Article
Immunology
Jie Liu, Wen-Ping Lin, Yao Xiao, Nyimi Bushabu Fidele, Hai-Jun Yu, Zhi-Jun Sun
Summary: VISTA is highly and stably expressed in oral squamous cell carcinoma (OSCC), primarily in myeloid-derived immunosuppressive cells (MDSCs). VISTA blockade reduces the immunosuppressive microenvironment and delays tumor growth, potentially by suppressing the quantity and function of MDSCs while boosting the function of tumor-infiltrating T cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Oncology
Zhuang Ding, Yijia He, Yong Fu, Nisha Zhu, Mengxiang Zhao, Yuxian Song, Xiaofeng Huang, Sheng Chen, Yan Yang, Caihong Zhang, Qingang Hu, Yanhong Ni, Liang Ding
Summary: CD38 is a poor prognostic biomarker for OSCC patients, governing immune microenvironment and circulating lymphocyte homeostasis. Co-expression with immune checkpoint molecules sheds new light on immune checkpoint therapy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Yang Yu, Huiwen Tang, Debora Franceschi, Prabhakar Mujagond, Aneesha Acharya, Yupei Deng, Bernd Lethaus, Vuk Savkovic, Ruediger Zimmerer, Dirk Ziebolz, Simin Li, Gerhard Schmalz
Summary: This study identifies the immune checkpoint genes associated with programmed death ligand-1 (PDL1) in oral and squamous cell carcinoma (OSCC) and determines the immune subtypes of these gene combinations. The findings provide a theoretical basis for prognostic immune subtyping of OSCC and highlight the importance of developing immunotherapeutic strategies for treating oral cancer.
FRONTIERS IN MEDICINE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Su-Wen Zhu, Shuo Wang, Zhi-Zhong Wu, Qi-Chao Yang, De-Run Chen, Shu-Cheng Wan, Zhi-Jun Sun
Summary: This study revealed the overexpression of CD168 in oral squamous cell carcinoma (OSCC) tissues, which was associated with worse patient survival and pathological grade. Additionally, CD168 expression was positively correlated with other marker expression in OSCC.
Article
Multidisciplinary Sciences
Jessica E. Kenison, Zhongyan Wang, Kangkang Yang, Megan Snyder, Francisco J. Quintana, David H. Sherr
Summary: The study shows the central role of AhR in regulating multiple immune checkpoints in oral squamous cell carcinoma. Deletion of AhR in mouse OSCC cells results in complete rejection of tumors and increased T cell activation. This suggests AhR as a potential target for modulating immune response in cancer treatment.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Oncology
Steffen Spoerl, Ramona Erber, Michael Gerken, Juergen Taxis, Nils Ludwig, Felix Nieberle, Niklas Biermann, Carol Immanuel Geppert, Tobias Ettl, Arndt Hartmann, Philipp Beckhove, Torsten E. Reichert, Gerrit Spanier, Silvia Spoerl
Summary: A20 has been identified as a potent inhibitor of NF-kappa B signaling in numerous clinical and preclinical studies. Its prognostic and therapeutic relevance has been investigated in various malignant diseases, but its characterization in oral squamous cell carcinoma (OSCC) is unknown. In this study, the expression of A20 in OSCC patients was examined using immunohistochemical staining. Higher expression of A20 in tumor infiltrating lymphocytes (TILs) was found to be associated with better overall survival (OS) and recurrence-free survival (RFS). These findings suggest a novel prognostic role for A20 in OSCC and highlight the potential for new therapeutic opportunities.
Article
Dentistry, Oral Surgery & Medicine
Shuo Wang, Xiao-Long Wang, Zhi-Zhong Wu, Qi-Chao Yang, Hong-Gang Xiong, Yao Xiao, Hao Li, Zhi-Jun Sun
Summary: The overexpression of RRM2 in oral squamous cell carcinoma is associated with disease progression, recurrence, and poor prognosis. RRM2 expression promotes cancer cell proliferation and migration while inhibiting apoptosis. This suggests that RRM2 could be a potential target for diagnosis, prognosis, and therapy of OSCC.
