Article
Biochemistry & Molecular Biology
Elena G. Varlamova, Mikhail Goltyaev, Valentina N. Mal'tseva, Egor A. Turovsky, Ruslan M. Sarimov, Alexander Simakin, Sergey Gudkov
Summary: Selenium nanoparticles (SeNP) have gained popularity for their high biocompatibility, stability, and selectivity, with numerous studies proving their anticarcinogenic effects. This study investigated the molecular mechanisms regulating SeNP-induced cytotoxic effects on four human cancer cell lines, highlighting varied concentration-dependent outcomes and the induction of apoptosis through different signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Veterinary Sciences
Hong Du, Yilei Zheng, Wei Zhang, Huaqiao Tang, Bo Jing, Haohuan Li, Funeng Xu, Juchun Lin, Hualin Fu, Lijen Chang, Gang Shu
Summary: The study found that NSe alleviated Cd-induced hepatic pathological changes, reduced ALT and AST activities as well as MDA content, and increased T-AOC, T-SOD, and GSH activities. Furthermore, NSe significantly increased mRNA expressions of Nrf2 pathway related molecules and showed potential in reducing Cd-induced liver injury by inhibiting oxidative stress and activating the Nrf2 pathway.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Environmental Sciences
Heba M. Abdou, Heba-Tallah Abd Elrahim Abd Elkader, Amel H. El-Gendy, Saber Mohamed Eweda
Summary: Exposure to bisphenol A (BPA) can lead to neurological damage in rats and promote inflammation. However, grape seed proanthocyanidins (GSPE) have neuroprotective effects against BPA-induced neurotoxicity.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Food Science & Technology
Archana Molangiri, Saikanth Varma, M. Satyavani, Saikrishna Kambham, Asim K. Duttaroy, Sanjay Basak
Summary: Early exposure to bisphenol may result in adverse reproductive health issues in later life. This study investigated the effects of orally administered bisphenol S (BPS) and bisphenol A (BPA) on testicular development in rats. The results showed that prenatal exposure to BPS can lead to changes in plasma testosterone levels, testis histology, inflammation, oxidative stress, and sperm DNA damage, potentially affecting male reproductive functions.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Reproductive Biology
Ali Asghar Khalil-Khalili, Mahdi Zhandi, Mojtaba Zaghari, Hassan Mehrabani-Yeganeh, Ali Reza Yousefi, Meysam Tavakoli-Alamooti
Summary: This study found that dietary supplementation of organic selenium could improve semen quality and fertility in male broiler breeder roosters under stress induced by dexamethasone. The injection of dexamethasone had negative effects on semen quality parameters, but these effects were mitigated by the addition of organic selenium in the diet. Overall, the results suggest that organic selenium supplementation may have a beneficial impact on mitigating the harmful effects of stress on semen quality and fertility in broiler breeder roosters.
Review
Biochemistry & Molecular Biology
Alice Au, Albaraa Mojadadi, Jia-Ying Shao, Gulfam Ahmad, Paul K. Witting
Summary: Dietary selenium intake is crucial for maintaining biological functions, and different chemical forms of selenium have varying health impacts. Recent studies have focused on the use of selenium nanoparticles, which show lower toxicity and higher bioavailability compared to traditional forms. These nanoparticles have shown promising effects on growth, reproduction, oxidative stress, and inflammation, making them potential candidates for agriculture and therapeutic applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Maria Nunzia De Luca, Marisa Colone, Riccardo Gambioli, Annarita Stringaro, Vittorio Unfer
Summary: Infertility is a global health problem affecting approximately 187 million couples worldwide, with oxidative stress being a common reason for male infertility. Antioxidant supplementation is considered effective in improving male fertility parameters due to their synergistic effects in decreasing ROS concentration. Additionally, natural molecules such as myo-inositol and d-chiro-inositol play a role in ameliorating sperm quality by regulating various cellular mechanisms.
