Review
Neurosciences
Chia-Chien Chen, Joshua C. Brumberg
Summary: Cellular structures form the foundation of the nervous system's functionality. Development can be influenced by external factors, with sensory experiences during critical periods impacting information processing in the brain and subsequently affecting behavior and cognition. Studying sensory experience alterations using the rodent whisker-to-barrel system model helps in understanding how structural plasticity in the brain allows for an integrated view of its functioning.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Cell Biology
YuMin M. Loh, Matthew P. Su, David A. Ellis, Marta Andres
Summary: The mosquito auditory system is highly frequency-selective and sensitive, and it is supported by an elaborate system of auditory efferent neurons that modulate the auditory function. This system can be targeted for mosquito control and serves as a unique insect model for studying auditory efferent networks.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Neurosciences
Ling Zhang, Yu-Zhu Gao, Chun-Jie Zhao, Jiang-Yan Xia, Jian-Jun Yang, Mu-Huo Ji
Summary: This study reveals that active MMP-9 mediates PNN remodeling, leading to reduced synaptic input and abnormal gamma oscillations in hippocampal CA1, ultimately contributing to cognitive impairments in SAE induced by LPS injection. Treatment with the MMP-9 inhibitor SB-3CT can rescue most of these abnormalities.
Article
Neurosciences
Sazia Sharmin, Jonu Pradhan, Zhe Zhang, Mark Bellingham, David Simmons, Michael Piper
Summary: Disruptions to sulfate supply or sulfation enzymes can impact brain development and function, with PNNs playing a key role in synaptic maturation and plasticity. The study reveals that mice with a mutation in the Slc13a4 gene exhibit abnormalities in social interaction and memory, potentially linked to deficits in PNN biology.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Psychiatry
Ting Xiang, Jiwu Liao, Yixian Cai, Mei Fan, Congrui Li, Xiaotao Zhang, Hongyao Li, Yushan Chen, Jiyang Pan
Summary: The study aimed to investigate the changes in various indexes of the GABAergic system in the peripheral blood of patients with insomnia disorder and identify related factors. The results showed that the mRNA levels of GABA(A) receptor alpha 1 and alpha 2 subunits were significantly lower in the insomnia disorder group compared to the normal control group. However, there was no significant difference in serum GABA levels between the two groups. Moreover, there was no significant correlation between the GABA levels and the mRNA expression levels of alpha 1 and alpha 2 subunits of GABA(A) receptors in the insomnia disorder group.
FRONTIERS IN PSYCHIATRY
(2023)
Correction
Biochemistry & Molecular Biology
Debora Napoli, Leonardo Lupori, Raffaele Mazziotti, Giulia Sagona, Sara Bagnoli, Muntaha Samad, Erika Kelmer Sacramento, Joanna Kirkpartick, Elena Putignano, Siwei Chen, Eva Terzibasi Tozzini, Paola Tognini, Pierre Baldi, Jessica C. F. Kwok, Alessandro Cellerino, Tommaso Pizzorusso
Summary: Research has shown that the expression of miR-29a in the visual cortex increases dramatically with age but is not experience-dependent. Precocious high levels of miR-29a can block ocular dominance plasticity and cause an early appearance of perineuronal nets, while inhibiting miR-29a in adult mice can activate ocular dominance plasticity and reduce perineuronal nets. This suggests that miR-29a plays a role in regulating the plasticity brakes that promote age-dependent stabilization of visual cortical connections.
Review
Clinical Neurology
Hector Carceller, Yaiza Gramuntell, Patrycja Klimczak, Juan Nacher
Summary: Perineuronal nets (PNNs) are specialized extracellular matrix structures that play a key role in the development and plasticity of neuronal circuits in the central nervous system. Understanding their structure, composition, and distribution can provide insights into the physiology and pathologic conditions of the CNS.
Article
Neurosciences
Jana Dubisova, Jana Svobodova Burianova, Lucie Svobodova, Pavol Makovicky, Noelia Martinez-Varea, Anda Cimpean, James W. Fawcett, Jessica C. F. Kwok, Sarka Kubinova
Summary: Memory retention was enhanced by attenuating perineuronal net formation using 4-MU treatment in mice, but the effect was not sustained.
BRAIN RESEARCH BULLETIN
(2022)
Review
Cell Biology
Bryce W. Duncan, Kelsey E. Murphy, Patricia F. Maness
Summary: Mammalian brain circuits are wired through dynamic formation and remodeling of excitatory and inhibitory synapses, mediated by a complex network of proteins including CAMs. The interactions of neuronal CAMs and receptor-ligands play a crucial role in synaptic regulation, leading to the formation and remodeling of synapses during development. Understanding these mechanisms provides insight into normal development as well as disorders related to synaptic connectivity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Neurosciences
Rong Hu, Kelin He, Bowen Chen, Yi Chen, Jieqi Zhang, Xingying Wu, Mengting Shi, Lei Wu, Ruijie Ma
Summary: Neurocan in the perineuronal net (PNN) can regulate the activity of PV-IN, and electroacupuncture (EA) can promote functional recovery in mice with spinal cord injury (SCI) by upregulating neurocan expression in the PNN.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Clinical Neurology
Afia B. Ali, Anam Islam, Andrew Constanti
Summary: Alzheimer's disease is a common neurological disorder characterized by memory loss and abnormal brain activity. Synaptic hyperactivity may be caused by an imbalance in phasic and tonic synaptic inhibition regulated by the GABA(A) inhibitory system and the perineuronal nets (PNNs) in the brain regions. This review summarizes the vulnerability of different types of interneurons, changes in GABA(A) receptor subtypes, and alterations in PNNs in Alzheimer's disease, highlighting their contribution to the disease mechanisms.
