Review
Immunology
Huan Zhang, Zhilin Zhang, Yiqun Liao, Wenjie Zhang, Dong Tang
Summary: The human gut microbiome plays a crucial role in human health, especially in the early development of host immunity. It is closely linked to the immune system and can influence the development of various diseases in infants and young children. The composition of the infant gut microbiome can predict disease risk and can be modulated to prevent and treat diseases. Maternal influences, including food delivery and feeding, have the most significant impact on the infant gut microbiota.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Cell Biology
Bastian Robinson Baarz, Lothar Rink
Summary: Nowadays, aging is recognized as a complex and dynamic process that affects almost all organs and cells in the human body. The immune system is particularly vulnerable to aging, and maintaining its integrity is crucial for preventing age-related diseases. Micronutrient intervention, especially adequate intake of the trace element zinc, has been identified as a potential strategy to slow immune aging. However, zinc deficiency is common among the elderly and can lead to increased susceptibility to infections and reduced immune response.
AGEING RESEARCH REVIEWS
(2022)
Review
Immunology
Bulmaro Cisneros, Ian Garcia-Aguirre, Juan Unzueta, Isabel Arrieta-Cruz, Oscar Gonzalez-Morales, Juan M. Dominguez-Larrieta, Aura Tamez-Gonzalez, Gerardo Leyva-Gomez, Jonathan J. Magana
Summary: The function of the immune system declines during aging, leading to compromised response against pathogens and chronic low-grade inflammation. This review discusses the molecules and mechanisms that regulate the relationship between immunosenescence and inflammaging, as well as therapeutic strategies to improve immunity in aged individuals.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Geriatrics & Gerontology
Jack Feehan, Nicholas Tripodi, Vasso Apostolopoulos
Summary: Cellular senescence is a critical part of human anti-tumor defence, but the accumulation of senescent cells with age can lead to various pathologies. Immunosenescence, the senescent change in immune cells, has a wide range of physiological effects and is partially responsible for many diseases associated with aging. Understanding the effects and mechanisms of immunosenescence can improve disease outcomes and prevention in older adults, and lead to new treatments for common illnesses.
Article
Microbiology
Nelly Amenyogbe, Pedro Dimitriu, Kinga K. Smolen, Eric M. Brown, Casey P. Shannon, Scott J. Tebbutt, Phillip J. Cooper, Arnaud Marchant, Tessa Goetghebuer, Monika Esser, Brett B. Finlay, Tobias R. Kollmann, William W. Mohn
Summary: This study identified differences in immune responses correlating to gut microbiomes across biogeographically diverse settings and evaluated biological plausibility using a mouse model.
Review
Geriatrics & Gerontology
Katarzyna Domaszewska, Michal Boraczynski, Yi-Yuan Tang, Joanna Gronek, Krystian Wochna, Tomasz Boraczynski, Dariusz Wielinski, Piotr Gronek
Summary: This review provides a brief summary of established findings in exercise immunology and immunogerontology, focusing on the main exercise-induced mechanisms associated with aging of the immune system.
Review
Immunology
Stephan En Jie Chee, Egle Solito
Summary: Alzheimer's Disease is a progressive neurodegenerative disease associated with aging, characterized by neuroinflammation and amyloid protein accumulation. Research suggests that AD may result from immune system dysregulation due to aging, and future therapies may focus on modulating the aged immune system.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Paulo J. P. L. Teixeira, Nicholas R. Colaianni, Theresa F. Law, Jonathan M. Conway, Sarah Gilbert, Haofan Li, Isai Salas-Gonzalez, Darshana Panda, Nicole M. Del Risco, Omri M. Finkel, Gabriel Castrillo, Piotr Mieczkowski, Corbin D. Jones, Jeffery L. Dangl
Summary: Plants have an innate immune system to fight off potential invaders based on the perception of microbial molecules. The root commensal bacteria can modulate a specific sector of the Arabidopsis immune system, highlighting the importance of extracellular strategies for pathogen suppression.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Salvatrice Mancuso, Marta Mattana, Melania Carlisi, Marco Santoro, Sergio Siragusa
Summary: B-cell lymphoma and lymphoproliferative diseases are a heterogeneous group of neoplasms accompanied by immune regulatory disorders. Immunological imbalance plays an important role in the development and progression of lymphoma. Modulating the immune system can have a profound impact on disease progression or resolution, making it a critical target for new therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Leah S. Hohman, Lisa C. Osborne
Summary: This review discusses emerging data on age-related loss of intestinal barrier integrity and suggests that IEC dysfunction may play a central role in age-associated alterations in microbiota composition and immune homeostasis.
Review
Biochemistry & Molecular Biology
Ana Elena Perez-Cobas, Jeronimo Rodriguez-Beltran, Fernando Baquero, Teresa M. Coque
Summary: A thriving multi-kingdom microbial ecosystem, known as the respiratory tract microbiome (RTM), has gained increasing research attention due to its contribution to human health. This review utilizes an ecological framework to understand the functioning and assembly of the RTM, highlighting its ecological models, microbiome establishment, community structure, diversity stability, and critical microbial interactions. Furthermore, the review outlines the RTM's responses to ecological disturbances and explores promising approaches to restore ecological balance.
TRENDS IN MICROBIOLOGY
(2023)
Article
Immunology
Jose M. Lemme-Dumit, Yang Song, Hnin Wai Lwin, Claudia Hernandez-Chavez, Sripriya Sundararajan, Rose M. Viscardi, Jacques Ravel, Marcela F. Pasetti, Bing Ma
Summary: This study investigated the fecal cytokine profile and gut microbiota in preterm neonates, and found that both immunological and microbiological factors play a critical role in the early development of intestinal barrier.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Clinical Neurology
Gina P. Sykes, Joseph Kamtchum-Tatuene, Sarina Falcione, Sarah Zehnder, Danielle Munsterman, Boryana Stamova, Bradley P. Ander, Frank R. Sharp, Glen Jickling
Summary: This study identified 166 genes associated with age in patients with acute ischemic stroke, with 69 of these genes confirmed in a validation cohort. The identified genes were related to changes in B-cell receptor signaling, lymphocyte proliferation, and leukocyte homeostasis, suggesting that aging immune system may influence age-related stroke risk and outcome.
Review
Immunology
Ling Zhao, Chen Hou, Naihong Yan
Summary: Neuroinflammation is an important cause of retinitis pigmentosa progression, and inflammation modulation plays a crucial role in treatment. Therapies targeting inflammation have shown potential in attenuating photoreceptor degeneration.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Rebecca G. Reed, Steven R. Presnell, Ahmad Al-Attar, Charles T. Lutz, Suzanne C. Segerstrom
Summary: Stressful life events can accelerate immune aging, but using cognitive reappraisal as an emotion regulation strategy may reduce these effects. This study investigated whether cognitive reappraisal moderates the relationship between life stressors and immune aging markers in older adults. The results showed that experiencing more frequent life stressors was associated with higher levels of late-differentiated NK cells, but this effect was explained by health-related stressors. Surprisingly, experiencing more frequent and less desirable stressors was associated with lower average levels of TNF-alpha. Moreover, cognitive reappraisal was found to moderate the associations between life stressors and late-differentiated NK cells between individuals and IL-6 within individuals.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
