Article
Medicine, General & Internal
Raymond Pranata, Joshua Henrina, Emir Yonas, Iwan C. S. Putra, Irvan Cahyadi, Michael A. Lim, Dian A. Munawar, Muhammad Munawar
Summary: The study found an association between obesity and atrial fibrillation recurrence, with an increased risk of recurrence as BMI increased. However, the risk of adverse events did not increase linearly with obesity, showing a nonlinear relationship. Compared to the lower BMI group, the highest BMI group had not only a higher rate of atrial fibrillation recurrence, but also a significantly increased risk of adverse events.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Cardiac & Cardiovascular Systems
Jonathan M. Kalman, Ahmed M. Al-Kaisey, Ramanathan Parameswaran, Joshua Hawson, Robert D. Anderson, Michael Lim, David Chieng, Stephen A. Joseph, Alex McLellan, Joseph B. Morton, Paul B. Sparks, Geoffrey Lee, Prashanthan Sanders, Peter M. Kistler
Summary: This study aimed to determine if the timing of catheter ablation for atrial fibrillation (AF) affects arrhythmia outcomes. The results showed that there was no significant difference in the atrial arrhythmia free survival at 12 months post-ablation between patients who underwent early ablation and those who underwent delayed ablation. Other secondary outcomes also showed no significant difference. Therefore, delaying AF ablation by 12 months for antiarrhythmic drug management does not reduce the efficacy of ablation.
EUROPEAN HEART JOURNAL
(2023)
Article
Medicine, General & Internal
Jan Budzianowski, Jaroslaw Hiczkiewicz, Katarzyna Lojewska, Edyta Kawka, Rafal Rutkowski, Katarzyna Korybalska
Summary: The study aimed to identify factors affecting early recurrence of atrial fibrillation following pulmonary veins isolation in obese men and women. Results revealed a complex pathogenesis of early recurrence depending on the patients' gender.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Gianluigi Bisleri, Arjun K. Pandey, Subodh Verma, Syed M. Ali Hassan, Bobby Yanagawa, Masud Khandaker, Mario Gaudino, Andrea M. Russo, Atul Verma, Deepak L. Bhatt, Andrew C. T. Ha
Summary: Hybrid ablation is a novel therapy that combines minimally invasive surgical and percutaneous catheter-based techniques for the management of atrial fibrillation (AF). Observational studies have shown approximately 70% success rates but higher risks compared to catheter-based ablation. Hybrid ablation is typically offered to patients with persistent or longstanding persistent AF, requiring two procedures. While a randomized trial demonstrated its superiority over catheter-based ablation, it also showed higher complication rates. Contemporary studies have shown a decrease in the incidence of serious complications. Additional randomized trials are needed to determine the risks, benefits, and cost effectiveness of hybrid ablation in clinical practice.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Geoffroy Ditac, Pierre Jean Cottinet, Minh Quyen Le, Daniel Grinberg, Josselin Duchateau, Kevin Gardey, Arnaud Dulac, Antoine Deliniere, Christelle Haddad, Julie Boussuge-Roze, Frederic Sacher, Pierre Jais, Philippe Chevalier, Francis Bessiere
Summary: Atrial fibrillation (AF) catheter ablation procedure contributes significantly to GHG emissions, with a carbon footprint of 76.9 kg CO2-e. With approximately 600,000 annual procedures worldwide, AF catheter ablation leads to 125 tons of CO2 emissions every day, equivalent to a daily car ride of 700,000 km. Electrophysiology catheters and patches are identified as the main contributors to the carbon footprint, highlighting the importance of reducing, reusing, and recycling these items.
Article
Cardiac & Cardiovascular Systems
Karim Benali, Paul Khairy, Nefissa Hammache, Adrian Petzl, Antoine Da Costa, Atul Verma, Jason G. Andrade, Laurent Macle
Summary: A systematic review and pooled analysis of randomized control trials showed that catheter ablation of atrial fibrillation is associated with low rates of procedure-related complications and mortality, which have declined over the past decade.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Elena Arbelo, Nikolaos Dagres
Summary: This article critically reviews the recommendations of the 2020 ESC guidelines for the management of AF in light of two landmark trials, emphasizing the safety of contemporary rhythm control treatment and the importance of personalized treatment strategies.