Article
Biochemistry & Molecular Biology
Jingshi Liu, Yongdong Niu, Bin Zhang, Qisi Sun, Haiyi Li, Lu Bai, Zhongjing Su
Summary: The expression levels of GPER1 are found to be associated with tumor type and survival rates in esophageal carcinoma. In overall esophageal carcinoma, low expression of GPER1 is correlated with poor survival rates, while overexpression of GPER1 is associated with the development of esophageal adenocarcinoma and its pre-cancerous lesion. Furthermore, the protein expression of GPER1 is higher in esophageal adenocarcinoma tissues compared to normal esophageal tissues, whereas it is lower in esophageal squamous cell carcinoma tissues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Shu-Hui Lin, Chiao-Wen Lin, Jeng-Wei Lu, Wei-En Yang, Yueh-Min Lin, Hsueh-Ju Lu, Shun-Fa Yang
Summary: This study found that IGF2BP2 protein plays a clinicopathological role in OSCC patients and is associated with lymph node metastasis, cancer stage, and patient survival. Elevated cytoplasmic IGF2BP2 expression levels are correlated with poor overall survival in OSCC patients.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Oncology
Manuel Olmos, Jacek Glajzer, Tjark-Ole Buentemeyer, Gesche Frohwitter, Jutta Ries, Markus Eckstein, Markus Hecht, Rainer Lutz, Marco Rainer Kesting, Manuel Weber
Summary: The treatment of oral cancer remains challenging, with poor prognosis in cases of early recurrence. Neoadjuvant immunotherapy may change the standard of care and improve survival rates in advanced oral cancer patients. In the presented case, neoadjuvant use of Pembrolizumab led to significant tumour regression and increased immune infiltration, indicating potential benefits for recurrent or advanced oral squamous cell carcinoma.
FRONTIERS IN ONCOLOGY
(2021)
Review
Immunology
Ana C. Madureira
Summary: This article provides an overview of PD-L1 expression in bladder-squamous-cell carcinoma and schistosomiasis, highlighting the importance of PD-L1 as a biomarker for diagnosis, disease aggressiveness, and ICB-therapy prognosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Chao Zhu, Jiang Li, Mianfeng Yao, Changyun Fang
Summary: In patients with oral squamous cell carcinoma (OSCC), activation of cGAS-STING pathway is associated with better prognosis, higher immune cell infiltration, elevated expression of immune-related genes, and enrichment of differentially expressed genes in immune-related biological pathways. These findings suggest the potential benefit of combining STING agonists and immune checkpoint inhibitors in OSCC patients.
Article
Immunology
Linlin Xiao, Chi Lin, Yueping Liu, Yajing Wu, Jun Wang
Summary: This article reports a rare case of an ESCC patient whose brain metastatic lesion completely disappeared after receiving ICIs treatment, providing supporting data for the use of ICIs as an option for treating brain metastases in ESCC patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jonas Eichberger, Silvia Spoerl, Gerrit Spanier, Ramona Erber, Juergen Taxis, Johannes Schuderer, Nils Ludwig, Mathias Fiedler, Felix Nieberle, Tobias Ettl, Carol I. Geppert, Torsten E. Reichert, Steffen Spoerl
Summary: The study indicated that high TIGIT expression correlated with improved overall survival and distant recurrence-free survival in patients with OSCC.
Article
Biotechnology & Applied Microbiology
Mengxue Zhang, Xiao Chen, He Chen, Minyue Zhou, Yaoqiang Liu, Yali Hou, Minhai Nie, Xuqian Liu
Summary: The study identified 6 potential biomarkers for the diagnosis of oral squamous cell carcinoma (OSCC) using protein microarray assay, with GDF15 as a prognostic indicator. Experimental results showed significantly higher expression levels of these proteins in cancer cells compared to normal cells, and upregulated expression in cancer tissues.
Article
Dentistry, Oral Surgery & Medicine
Yu-Yue Zhao, Jun-Xiang Lian, Zhou Lan, Ke-Long Zou, Wei-Ming Wang, Guang-Tao Yu
Summary: This study found that ferroptosis can reverse the immunosuppressive tumor microenvironment and promote anti-tumor immune response. High expression of GPX4 was associated with poor survival, while the expression of GPX4 was negatively correlated with calreticulin, a protein related to immunogenic cell death.
Article
Chemistry, Multidisciplinary
Wen Su, Wei Qiu, Shu-Jin Li, Shuo Wang, Jun Xie, Qi-Chao Yang, Jiming Xu, Junjie Zhang, Zhigang Xu, Zhi-Jun Sun
Summary: This study reports a combinational therapeutic strategy that combines tumor microenvironment-reactive oxygen species/pH dual-responsive signal transducers and activators of transcription 3 inhibitor nanoprodrugs with oncolytic herpes simplex virus 1 virotherapy to enhance immunotherapy. This strategy successfully activates robust T-cell-dependent antitumor responses, potentiating immune checkpoint blockade effects against local recurrence and pulmonary metastasis in preclinical cold murine triple-negative breast cancer and syngeneic oral cancer models.
