Article
Gastroenterology & Hepatology
Vu Q. Nguyen, Fabiano Celio, Maithili Chitnavis, Mohammad Shakhatreh, Jeffry Katz, Fabio Cominelli, Amitabh Chak, Paul Yeaton
Summary: This study examined the role of EUS in distinguishing between Crohn's disease and ulcerative colitis, finding that it can be used to diagnose active and inactive disease by measuring colon wall layer thickness and assessing transmural disease activity.
GASTROINTESTINAL ENDOSCOPY
(2023)
Article
Gastroenterology & Hepatology
Heming Yao, Kayvan Najarian, Jonathan Gryak, Shrinivas Bishu, Michael D. Rice, Akbar K. Waljee, H. Jeffrey Wilkins, Ryan W. Stidham
Summary: This study aimed to pilot a fully automated video analysis system for grading endoscopic disease in ulcerative colitis (UC). The results showed promising performance in predicting disease severity in high-resolution videos and clinical trial videos, supporting the potential for artificial intelligence to provide accurate endoscopic disease grading in UC.
GASTROINTESTINAL ENDOSCOPY
(2021)
Review
Gastroenterology & Hepatology
Akshita Gupta, Amy Yu, Laurent Peyrin-Biroulet, Ashwin N. Ananthakrishnan
Summary: In patients with UC in endoscopic remission, persistent histologic activity is associated with higher rates of relapse. Greater degree of normalization may have a stronger impact. Individual histologic features such as basal plasmacytosis, neutrophilic infiltrations, mucin depletion, and crypt architectural irregularities predicted relapse.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Adam E. Mikolajczyk, Nathaniel A. Cohen, Sydeaka Watson, Max Ackerman, Sarah R. Goeppinger, John Hart, Jerrold R. Turner, David T. Rubin
Summary: The study found minimal variability in the degree of inflammation among biopsy fragments within and among different colorectal segments in UC patients, indicating that even a single biopsy could effectively represent the inflammation status of the entire colorectum. These findings have important implications for using histology as a clinical target and trial endpoint in UC.
INFLAMMATORY BOWEL DISEASES
(2023)
Review
Immunology
John P. Thomas, Dezso Modos, Simon M. Rushbrook, Nick Powell, Tamas Korcsmaros
Summary: This review examines the interaction between bile acid metabolites and intestinal inflammation in inflammatory bowel disease (IBD), highlighting their role in regulation of the inflammatory milieu through pathways such as autophagy, apoptosis, and the inflammasome pathway. The study also discusses the potential of novel experimental and bioinformatics approaches to further advance our understanding of the role of bile acids in IBD and inform therapeutic strategies.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Gastroenterology & Hepatology
Hesam Ahmadi Nooredinvand, Andrew Poullis
Summary: Colonoscopy is the gold standard for diagnosing IBD and CRC, but it is invasive and carries risk. Non-invasive methods are limited, and research suggests that non-invasively obtained colorectal mucus may serve as a screening and diagnostic tool for IBD and CRC.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Gastroenterology & Hepatology
Ondrej Fabian, Lukas Bajer
Summary: Advances in diagnostics and treatment strategies for inflammatory bowel diseases have led to the establishment of new therapeutic goals. Achieving endoscopic remission is desired, but a significant proportion of patients in remission still show microscopic disease activity. Histological evaluation has shown better predictive value for clinical complications, but validated scoring indices are currently lacking.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Alina Ecaterina Jucan, Otilia Gavrilescu, Mihaela Dranga, Iolanda Valentina Popa, Ioana-Ruxandra Mihai, Vasile-Claudiu Mihai, Gabriela Stefanescu, Vasile Liviu Drug, Cristina Cijevschi Prelipcean, Radu-Alexandru Vulpoi, Oana-Bogdana Barboi, Irina Ciortescu, Catalina Mihai, Dingpei Long
Summary: Inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis, is a chronic intestinal disorder. Histological healing, in addition to clinical and endoscopic healing, is proposed as an important endpoint to assess disease activity and remission in IBD patients. New advanced techniques have the potential to revolutionize the field of IBD by improving the assessment and characterization of the disease, ultimately leading to better patient care.
Article
Nutrition & Dietetics
Marco Valvano, Marco Magistroni, Antonio Mancusi, Debora D'Ascenzo, Salvatore Longo, Gianpiero Stefanelli, Filippo Vernia, Angelo Viscido, Stefano Necozione, Giovanni Latella
Summary: This study suggests that blood vitamin D levels may be associated with disease activity and treatment response in patients with inflammatory bowel disease. Low vitamin D levels were significantly related to clinical, endoscopic, and histological activity in patients, potentially influencing the efficacy of biologic drugs.
