear
Pavel Starha
Summary: The development of multinuclear homometallic biologically active complexes in modern bioinorganic chemistry offers increased therapeutic effects and variations in mechanism of action. Combining different metal centers within heterometallic complexes ensures unique modes of action, with comparisons between structurally similar analogues playing a key role in research.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Chemistry, Organic
Linan Hou, Sheng Zhang, Ji Ma, Haiyu Wang, Tienan Jin, Masahiro Terada, Ming Bao
Summary: An organocatalytic atroposelective strategy for the construction of axially chiral compounds containing benzimidazole and quinoline rings is introduced. The reaction of 2-alkynylbenzimidazoles with ortho-aminophenylketones proceeds smoothly in the presence of chiral phosphoric acid, resulting in axially chiral heterobiaryls with good yields and enantioselectivities. This paper presents the first example of combining benzimidazole and quinoline rings at the 2- and 3-positions, respectively, into axially chiral heterobiaryls using this new strategy.
Article
Chemistry, Multidisciplinary
Sankar Monika, Rengan Ramesh
Summary: This study reports the synthesis of a new series of organometallic dinuclear ruthenium(ii) arene complexes and investigates their in vitro antiproliferative activity and cancer cell death mechanism. The formation of complexes was confirmed by various spectroscopic techniques. The synthesized complexes showed higher inhibition of cancer cells compared to the standard cisplatin drug, and apoptosis was confirmed through morphological changes and phosphatidylserine externalization.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Lindsey Paul, Khuslen Enkhbold, Sydney Robinson, Than Thar Aye, Yuna Chung, Daniel P. Harrison, Julie A. Pollock, Michael R. Norris
Summary: Photoactivated chemotherapy (PACT) is a promising strategy that targets cancer cells by using light irradiation to generate cytotoxic complexes. Ru polypyridyl complexes play an important role in PACT, but their study is complicated by excited-state electron transfer. To overcome this, researchers have developed a methodology to investigate each product individually and assess the structure-function relationship.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Chemistry, Physical
Mona A. Alamri, Mutlaq Al-Jahdali, Najlaa S. Al-Radadi, Mostafa A. Hussien
Summary: Three new triazene compounds with different substituents were synthesized and characterized, showing good DNA binding and cytotoxic activities, especially one compound exhibiting strong inhibition against both cell lines. Molecular docking studies indicated good correlations between compound binding and experimental cytotoxicity findings.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Inorganic & Nuclear
Stephen Mensah, Joseph D. Rosenthal, Mamta Dagar, Tyson Brown, Jonathan J. Mills, Christopher G. Hamaker, Gregory M. Ferrence, Michael I. Webb
Summary: The evolution of high virulence bacterial strains has led to the development of novel therapeutic agents. Metal-based therapeutics, with their structural variability and unique modes of action, show great promise. This study focused on the preparation and evaluation of ruthenium(ii)-arene complexes containing Schiff base ligands with an attached ferrocene, and identified a complex with prominent activity against clinically relevant bacterial strains.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Inorganic & Nuclear
Aditi Singh, Sanchaita Dey, Sanjib Panda, Goutam Kumar Lahiri
Summary: The paper investigates the electronic impact of ancillary ligands on the redox features of azobis(benzothiazole) in newly introduced ruthenium complexes, and characterizes four different oxidation states of the complexes through structural and spectroscopic analysis.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Abirami Arunachalam, Ramesh Rengan, Devan Umapathy, Antony Joseph Velanganni Arockiam
Summary: This study describes the synthesis and characterization of six new arene ruthenium(II) complexes containing biphenyl benzhydrazone ligands and evaluates their antiproliferative properties. The complexes demonstrated significant cytotoxicity against cancer cells and have the potential to be used as alternate anticancer drugs to platinum drugs.
Article
Chemistry, Inorganic & Nuclear
Nourhan M. Ibrahim, Rabaa M. Khaled, Mohamed A. Ragheb, Krzysztof Radacki, Ahmad M. Farag, Ahmed M. Mansour
Summary: The study examined the release mechanism of CO molecules, photolysis characteristics, and cytotoxicity of [RuCl2(CO)(2)L-R] compounds on breast cancer cells. Illumination increased the cytotoxicity of the compounds, with released CO and metal fragments potentially being the main causes of cytotoxicity.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Dmitry I. Pavlov, Denis G. Samsonenko, Laura Bonfili, Massimiliano Cuccioloni, Enrico Benassi, Riccardo Pettinari, Andrei S. Potapov, Vladislava V. Matveevskaya
Summary: Six new arene-ruthenium(II) complexes with different arene and oxime ligands were synthesized and characterized. The complexes exhibited a half-sandwich piano-stool geometry and showed promising anti-proliferative activity.