ADVANCED MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Hao Cui, Yan You, Guo-Wang Cheng, Zhou Lan, Ke-Long Zou, Qiu-Ying Mai, Yan-Hua Han, Hao Chen, Yu-Yue Zhao, Guang-Tao Yu
Summary: Oral diseases, with their high morbidity, have caused significant physical and mental damage to people worldwide. They have become an urgent global health problem due to the increasing burden on individuals and society. The rapid advancement of advanced materials and technologies has also revolutionized the treatment methods and strategies for oral diseases. This review provides a systematic summary of the application strategies in advanced materials and technologies, based on the etiology of the diseases and a comparison of old and new materials, as well as the challenges and future directions for their development in oral disease treatment. It will serve as a guide for both fundamental research and clinical translation in oral medicine.
SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS
(2023)
Article
Engineering, Biomedical
Shu-Cheng Wan, Meng-Jie Ye, Qi-Chao Yang, Tian Zhang, Meng-Jie Zhang, Xian-Bin Ma, Ji-Ming Xu, Shuo Wang, Zhi-Zhong Wu, Lei-Lei Yang, Xue-Meng Shen, Zhigang Xu, Zhi-Jun Sun
Summary: Pyroptosis triggers antitumor immunity and this study introduces a dual-responsive diselenide-based pyroptosis inducer that has excellent tumor microenvironment targeting effects. It can remodel the immunostimulated tumor microenvironment and trigger a robust immune response. Combined with αPD-1 therapy, it effectively inhibits the growth of remote tumors and prolongs survival.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Biomedical
Yuyue Zhao, Yuanwei Pan, Kelong Zou, Zhou Lan, Guowang Cheng, Qiuying Mai, Hao Cui, Qianfang Meng, Tongkai Chen, Lang Rao, Limin Ma, Guangtao Yu
Summary: We have developed a nanoplatform capable of improving the immunosuppressive tumor microenvironment (TME) by actively targeting it. By camouflaging the surface of gold nanorods (GNRs) with myeloid-derived suppressor cells (MDSCs) membrane, we have achieved targeted adjustment of the TME. This nanoplatform also enables multimodal cancer imaging and dual immunotherapy.
BIOACTIVE MATERIALS
(2023)
Article
Oncology
Boxin Zhang, Hao Li, Yuan-Tong Liu, Dian Xiong, Lu Zhang, Zhi-Jun Sun
Summary: This study investigated the spatial architecture of immune cells in tertiary lymphoid structures (TLSs) associated with head and neck squamous cell carcinoma (HNSC). It identified chemokine receptors associated with TLSs and portrayed the cellular atlas using multiplex immunohistochemistry. The study also explored the functions and evolutionary trajectory of cells in TLSs, and proposed a method to enhance the antitumor immune response by inducing neogenesis TLSs in HNSC.
Article
Oncology
Yuan -Yuan Wang, Zhi-Zhong Wu, Cong-Fa Huang, Zhi-Jun Sun
Summary: Immunotherapy, particularly immune checkpoint blockade (ICB), has shown promise in cancer treatment but its efficacy is limited. This study focuses on understanding the alterations in the systemic immune system and immune macroenvironment and explores the role of the spleen, especially erythroid progenitor cells (EPCs), in tumor progression and immunotherapy. The findings suggest the potential for further research on EPCs and their mechanisms in tumor treatment.
Article
Immunology
Jie Liu, Wen -Ping Lin, Wen Su, Zhi-Zhong Wu, Qi-Chao Yang, Shuo Wang, Ting-Guan Sun, Cong-Fa Huang, Xiao-Long Wang, Zhi-Jun Sun
Summary: Combining EZH2 inhibitor and MDSC inhibitor can improve the response rate to immune-checkpoint-blocking therapy and reverse HNSCC-specific immunotherapeutic resistance, making it a promising strategy for overcoming resistance to ICB therapy.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
H. Li, S. -W. Zhu, J. -J. Zhou, D. -R Chen, J. Liu, Z. -Z Wu, W. -Y Wang, M. -J Zhang, Z. -J Sun
Summary: Immune checkpoint blockade therapy targeting PD-1/PD-L1 shows limited efficacy in head and neck squamous cell carcinoma (HNSCC), however, recent findings suggest that the presence of tertiary lymphoid structures (TLSs) in tumor tissue is associated with better prognosis and response to therapy. This study analyzed TCGA-HNSCC data and identified an immune classification for the tumor microenvironment (TME) of HNSCC and found that TLS enrichment was correlated with improved prognosis and response to immune checkpoint blockade treatment. Further experiments demonstrated that inducing TLS formation enhanced the response to PD-1 blockade treatment in HPV- HNSCC mouse models by increasing the presence of specific immune cells in the TME. The results suggest that inducing TLS formation could be a potential therapeutic approach for improving the response rate to immune checkpoint blockade therapy in HPV- HNSCC patients.
