Are toll-like receptors potential drug targets for atherosclerosis? Evidence from genetic studies to date

Association analyses based on false discovery rate implicate new loci for coronary artery disease

(2017) Christopher P Nelson et al.   NATURE GENETICS

Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease

(2017) Marc S. Sabatine et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Understanding human immune function using the resources from the Human Functional Genomics Project

(2016) Mihai G Netea et al.   NATURE MEDICINE

Inter-individual variability and genetic influences on cytokine responses to bacteria and fungi

(2016) Yang Li et al.   NATURE MEDICINE

Genetic Analysis of Leukocyte Type-I Interferon Production and Risk of Coronary Artery Disease

(2015) C. P. Nelson et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Systems Genetics Analysis of Genome-Wide Association Study Reveals Novel Associations Between Key Biological Processes and Coronary Artery DiseaseSignificance

(2015) Sujoy Ghosh et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

TLR1, 2, 4, 6 and 9 Variants Associated with Tuberculosis Susceptibility: A Systematic Review and Meta-Analysis

(2015) Haiko Schurz et al.   PLoS One

Protective Role for Toll-Like Receptor-9 in the Development of Atherosclerosis in Apolipoprotein E–Deficient Mice

(2014) Christine Koulis et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Common Genetic Variants Modulate Pathogen-Sensing Responses in Human Dendritic Cells

(2014) M. N. Lee et al.   SCIENCE

Innate Immune Activity Conditions the Effect of Regulatory Variants upon Monocyte Gene Expression

(2014) B. P. Fairfax et al.   SCIENCE

Characterizing the genetic basis of innate immune response in TLR4-activated human monocytes

(2014) Sarah Kim et al.   Nature Communications

Integrative Genomics Reveals Novel Molecular Pathways and Gene Networks for Coronary Artery Disease

(2014) Ville-Petteri Mäkinen et al.   PLoS Genetics

Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease

(2013) Joyce BJ van Meurs et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Increased cytokine response after toll-like receptor stimulation in patients with stable coronary artery disease

(2013) E.H.A.M. Elsenberg et al.   ATHEROSCLEROSIS

Multiethnic Meta-Analysis of Genome-Wide Association Studies in >100 000 Subjects Identifies 23 Fibrinogen-Associated Loci but No Strong Evidence of a Causal Association Between Circulating Fibrinogen and Cardiovascular Disease

(2013) Maria Sabater-Lleal et al.   CIRCULATION

Randomized, Double-Blind, Placebo-Controlled, Dose-Escalating Phase I, Healthy Subjects Study of Intravenous OPN-305, a Humanized Anti-TLR2 Antibody

(2013) M Reilly et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Identification of Genetic Loci Associated With Helicobacter pylori Serologic Status

(2013) Julia Mayerle et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Secretory Phospholipase A 2 -IIA and Cardiovascular Disease

(2013) Michael V. Holmes et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Common variants associated with plasma triglycerides and risk for coronary artery disease

(2013) Ron Do et al.   NATURE GENETICS

Genome-Wide Association Study of Genetic Variants in LPS-Stimulated IL-6, IL-8, IL-10, IL-1ra and TNF-α Cytokine Response in a Danish Cohort

(2013) Margit Hørup Larsen et al.   PLoS One

Toll-Like Receptor 7 Protects From Atherosclerosis by Constraining “Inflammatory” Macrophage Activation

(2012) Maria Salagianni et al.   CIRCULATION

The genetics of type I interferon in systemic lupus erythematosus

(2012) Paola G Bronson et al.   CURRENT OPINION IN IMMUNOLOGY

Infections in Patients with Rheumatic Diseases Treated with TNF Antagonists

(2012) Beatriz Perez-Zafrilla et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Variation in the TLR10/TLR1/TLR6 locus is the major genetic determinant of interindividual difference in TLR1/2-mediated responses

(2012) C Mikacenic et al.   GENES AND IMMUNITY

Architecture of the human regulatory network derived from ENCODE data

(2012) Mark B. Gerstein et al.   NATURE

Insights into the regulation of protein abundance from proteomic and transcriptomic analyses

(2012) Christine Vogel et al.   NATURE REVIEWS GENETICS

A Tale of Coronary Artery Disease and Myocardial Infarction

(2012) Elizabeth G. Nabel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Meta-Analysis of Genome-Wide Association Studies in >80 000 Subjects Identifies Multiple Loci for C-Reactive Protein Levels

(2011) Abbas Dehghan et al.   CIRCULATION

Defects of pattern recognition: primary immunodeficiencies of the innate immune system

(2011) Mihai G Netea et al.   CURRENT OPINION IN PHARMACOLOGY

Unexpected protective role for Toll-like receptor 3 in the arterial wall

(2011) J. E. Cole et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myeloid Type I Interferon Signaling Promotes Atherosclerosis by Stimulating Macrophage Recruitment to Lesions

(2010) Pieter Goossens et al.   Cell Metabolism

The Alternative Pathway Is Critical for Pathogenic Complement Activation in Endotoxin- and Diet-Induced Atherosclerosis in Low-Density Lipoprotein Receptor–Deficient Mice

(2010) Talat H. Malik et al.   CIRCULATION

Mendelian Randomization as Applied to Coronary Heart Disease, Including Recent Advances Incorporating New Technology

(2010) Sarah J. Lewis   Circulation-Cardiovascular Genetics

Genetic Loci Associated With C-Reactive Protein Levels and Risk of Coronary Heart Disease

(2009) Paul Elliott   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Obesity, inflammation, and atherosclerosis

(2009) Viviane Z. Rocha et al.   Nature Reviews Cardiology

Toll-Like Receptor Polymorphisms and Susceptibility to Urinary Tract Infections in Adult Women

(2009) Thomas R. Hawn et al.   PLoS One

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(2008) Bart Ferwerda et al.   MOLECULAR MEDICINE

Lifelong Reduction of LDL-Cholesterol Related to a Common Variant in the LDL-Receptor Gene Decreases the Risk of Coronary Artery Disease—A Mendelian Randomisation Study

(2008) Patrick Linsel-Nitschke et al.   PLoS One

The Roles of Pathogen-Associated Molecular Patterns in Atherosclerosis

(2008) Clett Erridge   TRENDS IN CARDIOVASCULAR MEDICINE

Interferon-beta attenuates angiotensin II-accelerated atherosclerosis and vascular remodeling in apolipoprotein E deficient mice

(2007) Le-Ning Zhang et al.   ATHEROSCLEROSIS

Monocyte toll-like receptor 2 and 4 responses and expression following percutaneous coronary intervention: association with lesion stenosis and fractional flow reserve

(2007) D Versteeg et al.   HEART