INORGANICA CHIMICA ACTA
(2022)
Article
Chemistry, Organic
Tamilthendral Veerappan, Ramesh Rengan
Summary: A sustainable synthesis of substituted pyrazoles is achieved via an eco-friendly dehydrogenative annulation reaction using newly synthesized binuclear Ru-(II) p-cymene complexes. The reaction proceeds under mild conditions, producing H(2)O/H-2 as the only byproduct, and yields a range of polysubstituted pyrazoles and a therapeutic gout medicine analogue successfully.
Article
Chemistry, Inorganic & Nuclear
Srividya Swaminathan, Jebiti Haribabu, Mahendiran Dharmasivam, Nikhil Maroli, Jayachandra Prakasan Jayadharini, Nithya Balakrishnan, Nattamai Bhuvanesh, Cesar Echeverria, Ramasamy Karvembu
Summary: We designed and synthesized bipodal ligands with varying substitution on the phenyl group spacer. Ligands and complexes with different arene units were successfully synthesized and characterized. The coordination behavior of the ligands was minimally influenced by substitution change, but differences were observed in the anticancer activity of the complexes. DFT and X-ray diffraction studies revealed structural variations between the different substitutions, and UV-visible spectroscopy determined the correlation between anticancer activity, hydrolysis rate, and lipophilicity index of the complexes. Staining assays, flow cytometry, and Western blot analysis confirmed the apoptotic cell death mechanism of the active complexes.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Applied
Komal M. Vyas, Deepu Sharma, Sri Krishna Jayadev Magani, Shaikh M. Mobin, Suman Mukhopadhyay
Summary: Two new arene ruthenium(II) complexes were synthesized and screened for cytotoxic activity, with one showing higher cytotoxicity against cancer cell lines and the other exhibiting anti-migratory properties.
APPLIED ORGANOMETALLIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Stefan Nikolic, Jemma Arakelyan, Vladimir Kushnarev, Samah Mutasim Alfadul, Dalibor Stankovic, Yaroslav I. Kraynik, Sanja Grguric-Sipka, Maria V. Babak
Summary: The astable half-sandwich Ru-dipyridophenazine complex can significantly decrease tumor burden in mouse xenografts without causing kidney and liver toxicity, and its mechanism of action is linked to DNA degradation and ROS induction.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Igor Echevarria, Monica Vaquero, Blanca R. Manzano, Felix A. Jalon, Roberto Quesada, Gustavo Espino
Summary: Photoredox catalysis is a powerful tool in inorganic synthesis, and this paper presents an efficient and selective photocatalytic procedure for the oxidative dehydrogenation of partially saturated N-heterocycles to produce N-heteroarenes. The researchers established structure-activity relationships and proposed a dual mechanism for the reactions based on in-depth experimental and theoretical studies.
INORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Igor Echevarria, Elisenda Zafon, Silvia Barrabes, Sonia Ramos-Gomez, Natividad Ortega, Blanca R. Manzano, Felix A. Jalon, Roberto Quesada, Gustavo Espino, Anna Massaguer, Maria Angeles Martinez
Summary: This article describes the synthesis and evaluation of a family of Ir(III) complexes as potential photosensitizers for photodynamic therapy (PDT). The complexes exhibit cytotoxic activity in the absence of light irradiation and enhanced cytotoxic activity under irradiation. The uptake mechanism of the complexes in prostate cancer cells was identified as endocytosis, and they mainly accumulate in the mitochondria. The complexes induce apoptosis in cancer cells under irradiation, likely through damage to mitochondrial DNA and mitochondrial membrane depolarization.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Alejandro Sanchez-Melgar, Pedro J. Izquierdo-Ramirez, Christian Grinan-Ferre, Merce Pallas, Mairena Martin, Jose Luis Albasanz
Summary: Age is a prominent factor for dysregulation of cholesterol metabolism in the brain of SAMP8 mice, and resveratrol exhibits different neuroprotective effects on Aβ processing or cholesterol metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Sonia Munoz-Lopez, Alejandro Sanchez-Melgar, Mairena Martin, Jose Luis Albasanz
Summary: Despite the lack of effective treatment for cancer, natural compounds such as resveratrol have shown promise in cancer therapy. Resveratrol can modulate various signaling pathways related to cancer initiation and progression. This study investigates the impact of resveratrol treatment on adenosinergic pathway components and cell viability in HeLa and SH-SY5Y cell lines, revealing changes in the pathway that may contribute to the anti-tumoral effects of resveratrol.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Chemistry, Applied
Jorge Leal, Gema Dura, Felix A. Jalon, Elisenda Zafon, Anna Massaguer, Jose Vicente Cuevas, Lucia Santos, Ana M. Rodriguez, Blanca R. Manzano
Summary: Luminescent platinum cyclometalated complexes have applications in optoelectronic and biological fields, especially in anticancer activity. A series of these complexes with different ligands were synthesized, and their emission wavelengths could be tuned. Density-functional theory provided descriptions of their molecular orbital characteristics, and time-dependent DFT calculations showed different excited states for different complexes. Biological studies demonstrated that some complexes exhibited cytotoxic activity against human cervical and lung carcinoma cells, and microscopy assays showed their accumulation in cytoplasmic organelles. The disruption of mitochondrial metabolism was observed, leading to a decrease in cellular ATP content. These complexes may have potential as alternative anticancer drugs.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Marta Martinez-Alonso, Albert Gandioso, Chloe Thibaudeau, Xue Qin, Philippe Arnoux, Nurikamal Demeubayeva, Vincent Guerineau, Celine Frochot, Alain C. Jung, Christian Gaiddon, Gilles Gasser
Summary: A novel Ru(II) cyclometalated photosensitizer, Ru-NH2, and its bioconjugates, Ru-Mal-CTX and Ru-BAA-CTX, were synthesized and characterized. Ru-NH2 showed absorption maxima around 580 nm and generated singlet oxygen upon light irradiation. In vitro experiments demonstrated the excellent phototoxicity of Ru-NH2 towards CT-26 and SQ20B cells under specific light conditions.