Review
Neurosciences
George Perlman, Arnaud Tanti, Naguib Mechawar
Summary: PV interneuron alterations in psychiatric disorders, influenced by stress, can be protected by antidepressant treatment from stress-induced apparent PV cell loss.
NEUROBIOLOGY OF STRESS
(2021)
Article
Pharmacology & Pharmacy
Ailing Huang, Yang Chen, Shaoshuang Wang, Hailiang Du, Ao Guan, Huanghui Wu, Qian Zhai, Na Duan, Xuying Li, Pin Zhao, Yulin Zhu, Juan Bai, Ye Xiao, Tingting Yang, Qiang Wang, Bin Deng
Summary: In this study, a post-stroke anxiety (PSA) model was established in male C57BL/6 mice and esketamine was administered to alleviate anxiety-like behavior. Esketamine was found to reduce microglial activation, inflammatory cytokine expression, and the expression of HDAC3 and NF-kappa B in the cortex of PSA mice. These findings provide a potential therapeutic target for treating post-stroke anxiety.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Physiology
Nan Zhang, Zili Yan, Hailan Liu, Meng Yu, Yang He, Hesong Liu, Chen Liang, Longlong Tu, Lina Wang, Na Yin, Junying Han, Nikolas Scarcelli, Yongjie Yang, Chunmei Wang, Tianshu Zeng, Lu-Lu Chen, Yong Xu
Summary: The study revealed that hypothalamic PNNs are regulated in a region-specific manner by sex, gonadal hormones, and dietary interventions. Gonadal hormones are necessary for maintaining normal PNNs in the arcuate nucleus of the hypothalamus in both male and female mice, while PNNs in the terete hypothalamic nucleus exhibit sexual dimorphism. Additionally, high-fat diet feeding increases terete PNNs only in female mice but not in male mice.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Neurosciences
Xianshu Bai, Frank Kirchhoff, Anja Scheller
Summary: This review focuses on the role of GABA as the main inhibitory neurotransmitter in the CNS, particularly in the oligodendrocyte lineage. It discusses the physiological functions of GABA receptors within this lineage and their potential as targets for treatments of CNS diseases.
NEUROSCIENCE BULLETIN
(2021)
Article
Neurosciences
Matthew A. Smith, Christina Z. Xia, Christine M. Dengler-Crish, Kelly M. Fening, Denise M. Inman, Brett R. Schofield, Samuel D. Crish
JOURNAL OF COMPARATIVE NEUROLOGY
(2016)
Article
Neurosciences
Nichole L. Beebe, Jesse W. Young, Jeffrey G. Mellott, Brett R. Schofield
JOURNAL OF NEUROSCIENCE
(2016)
Article
Anatomy & Morphology
Jeffrey G. Mellott, Nichole L. Beebe, Brett R. Schofield
BRAIN STRUCTURE & FUNCTION
(2018)
Article
Neurosciences
Nichole L. Beebe, Brett R. Schofield
JOURNAL OF COMPARATIVE NEUROLOGY
(2018)
Article
Anatomy & Morphology
Kyle T. Nakamoto, Jeffrey G. Mellott, Jeanette Killius, Megan E. Storey-Workley, Colleen S. Sowick, Brett R. Schofield
FRONTIERS IN NEUROANATOMY
(2014)
Article
Anatomy & Morphology
Brett R. Schofield, Susan D. Motts, Jeffrey G. Mellott, Nichole L. Foster
FRONTIERS IN NEUROANATOMY
(2014)
Article
Anatomy & Morphology
Jeffrey G. Mellott, Nichole L. Foster, Kyle T. Nakamoto, Susan D. Motts, Brett R. Schofield
FRONTIERS IN NEUROANATOMY
(2014)
Article
Anatomy & Morphology
Nichole L. Foster, Jeffrey G. Mellott, Brett R. Schofield
FRONTIERS IN NEUROANATOMY
(2014)
Article
Anatomy & Morphology
Jeffrey G. Mellott, Nichole L. Foster, Andrew P. Ohl, Brett R. Schofield
FRONTIERS IN NEUROANATOMY
(2014)
Article
Anatomy & Morphology
Brett R. Schofield, Jeffrey G. Mellott, Susan D. Motts
FRONTIERS IN NEUROANATOMY
(2014)
Article
Neurosciences
Jeffrey G. Mellott, Nichole L. Beebe, Brett R. Schofield
JOURNAL OF COMPARATIVE NEUROLOGY
(2019)
Article
Biology
David Goyer, Marina A. Silveira, Alexander P. George, Nichole L. Beebe, Ryan M. Edelbrock, Peter T. Malinski, Brett R. Schofield, Michael T. Roberts
Article
Neurosciences
N. L. Beebe, J. G. Mellott, B. R. Schofield
Article
Neurosciences
Jeffrey G. Mellott, Martha E. Bickford, Brett R. Schofield
FRONTIERS IN SYSTEMS NEUROSCIENCE
(2014)