Review
Pharmacology & Pharmacy
Hashem Etayash, Robert E. W. Hancock
Summary: Amphiphilic antimicrobial polymers and surface engineered polymeric-brush-tethered HDP are promising strategies that aim to overcome limitations of HDPs, enhance physicochemical properties and therapeutic performance, and address unmet therapeutic needs.
Article
Biotechnology & Applied Microbiology
Adria Lopez-Cano, Marc Martinez-Miguel, Judith Guasch, Imma Ratera, Anna Aris, Elena Garcia-Fruitos
Summary: The emergence of antibiotic-resistant microorganisms has led to the development of alternative antimicrobial therapies such as host defense peptides (HDPs). In this study, the impact of different strains of Escherichia coli on the activity and stability of recombinant defensins was assessed. The results showed that the strain used as the cell factory had a clear impact on both the quantity and quality of the HDPs produced.
MICROBIAL CELL FACTORIES
(2022)
Article
Biochemistry & Molecular Biology
Luis A. Estrella, Elizabeth A. Yates, Kenan P. Fears, Janna N. Schultzhaus, Heonjune Ryou, Dagmar H. Leary, Christopher R. So
Summary: Barnacles integrate protein components into nanofibers for permanent underwater attachment, the design principles and chemistry of which remain to be fully understood. The use of engineered bacterial biofilms to display a library of amyloid materials outside of the cell sheds light on the evolution of adhesive nanomaterials.
Article
Agricultural Engineering
Shuai Jiang, Heyun Wu, Zhuoyue Yao, Ran Li, Qian Ma, Xixian Xie
Summary: The improvement of industrial microbes' production phenotype is necessary and challenging. Optimizing environmental factors helps to activate potential genetic determiners and enhance production. This study dissected the mechanism of L-arginine overproduction triggered by betaine and identified beneficial genes for further improvement. It also revealed the role of betaine in modulating gene transcription and developed a superior L-arginine overproducer that does not require betaine.
BIORESOURCE TECHNOLOGY
(2023)
Review
Microbiology
Lindsey Dzierozynski, Jessica Queen, Cynthia L. Sears
Summary: This commentary discusses the influence of host genetics on the microbiome and highlights the need for mechanistic experimental studies to understand the interplay between host genes and the microbiome.
CELL HOST & MICROBE
(2023)
Review
Microbiology
Xueqi Chen, Shan Su, Yan Yan, Limei Yin, Lihong Liu
Summary: The World Health Organization has identified Pseudomonas aeruginosa as one of the 12 drug-resistant bacteria that pose a significant threat to human health. In China, P. aeruginosa is a common pathogen in hospital acquired pneumonia, accounting for 16.9-22.0%. The excessive use of antibiotics has led to the emergence of multidrug-resistant strains, presenting a major challenge to conventional antibiotics and therapeutic approaches.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Medicine, General & Internal
Razie Kamali Dolatabadi, Awat Feizi, Mehrdad Halaji, Hossein Fazeli, Peyman Adibi
Summary: This study revealed that colonization by AIEC is more frequent in IBD and is associated with IBD (CD and UC). The most frequent AIEC phylogroup in the IBD, CD, and control groups was B-2.
FRONTIERS IN MEDICINE
(2021)
Review
Medicine, General & Internal
Lie Zheng, Sheng-Lei Duan, Yan-Cheng Dai, Shi-Cheng Wu
Summary: This review explores the relationship between adherent invasive E. coli (AIEC) and inflammatory bowel disease (IBD), including the relationship between AIEC and the intestinal immune system, the prevalence and relevance of AIEC in patients with Crohn's disease and ulcerative colitis, and the relationship between AIEC and disease site, activity, and postoperative recurrence. Furthermore, potential therapeutic strategies to attenuate AIEC colonization in the intestinal mucosa are highlighted.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Infectious Diseases
Yohannes E. Messele, Darren J. Trott, Mauida F. Hasoon, Tania Veltman, Joe P. McMeniman, Stephen P. Kidd, Steven P. Djordjevic, Kiro R. Petrovski, Wai Y. Low
Summary: The genetic characteristics and phylogenetic relationships among Escherichia coli isolates from cattle, pigs, poultry, and humans were analyzed using whole genome sequencing data. Most cattle and pig isolates belonged to phylogroups A and B1, while avian and human isolates belonged to B2 and D. Some cattle isolates carried extended-spectrum and AmpC beta-lactamase genes. The results indicate that cattle isolates from feedlots pose a reduced risk of being a source of clinically important antimicrobial-resistant E. coli.
Article
Biology
Sriram Srikant, Chantal K. Guegler, Michael T. Laub
Summary: This study reveals the mechanism by which phages overcome bacterial defense systems through experimental evolution. The emergence of one counter-defense mechanism can lead to the loss of other mechanisms, thus constraining the host range of phages.