Review
Nutrition & Dietetics
Diego Fernandez-Lazaro, Carlos Dominguez-Ortega, Natalia Busto, Mirian Santamaria-Pelaez, Enrique Roche, Eduardo Gutierez-Abejon, Juan Mielgo-Ayuso
Summary: N-acetylcysteine (NAC) is a sports supplement that can improve physical performance by modulating exercise-induced oxidative damage and maintaining glutathione homeostasis. A systematic review of studies on NAC supplementation in adult men found that it has beneficial effects on exercise performance, antioxidant capacity, and glutathione homeostasis. However, the evidence for its effects on haematological markers, inflammatory response, and muscle behavior is not clear. Overall, NAC supplementation appears to be safe and effective, but more research is needed to fully understand its relevance.
Article
Food Science & Technology
Mari Mar Cavia, Nerea Arlanzon, Natalia Busto, Celia Carrillo, Sara R. Alonso-Torre
Summary: Various factors, including apple variety, maturity, farming and storage conditions, and fermentation method, can influence the polyphenol content and antioxidant capacity of ciders, leading to differences in values among ciders from different origins. This study aimed to characterize Spanish ciders in terms of their polyphenol content and antioxidant capacity, and determine whether these properties change after digestion. The Basque Country ciders showed higher levels of polyphenols and antioxidant capacity compared to ciders from other regions, and the in vitro digestion process resulted in a loss of phenolic compounds.
Article
Biochemistry & Molecular Biology
Borja Diaz de Grenu, Diego M. Fernandez-Aroca, Juan A. Organero, Gema Dura, Felix Angel Jalon, Ricardo Sanchez-Prieto, M. Jose Ruiz-Hidalgo, Ana Maria Rodriguez, Lucia Santos, Jose L. Albasanz, Blanca R. Manzano
Summary: Compound 6, a new derivative of aromatase inhibitors, exhibits higher inhibitory activity and potent cytostatic behavior compared to established inhibitors, making it a promising candidate for hormone-dependent cancer treatment.
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Alicia Marco, Gloria Vigueras, Natalia Busto, Natalia Cutillas, Delia Bautista, Jose Ruiz
Summary: New valproate Ir(iii) and Rh(iii) half-sandwich conjugates with a C,N-phenylbenzimidazole chelated ligand have been synthesized and characterized. The conjugation of valproic acid to organometallic fragments appears to enhance the antibacterial activity of the complexes against Enterococcus faecium and Staphylococcus aureus Gram-positive bacteria.
DALTON TRANSACTIONS
(2023)
Article
Oncology
M. Isabel Acuna, Ana R. Rubio, Marta Martinez-Alonso, Natalia Busto, Ana Maria Rodriguez, Nerea Davila-Ferreira, Carl Smythe, Gustavo Espino, Begona Garcia, Fernando Dominguez
Summary: Iridium complexes have potential as cancer drug candidates due to their structural versatility and ability to target mitochondria. The most promising complex, 1[C,NH], induces cell death by disrupting mitochondria membrane permeability. In vivo studies in mice showed reduced tumor burden. These findings could guide the development of next-generation anticancer drugs.
Article
Biochemistry & Molecular Biology
Natalia Busto, Joana Leitao-Castro, Alfonso T. Garcia-Sosa, Francisco Cadete, Carolina S. Marques, Renata Freitas, Anthony J. Burke
Summary: Molecular hybridization approaches have been used to develop a series of novel N-1,2,3-triazole-isatin hybrids, which show promising anti-proliferative activity against tumor cells. The compounds outperformed cis-platin in terms of anti-proliferation, and potential biological targets, including histone acetyltransferase P-300 and acyl-protein thioesterase 2, were identified. These compounds exhibit advantageous pharmacological properties and affect transcriptional regulation in oncological contexts.
RSC MEDICINAL CHEMISTRY
(2022)