Article
Gastroenterology & Hepatology
Vera E. R. Asscher, Sanne N. Waars, Andrea E. Van Der Meulen-de Jong, Rogier J. L. Stuyt, A. Martine C. Baven-Pronk, Sander van Der Marel, Rutger J. Jacobs, Jeoffrey J. L. Haans, Lennart J. Meijer, Jacqueline D. Klijnsma-Slagboom, Marijn H. Duin, Milou E. R. Peters, Felicia V. Y. L. Lee-Kong, Nanda E. Provoost, Femke Tijdeman, Kenan T. van Dijk, Monse W. M. Wieland, Mirre G. M. Verstegen, Melissa E. van Der Meijs, Annemijn D. Maan, Floor J. van Deudekom, Simon P. Mooijaart, P. W. Jeroen Maljaars
Summary: This study aimed to assess geriatric characteristics in older patients with inflammatory bowel disease (IBD) and evaluate the impact of these characteristics on disease burden. The results showed that deficits in geriatric assessment were prevalent in older patients with IBD, and clinical and biochemical disease activity were associated with these deficits. Additionally, deficits in geriatric assessment were found to be independently associated with lower health-related quality of life.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Monica State, Paul Balanescu, Theodor Voiosu, Andreea Bengus, Andrei Voiosu, Andrei Coman, Petronel Mustatea, Lucian Negreanu, Radu Bogdan Mateescu, Cristiana Popp
Summary: This study investigated mucosal and histologic remission rates and potential predictors of these outcomes in UC patients. The results showed that mucosal healing and histologic remission rates are low in real-life settings. It was also found that a good quality of life and normal inflammatory markers are associated with mucosal and histologic healing.
Review
Biochemistry & Molecular Biology
Maximos Frountzas, Eva Karanikki, Orsalia Toutouza, Demosthenis Sotirakis, Dimitrios Schizas, Panagiotis Theofilis, Dimitris Tousoulis, Konstantinos G. Toutouzas
Summary: Cyanidin-3-O-glucoside (C3G) is a widely distributed anthocyanin in edible fruits, and it has been shown to have anti-inflammatory, neuro-protective, antimicrobial, anti-viral, anti-thrombotic, and epigenetic activities. However, the intake of C3G varies among different populations and individuals. C3G has been suggested to have potential therapeutic effects on inflammatory bowel diseases (IBD) as it can inhibit inflammatory pathways, modulate antioxidant enzymes, and reduce pro-inflammatory cytokines. Moreover, C3G can also modulate gut microbiota and mitigate dysbiosis, which is important in IBD management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Gastroenterology & Hepatology
Partha Pal, Mohan Ramchandani, Rajendra Patel, Rupa Banerjee, Swathi Kanaganti, Rajesh Gupta, Manu Tandan, Duvvuru Nageshwar Reddy
Summary: Confocal laser endomicroscopy (CLE) and endocytoscopy (EC) are ultra-high definition imaging modalities that enable real-time histological assessment. Their role in current clinical decision making in inflammatory bowel disease management is not well defined.
DIGESTIVE ENDOSCOPY
(2023)
Review
Gastroenterology & Hepatology
Reena Khanna, Christopher Ma, Vipul Jairath, Niels Vande Casteele, Guangyong Zou, Brian G. Feagan
Summary: Poor correlation between symptoms and active luminal inflammation has been established in patients with Crohn's disease and ulcerative colitis, leading to the use of endoscopic assessment. However, the current endoscopic indices used for evaluation are not completely validated and have limitations for clinical use.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Medicine, General & Internal
Malgorzata Godala, Ewelina Gaszynska, Konrad Walczak, Ewa Malecka-Wojciesko
Summary: This study assessed the usefulness of serum IL-6, IL-1 beta, and IL-10 in determining the activity and nutritional status in patients with inflammatory bowel diseases (IBD). The results showed that IL-6 and IL-1 beta may provide additional information about the nutritional status of IBD patients, while IL-10 can be considered as a non-invasive biomarker of IBD activity.
