Phosphorylation by the stress-activated MAPK Slt2 down-regulates the yeast TOR complex 2

TOR Complex 2-regulated protein kinase Ypk1 controls sterol distribution by inhibiting StARkin domain-containing proteins located at plasma membrane-endoplasmic reticulum contact sites

(2018) Françoise M. Roelants et al.   MOLECULAR BIOLOGY OF THE CELL

The Stress-Sensing TORC2 Complex Activates Yeast AGC-Family Protein Kinase Ypk1 at Multiple Novel Sites

(2017) Kristin L. Leskoske et al.   GENETICS

Ypk1/Ypk2 kinases maintain Rho1 at the plasma membrane by flippase-dependent lipid remodelling after membrane stresses

(2017) Riko Hatakeyama et al.   JOURNAL OF CELL SCIENCE

TOR Complex 2-Regulated Protein Kinase Fpk1 Stimulates Endocytosis via Inhibition of Ark1/Prk1-Related Protein Kinase Akl1 in Saccharomyces cerevisiae

(2017) Françoise M. Roelants et al.   MOLECULAR AND CELLULAR BIOLOGY

Cryo-EM structure of Saccharomyces cerevisiae target of rapamycin complex 2

(2017) Manikandan Karuppasamy et al.   Nature Communications

The Stress-Sensing TORC2 Complex Activates Yeast AGC-Family Protein Kinase Ypk1 at Multiple Novel Sites

(2017) Kristin L. Leskoske et al.   GENETICS

Sphingolipid biosynthesis upregulation by TOR complex 2-Ypk1 signaling during yeast adaptive response to acetic acid stress

(2016) J. F. Guerreiro et al.   BIOCHEMICAL JOURNAL

TORC2 Structure and Function

(2016) Christl Gaubitz et al.   TRENDS IN BIOCHEMICAL SCIENCES

mCAL: A New Approach for Versatile Multiplex Action of Cas9 Using One sgRNA and Loci Flanked by a Programmed Target Sequence

(2016) Gregory C. Finnigan et al.   G3-Genes Genomes Genetics

Yeast Proteome Dynamics from Single Cell Imaging and Automated Analysis

(2015) Yolanda T. Chong et al.   CELL

TORC2 and eisosomes are spatially interdependent, requiring optimal level of phosphatidylinositol 4, 5-bisphosphate for their integrity

(2015) Katelyn Bartlett et al.   JOURNAL OF BIOSCIENCES

Methylglyoxal Activates the Target of Rapamycin Complex 2-Protein Kinase C Signaling Pathway in Saccharomyces cerevisiae

(2015) Wataru Nomura et al.   MOLECULAR AND CELLULAR BIOLOGY

Delayed Turnover of Unphosphorylated Ssk1 during Carbon Stress Activates the Yeast Hog1 Map Kinase Pathway

(2015) Milene Carmes Vallejo et al.   PLoS One

Down-regulation of TORC2-Ypk1 signaling promotes MAPK-independent survival under hyperosmotic stress

(2015) Alexander Muir et al.   eLife

Fungal Membrane Organization: The Eisosome Concept

(2014) Lois M. Douglas et al.   Annual Review of Microbiology

Glucose Activates TORC2-Gad8 Protein via Positive Regulation of the cAMP/cAMP-dependent Protein Kinase A (PKA) Pathway and Negative Regulation of the Pmk1 Protein-Mitogen-activated Protein Kinase Pathway

(2014) Adiel Cohen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Specific  -Arrestins Negatively Regulate Saccharomyces cerevisiae Pheromone Response by Down-Modulating the G-Protein-Coupled Receptor Ste2

(2014) C. G. Alvaro et al.   MOLECULAR AND CELLULAR BIOLOGY

TOR complex 2–Ypk1 signaling regulates actin polarization via reactive oxygen species

(2014) Brad J. Niles et al.   MOLECULAR BIOLOGY OF THE CELL

TORC2-dependent protein kinase Ypk1 phosphorylates ceramide synthase to stimulate synthesis of complex sphingolipids

(2014) Alexander Muir et al.   eLife

Activation of the yeast cell wall integrity MAPK pathway by zymolyase depends on protease and glucanase activities and requires the mucin-like protein Hkr1 but not Msb2

(2013) José M. Rodríguez-Peña et al.   FEBS LETTERS

A bright monomeric green fluorescent protein derived from Branchiostoma lanceolatum