Article
Biochemistry & Molecular Biology
Xiaoqi Yang, Yang Fu, Jiabin Zhang, Jiaqi Liu, Xin Liu, Yuxuan Peng, San Loon Kyin, Mengdi Zhang, Donghai Zhou
Summary: Nano-selenium (SeNPs) with small particles can be absorbed by the body and exhibit biological activity. YC-3-SeNPs were biosynthesized by Bacillus cereus YC-3, while CST-SeNPs were chemically synthesized and encapsulated with chitosan. Both types of SeNPs showed excellent stability and the ability to scavenge free radicals, with YC-3-SeNPs being less toxic than CST-SeNPs. YC-3-SeNPs and CST-SeNPs may inhibit oxidative stress and apoptosis in cardiomyocytes, making them potential treatments for cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Environmental Sciences
XueXia Liu, ZhiXin Wang, Fujun Liu
Summary: Mice treated with BPA exhibited decreased sperm quality, lower serum testosterone levels, and a sub-fertile phenotype, mainly due to impaired germ cell proliferation. BPA had a concentration-dependent inhibition effect on germ cell proliferation, leading to reduced male fertility.
Article
Biochemistry & Molecular Biology
Zaozao Pan, Jiaqiang Huang, Ting Hu, Yonghong Zhang, Lingyu Zhang, Jiaxi Zhang, Defeng Cui, Lu Li, Jing Wang, Qiong Wu
Summary: In this study, the protective effects of chitosan-coated selenium nanoparticles (SeNPs) and inorganic selenium (Na2SeO3) on bisphenol A (BPA)-induced toxicity in porcine intestinal epithelial cells (IPEC-J2) were compared. The results showed that SeNPs and Na2SeO3 both attenuated the cellular damage caused by BPA. SeNPs were more effective than Na2SeO3 in protecting against BPA-induced tight junction function injury, proinflammatory response, oxidative stress, apoptosis, and endoplasmic reticulum stress. These findings suggest that selenium nanoparticles may be an effective tool for preventing BPA toxicity in animals and humans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Zejun Wu, Linxi Yuan, Chengxi Sun, Xiao Xu, Wenyao Shi, Lei Han, Chenxi Wu
Summary: Currently, nano-plastics have become prevalent in agricultural soils, posing a potential risk to food safety through uptake by crops. This study examined the effects of single and combined applications of nano-size polystyrene (PS) and selenite on lettuce. The results showed that nano-PS had negative impacts on plant growth and physiological functions, while exogenous selenite significantly mitigated the toxic effects of nano-PS, particularly at higher selenium levels.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Cell Biology
Huijie Chen, Yue Zhang, Mengmeng Zou, Xue Qi, Shiwen Xu
Summary: Bisphenol A (BPA) exposure exacerbates apoptosis and necroptosis in selenium-deficient chicken kidneys through regulation of oxidative stress and the PI3K/AKT signaling pathway.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Medicine, Research & Experimental
Keyi Liu, Surekha Kadannagari, Jack Deruiter, Suhrud Pathak, Kodye L. Abbott, Julia M. Salamat, Satyanarayana R. Pondugula, Benson T. Akingbemi, Muralikrishnan Dhanasekaran
Summary: The current literature suggests that BPS, a substitute for BPA, may have negative effects on liver function. However, this study found that acute exposure to BPS had minimal impact on hepatocellular functions in newborn rats, and even showed hepatoprotective effects.
Article
Nutrition & Dietetics
Teofana Otilia Bizerea-Moga, Laura Pitulice, Otilia Bizerea-Spiridon, Tudor Voicu Moga
Summary: Selenium plays a crucial role in reproductive function, particularly through the antioxidant glutathione peroxidase (GPx); serum selenium content reflects the fertility competence of the young population and is vital for guiding dietary adjustments and maintaining normal reproductive function.