Article
Physiology
Jae-Hyuk Lee, Oh-Seok Kwon, Hee Tae Yu, Tae-Hoon Kim, Jae-Sun Uhm, Boyoung Joung, Moon-Hyoung Lee, Hui-Nam Pak
Summary: Catheter ablation is an effective method for treating atrial fibrillation, but it may lead to atrial tissue damage and increase the risk of stiff LA physiology. Factors such as diabetes, E/Em ratio, LA pulse pressure, low LA voltage, empirical extra-PV ablation, and radiofrequency ablation duration are associated with stiff LA physiology after AFCA.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Ramanathan Parameswaran, Ahmed M. Al-Kaisey, Jonathan M. Kalman
Summary: Catheter ablation is a key strategy for managing atrial fibrillation, with technological advancements focusing on improving safety and effectiveness. Guidelines recommend the procedure for symptomatic patients with paroxysmal or persistent AF, but evidence from trials is mixed. Pulmonary vein isolation remains a cornerstone technique in AF ablation, with ongoing developments in technology aimed at enhancing patient outcomes.
NATURE REVIEWS CARDIOLOGY
(2021)
Review
Immunology
Dishiwen Liu, Yajia Li, Qingyan Zhao
Summary: Atrial fibrillation (AF) is a serious healthcare burden with high morbidity and complications. Catheter ablation, although curable, currently has a low long-term success rate. Inflammation and fibrosis play significant roles in AF progression, and the artificial inflammatory response caused by catheter ablation may impact long-term prognosis. This review focuses on the different types of inflammatory cell death induced by various ablation techniques, as well as the structural and electrical remodeling caused by inflammation and its association with AF recurrence after catheter ablation. Pulsed-field ablation shows promise as a revolutionary innovation with faster, safer, better tissue selectivity, and less inflammatory response.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Lu Zhou, Liu He, Wei Wang, Changyi Li, Songnan Li, Ribo Tang, Caihua Sang, Nian Liu, Chenxi Jiang, Ronghui Yu, Deyong Long, Xin Du, Jianzeng Dong, Changsheng Ma
Summary: This study aimed to compare the effect of catheter ablation and drug therapy on recurrent AT/AF patients after AF catheter ablation. The results showed that repeat catheter ablation may significantly reduce the risk of composite cardiovascular mortality, ischemic stroke, and major bleeding events compared to medical therapy in patients with recurrent AT/AF after a catheter ablation procedure. However, there were no statistically significant differences between the two groups in terms of secondary endpoints.
Review
Cardiac & Cardiovascular Systems
Zhi-Jie Mao, Yan Pei, Hui Lin, Yin Xiang, Zhou-Qing Huang, Fang-Yi Xiao, Yi-He Chen
Summary: High-power radiofrequency catheter ablation shows superior efficacy in maintaining sinus rhythm for patients with atrial fibrillation, while also reducing procedure and fluoroscopy times. Additionally, there is no significant difference in the risk of complications between high-power and conventional-power ablation techniques.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Medicine, General & Internal
Francesco Maria Angelo Brasca, Roberto Mene, Giovanni Battista Perego
Summary: Atrial fibrillation (AF) is a common arrhythmia, especially in patients with structural heart disease (SHD). Catheter ablation (CA) has emerged as an effective strategy for rhythm control in AF patients and has potential benefits beyond symptom relief. This review summarizes the current knowledge of CA in SHD patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Luigi Di Biase, Juan Carlos Diaz, Xiao-Dong Zhang, Jorge Romero
Summary: Pulsed field ablation is a novel energy source for the treatment of atrial fibrillation, with advantages in both safety and effectiveness compared to other energy sources, allowing targeted treatment and minimizing damage.