JOURNAL OF CLINICAL MEDICINE
(2023)
Letter
Gastroenterology & Hepatology
Rish K. Pai, Reena Khanna, Geert R. D'Haens, William J. Sandborn, Jenny Jeyarajah, Brian G. Feagan, Niels Vande Casteele, Vipul Jairath
Article
Gastroenterology & Hepatology
Robert Battat, Parambir S. Dulai, Niels Vande Casteele, Elisabeth Evans, Kelly D. Hester, Edvelyn Webster, Anjali Jain, James A. Proudfoot, Ara Mairalles, Jennifer Neill, Siddharth Singh, John T. Chang, Jesus Rivera-Nieves, William J. Sandborn, Brigid S. Boland
INFLAMMATORY BOWEL DISEASES
(2019)
Review
Biotechnology & Applied Microbiology
Robert Battat, Parambir S. Dulai, Vipul Jairath, Niels Vande Casteele
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2019)
Review
Gastroenterology & Hepatology
Christopher Ma, Jeffrey K. Lee, Anish R. Mitra, Anouar Teriaky, Daksh Choudhary, Tran M. Nguyen, Niels Vande Casteele, Reena Khanna, Remo Panaccione, Brian G. Feagan, Vipul Jairath
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2019)
Review
Gastroenterology & Hepatology
Parambir S. Dulai, Siddharth Singh, Niels Vande Casteele, Brigid S. Boland, Jesus Rivera-Nieves, Peter B. Ernst, Lars Eckmann, Kim E. Barrett, John T. Chang, William J. Sandborn
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2019)
Editorial Material
Gastroenterology & Hepatology
Niels Vande Casteele, Vipul Jairath
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2019)
Article
Gastroenterology & Hepatology
Marjolijn Duijvestein, Jenny Jeyarajah, Leonardo Guizzetti, Guangyong Zou, Claire E. Parker, Tanja Van Viegen, Niels VandeCasteele, Reena Khanna, Annegret Van Der Aa, William J. Sandborn, Brian G. Feagan, Geert R. D'Haens, Vipul Jairath
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2020)
Article
Gastroenterology & Hepatology
Parambir S. Dulai, Siddharth Singh, Vipul Jairath, Christopher Ma, Neeraj Narula, Niels Vande Casteele, Laurent Peyrin-Biroulet, Severine Vermeire, Geert D'Haens, Brian G. Feagan, William J. Sandborn
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2020)
Article
Gastroenterology & Hepatology
Parambir S. Dulai, Siddharth Singh, Niels Vande Casteele, Joseph Meserve, Adam Winters, Shreya Chablaney, Satimai Aniwan, Preeti Shashi, Gursimran Kochhar, Aaron Weiss, Jenna L. Koliani-Pace, Youran Gao, Brigid S. Boland, John T. Chang, David Faleck, Robert Hirten, Ryan Ungaro, Dana Lukin, Keith Sultan, David Hudesman, Shannon Chang, Matthew Bohm, Sashidhar Varma, Monika Fischer, Eugenia Shmidt, Arun Swaminath, Nitin Gupta, Maria Rosario, Vipul Jairath, Leonardo Guizzetti, Brian G. Feagan, Corey A. Siegel, Bo Shen, Sunanda Kane, Edward V. Loftus, William J. Sandborn, Bruce E. Sands, Jean-Frederic Colombel, Karen Lasch, Charlie Cao
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2020)
Article
Gastroenterology & Hepatology
Edward Yang, Nicola Panaccione, Natalie Whitmire, Parambir S. Dulai, Niels Vande Casteele, Siddharth Singh, Brigid S. Boland, Angelina Collins, William J. Sandborn, Remo Panaccione, Robert Battat
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2020)
Letter
Gastroenterology & Hepatology
Konstantinos Papamichael, William T. Clarke, Niels Vande Casteele, Katharine A. Germansky, Joseph D. Feuerstein, Gil Y. Melmed, Corey A. Siegel, Peter M. Irving, Adam S. Cheifetz
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Niels Vande Casteele, Vipul Jairath, Jenny Jeyarajah, Parambir S. Dulai, Siddharth Singh, Lisa M. Shackelton, Brian G. Feagan, William J. Sandborn
Summary: This study analyzed data from UC patients treated with infliximab, identifying factors such as high baseline infliximab clearance, stool frequency, and rectal bleeding scores negatively influencing endoscopic healing. A clinical decision support tool (CDST) was developed to assist in therapy decision making and precision medicine applications.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Pavine L. C. Lefevre, Niels Vande Casteele
JOURNAL OF CROHNS & COLITIS
(2020)
Review
Gastroenterology & Hepatology
Azucena Salas, Cristian Hernandez-Rocha, Marjolijn Duijvestein, William Faubion, Dermot McGovern, Severine Vermeire, Stefania Vetrano, Niels Vande Casteele
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2020)
Meeting Abstract
Gastroenterology & Hepatology
Edward Yang, Nicola Panaccione, Natalie Whitmire, Parambir Dulai, Niels Vande Casteele, Siddharth Singh, Brigid Boland, Angelina Collins, William J. Sandborn, Remo Panaccione, Robert Battat