GENETIC TESTS TO IDENTIFY RISK FOR BREAST CANCER

OBJECTIVES: To describe the currently available genetic tests that identify hereditary risk for breast cancer. DATA SOURCES: Systematic review of scientific literature, clinical practice guidelines, and data published by test manufacturers. CONCLUSION: Changes in gene patent laws and advances in sequencing technologies have resulted in rapid expansion of genetic testing. While BRCA1/2 are the most recognized genes linked to breast cancer, several laboratories now offer multi-gene panels to detect many risk-related mutations.