(2013) Nathan C Shaner et al.   NATURE METHODS

An expanded tool kit for the auxin-inducible degron system in budding yeast

(2013) Magdalena Morawska et al.   YEAST

Response to Hyperosmotic Stress

(2012) H. Saito et al.   GENETICS

Phosphoproteomic Analysis of Protein Kinase C Signaling inSaccharomyces cerevisiaeReveals Slt2 Mitogen-activated Protein Kinase (MAPK)-dependent Phosphorylation of Eisosome Core Components

(2012) Victoria Mascaraque et al.   MOLECULAR & CELLULAR PROTEOMICS

Sphingolipids Regulate the Yeast High-Osmolarity Glycerol Response Pathway

(2012) M. Tanigawa et al.   MOLECULAR AND CELLULAR BIOLOGY

Reciprocal Phosphorylation of Yeast Glycerol-3-Phosphate Dehydrogenases in Adaptation to Distinct Types of Stress

(2012) Y. J. Lee et al.   MOLECULAR AND CELLULAR BIOLOGY

Orm protein phosphoregulation mediates transient sphingolipid biosynthesis response to heat stress via the Pkh-Ypk and Cdc55-PP2A pathways

(2012) Yidi Sun et al.   MOLECULAR BIOLOGY OF THE CELL

Plasma membrane stress induces relocalization of Slm proteins and activation of TORC2 to promote sphingolipid synthesis

(2012) Doris Berchtold et al.   NATURE CELL BIOLOGY

Patchwork organization of the yeast plasma membrane into numerous coexisting domains

(2012) Felix Spira et al.   NATURE CELL BIOLOGY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Plasma membrane recruitment and activation of the AGC kinase Ypk1 is mediated by target of rapamycin complex 2 (TORC2) and its effector proteins Slm1 and Slm2

(2012) B. J. Niles et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Hog1 Mitogen-Activated Protein Kinase Mediates a Hypoxic Response inSaccharomyces cerevisiae

(2011) Mark J. Hickman et al.   GENETICS

Regulation of Cell Wall Biogenesis inSaccharomyces cerevisiae: The Cell Wall Integrity Signaling Pathway

(2011) David E. Levin   GENETICS

Target of Rapamycin Complex 2 Signals to Downstream Effector Yeast Protein Kinase 2 (Ypk2) through Adheres-Voraciously-to-Target-of-Rapamycin-2 Protein 1 (Avo1) inSaccharomyces cerevisiae

(2011) Hsien-Ching Liao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Requirements of Slm proteins for proper eisosome organization, endocytic trafficking and recycling in the yeast Saccharomyces cerevisiae

(2011) Chitra Kamble et al.   JOURNAL OF BIOSCIENCES

Eisosome proteins assemble into a membrane scaffold

(2011) Lena Karotki et al.   JOURNAL OF CELL BIOLOGY

Reassessment of the role of plasma membrane domains in the regulation of vesicular traffic in yeast

(2011) T. Brach et al.   JOURNAL OF CELL SCIENCE

The eisosome core is composed of BAR domain proteins

(2011) Agustina Olivera-Couto et al.   MOLECULAR BIOLOGY OF THE CELL

Protein kinase Ypk1 phosphorylates regulatory proteins Orm1 and Orm2 to control sphingolipid homeostasis in Saccharomyces cerevisiae

(2011) F. M. Roelants et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rho GTPases: regulation of cell polarity and growth in yeasts

(2010) Pilar Perez et al.   BIOCHEMICAL JOURNAL

A systematic screen for protein–lipid interactions in Saccharomyces cerevisiae

(2010) Oriol Gallego et al.   Molecular Systems Biology

The Genetic Landscape of a Cell

(2010) M. Costanzo et al.   SCIENCE

Deciphering Protein Kinase Specificity Through Large-Scale Analysis of Yeast Phosphorylation Site Motifs

(2010) J. Mok et al.   Science Signaling

Our Paths Might Cross: the Role of the Fungal Cell Wall Integrity Pathway in Stress Response and Cross Talk with Other Stress Response Pathways

(2009) Beth Burgwyn Fuchs et al.   EUKARYOTIC CELL

The High Osmotic Response and Cell Wall Integrity Pathways Cooperate to Regulate Transcriptional Responses to Zymolyase-induced Cell Wall Stress inSaccharomyces cerevisiae

(2009) Raúl García et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Furrow-like invaginations of the yeast plasma membrane correspond to membrane compartment of Can1

(2009) V. Stradalova et al.   JOURNAL OF CELL SCIENCE

TORC2 Plasma Membrane Localization Is Essential for Cell Viability and Restricted to a Distinct Domain

(2009) Doris Berchtold et al.   MOLECULAR BIOLOGY OF THE CELL

Separation and detection of large phosphoproteins using Phos-tag SDS-PAGE

(2009) Eiji Kinoshita et al.   Nature Protocols