TRENDS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Medicine, General & Internal
Shaojie Chen, Yuehui Yin, Zhiyu Ling, Christian Meyer, Helmut Puererfellner, Martin Martinek, Marcio Galindo Kiuchi, Piotr Futyma, Lin Zhu, Alexandra Schratter, Jiazhi Wang, Willem-Jan Acou, Philipp Sommer, Feifan Ouyang, Shaowen Liu, Julian K. R. Chun, Boris Schmidt
Summary: Catheter ablation is an effective therapeutic option for atrial fibrillation, reducing AF burden and improving clinical outcomes. Early rhythm control is associated with lower risk of adverse cardiovascular outcomes. CA as an initial first line strategy significantly reduces arrhythmia recurrence and rehospitalization in patients with paroxysmal AF. CA lowers the risk of progression from paroxysmal AF to persistent AF. In persistent AF, overall clinical success after ablation is unsatisfactory, but better outcomes are observed in patients with early persistent AF. Adjunctive ablations on top of PVI can further reduce arrhythmia recurrence.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
David Padilla-Cueto, Elisenda Ferro, Paz Garre, Susanna Prat, Jean Baptiste Guichard, Rosario J. Perea, Jose Maria Tolosana, Eduard Guasch, Elena Arbelo, Andreu Porta-Sanchez, Ivo Roca-Luque, Marta Sitges, Josep Brugada, Lluis Mont, Till F. Althoff
Summary: This study investigates the ability of late gadolinium enhancement-magnetic resonance imaging (LGE-MRI) to non-invasively rule out pulmonary vein (PV) reconnection. The results show that LGE-MRI has high sensitivity (98.9%) but low specificity (55.6%) in predicting electrical PV reconnection. LGE lesions without discontinuation can rule out PV reconnection with a high negative predictive value (96.9%), and complete LGE lesion sets encircling all PVs are highly unlikely to show any PV reconnection (negative predictive value: 94.4%).
Article
Cardiac & Cardiovascular Systems
Andrea Saglietto, Fiorenzo Gaita, Carina Blomstrom-Lundqvist, Elena Arbelo, Nikolaos Dagres, Josep Brugada, Aldo Pietro Maggioni, Luigi Tavazzi, Josef Kautzner, Gaetano Maria De Ferrari, Matteo Anselmino
Summary: This study aimed to develop a machine-learning scoring system based on easily accessible clinical variables from the ESC-EHRA Atrial Fibrillation Ablation Long-Term Registry to predict the probability of 1-year arrhythmic recurrence after catheter ablation for AF patients. Among four different supervised machine-learning models, the random forest model achieved the best performance with a 19-variable version, outperforming existing scores. The final calibrated model, available as a web calculator, showed significantly better predictive performance.
Article
Medicine, General & Internal
Ivan J. Nunez-Gil, Gisela Feltes, Maria C. Viana-Llamas, Sergio Raposeiras-Roubin, Rodolfo Romero, Emilio Alfonso-Rodriguez, Aitor Uribarri, Francesco Santoro, Victor Becerra-Munoz, Martino Pepe, Alex F. Castro-Mejia, Jaime Signes-Costa, Adelina Gonzalez, Francisco Marin, Javier Lopez-Pais, Enrico Cerrato, Olalla Vazquez-Cancela, Carolina Espejo-Paeres, Alvaro Lopez Masjuan, Lazar Velicki, Ibrahim El-Battrawy, Harish Ramakrishna, Antonio Fernandez-Ortiz, Julian Perez-Villacastin
Summary: This study analyzed the long-term outcomes and prognostic factors of COVID-19 survivors and found that patients with underlying heart disease continue to face a more complex clinical profile and worse outcomes, including increased mortality. Vaccination was found to be beneficial for the survival of patients with heart disease during follow-up.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biology
Natalia N. N. Beliaeva, Tatiana R. R. Moshonkina, Oleg V. V. Mamontov, Elena N. N. Zharova, Heber Ivan Condori Leandro, Nigar Z. Z. Gasimova, Evgeny N. N. Mikhaylov
Summary: Orthostatic hypotension is a complex medical problem, and transcutaneous spinal cord stimulation (t-SCS) may be a potential treatment option. A feasibility study involving three patients with orthostatic hypotension showed that t-SCS led to elevated blood pressure in a supine position. Further investigation on a larger patient population is needed to validate these results.