Review
Pharmacology & Pharmacy
Xin Deng, Peng Ouyang, Wei Xu, Erhua Yang, Zhen Bao, Yijing Wu, Jin Gong, Jinghua Pan
Summary: Hepatic ischemia-reperfusion injury (HIRI) is an additional injury to ischemic tissue after hepatic revascularization, and its pathological mechanism is complex. Recent studies have found that the antioxidant treatment of nano selenium can reduce the excessive production of reactive oxygen species (ROS) and play a potential protective role in reducing HIRI.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Environmental Sciences
Walaa M. S. Ahmed, Marwa A. Ibrahim, Nermeen A. Helmy, Akram M. ElKashlan, Abeer H. Elmaidomy, Amr R. Zaki
Summary: This study aimed to investigate the effect of Premna odorata on hepatic and nephrotoxicity induced by aluminum chloride in rats. The results showed that Premna odorata extract could alleviate the harmful effects of aluminum chloride on liver and kidney function, reduce oxidative stress levels, and improve tissue structure.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yasmin A. Ebedy, Mohamed O. Elshazly, Neven H. Hassan, Marwa A. Ibrahim, Eman Hassanen
Summary: Carbendazim is a common environmental pollutant that can severely damage human health. This study aims to clarify the mechanisms of carbendazim-induced hepatorenal toxicity. The results showed that carbendazim caused pathological alterations, inflammation, and oxidative stress in the liver and kidneys, leading to dose- and time-dependent damage. The findings highlight the importance of understanding the toxic effects of carbendazim.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
A. H. El Kasas, I. M. Farag, H. R. Darwish, Y. A. Soliman, E. M. El Nagar, Marwa A. Ibrahim, Shaimaa Kamel, Mohamad Warda
Summary: This study analyzed the expression of the sodium pump gene in dromedary tissues using real-time PCR and found that the expression of the sodium pump gene was significantly higher in the adrenal gland and brain than in other organs. These findings highlight the importance of the sodium pump in these organs.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Yasmin A. Ebedy, Eman Hassanen, Ahmed M. Hussien, Marwa A. Ibrahim, M. O. Elshazly
Summary: Carbendazim is a common fungicide used in agriculture, but it can contaminate the environment and cause health problems. Its neurotoxicity is not well studied. This research found that carbendazim induced neurotoxicity in rats through oxidative stress and activation of NF-kappa B pathway. The study suggests reducing the use of carbendazim and finding alternative solutions to minimize its toxicity.
NEUROCHEMICAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Peter A. Noshy, Abdel Azeim A. Khalaf, Marwa A. Ibrahim, Aya M. Mekkawy, Rehab E. Abdelrahman, Ahmed Farghali, Ahmed Abd-Eltawab Tammam, Amr R. Zaki
Summary: This study found that nickel oxide nanoparticles (NiO NPs) induced testicular and spermatological damages in male rats, while co-administration of hesperidin (HSP) significantly alleviated these damages.
Article
Biochemistry & Molecular Biology
Nema A. Soliman, Muhammad T. Abdel Ghafar, Norhan A. AbuoHashish, Marwa A. Ibrahim, Asmaa M. Eid, Rehab M. El-Gohary, Rehab E. Abo El Gheit, Amira M. Elshamy
Summary: Chronic alcohol consumption can cause irreversible neurodegeneration, but the underlying mechanisms and therapeutic interventions are not fully understood. This study found that the natural citrus flavonoid naringenin can protect the brain cortex against alcohol-induced neurodegeneration by targeting multiple signaling pathways.
NEUROCHEMICAL RESEARCH
(2023)
Article
Agriculture, Dairy & Animal Science
M. A. El-Sayed, N. S. Ibrahim, H. A. E. M. Assi, M. A. El-Gawad, W. S. Mohammed, M. A. Ibrahim, N. M. Mesalam, A. E. Abdel-Moneim
Summary: Investigations were conducted on the polymorphism of LDH-A and DR-D4 genes, neurotransmitter values, and cytogenetic indices in three sexed pigeon breeds, including non-racing pigeons, long-distance racing pigeons (Jan Aarden), and short-distance racing pigeons (Janssen). The long-distance pigeons exhibited the highest concentration of brain neurotransmitters among the breeds. Both LDH-A and DR-D4 genes showed polymorphisms indicating different levels of biodiversity among the pigeon breeds. The findings suggest that these genetic and neurotransmitter markers can be useful for genetic characterization and conservation programs of racing pigeon breeds.