JOURNAL OF DENTAL RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Qiuying Mai, Yanhua Han, Guopan Cheng, Rui Ma, Zhao Yan, Xiaojia Chen, Guangtao Yu, Tongkai Chen, Shu Zhang
Summary: Around 50% of men and 15-30% of women suffer from hair-related problems, causing significant psychological burden. Traditional treatments, such as drug therapy and transplantation, face challenges like adverse effects and poor drug penetration. Therefore, efforts have been made to enhance drug permeation for hair regrowth. This review focuses on transdermal strategies involving external stimulation, regeneration, and microneedles, as well as natural products as alternative agents. It also discusses skin visualization strategies and provides information on relevant patents and clinical trials.
Article
Multidisciplinary Sciences
Qi-Chao Yang, Shuo Wang, Yuan-Tong Liu, An Song, Zhi-Zhong Wu, Shu-Cheng Wan, Hui-Min Li, Zhi-Jun Sun
Summary: PCSK9 expression is upregulated in HNSCC tissues and higher expression is associated with poorer prognosis. Inhibition of PCSK9 suppresses cancer cell stemness via LDLR-dependent mechanism. PCSK9 inhibition enhances CD8(+) T cell infiltration, reduces MDSCs, and improves the efficacy of anti-PD-1 ICB therapy in HNSCC.
Article
Otorhinolaryngology
Meng-Jie Zhang, Jie Liu, Shu-Cheng Wan, Jia-Xing Li, Shuo Wang, Nyimi Bushabu Fidele, Cong-Fa Huang, Zhi-Jun Sun
Summary: The study reveals that CSRP2 plays a crucial role in head and neck squamous cell carcinoma (HNSCC), and its overexpression is associated with poor prognosis. CSRP2 is involved in the regulation of cancer stemness and epithelial-to-mesenchymal transition (EMT) in HNSCC. This research provides a potential therapeutic target for the treatment of HNSCC.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Chemistry, Multidisciplinary
Liang Zhang, Shu-Cheng Wan, Jianyu Zhang, Meng-Jie Zhang, Qi-Chao Yang, Boxin Zhang, Wu-Yin Wang, Jianwei Sun, Ryan T. K. Kwok, Jacky W. Y. Lam, Hexiang Deng, Zhi-Jun Sun, Ben Zhong Tang
Summary: Covalent organic frameworks (COFs) have shown potential as porous materials for cancer phototherapy due to their unique characteristics. However, the aggregation-caused quenching effect and apoptosis resistance limit their effectiveness. This study demonstrated that linking AIEgens into COF networks was an effective strategy for inducing pyroptosis and enhancing antitumor immunity. The synergized system of AIE COF and αPD-1 effectively eradicated tumors and inhibited recurrence and metastasis in a tumor model.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Oncology
Zhou Lan, Ke-Long Zou, Hao Cui, Yu-Yue Zhao, Guang-Tao Yu
Summary: Porphyromonas gingivalis, an oral bacteria, can suppress the growth of oral squamous cell carcinoma by inducing cell cycle arrest, suppressing mucin and chemokine expression, and reversing the immunosuppressive tumor microenvironment.
MOLECULAR ONCOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Yuantong Liu, Shujin Li, Shuo Wang, Qichao Yang, Zhizhong Wu, Mengjie Zhang, Lei Chen, Zhijun Sun
Summary: Cancer stem cell-like cells (CSCs) play a crucial role in the heterogeneity, metastasis, and treatment resistance of head and neck squamous cell carcinoma (HNSCC). The gene LIMP-2 has been identified as a potential therapeutic target for regulating HNSCC progression and CSC properties. High expression of LIMP-2 suggests poor prognosis and potential immunotherapy resistance in HNSCC patients. Mechanistically, enhanced autophagy mediated by LIMP-2 helps HNSCC maintain stemness and facilitates the transcription of downstream target genes.
INTERNATIONAL JOURNAL OF ORAL SCIENCE
(2023)