Article
Cardiac & Cardiovascular Systems
Patricia Zerlang Fruelund, Anders Sommer, Soren Lundbye-Christensen, Claus Graff, Peter Sogaard, Sam Riahi, Tomas Zaremba
Summary: This study investigates the association between chronic right ventricular pacing, right ventricular lead position, and left ventricular contractile dyssynchrony. The study finds that left ventricular anterior-inferior dyssynchrony is independently associated with pacing-induced cardiomyopathy. Additionally, the highest degree of anterior-inferior dyssynchrony is observed when the right ventricular lead is positioned on the posterior septum.
CARDIOVASCULAR ULTRASOUND
(2023)
Article
Cardiac & Cardiovascular Systems
Toru Kondo, Karola S. Jering, Pardeep S. Jhund, Inder S. Anand, Akshay S. Desai, Carolyn S. P. Lam, Aldo P. Maggioni, Felipe A. Martinez, Milton Packer, Mark C. Petrie, Marc A. Pfeffer, Margaret M. Redfield, Jean L. Rouleau, Dirk J. van Veldhuisen, Faiez Zannad, Michael R. Zile, Scott D. Solomon, John J. V. McMurray
Summary: This study validated a simple risk model for predicting stroke risk in heart failure patients with preserved ejection fraction but without atrial fibrillation. The results showed that the risk for stroke increased with increasing risk score, suggesting the use of anticoagulation therapy in high-risk patients.
CIRCULATION-HEART FAILURE
(2023)
Review
Cardiac & Cardiovascular Systems
Annachiara Pingitore, Mariangela Peruzzi, Sofia Calaciura Clarich, Zefferino Palama, Luigi Sciarra, Elena Cavarretta
Summary: Athletes undergo regular sports medicine examinations and electrocardiography to screen for arrhythmias, although these methods may not always be successful in identifying rhythm disturbances. However, there is a lack of research on the frequency of cardiac symptoms and the use of cardiac monitoring specifically in athletes. This review aims to provide physicians in the field of sports cardiology with various options for heart rhythm monitoring in order to tailor the diagnostic process and improve diagnostic accuracy when an arrhythmia is suspected in an athlete.
CLINICAL CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Vicente Artola Arita, Martijn E. Van de Lande, Neda Khalilian Ekrami, Bao-Oanh Nguyen, Joost M. Van Melle, Bastiaan Geelhoed, Ruben R. De With, Vanessa Weberndorfer, Omer Erkuner, Hans Hillege, Dominik Linz, Hugo Ten Cate, Henri M. H. Spronk, Tim Koldenhof, Robert G. Tieleman, Ulrich Schotten, Harry J. G. M. Crijns, Isabelle C. Van Gelder, Michiel Rienstra
Summary: This study aimed to assess whether the 4S-AF scheme predicts AF progression in patients with self-terminating AF. The study found that the 4S-AF scheme does not predict AF progression, but the 3S-AF scheme can predict progression. Therefore, the 3S-AF scheme may be more appropriate for predicting AF progression.
Editorial Material
Cardiac & Cardiovascular Systems
Chris J. Kapelios, Lina Benson, Maria G. Crespo-Leiro, Stefan D. Anker, Andrew J. S. Coats, Ovidiu Chioncel, Gerasimos Filippatos, Mitja Lainscak, Theresa McDonagh, Alexandre Mebazaa, Marco Metra, Massimo F. Piepoli, Giuseppe M. C. Rosano, Frank Ruschitzka, Gianluigi Savarese, Petar M. Seferovic, Maurizio Volterrani, Aldo P. Maggioni, Lars H. Lund
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Maria Hee Jung Park Frausing, Martijn E. Van De Lande, Alexander H. Maass, Bao-Oanh Nguyen, Martin E. W. Hemels, Robert G. Tieleman, Tim Koldenhof, Mirko De Melis, Dominik Linz, Ulrich Schotten, Vanessa Weberndoerfer, Harry J. G. M. Crijns, Isabelle C. Van Gelder, Jens Cosedis Nielsen, Michiel Rienstra
Summary: This study aimed to examine brady- and tachyarrhythmias using continuous rhythm monitoring in patients with paroxysmal self-terminating AF (PAF). The results showed that almost half of the PAF patients experienced severe bradyarrhythmias or rapid ventricular tachyarrhythmias during continuous rhythm monitoring.