BRAZILIAN JOURNAL OF POULTRY SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Neven H. Hassan, Sally Mehanna, Ahmed M. Hussien, Marwa A. Ibrahim, Eman I. Hassanen
Summary: This study investigated the dose-dependent hepatorenal toxicity of HML in rats and revealed that it induces oxidative stress-mediated NF-kappa B signaling pathway in response to pro-inflammatory cytokines such as TNF-alpha and IL-1 beta. Limiting the use of HML in agriculture and veterinary practices and finding alternative agents are necessary to avoid the health risks associated with HML exposure.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Cell & Tissue Engineering
Mariam F. Farid, Yara S. Abouelela, Noha A. E. Yasin, Asmaa K. Al-Mokaddem, Abdelbary Prince, Marwa A. Ibrahim, Hamdy Rizk
Summary: This study aimed to evaluate the regenerative capacity of low-level laser-activated SVF in an MS cat model. The results showed that SVF treatment significantly improved locomotion activity, BBB scores, lesion extent, and expression of neurotrophic factors. SVF treatment also led to an increase in oligodendrocyte transcription factor and myelin basic protein, and a reduction in apoptosis and axonal degeneration, demonstrating its potential for remyelination and regeneration in MS.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Eman I. Hassanen, Rehab E. Abdelrahman, Hassan Aboul-Ella, Marwa A. Ibrahim, Samaa El-Dek, Mohamed Shaalan
Summary: Cobalt ferrite nanoparticles (CFN) are widely used in various fields and have been found to induce dose-dependent oxidative stress and pulmonary toxicity in rats, while a low dosage of CFN does not exhibit significant toxicity. Understanding the mechanisms of CFN-induced pulmonary toxicity is important for risk assessment and human health protection.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Plant Sciences
Rana M. Ibrahim, Nariman E. Mahdy, Passent M. Abdel-Baki, Shymaa A. El Badawy, Sara E. Ali, Marwa A. Ibrahim, Marwa S. Khattab, Khaled Y. Farroh, Shaimaa R. Emam
Summary: This study characterized the chemical composition of Aloe marlothii gel and investigated its synthesized chitosan loaded nanoparticles (CS-AM NPs) in a mouse model of APAP-induced hepatotoxicity. The results showed that Aloe marlothii gel protected liver enzymes and exhibited antioxidant activity, while reducing hepatic malondialdehyde, lactate dehydrogenase, and TNF-α levels. Additionally, Aloe marlothii gel downregulated the expression of caspase-3 and JNK genes. These findings suggest that both Aloe marlothii and CS-AM NPs have hepatoprotective effects through their antioxidant, anti-inflammatory, and antiapoptotic properties, with CS-AM NPs being more effective than Aloe marlothii.
SOUTH AFRICAN JOURNAL OF BOTANY
(2023)
Article
Instruments & Instrumentation
Asmaa K. Abdelghany, Amr Gamal, Ahmed Abdel-Wahab, Abdel-Razik H. Abdel-Razik, Salma. I. El-Samannoudy, Marwa A. Ibrahim, Walid Hamdy Hassan, Fatma I. Abo El-Ela
Summary: Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by memory loss and behavioral changes. Aluminum, a main risk factor in AD development, can be targeted using nanoparticles like niosomes. This study developed a SP-loaded niosome formulation for drug delivery and demonstrated its effectiveness in improving cognition and alleviating brain oxidative stress in an AD rat model induced by AlCl3.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Correction
Pharmacology & Pharmacy
R. E. Abo El Gheit, N. A. Soliman, S. A. Nagla, R. M. El-Sayed, G. A. Badawi, M. N. Emam, M. T. Abdel Ghafar, M. A. A. Ibrahim, N. R. M. Elswaidy, D. A. Radwan, H. A. Alshenawy, H. E. Khaled, S. Kamel, M. H. El-Saka, N. M. Madi, R. L. Younis
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Amir Eid, Sherien S. Ghaleb, Amr Zaki, Marwa Ibrahim, Ahmed A. Farghali, Lamiaa E. Ali, Mohamed A. Abdelgawad, Mohammed M. Ghoneim, Rasha Hamed Al-Serwi, Randa M. Hassan, Manar Ahmad
Summary: This study demonstrates that hesperidin can protect against brain damage caused by titanium dioxide nanoparticles, reducing oxidative stress and inflammation, and improving histological changes in brain tissue.
Article
Biology
Taghreed Ahmed Hassan, Mohamed Ahmed Maher, Amr Fekry El Karmoty, Zainab Sabry Othman Ahmed, Marwa A. Ibrahim, Hamdy Rizk, Ayman Tolba Reyad
Summary: BMMSCs showed the highest potential for chondrogenesis compared to ADMSCs and EMSCs, making them the preferred choice for treating degenerative cartilaginous disorders.
BIOLOGICAL RESEARCH
(2022)