Regulation of MLL/COMPASS stability through its proteolytic cleavage by taspase1 as a possible approach for clinical therapy of leukemia

A cytoplasmic COMPASS is necessary for cell survival and triple-negative breast cancer pathogenesis by regulating metabolism

(2017) Lu Wang et al.   GENES & DEVELOPMENT

An Evolutionary Conserved Epigenetic Mark of Polycomb Response Elements Implemented by Trx/MLL/COMPASS

(2016) Ryan Rickels et al.   MOLECULAR CELL

Reprogramming of the Epigenome by MLL1 Links Early-Life Environmental Exposures to Prostate Cancer Risk

(2016) Quan Wang et al.   MOLECULAR ENDOCRINOLOGY

Epigenetic balance of gene expression by Polycomb and COMPASS families

(2016) Andrea Piunti et al.   SCIENCE

PAF1, a Molecular Regulator of Promoter-Proximal Pausing by RNA Polymerase II

(2015) Fei Xavier Chen et al.   CELL

Fly versus man: evolutionary impairment of nucleolar targeting affects the degradome of Drosophila’s Taspase1

(2015) Désirée Wünsch et al.   FASEB JOURNAL

Taspase1: a 'misunderstood' protease with translational cancer relevance

(2015) D Wünsch et al.   ONCOGENE

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Trimmomatic: a flexible trimmer for Illumina sequence data

(2014) Anthony M. Bolger et al.   BIOINFORMATICS

ngs.plot: Quick mining and visualization of next-generation sequencing data by integrating genomic databases

(2014) Li Shen et al.   BMC GENOMICS

CARM1 Methylates Chromatin Remodeling Factor BAF155 to Enhance Tumor Progression and Metastasis

(2014) Lu Wang et al.   CANCER CELL

Taspase1 cleaves MLL1 to activate cyclin E for HER2/neu breast tumorigenesis

(2014) Yiyu Dong et al.   CELL RESEARCH

PhosphoSitePlus, 2014: mutations, PTMs and recalibrations

(2014) Peter V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

IL-13Rα2 mediates PNR-induced migration and metastasis in ERα-negative breast cancer

(2014) Z Zhao et al.   ONCOGENE

The Mll2 branch of the COMPASS family regulates bivalent promoters in mouse embryonic stem cells

(2013) Deqing Hu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

MLL Becomes Functional through Intra-Molecular Interaction Not by Proteolytic Processing

(2013) Akihiko Yokoyama et al.   PLoS One

Systematic Analyses of the Cytotoxic Effects of Compound 11a, a Putative Synthetic Agonist of Photoreceptor-Specific Nuclear Receptor (PNR), in Cancer Cell Lines

(2013) Zibo Zhao et al.   PLoS One

Software for Computing and Annotating Genomic Ranges

(2013) Michael Lawrence et al.   PLoS Computational Biology

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

(2013) Daehwan Kim et al.   GENOME BIOLOGY

The many facets of MLL1 regulation

(2012) Pamela Zhang et al.   BIOPOLYMERS

Targeting Taspase1 for Cancer Therapy--Letter

(2012) R. H. Stauber et al.   CANCER RESEARCH

A Subset of Mixed Lineage Leukemia Proteins Has Plant Homeodomain (PHD)-mediated E3 Ligase Activity

(2012) Jingya Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The super elongation complex (SEC) family in transcriptional control

(2012) Zhuojuan Luo et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Chemico-genetic strategies to inhibit the leukemic potential of threonine aspartase-1

(2012) D Wünsch et al.   Blood Cancer Journal

ECSASB2 mediates MLL degradation during hematopoietic differentiation

(2011) J. Wang et al.   BLOOD

A Pharmacologic Inhibitor of the Protease Taspase1 Effectively Inhibits Breast and Brain Tumor Growth

(2011) D. Y. Chen et al.   CANCER RESEARCH

O-GlcNAc Transferase Catalyzes Site-Specific Proteolysis of HCF-1

(2011) Francesca Capotosti et al.   CELL

The super elongation complex (SEC) and MLL in development and disease

(2011) E. Smith et al.   GENES & DEVELOPMENT

Proteolytically cleaved MLL subunits are susceptible to distinct degradation pathways

(2011) A. Yokoyama et al.   JOURNAL OF CELL SCIENCE

Nuclear transport receptor karyopherin-α2 promotes malignant breast cancer phenotypes in vitro

(2011) E Noetzel et al.   ONCOGENE

Crosstalk between O-GlcNAcylation and proteolytic cleavage regulates the host cell factor-1 maturation pathway

(2011) S. Daou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Importin-Alpha/Nucleophosmin Switch Controls Taspase1 Protease Function

(2011) Carolin Bier et al.   TRAFFIC

BEDTools: a flexible suite of utilities for comparing genomic features

(2010) Aaron R. Quinlan et al.   BIOINFORMATICS

Epigenetic regulator MLL2 shows altered expression in cancer cell lines and tumors from human breast and colon

(2010) Thanemozhi G Natarajan et al.   Cancer Cell International

Taspase1 Functions as a Non-Oncogene Addiction Protease that Coordinates Cancer Cell Proliferation and Apoptosis

(2010) D. Y. Chen et al.   CANCER RESEARCH

Discovery and SAR of 5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic Acid (CX-4945), the First Clinical Stage Inhibitor of Protein Kinase CK2 for the Treatment of Cancer

(2010) Fabrice Pierre et al.   JOURNAL OF MEDICINAL CHEMISTRY

AFF4, a Component of the ELL/P-TEFb Elongation Complex and a Shared Subunit of MLL Chimeras, Can Link Transcription Elongation to Leukemia

(2010) Chengqi Lin et al.   MOLECULAR CELL

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Global Analysis of H3K4 Methylation Defines MLL Family Member Targets and Points to a Role for MLL1-Mediated H3K4 Methylation in the Regulation of Transcriptional Initiation by RNA Polymerase II

(2009) P. Wang et al.   MOLECULAR AND CELLULAR BIOLOGY

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

(2009) Ben Langmead et al.   GENOME BIOLOGY

Model-based Analysis of ChIP-Seq (MACS)

(2008) Yong Zhang et al.   GENOME BIOLOGY