Article
Hematology
Cecilia Becattini, Giancarlo P. Agnelli, Aldo Maggioni, Francesco Dentali, Andrea Fabbri, Iolanda Enea, Fulvio Pomero, Maria Pia Ruggieri, Andrea di Lenarda, Ludovica Anna Cimini, Giuseppe Pepe, Susanna Cozzio, Donata M. Lucci, Michele Gulizia, COPE Investigators
Summary: The COPE study aimed to assess contemporary clinical management and outcomes in patients with acute symptomatic PE. The majority of patients with PE receive risk stratification and treatment with direct oral anticoagulants. However, in-hospital mortality is still high in intermediate and high-risk patients, calling for further research to reduce mortality.
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Cardiac & Cardiovascular Systems
Darryl Wan, Mahshid Dehghan, Russell J. de Souza, Chinthanie Ramasundarahettige, John W. Eikelboom, Jackie Bosch, Aldo P. Maggioni, Deepak L. Bhatt, Salim Yusuf, Sonia S. Anand
Summary: This study examined the association between dietary patterns and the risk of recurrent major adverse cardiovascular and limb events in patients with coronary artery disease (CAD) and peripheral artery disease (PAD). The findings suggest that poor diet quality is independently associated with a higher risk of such events.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Marek Kiliszek, Beata Uzieblo-Zyczkowska, Krystian Krzyzanowski, Agnieszka Jurek, Robert Wierzbowski, Magdalena Smalc-Stasiak, Pawel Krzesinski
Summary: This study aimed to investigate the relationship between left atrial function parameters and pulmonary vein isolation (PVI) outcomes in atrial fibrillation (AF) patients. A total of 221 patients who underwent PVI between 2019 and 2021 were included. Echocardiography was performed on the day of ablation to analyze left atrial strain. The primary endpoint was the recurrence of atrial tachyarrhythmia during follow-up. The results showed that left atrial appendage emptying velocity (LAAV) was a significant predictor of AF recurrence in patients with sinus rhythm, but no left atrial strain parameters were found to predict AF recurrence in AF patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Correction
Cardiac & Cardiovascular Systems
Suleman Aktaa, Gorav Batra, Stefan K. James, Daniel J. Blackman, Peter F. Ludman, Mamas A. Mamas, Mohamed Abdel-Waha, Gianni D. Angelini, Martin Czerny, Victoria Delgado, Giuseppe De Luca, Eustachio Agricola, Dan Foldage, Christian W. Hamm, Bernard Iung, Norman Mangner, Julinda Mehilli, Gavin J. Murphy, Darren Mylotte, Radoslaw Parma, Anna Sonia Petronio, Bodgan A. Popescu, Lars Sondergaard, Rui C. Teles, Manel Sabate, Christian J. Terkelsen, Luca Testa, Jianhua Wu, Aldo P. Maggioni, Lars Wallentin, Barbara Casade, Chris P. Gale
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Review
Cardiac & Cardiovascular Systems
Alberto Aimo, Vincenzo Castiglione, Iacopo Fabiani, Paolo Morfino, Michele Emdin, Roberto Ferrari, Luigi Tavazzi, Aldo Pietro Maggioni, Claudio Rapezzi
Summary: In this paper, a 10-step approach to interpreting neutral or negative trials is proposed to exclude important methodological issues before concluding that the treatment is truly ineffective. The approach is discussed using classic trials from the past and notable examples among superiority trials published in recent years.
GIORNALE ITALIANO DI CARDIOLOGIA
(2023)