Review
Biochemistry & Molecular Biology
Matthew Drayton, Julia P. Deisinger, Kevin C. Ludwig, Nigare Raheem, Anna Mueller, Tanja Schneider, Suzana K. Straus
Summary: The rapid rise of multidrug-resistant bacteria has raised concerns about the effectiveness of traditional antibiotics. Antimicrobial peptides, with their diverse mechanisms of actions, offer a promising solution to combat these pathogens. This review discusses the mechanisms of antibiotic resistance and the potential of antimicrobial peptides in providing a more robust treatment of bacterial infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Aetas Amponnawarat, Chalatip Chompunud Na Ayudhya, Hydar Ali
Summary: Pseudomonas aeruginosa infections are difficult to treat due to biofilm formation and antibiotic resistance, but a lipidated HDP mimetic called murepavadin has shown antibacterial activity against multi-drug-resistant strains. Murepavadin activates human MCs via MRGPRX2 and murine MCs via MrgprB2, potentially contributing to bacterial clearance and wound healing.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Queralt Bonet-Rossinyol, Carla Camprubi-Font, Mireia Lopez-Siles, Margarita Martinez-Medina
Summary: This study compared the gene expression differences between AIEC and non-AIEC strains using transcriptomics and identified several genes that may contribute to the pathogenicity of AIEC. Two potential biomarkers for AIEC identification were also proposed.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Microbiology
Takaomi Sasaki, Saya Takita, Takashi Fujishiro, Yunosuke Shintani, Satoki Nojiri, Ryota Yasui, Tetsuro Yonesaki, Yuichi Otsuka
Summary: Bacteria have developed defense mechanisms, such as abortive infection (Abi), to protect against phages. The AbpAB defense system in Escherichia coli inhibits the propagation of lytic phages and the induction of lysogenic phages by sensing the presence of phages and DNA-protein complexes. AbpA and AbpB in the AbpAB system play crucial roles in phage defense through their nuclease and RNA helicase domains.
Review
Agronomy
Fernando Lobo, Alicia Boto
Summary: Host-defense peptides (HDP) are emerging as promising phytosanitaries due to their potency, low toxicity, and low induction of antimicrobial resistance. They are natural compounds that have been used by animals and plants for millions of years to defend against pathogens. HDPs are being discovered through genome mining and produced using biofactories. Truncated or modified peptides have been developed to improve their bioactivities and reduce production costs. The combination of HDP and other antimicrobials, as well as the development of hybrid molecules, has shown promising results. However, cautionary measures need to be taken for the sustainable use of HDPs.
Review
Medicine, Research & Experimental
Joseph B. McPhee, Jonathan D. Schertzer
Article
Medicine, Research & Experimental
Emmanuel Denou, Karine Lolmede, Lucile Garidou, Celine Pomie, Chantal Chabo, Trevor C. Lau, Morgan D. Fullerton, Giulia Nigro, Alexia Zakaroff-Girard, Elodie Luche, Celine Garret, Matteo Serino, Jacques Amar, Michael Courtney, Joseph F. Cavallari, Brandyn D. Henriksbo, Nicole G. Barra, Kevin P. Foley, Joseph B. McPhee, Brittany M. Duggan, Hayley M. O'Neill, Amanda J. Lee, Philippe Sansonetti, Ali A. Ashkar, Waliul I. Khan, Michael G. Surette, Anne Bouloumie, Gregory R. Steinberg, Remy Burcelin, Jonathan D. Schertzer
EMBO MOLECULAR MEDICINE
(2015)
Article
Biochemistry & Molecular Biology
David T. Mulder, Joseph B. McPhee, Sarah A. Reid-Yu, Peter J. Stogios, Alexei Savchenko, Brian K. Coombes
MOLECULAR MICROBIOLOGY
(2015)
Article
Immunology
Taylor J. Schoberle, Lawton K. Chung, Joseph B. McPhee, Ben Bogin, James B. Bliska
INFECTION AND IMMUNITY
(2016)
Article
Microbiology
Cherrie L. Small, Lydia Xing, Joseph B. McPhee, Hong T. Law, Brian K. Coombes
Article
Microbiology
Hana S. Fukuto, Viveka Vadyvaloo, Joseph B. McPhee, Hendrik N. Poinar, Edward C. Holmes, James B. Bliska
JOURNAL OF BACTERIOLOGY
(2018)
Article
Microbiology
Amy L. Kullas, Michael McClelland, Hee-Jeong Yang, Jason W. Tam, AnnMarie Torres, Steffen Porwollik, Patricio Mena, Joseph B. McPhee, Lydia Bogomolnaya, Helene Andrews-Polymenis, Adrianus W. M. van der Velden
CELL HOST & MICROBE
(2012)
Article
Immunology
Joseph B. McPhee, Patricio Mena, Yue Zhang, James B. Bliska
INFECTION AND IMMUNITY
(2012)
Article
Immunology
Joseph B. McPhee, Cherrie L. Small, Sarah A. Reid-Yu, John R. Brannon, Herve Le Moual, Brian K. Coombes
INFECTION AND IMMUNITY
(2014)
Letter
Biochemistry & Molecular Biology
Joseph B. McPhee, James B. Bliska
Article
Multidisciplinary Sciences
Kirsten I. Bos, Verena J. Schuenemann, G. Brian Golding, Hernan A. Burbano, Nicholas Waglechner, Brian K. Coombes, Joseph B. McPhee, Sharon N. DeWitte, Matthias Meyer, Sarah Schmedes, James Wood, David J. D. Earn, D. Ann Herring, Peter Bauer, Hendrik N. Poinar, Johannes Krause
Article
Multidisciplinary Sciences
Cherrie-Lee N. Small, Sarah A. Reid-Yu, Joseph B. McPhee, Brian K. Coombes
NATURE COMMUNICATIONS
(2013)
Article
Microbiology
Chhatra B. Kunwar, Sarah Birstonas, Joseph B. McPhee, Debora Barnett Foster
Article
Immunology
Youn Hee Cho, Monir Riasad Fadle Aziz, Avery Malpass, Tanuja Sutradhar, Jasika Bashal, Veronica Cojocari, Joseph B. B. McPhee
Summary: Bacteria that colonize eukaryotic surfaces have evolved strategies to detect and resist host-produced antimicrobial molecules. This study shows that Omptin family proteases in Escherichia coli and Citrobacter rodentium are regulated by the PhoPQ system. Each Omptin protein confers unique survival advantages against specific host antimicrobial factors.
INFECTION AND IMMUNITY
(2023)